NO991691L - Cancer immunoterapi ved Õ bruke tumorceller kombinert med blandede lymfosytter - Google Patents

Cancer immunoterapi ved Õ bruke tumorceller kombinert med blandede lymfosytter

Info

Publication number
NO991691L
NO991691L NO991691A NO991691A NO991691L NO 991691 L NO991691 L NO 991691L NO 991691 A NO991691 A NO 991691A NO 991691 A NO991691 A NO 991691A NO 991691 L NO991691 L NO 991691L
Authority
NO
Norway
Prior art keywords
tumor
stimulated
lymphocytes
allogeneic
cancer immunotherapy
Prior art date
Application number
NO991691A
Other languages
English (en)
Other versions
NO991691D0 (no
Inventor
John C Hiserodt
James A Thompson
Gale A Granger
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of NO991691D0 publication Critical patent/NO991691D0/no
Publication of NO991691L publication Critical patent/NO991691L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Denne oppfinnelsen omfatter cellulære vaksiner og metoder for å bruke dem i cancer immunoterapi, spesielt hos mennesker. Vaksinene omfatter stimulerte lymfosytter allogene til individet som blir behandlet, sammen med en kilde av tumorassosierte antigen. Allogene lymfosytter kan bli stimulert ved å kombinere eller samdyrke dem med leukosytter ervervet fra individet som skal bli behandlet eller danne andre tredjeparts donorer. Tumorantigen kan bli tilveiebragt i form av primær tumorceller, tumorcellelinjer eller tumorekstrakter fremstilt fra individet. Stimulerte allogene lymfosytter og tumorantigen blir kombinert og administrert på et sted fjernt fra primærtumoren for å "prime" eller "booste" en systematisk cellulær antitumorimmunrespons. Denne tilnærmingen overvinner den naturlige motstridige evnen til immunsystemet for stimulering av tumorantigener som danner en vertsrespons og potensielt forbedrer det kliniske utkommet.
NO991691A 1996-10-11 1999-04-09 Cancer immunoterapi ved Õ bruke tumorceller kombinert med blandede lymfosytter NO991691L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2854896P 1996-10-11 1996-10-11
PCT/US1997/018718 WO1998016238A2 (en) 1996-10-11 1997-10-10 Cancer immunotherapy using tumor cells combined with mixed lymphocytes

Publications (2)

Publication Number Publication Date
NO991691D0 NO991691D0 (no) 1999-04-09
NO991691L true NO991691L (no) 1999-06-09

Family

ID=21844058

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991691A NO991691L (no) 1996-10-11 1999-04-09 Cancer immunoterapi ved Õ bruke tumorceller kombinert med blandede lymfosytter

Country Status (13)

Country Link
US (1) US6207147B1 (no)
EP (1) EP0930887B1 (no)
JP (1) JP2001509135A (no)
KR (1) KR20000049096A (no)
CN (1) CN1237909A (no)
AR (1) AR004445A1 (no)
AT (1) ATE229810T1 (no)
AU (1) AU743855B2 (no)
BR (1) BR9712988A (no)
CA (1) CA2267157C (no)
DE (1) DE69718029T2 (no)
NO (1) NO991691L (no)
WO (1) WO1998016238A2 (no)

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Also Published As

Publication number Publication date
WO1998016238A3 (en) 1998-09-11
JP2001509135A (ja) 2001-07-10
ATE229810T1 (de) 2003-01-15
KR20000049096A (ko) 2000-07-25
CA2267157A1 (en) 1998-04-23
CA2267157C (en) 2005-05-31
DE69718029D1 (de) 2003-01-30
AR004445A1 (es) 1998-12-16
NO991691D0 (no) 1999-04-09
EP0930887A2 (en) 1999-07-28
BR9712988A (pt) 2000-10-24
AU743855B2 (en) 2002-02-07
US6207147B1 (en) 2001-03-27
DE69718029T2 (de) 2003-10-16
CN1237909A (zh) 1999-12-08
EP0930887B1 (en) 2002-12-18
WO1998016238A2 (en) 1998-04-23
AU4824297A (en) 1998-05-11

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