NO985039L - Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler - Google Patents

Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Info

Publication number: NO985039L
Authority: NO; Norway
Prior art keywords: alkyl; hydrogen; independently; nr8r1; trifluoromethyl
Prior art date: 1996-04-30

Application number

NO985039A

Other languages

English (en)

Norwegian (no)

Other versions

NO985039D0 (no

Inventor

Steven Jeffrey Busch

Kim Seng Chen

Michael Louis Edwards

Jr James Edward Matt

Roger Alan Parker

Mark Joseph Vaal

Paul Steven Wright

Mark Thirston Yates

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-30

Filing date

1998-10-29

Publication date

1998-12-21

1998-10-29 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-10-29 Publication of NO985039D0 publication Critical patent/NO985039D0/no

1998-12-21 Publication of NO985039L publication Critical patent/NO985039L/no

Links

230000000879 anti-atherosclerotic effect Effects 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 1
102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 abstract 1
108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000006866 deterioration Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
-1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
239000011368 organic material Substances 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
238000005502 peroxidation Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO985039A 1996-04-30 1998-10-29 Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler NO985039L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/637,968 US5608095A (en)	1996-04-30	1996-04-30	Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PCT/US1997/003335 WO1997041129A1 (en)	1996-04-30	1997-03-03	Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (2)

Publication Number	Publication Date
NO985039D0 NO985039D0 (no)	1998-10-29
NO985039L true NO985039L (no)	1998-12-21

Family

ID=24558107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO985039A NO985039L (no)	1996-04-30	1998-10-29	Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Country Status (19)

Country	Link
US (1)	US5608095A (de)
EP (1)	EP0900225B1 (de)
JP (1)	JP4309473B2 (de)
KR (1)	KR100503181B1 (de)
CN (1)	CN1216993A (de)
AR (1)	AR006890A1 (de)
AT (1)	ATE212639T1 (de)
AU (1)	AU711322B2 (de)
BR (1)	BR9709190A (de)
CA (1)	CA2251991C (de)
DE (1)	DE69710191T2 (de)
DK (1)	DK0900225T3 (de)
ES (1)	ES2167716T3 (de)
IL (1)	IL126758A0 (de)
NO (1)	NO985039L (de)
PT (1)	PT900225E (de)
TW (1)	TW474940B (de)
WO (1)	WO1997041129A1 (de)
ZA (1)	ZA973503B (de)

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JP2002506443A (ja) *	1997-06-25	2002-02-26	アベンティス・ファーマスーティカルズ・インコーポレイテッド	２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
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CN1332849A (zh) *	1998-11-09	2002-01-23	埃瑟若詹尼克斯公司	降低血浆胆固醇水平的方法和组合物
US6020383A (en) *	1999-01-11	2000-02-01	Eastman Chemicals Company	Method for reducing blood cholesterol and/or blood triglycerides
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US20030153536A1 (en) *	2001-10-25	2003-08-14	Mitchell Glass	Compounds and methods of treating transplant rejection
AU2002352826B2 (en) *	2001-11-09	2009-05-28	Atherogenics, Inc.	Methods of reversing and preventing cardiovascular pathologies
CN1596240A (zh) *	2001-12-19	2005-03-16	阿特罗吉尼克斯公司	查耳酮衍生物及其治疗疾病的用途
US6960683B2 (en) *	2002-07-12	2005-11-01	Atherogenics, Inc.	Salt forms of poorly soluble probucol esters and ethers
AU2003266165A1 (en) *	2002-09-13	2004-04-30	Hossein Dovlatabadi	Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
US20040181075A1 (en) *	2002-12-19	2004-09-16	Weingarten M. David	Process of making chalcone derivatives
WO2004062622A2 (en) *	2003-01-13	2004-07-29	Atherogenics, Inc.	Process of preparing esters and ethers of probucol and derivatives thereof
WO2004108094A2 (en) *	2003-06-06	2004-12-16	Atherogenics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) *	2003-10-17	2005-05-06	Amylin Pharmaceuticals, Inc.	Silyl phenols for promoting vascular health
WO2005112914A2 (en)	2004-04-20	2005-12-01	Atherogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7294737B2 (en)	2004-04-20	2007-11-13	Atherogenics, Inc.	Process of preparing esters and ethers of probucol and derivatives thereof
US20060063828A1 (en) *	2004-06-28	2006-03-23	Weingarten M D	1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
JP2008505097A (ja) *	2004-07-01	2008-02-21	アセロジエニクス・インコーポレイテツド	糖尿病性血管疾患を治療するための化合物および方法
WO2008118948A1 (en) *	2007-03-26	2008-10-02	Atherogenics, Inc.	Methods and compositions of derivatives of probucol for the treatment of diabetes
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1996
- 1996-04-30 US US08/637,968 patent/US5608095A/en not_active Expired - Fee Related
1997
- 1997-03-03 BR BR9709190A patent/BR9709190A/pt active Search and Examination
- 1997-03-03 AT AT97907998T patent/ATE212639T1/de not_active IP Right Cessation
- 1997-03-03 JP JP53886297A patent/JP4309473B2/ja not_active Expired - Fee Related
- 1997-03-03 WO PCT/US1997/003335 patent/WO1997041129A1/en not_active Ceased
- 1997-03-03 IL IL12675897A patent/IL126758A0/xx unknown
- 1997-03-03 ES ES97907998T patent/ES2167716T3/es not_active Expired - Lifetime
- 1997-03-03 KR KR1019980708692A patent/KR100503181B1/ko not_active Expired - Fee Related
- 1997-03-03 DK DK97907998T patent/DK0900225T3/da active
- 1997-03-03 CN CN97194267A patent/CN1216993A/zh active Pending
- 1997-03-03 AU AU19854/97A patent/AU711322B2/en not_active Ceased
- 1997-03-03 CA CA002251991A patent/CA2251991C/en not_active Expired - Fee Related
- 1997-03-03 DE DE69710191T patent/DE69710191T2/de not_active Expired - Fee Related
- 1997-03-03 EP EP97907998A patent/EP0900225B1/de not_active Expired - Lifetime
- 1997-03-03 PT PT97907998T patent/PT900225E/pt unknown
- 1997-04-23 ZA ZA9703503A patent/ZA973503B/xx unknown
- 1997-04-23 TW TW086105269A patent/TW474940B/zh active
- 1997-04-29 AR ARP970101749A patent/AR006890A1/es unknown
1998
- 1998-10-29 NO NO985039A patent/NO985039L/no unknown

Also Published As

Publication number	Publication date
CA2251991C (en)	2002-05-14
EP0900225B1 (de)	2002-01-30
NO985039D0 (no)	1998-10-29
CN1216993A (zh)	1999-05-19
JP4309473B2 (ja)	2009-08-05
DE69710191D1 (de)	2002-03-14
TW474940B (en)	2002-02-01
CA2251991A1 (en)	1997-11-06
AU711322B2 (en)	1999-10-14
AU1985497A (en)	1997-11-19
AR006890A1 (es)	1999-09-29
US5608095A (en)	1997-03-04
PT900225E (pt)	2002-06-28
WO1997041129A1 (en)	1997-11-06
DK0900225T3 (da)	2002-05-13
JP2001509782A (ja)	2001-07-24
DE69710191T2 (de)	2002-07-25
KR100503181B1 (ko)	2006-03-03
IL126758A0 (en)	1999-08-17
ZA973503B (en)	1997-10-30
EP0900225A1 (de)	1999-03-10
BR9709190A (pt)	1999-08-10
ATE212639T1 (de)	2002-02-15
ES2167716T3 (es)	2002-05-16
KR20000065101A (ko)	2000-11-06

Publication	Publication Date	Title
NO985039L (no)	1998-12-21	Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler
DK1076663T3 (da)	2004-06-01	Funktionaliserede alkyl- og alkenylsidekædederivater af glycinamider som farnesyltransferaseinhibitorer
PT1244451E (pt)	2006-10-31	Bloqueadores piperazina e piperidina substituidas do canal de calcio
NO993868L (no)	1999-10-12	3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme
DE69923849D1 (de)	2005-03-31	Quinolin-2-on-derivate verwendbar als antikrebsmittel
NO20024217L (no)	2002-10-09	1,5-benzotiazepiner og deres anvendelse som hypolidmidler
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