NO986017L - N-[4-(Heteroarylmetyl)fenyl]-Heteroarylaminer - Google Patents

N-[4-(Heteroarylmetyl)fenyl]-Heteroarylaminer

Info

Publication number
NO986017L
NO986017L NO986017A NO986017A NO986017L NO 986017 L NO986017 L NO 986017L NO 986017 A NO986017 A NO 986017A NO 986017 A NO986017 A NO 986017A NO 986017 L NO986017 L NO 986017L
Authority
NO
Norway
Prior art keywords
heteroarylaminer
heteroarylmethyl
phenyl
Prior art date
Application number
NO986017A
Other languages
English (en)
Other versions
NO986017D0 (no
NO312102B1 (no
Inventor
Marc Gaston Venet
Dominique Jean-Pierre Mabire
Jean Fernand Armand Lacrampe
Gurard Charles Sanz
Original Assignee
Janssen Pharmaceutia Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutia Nv filed Critical Janssen Pharmaceutia Nv
Publication of NO986017D0 publication Critical patent/NO986017D0/no
Publication of NO986017L publication Critical patent/NO986017L/no
Publication of NO312102B1 publication Critical patent/NO312102B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19986017A 1996-06-27 1998-12-21 N-[4-(Heteroarylmetyl)fenyl]-Heteroarylaminer NO312102B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201781 1996-06-27
PCT/EP1997/003248 WO1997049704A1 (en) 1996-06-27 1997-06-19 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

Publications (3)

Publication Number Publication Date
NO986017D0 NO986017D0 (no) 1998-12-21
NO986017L true NO986017L (no) 1999-02-19
NO312102B1 NO312102B1 (no) 2002-03-18

Family

ID=8224119

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19986017A NO312102B1 (no) 1996-06-27 1998-12-21 N-[4-(Heteroarylmetyl)fenyl]-Heteroarylaminer

Country Status (32)

Country Link
US (5) US6124330A (no)
EP (1) EP0907650B1 (no)
JP (1) JP3404749B2 (no)
KR (1) KR100365312B1 (no)
CN (1) CN1102593C (no)
AR (1) AR007626A1 (no)
AT (1) ATE229019T1 (no)
AU (1) AU711575B2 (no)
BG (1) BG63545B1 (no)
BR (1) BR9710002A (no)
CA (1) CA2258165C (no)
CZ (1) CZ297769B6 (no)
DE (1) DE69717627T2 (no)
DK (1) DK0907650T3 (no)
EE (1) EE03688B1 (no)
ES (1) ES2188957T3 (no)
HU (1) HU223093B1 (no)
ID (1) ID17275A (no)
IL (1) IL127740A (no)
MY (1) MY116917A (no)
NO (1) NO312102B1 (no)
NZ (1) NZ333382A (no)
PL (1) PL201704B1 (no)
PT (1) PT907650E (no)
RU (1) RU2190611C2 (no)
SI (1) SI0907650T1 (no)
SK (1) SK282769B6 (no)
TR (1) TR199802709T2 (no)
TW (1) TW490464B (no)
UA (1) UA53649C2 (no)
WO (1) WO1997049704A1 (no)
ZA (1) ZA975698B (no)

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AU2160899A (en) 1997-12-11 1999-06-28 Janssen Pharmaceutica N.V. Retinoic acid mimetic anilides
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
DE19951701A1 (de) 1999-10-27 2001-05-03 Aventis Pharma Gmbh Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten
WO2003088847A1 (en) * 2002-04-17 2003-10-30 Tyco Healthcare Group Lp Method and apparatus for anastomosis including an expandable anchor
JP2006507299A (ja) 2002-10-30 2006-03-02 メルク　エンド　カムパニー　インコーポレーテッド Ａｋｔ活性の阻害薬
EP1620095A4 (en) 2003-04-24 2009-04-01 Merck & Co Inc HEMMER OF ACT ACTIVITY
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
NZ544472A (en) 2003-07-03 2009-04-30 Myriad Genetics Inc Compounds and therapeutical use thereof
DE10337942A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Aminobenzimidazolderivate
NZ553341A (en) 2004-09-24 2010-11-26 Allergan Inc 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
NZ553290A (en) * 2004-09-24 2010-11-26 Allergan Inc 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
WO2006036507A1 (en) 2004-09-24 2006-04-06 Allergan, Inc. 4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
BRPI0516217A (pt) * 2004-09-28 2008-08-26 Allergan Inc compostos de 4-benzil-1,3-diidro-imidazol-2-tionas não-substituìdos e substituìdos que atuam como agonistas especìficos ou seletivos alfa2-adrenérgicos e métodos de utilização dos mesmos
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
MX2008009215A (es) * 2006-01-17 2008-12-10 Barrier Therapeutics Inc Tratamiento de trastornos inflamatorios con compuestos de triazol.
EP2114895A4 (en) 2006-10-17 2011-06-22 Stiefel Laboratories TALARAZOLMETABOLITEN
PT2201006E (pt) * 2007-10-18 2011-05-05 Domp S P A Derivados de (r)-4-(heteroaril)-feniletilo e composi??es farmac?uticas que os cont?m
GB0811091D0 (en) * 2008-06-17 2008-07-23 Cancer Rec Tech Ltd CYP26 Inhibitors
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
CN102985420B (zh) 2010-06-01 2017-07-04 安吉翁生物医药有限公司 细胞色素p450抑制剂及其用途
KR101108577B1 (ko) * 2010-07-28 2012-01-30 국제엘렉트릭코리아 주식회사 테이프 히터
KR20180099933A (ko) 2010-11-19 2018-09-05 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
WO2013028771A1 (en) 2011-08-23 2013-02-28 Leong Hwei Xian Reversing intestinal inflammation by inhibiting retinoic acid metabolism
CA2957785C (en) 2014-08-11 2023-01-03 Angion Biomedica Corporation Cytochrome p450 inhibitors and uses thereof
JP2018501279A (ja) 2014-12-31 2018-01-18 アンギオン バイオメディカ コーポレイション 疾患を治療するための方法及び薬剤
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
CN106588780A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的制备工艺
CN106588779A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种合成盐酸右美托咪定中间体的方法
CN106632051A (zh) * 2016-12-15 2017-05-10 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的合成方法
KR20210055340A (ko) 2019-11-07 2021-05-17 정화종 화물 커버
CN115462347B (zh) * 2021-08-13 2024-07-16 广州市妇女儿童医疗中心 视黄酸代谢通路在先天性巨结肠疾病中的应用

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NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
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TW282469B (no) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
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BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
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WO1997049704A1 (en) * 1996-06-27 1997-12-31 Janssen Pharmaceutica N.V. N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

Also Published As

Publication number Publication date
CA2258165C (en) 2009-03-03
AR007626A1 (es) 1999-11-10
WO1997049704A1 (en) 1997-12-31
US6124330A (en) 2000-09-26
TR199802709T2 (xx) 1999-02-22
US7378433B2 (en) 2008-05-27
UA53649C2 (uk) 2003-02-17
CN1223654A (zh) 1999-07-21
SK282769B6 (sk) 2002-12-03
HUP9902138A2 (hu) 1999-10-28
SI0907650T1 (en) 2003-06-30
BG103013A (en) 1999-09-30
US6486187B1 (en) 2002-11-26
NO986017D0 (no) 1998-12-21
ATE229019T1 (de) 2002-12-15
AU711575B2 (en) 1999-10-14
IL127740A0 (en) 1999-10-28
US20030176419A1 (en) 2003-09-18
MY116917A (en) 2004-04-30
KR20000016196A (ko) 2000-03-25
EP0907650B1 (en) 2002-12-04
US7205312B2 (en) 2007-04-17
HK1018458A1 (en) 1999-12-24
JP3404749B2 (ja) 2003-05-12
ID17275A (id) 1997-12-18
CZ297769B6 (cs) 2007-03-28
TW490464B (en) 2002-06-11
PT907650E (pt) 2003-04-30
CZ423198A3 (cs) 1999-05-12
DE69717627D1 (de) 2003-01-16
DE69717627T2 (de) 2003-09-18
US20050113378A1 (en) 2005-05-26
CA2258165A1 (en) 1997-12-31
CN1102593C (zh) 2003-03-05
HU223093B1 (hu) 2004-03-29
IL127740A (en) 2001-09-13
PL201704B1 (pl) 2009-04-30
ZA975698B (en) 1999-01-20
KR100365312B1 (ko) 2003-03-06
SK178198A3 (en) 2000-05-16
BG63545B1 (bg) 2002-04-30
EP0907650A1 (en) 1999-04-14
PL330816A1 (en) 1999-06-07
EE9800437A (et) 1999-06-15
RU2190611C2 (ru) 2002-10-10
JP2000503670A (ja) 2000-03-28
BR9710002A (pt) 1999-08-10
DK0907650T3 (da) 2003-03-10
US20070088062A1 (en) 2007-04-19
EE03688B1 (et) 2002-04-15
US6833375B2 (en) 2004-12-21
NZ333382A (en) 2000-05-26
AU3435697A (en) 1998-01-14
ES2188957T3 (es) 2003-07-01
HUP9902138A3 (en) 2001-10-29
NO312102B1 (no) 2002-03-18

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