NO990793L - 7 <alfa> - (<Epsilon> -aminoalkyl) - ° stratrienes, processes for their preparation, pharmaceuticals containing them, and their use in the manufacture of pharmaceuticals - Google Patents

7 <alfa> - (<Epsilon> -aminoalkyl) - ° stratrienes, processes for their preparation, pharmaceuticals containing them, and their use in the manufacture of pharmaceuticals

Info

Publication number
NO990793L
NO990793L NO990793A NO990793A NO990793L NO 990793 L NO990793 L NO 990793L NO 990793 A NO990793 A NO 990793A NO 990793 A NO990793 A NO 990793A NO 990793 L NO990793 L NO 990793L
Authority
NO
Norway
Prior art keywords
pharmaceuticals
stratrienes
alfa
epsilon
aminoalkyl
Prior art date
Application number
NO990793A
Other languages
Norwegian (no)
Other versions
NO990793D0 (en
NO315655B1 (en
Inventor
Rolf Bohlmann
Dieter Bittler
Josef Heindi
Nikolaus Heinrich
Helmut Hofmeister
Hermann Kuenzer
Gerhard Sauer
Christa Hegele-Hartung
Rosemarie Lichtner
Yukishige Nishino
Karsten Parczyk
Martin Schneider
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO990793D0 publication Critical patent/NO990793D0/en
Publication of NO990793L publication Critical patent/NO990793L/en
Publication of NO315655B1 publication Critical patent/NO315655B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19990793A 1996-08-20 1999-02-19 7 <alfa> - (<Epsilon> -aminoalkyl) -ostratrienes, pharmaceutical preparations containing them, and their use in the manufacture of pharmaceuticals NO315655B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635525A DE19635525A1 (en) 1996-08-20 1996-08-20 New 7-alpha-(xi-aminoalkyl)- oestratriene derivatives
PCT/EP1997/004517 WO1998007740A1 (en) 1996-08-20 1997-08-20 7α-(κ-AMINOALKYL)ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7α-(κ-AMINOALKYL)ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS

Publications (3)

Publication Number Publication Date
NO990793D0 NO990793D0 (en) 1999-02-19
NO990793L true NO990793L (en) 1999-04-20
NO315655B1 NO315655B1 (en) 2003-10-06

Family

ID=7804367

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990793A NO315655B1 (en) 1996-08-20 1999-02-19 7 <alfa> - (<Epsilon> -aminoalkyl) -ostratrienes, pharmaceutical preparations containing them, and their use in the manufacture of pharmaceuticals

Country Status (29)

Country Link
EP (1) EP0920441B1 (en)
JP (1) JP2001503024A (en)
KR (1) KR20000068261A (en)
CN (1) CN1231670A (en)
AR (1) AR009278A1 (en)
AT (1) ATE231882T1 (en)
AU (1) AU728843B2 (en)
BG (1) BG62972B1 (en)
BR (1) BR9711328A (en)
CA (1) CA2263708A1 (en)
CZ (1) CZ57999A3 (en)
DE (2) DE19635525A1 (en)
DK (1) DK0920441T3 (en)
EA (1) EA001577B1 (en)
EE (1) EE04021B1 (en)
ES (1) ES2191857T3 (en)
HU (1) HUP9903106A3 (en)
IL (1) IL128601A (en)
IS (1) IS4976A (en)
NO (1) NO315655B1 (en)
NZ (1) NZ334277A (en)
PL (1) PL186309B1 (en)
PT (1) PT920441E (en)
SK (1) SK18899A3 (en)
TR (1) TR199900432T2 (en)
TW (1) TW552267B (en)
UA (1) UA50792C2 (en)
WO (1) WO1998007740A1 (en)
ZA (1) ZA977482B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR015500A1 (en) * 1997-12-23 2001-05-02 Schering Ag 11 BETA-HALOGEN-STRATRIENS REPLACED IN 7 ALPHA, PROCEDURE FOR PREPARING PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH 11 BETA-HALOGEN-STRATRIENS REPLACED IN 7 ALPHA, AS WELL AS USED IN THE PREPARATION OF MEDICINES.
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6054446A (en) 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19807791A1 (en) 1998-02-19 1999-08-26 Schering Ag Combination preparation of estrogen with 7-aminoalkyl-estratriene antiestrogen, useful in hormone replacement therapy, e.g. for treatment osteoporosis, Alzheimer's disease and hot flushes
DE19833786A1 (en) * 1998-07-18 2000-01-20 Schering Ag New diphenyl-benzocycloheptene derivatives, are tissue-selective estrogens and antiestrogens useful e.g. for treating osteoporosis or hormone-dependent tumors or in hormone replacement therapy
DE19842123C1 (en) * 1998-09-05 2000-07-13 Schering Ag 11beta-fluoro-7alpha- (14,14,15,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl) estra-1,3,5 (10) - triene-3,17beta-diol as crystalline solvate
DE19906159A1 (en) * 1999-02-09 2000-08-10 Schering Ag 16-hydroxyestratrienes as selectively active estrogens
WO2001012622A1 (en) * 1999-08-18 2001-02-22 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
DE10019171A1 (en) * 2000-04-07 2001-10-18 Schering Ag Compositions for use as penetration enhancers in transdermal formulations for highly lipophilic active ingredients
AU2006202187B2 (en) * 2001-11-27 2008-11-06 Bayer Schering Pharma Aktiengesellschaft 17alpah-alkyl-17beta-oxy-estratrienes and intermediate products for their production, uses thereof and pharmaceutical preparations
DE10159217A1 (en) * 2001-11-27 2003-06-05 Schering Ag 17alpha-alkyl-17ß-oxy-estratrienes and intermediates for their preparation, use of 17alpha-alkyl-17ß-oxy-estratriene for the preparation of medicaments and pharmaceutical preparations
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
JP2007506805A (en) 2004-07-27 2007-03-22 シコール インコーポレイティド Process for the preparation of 7α-alkylated 19-nor steroids
AU2006317486B9 (en) 2005-11-22 2011-08-04 Sumitomo Chemical Company, Limited Organic sulfur compounds and use thereof as arthropodicides
DE102007023614A1 (en) 2007-05-21 2008-11-27 Bayer Schering Pharma Aktiengesellschaft New amide compounds used for treatment of gynecological diseases e.g. endometriosis, for female fertility control and female hormone replacement therapy, has general formula
DE102007049630A1 (en) 2007-10-11 2009-10-29 Bayer Schering Pharma Aktiengesellschaft New amide compounds used for therapy and/or prophylaxis of gynecological diseases e.g. endometriosis, for female fertility control and female hormone replacement therapy
JP5298631B2 (en) 2007-05-18 2013-09-25 住友化学株式会社 Organic sulfur compounds and their use for controlling harmful arthropods
JP2009001551A (en) 2007-05-18 2009-01-08 Sumitomo Chemical Co Ltd Organic sulfur compounds and their use for controlling harmful arthropods
TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
DE102007032800A1 (en) 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
SG185311A1 (en) 2007-10-16 2012-11-29 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
DE102007058747A1 (en) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
EP2070941A1 (en) 2007-12-14 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Stereoselective synthesis of selective estrogen receptor down-regulators
EP2070909A1 (en) 2007-12-15 2009-06-17 Bayer Schering Pharma AG Non-steroidal progesterone receptor modulators
DE102008057230A1 (en) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistic pharmaceutical combination with an estrogen receptor antagonist and a progestin
JP5212350B2 (en) 2008-12-24 2013-06-19 住友化学株式会社 Halogen-containing organic sulfur compounds and uses thereof
EP2258375A1 (en) 2009-06-04 2010-12-08 Bayer Schering Pharma Aktiengesellschaft 17B-alkyl-17alpha-oxy-estratrienes
DE102009034366A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-methyleneoxyalkylene aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034367A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene derivatives, process for their preparation and their use for the treatment of diseases
DE102009034362A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034368A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034525A1 (en) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034526A1 (en) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-ethynylphenyl derivatives, process for their preparation and their use for the treatment of diseases
WO2011092127A1 (en) 2010-01-26 2011-08-04 Bayer Schering Pharma Aktiengesellschaft 14,17-bridged estratriene derivatives comprising heterocyclic bioisosteres for the phenolic a-ring
DE102010007722A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
DE102010007719A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
KR20200144591A (en) 2010-06-16 2020-12-29 앙도르쉐르슈 인코포레이티드 Methods of treating or preventing estrogen-related diseases
DE102010030538A1 (en) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo [7] annulene derivatives, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicaments
DE102011004899A1 (en) 2011-03-01 2012-09-06 Bayer Pharma Aktiengesellschaft New 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl-derivatives are progesterone receptor antagonists useful to treat and prevent e.g. uterine fibroids, endometriosis, heavy menstrual bleeding and meningioma
HRP20230747T1 (en) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
DE102011087987A1 (en) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo [7] annulene derivatives, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicaments
JP2015508825A (en) 2012-02-29 2015-03-23 レプロス セラピューティクス インコーポレイティド Combination therapy to treat androgen deficiency
SMT201800657T1 (en) 2013-03-13 2019-01-11 Sage Therapeutics Inc Neuroactive steroids and methods of use thereof
TN2015000454A1 (en) 2013-04-11 2017-04-06 Bayer Pharma AG Progesterone receptor antagonist dosage form
CA2909418A1 (en) * 2013-04-18 2014-10-23 Xi'an Libang Pharmaceutical Technology Co., Ltd. Ester derivative of 7-.alpha.-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)n onyl]-estra-1,3,5(10)-triene-3,17.beta.-diol having anticancer activity and preparation method thereof
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PL3319611T3 (en) 2015-07-06 2021-07-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2018009867A1 (en) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3519422T (en) 2016-09-30 2022-12-05 Sage Therapeutics Inc C7 substituted oxysterols and methods as nmda modulators
DK4105223T3 (en) 2016-10-18 2025-07-07 Sage Therapeutics Inc OXYSTEROLS AND METHODS OF USING THEREOF
CN115505019B (en) * 2022-11-07 2024-01-26 南宁师范大学 7-amide substituted estrogen compounds and their preparation methods and applications
CN116041412A (en) * 2023-01-13 2023-05-02 香港中文大学（深圳） Fulvestrant derivative and its preparation method, application and medicine for treating breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
HU208150B (en) * 1988-10-31 1993-08-30 Endorecherche Inc Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
DE3925507A1 (en) * 1989-07-28 1991-01-31 Schering Ag 14,17 (ALPHA) ETHENO AND ETHANOESTRATRIA, METHOD FOR PRODUCING THESE COMPOUNDS, AND THEIR USE FOR PRODUCING MEDICINAL PRODUCTS
DE4218743C2 (en) * 1992-06-04 2001-10-25 Schering Ag Process for the preparation of C (7) -substituted Estra-1,3,5 (10) -trienes and new starting products for this process

Also Published As

Publication number Publication date
ATE231882T1 (en) 2003-02-15
BG103185A (en) 1999-11-30
TW552267B (en) 2003-09-11
EE04021B1 (en) 2003-04-15
CA2263708A1 (en) 1998-02-26
TR199900432T2 (en) 1999-04-21
NO990793D0 (en) 1999-02-19
BR9711328A (en) 1999-08-17
IL128601A (en) 2003-07-31
JP2001503024A (en) 2001-03-06
ES2191857T3 (en) 2003-09-16
DE59709239D1 (en) 2003-03-06
EA199900210A1 (en) 1999-08-26
IL128601A0 (en) 2000-01-31
HUP9903106A3 (en) 2000-05-29
NZ334277A (en) 2000-10-27
ZA977482B (en) 1998-02-23
EP0920441A1 (en) 1999-06-09
CZ57999A3 (en) 1999-08-11
DK0920441T3 (en) 2003-05-26
HUP9903106A2 (en) 2000-03-28
CN1231670A (en) 1999-10-13
AR009278A1 (en) 2000-04-12
SK18899A3 (en) 1999-08-06
PL331863A1 (en) 1999-08-16
EE9900075A (en) 1999-10-15
BG62972B1 (en) 2000-12-29
UA50792C2 (en) 2002-11-15
EP0920441B1 (en) 2003-01-29
PL186309B1 (en) 2003-12-31
AU728843B2 (en) 2001-01-18
DE19635525A1 (en) 1998-02-26
IS4976A (en) 1999-02-11
AU4552097A (en) 1998-03-06
EA001577B1 (en) 2001-06-25
NO315655B1 (en) 2003-10-06
WO1998007740A1 (en) 1998-02-26
PT920441E (en) 2003-06-30
KR20000068261A (en) 2000-11-25

Similar Documents

Publication Publication Date Title
NO990793D0 (en) 7 &lt;alfa&gt; - (&lt;Epsilon&gt; -aminoalkyl) - ° stratrienes, processes for their preparation, pharmaceuticals containing them, and their use in the manufacture of pharmaceuticals
NO304488B1 (en) 5-membered heteroaryloxazolidinones, their use in the manufacture of drugs and drugs containing the compound
NO984852D0 (en) New benzazepine derivatives, drugs containing the compounds and their use in the manufacture of the drugs
HUP0102187A3 (en) Azolo triazines and pyrimidines, pharmaceutical compositions containing them and use of the compounds
DE69415163D1 (en) CONSTRUCTION SET CONTAINING 1,1,1,2,3,4,4,5,5,5, -DECAFLUORPENTANE AND n-PROPANOL
NO20021714D0 (en) 2-Phenyl-substituted imidazotriazinones, process for their preparation and use of the compounds
NO984082L (en) Pyrimido [5,4-d] pyrimidines, medicaments containing these compounds, their use and method of preparation thereof
AP9400654A0 (en) Novel imidazole compounds, processes for the preparation thereof and their use in therapay
NO20010013L (en) Sulfur-substituted sulfonylaminocarboxylic acid N-arylamides, their preparation and use as well as pharmaceutical preparations containing the compounds
AU3813499A (en) The use of dihydropyrimidines as medicaments, and novel substances
NO20010277L (en) Benzocycloheptenes, processes for their preparation, pharmaceutical preparations containing them, and their use in the manufacture of medicaments
NO169446C (en) PROCEDURE FOR THE PREPARATION OF RIG POLYURETAN FOAM, AND THE PROCEDURAL MATERIAL FOR USE IN THE PROCEDURE
NO308287B1 (en) Substituted 4-phenyl-6-amino-nicotinic acid derivatives, drugs containing them and their use
FI955234L (en) Enzyme dispersions, their preparation and mixtures containing them
ZA941993B (en) Amidine derivatives containing heterocyclic groups the preparation and use thereof
ID17076A (en) 2,4-DISUBSTITUTION OF PYRIMIDINE, THE PROCESS FOR MAKING THE SAME SUBSTANCE AND PHARMACY COMPOSITION CONTAINING THE SAME SUBSTANCE
NO306060B1 (en) Substituted cinnamic acid guanides, their use, and drugs containing the guanides
NO960529D0 (en) Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the preparation of pharmaceutical compositions and pharmaceutical compositions containing the compounds
EP1109904A4 (en) Novel molecules of the herpes virus-entry-mediator-related protein family and uses thereof
ID24222A (en) 3-SUBSTITUTED 3, 3,5,5,7-TETRAHIDROPIROLO [3 &#39;, 4&#39;: 4,5] TIENO- [2,3-d] PYRIMIDINS, MANUFACTURE AND USE
ID23156A (en) AMIDINA&#39;S DEMONSTRATIONS, THE PROCESS OF MAKING COMPOSITION AND ITS USE
DE59908123D1 (en) 2,5-SUBSTITUTED BENZOLSULFONYL UREAS AND THIOURES, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME
NO308528B1 (en) Substituted 1-naphthoylguanidines, their use in the manufacture of medicaments and curing agents containing the compounds
PL312984A1 (en) Leucoindigo preparation in the form of granules
NO965370L (en) Substituted chromanylsulfonyl (thio) ureas, processes for their preparation, their use in pharmaceutical compositions and pharmaceutical compositions containing the compounds

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees