NO991419L - Farmas°ytiske sammensetninger omfattende S-alkylisotiouroniumderivater - Google Patents

Farmas°ytiske sammensetninger omfattende S-alkylisotiouroniumderivater

Info

Publication number: NO991419L
Authority: NO; Norway
Prior art keywords: pct; pharmaceutical compositions; sec; processes; alkylisothiouronium
Prior art date: 1996-09-26

Application number

NO991419A

Other languages

English (en)

Other versions

NO991419D0 (no

NO326600B1 (no

Inventor

I Lev Mizrakh

I Victor Gikavy

V Valentin Znamensky

V Evgeni Arzamastsev

B Lev Shagalov

Valeri Kovtun

H Vladimir Jashounsky

V Victor Darchuk

G Marina Kochetkova

I Galina Bondareva

A Olga Terekhova

Original Assignee

Meditor Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-26

Filing date

1999-03-24

Publication date

1999-05-21

1996-09-26 Priority claimed from RU96119163A external-priority patent/RU2142796C1/ru

1997-09-19 Priority claimed from RU97115433/14A external-priority patent/RU2187309C2/ru

1999-03-24 Application filed by Meditor Pharmaceuticals Ltd filed Critical Meditor Pharmaceuticals Ltd

1999-03-24 Publication of NO991419D0 publication Critical patent/NO991419D0/no

1999-05-21 Publication of NO991419L publication Critical patent/NO991419L/no

2009-01-19 Publication of NO326600B1 publication Critical patent/NO326600B1/no

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
208000032843 Hemorrhage Diseases 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
208000011861 acute hypotension Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000222 hyperoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1
231100000572 poisoning Toxicity 0.000 abstract 1
230000000607 poisoning effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

NO19991419A 1996-09-26 1999-03-24 S-metylisotiouroniumdimetylfosfat, farmasoytisk sammensetning samt anvendelse av S-alkylisotiouronium derivater for fremstilling av et medikament for okning av arterielt blodtrykk NO326600B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
RU96119163A RU2142796C1 (ru)	1996-09-26	1996-09-26	Лекарственное противошоковое средство
RU97115433/14A RU2187309C2 (ru)	1997-09-19	1997-09-19	Средство, влияющее на артериальное давление
PCT/IL1997/000314 WO1998013036A1 (en)	1996-09-26	1997-09-25	Pharmaceutical compositions comprising s-alkylisothiouronium derivatives

Publications (3)

Publication Number	Publication Date
NO991419D0 NO991419D0 (no)	1999-03-24
NO991419L true NO991419L (no)	1999-05-21
NO326600B1 NO326600B1 (no)	2009-01-19

Family

ID=26653892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19991419A NO326600B1 (no)	1996-09-26	1999-03-24	S-metylisotiouroniumdimetylfosfat, farmasoytisk sammensetning samt anvendelse av S-alkylisotiouronium derivater for fremstilling av et medikament for okning av arterielt blodtrykk

Country Status (17)

Country	Link
US (1)	US6160008A (no)
EP (1)	EP0928191B1 (no)
JP (1)	JP4260888B2 (no)
KR (1)	KR100575507B1 (no)
CN (1)	CN1116871C (no)
AT (1)	ATE222758T1 (no)
AU (1)	AU717712B2 (no)
BR (1)	BR9712851A (no)
CA (1)	CA2266533C (no)
DE (1)	DE69715013T2 (no)
DK (1)	DK0928191T3 (no)
ES (1)	ES2182116T3 (no)
IL (1)	IL129020A (no)
NO (1)	NO326600B1 (no)
PT (1)	PT928191E (no)
TR (1)	TR199900783T2 (no)
WO (1)	WO1998013036A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100448439C (zh) *	2000-09-05	2009-01-07	麦迪特制药有限公司	用于头痛、偏头痛、恶心和呕吐的药物组合物
AU2006288655A1 (en) *	2005-09-06	2007-03-15	Meditor Pharmaceuticals Ltd.	Prevention of hypotension and stabilization of blood pressure in hemodialysis patients
US20090186854A1 (en) *	2006-03-23	2009-07-23	Meditor Pharmaceuticals Ltd.	S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
EP2167050A1 (en) *	2007-06-13	2010-03-31	Meditor Pharmaceuticals Ltd.	Taste masked pharmaceutical compositions of s-alkylisothiouronium derivatives
US20100305210A1 (en) *	2007-11-06	2010-12-02	Barkan-Farma S.R.L.	S-alkylisothiouronium derivatives for treating abnormal uterine bleeding disorders
US12011423B2 (en)	2007-11-06	2024-06-18	Foraviset Ltd.	S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
MD3619G2 (ro) *	2007-11-06	2009-01-31	Рафаэль Баркан	Remediu medicamentos nazal cu acţiune anticongestivă
CN104140386A (zh) *	2014-02-12	2014-11-12	上海应用技术学院	一种2-苄基-异硫脲三氟乙酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3123636A (en) *		1964-03-03		Thiuronium h alii
US3116327A (en) *	1960-07-22	1963-12-31	Baxter Laboratories Inc	Upsilon-dimethylaminopropyl isothiourea and acid addition salts thereof
US3657337A (en) *	1967-12-04	1972-04-18	Sandoz Ag	Benzylideneamino guanidines
FR2419675A1 (fr) *	1978-03-16	1979-10-12	Philagro Sa	Compositions fongicides a base de phosphites d'isothiouronium
AT395012B (de) *	1986-06-27	1992-08-25	Richter Gedeon Vegyeszet	Verfahren zur herstellung von n-(1(s)\|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen

1997
- 1997-09-25 CN CN97199137A patent/CN1116871C/zh not_active Expired - Fee Related
- 1997-09-25 AU AU43178/97A patent/AU717712B2/en not_active Ceased
- 1997-09-25 ES ES97941178T patent/ES2182116T3/es not_active Expired - Lifetime
- 1997-09-25 BR BR9712851-1A patent/BR9712851A/pt not_active IP Right Cessation
- 1997-09-25 AT AT97941178T patent/ATE222758T1/de active
- 1997-09-25 PT PT97941178T patent/PT928191E/pt unknown
- 1997-09-25 JP JP51546498A patent/JP4260888B2/ja not_active Expired - Fee Related
- 1997-09-25 KR KR1019997002578A patent/KR100575507B1/ko not_active Expired - Fee Related
- 1997-09-25 TR TR1999/00783T patent/TR199900783T2/xx unknown
- 1997-09-25 DK DK97941178T patent/DK0928191T3/da active
- 1997-09-25 US US09/269,405 patent/US6160008A/en not_active Expired - Fee Related
- 1997-09-25 DE DE69715013T patent/DE69715013T2/de not_active Expired - Lifetime
- 1997-09-25 CA CA002266533A patent/CA2266533C/en not_active Expired - Fee Related
- 1997-09-25 WO PCT/IL1997/000314 patent/WO1998013036A1/en not_active Ceased
- 1997-09-25 IL IL12902097A patent/IL129020A/en not_active IP Right Cessation
- 1997-09-25 EP EP97941178A patent/EP0928191B1/en not_active Expired - Lifetime
1999
- 1999-03-24 NO NO19991419A patent/NO326600B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1998013036A1 (en)	1998-04-02
JP2001501928A (ja)	2001-02-13
KR100575507B1 (ko)	2006-05-03
EP0928191A1 (en)	1999-07-14
DE69715013T2 (de)	2003-05-22
NO991419D0 (no)	1999-03-24
CN1116871C (zh)	2003-08-06
ES2182116T3 (es)	2003-03-01
IL129020A (en)	2004-06-20
US6160008A (en)	2000-12-12
DK0928191T3 (da)	2002-12-30
BR9712851A (pt)	2000-01-18
KR20000048636A (ko)	2000-07-25
ATE222758T1 (de)	2002-09-15
TR199900783T2 (xx)	1999-07-21
JP4260888B2 (ja)	2009-04-30
CA2266533A1 (en)	1998-04-02
AU717712B2 (en)	2000-03-30
EP0928191B1 (en)	2002-08-28
IL129020A0 (en)	2000-02-17
CA2266533C (en)	2007-08-07
PT928191E (pt)	2003-01-31
AU4317897A (en)	1998-04-17
HK1022833A1 (en)	2000-08-25
DE69715013D1 (de)	2002-10-02
NO326600B1 (no)	2009-01-19
CN1234737A (zh)	1999-11-10

Legal Events

Date	Code	Title	Description
2012-04-30	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
CY2607B2 (en)	2010-04-28	Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanylcyclyse agonists
DE69506882D1 (de)	1999-02-04	Wasserlösliche organische salze von kreatin
DE50213524D1 (de)	2009-06-18	Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen
EP0876387A4 (en)	1999-12-01	PROCESS FOR IMPROVING THE BIOLOGICAL AND ANTIVIRAL ACTIVITY OF PROTEASE INHIBITORS
DE69938255D1 (de)	2008-04-10	Verfahren und zusammensetzung zur konservierung von adenoviren
TR199901191T2 (xx)	1999-12-21	Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
DE69819360D1 (de)	2003-12-04	Neue psoralene zur inaktivierung von pathogenen
ATE268750T1 (de)	2004-06-15	Proteintyrosinphosphatase inhibitoren
TR199900310T2 (xx)	1999-04-21	Trombin inhibit�rleri
NO980178D0 (no)	1998-01-14	Cyklo-oksygenase-inhibitor og amidin-derivatsalter, fremgangsmåte for fremstilling derav, anvendelse derav som legemidler, og farmasöytiske blandinger inneholdende slike derivater
ES2117976T3 (es)	1998-09-01	Preparacion de derivados n-acetil neuraminicos.
ATE232191T1 (de)	2003-02-15	Verfahren und zusammensetzung zur inhibierung der polymerisierung von ethylenisch ungesättigten kohlenwasserstoffen
NO991419D0 (no)	1999-03-24	Farmas°ytiske sammensetninger omfattende S-alkylisotiouroniumderivater
KR960006915A (ko)	1996-03-22	췌장염의 치료 조성물
ATE302002T1 (de)	2005-09-15	Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit
ES2195586T3 (es)	2003-12-01	Almidon modificado, estable respecto a la sal.
ES2168816T3 (es)	2002-06-16	Cemento de inyeccion que contiene inhibidores de la corrosion.
EA200000522A1 (ru)	2000-10-30	5-htагонисты
ATE200805T1 (de)	2001-05-15	Verfahren zur reduktion von schwefel- und küpenfarbstoffen
DK0640098T3 (da)	2002-10-28	S-gen fra hundecoronavirus og anvendelser deraf
DE69330465D1 (de)	2001-08-23	Verfahren zur behandlung von chronischer prostatitis mit 17-beta-n-tertbutylcarbamoyl-4-aza-5 alpha-androst-1-en-3-one
ATE201197T1 (de)	2001-06-15	Diarinopropanole abgeleitet von aminosäuren
DE59611397D1 (de)	2006-12-14	Verfahren zur bekämpfung von fischmycosen und einzelligen ektoparasiten
NO992228D0 (no)	1999-05-07	1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor
ES2185154T3 (es)	2003-04-16	Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.