NO990832L - Syntese av bis-endolylmaleimider - Google Patents

Syntese av bis-endolylmaleimider

Info

Publication number
NO990832L
NO990832L NO990832A NO990832A NO990832L NO 990832 L NO990832 L NO 990832L NO 990832 A NO990832 A NO 990832A NO 990832 A NO990832 A NO 990832A NO 990832 L NO990832 L NO 990832L
Authority
NO
Norway
Prior art keywords
endolylmaleimides
bis
synthesis
reaction
optionally substituted
Prior art date
Application number
NO990832A
Other languages
English (en)
Norwegian (no)
Other versions
NO990832D0 (no
Inventor
Mary Margaret Faul
Jr Leonard L Winneroski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO990832D0 publication Critical patent/NO990832D0/no
Publication of NO990832L publication Critical patent/NO990832L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO990832A 1996-08-23 1999-02-22 Syntese av bis-endolylmaleimider NO990832L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2412096P 1996-08-23 1996-08-23
PCT/US1997/014771 WO1998007693A1 (en) 1996-08-23 1997-08-22 Synthesis of bisindolylmalimides

Publications (2)

Publication Number Publication Date
NO990832D0 NO990832D0 (no) 1999-02-22
NO990832L true NO990832L (no) 1999-04-13

Family

ID=21818966

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990832A NO990832L (no) 1996-08-23 1999-02-22 Syntese av bis-endolylmaleimider

Country Status (16)

Country Link
US (2) US5990319A (ja)
EP (1) EP0825190A1 (ja)
JP (1) JP2000516632A (ja)
KR (1) KR20000068323A (ja)
CN (1) CN1228082A (ja)
AU (1) AU716840B2 (ja)
BR (1) BR9711363A (ja)
CA (1) CA2263862A1 (ja)
EA (1) EA001392B1 (ja)
HU (1) HUP0003203A3 (ja)
IL (1) IL128376A0 (ja)
NO (1) NO990832L (ja)
NZ (1) NZ334030A (ja)
PL (1) PL331899A1 (ja)
WO (1) WO1998007693A1 (ja)
YU (1) YU9499A (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
DK1846406T5 (da) 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
CN101801937A (zh) 2007-06-22 2010-08-11 艾科尔公司 喹唑啉酮化合物及其使用方法
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
JP5490688B2 (ja) 2007-06-22 2014-05-14 アークル インコーポレイテッド 癌の治療のためのインドリルピロリジン
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
CA2870520A1 (en) * 2012-04-23 2013-10-31 Arqule, Inc. Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same
CN104496970B (zh) * 2014-12-17 2017-01-11 河南师范大学 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用
CN104710412B (zh) * 2015-03-27 2017-03-22 河南师范大学 具有抗癌活性的3,4‑二（3‑吲哚）‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5339712A (en) * 1993-10-25 1994-08-23 Daryoush Keyvani Hand tool having offset work elements
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
HUP0003203A3 (en) 2002-01-28
KR20000068323A (ko) 2000-11-25
CN1228082A (zh) 1999-09-08
US5948907A (en) 1999-09-07
AU4157097A (en) 1998-03-06
BR9711363A (pt) 1999-08-17
YU9499A (sh) 2000-03-21
JP2000516632A (ja) 2000-12-12
PL331899A1 (en) 1999-08-16
WO1998007693A1 (en) 1998-02-26
IL128376A0 (en) 2000-01-31
EA001392B1 (ru) 2001-02-26
HUP0003203A2 (hu) 2001-06-28
NZ334030A (en) 2000-08-25
EA199900221A1 (ru) 1999-08-26
NO990832D0 (no) 1999-02-22
AU716840B2 (en) 2000-03-09
US5990319A (en) 1999-11-23
EP0825190A1 (en) 1998-02-25
CA2263862A1 (en) 1998-02-26

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application