NO992229L - (4R, 5S, 6S, 7R) -Hexahydro-1- [5- (3-aminoinazol) methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2H-1,3- diazepin-2-one, its preparation and its use as an HIV protease inhibitor - Google Patents
(4R, 5S, 6S, 7R) -Hexahydro-1- [5- (3-aminoinazol) methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2H-1,3- diazepin-2-one, its preparation and its use as an HIV protease inhibitorInfo
- Publication number
- NO992229L NO992229L NO992229A NO992229A NO992229L NO 992229 L NO992229 L NO 992229L NO 992229 A NO992229 A NO 992229A NO 992229 A NO992229 A NO 992229A NO 992229 L NO992229 L NO 992229L
- Authority
- NO
- Norway
- Prior art keywords
- hiv protease
- aminoinazol
- diazepin
- phenylmethyl
- hexahydro
- Prior art date
Links
- HHVIPGYWIHLNFW-UHFFFAOYSA-N 4-benzyl-1,3-diazepin-2-one Chemical compound O=C1N=CC=CC(CC=2C=CC=CC=2)=N1 HHVIPGYWIHLNFW-UHFFFAOYSA-N 0.000 title 1
- 229940122440 HIV protease inhibitor Drugs 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Det er beskrevet en oppfinnelse vedrørende forbindelser av formel (I) eller farmasøytiske godtagbare saltformer eller prodrugformer herav, som er egnet som inhibitorer til HIV protease og til farmasøytiske sammensetninger og diagnosesett omfattende den selv samme og fremgangsmåter for anvendelse av den selv samme til behandling av virusinfeksjon eller som en analysestandard eller et reagens.An invention is described for compounds of formula (I) or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease and for pharmaceutical compositions and diagnostic kits comprising the same and methods of using the same for treating viral infection. or as an assay standard or reagent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74710396A | 1996-11-08 | 1996-11-08 | |
| US2974696P | 1996-11-08 | 1996-11-08 | |
| PCT/US1997/020036 WO1998020009A1 (en) | 1996-11-08 | 1997-11-04 | (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992229D0 NO992229D0 (en) | 1999-05-07 |
| NO992229L true NO992229L (en) | 1999-06-07 |
Family
ID=26705295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992229A NO992229L (en) | 1996-11-08 | 1999-05-07 | (4R, 5S, 6S, 7R) -Hexahydro-1- [5- (3-aminoinazol) methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2H-1,3- diazepin-2-one, its preparation and its use as an HIV protease inhibitor |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0937066A1 (en) |
| JP (1) | JP2001503429A (en) |
| KR (1) | KR20000053123A (en) |
| CN (1) | CN1235601A (en) |
| AU (1) | AU722489B2 (en) |
| BR (1) | BR9712755A (en) |
| CA (1) | CA2270963A1 (en) |
| CZ (1) | CZ157499A3 (en) |
| EA (1) | EA001154B1 (en) |
| EE (1) | EE9900187A (en) |
| HU (1) | HUP9904143A3 (en) |
| IL (1) | IL129726A0 (en) |
| LV (1) | LV12374B (en) |
| NO (1) | NO992229L (en) |
| NZ (1) | NZ335919A (en) |
| PL (1) | PL333412A1 (en) |
| SI (1) | SI9720071A (en) |
| SK (1) | SK59599A3 (en) |
| WO (1) | WO1998020009A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6870098A (en) * | 1997-03-31 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| CA2335617C (en) * | 1998-06-24 | 2009-12-15 | Novirio Pharmaceuticals Limited | Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv |
| FR2810039B1 (en) | 2000-06-13 | 2007-05-25 | Centre Nat Rech Scient | CYCLIC UREA COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69221309T2 (en) * | 1991-10-11 | 1997-12-11 | The Du Pont Merck Pharmaceutical Co., Wilmington, Del. | CYCLIC UREAUTIES AND ANALOGA USED AS RETROVIRAL PROTEASE INHIBITORS |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
-
1997
- 1997-11-04 CA CA002270963A patent/CA2270963A1/en not_active Abandoned
- 1997-11-04 BR BR9712755-8A patent/BR9712755A/en unknown
- 1997-11-04 KR KR1019990704049A patent/KR20000053123A/en not_active Withdrawn
- 1997-11-04 CZ CZ991574A patent/CZ157499A3/en unknown
- 1997-11-04 EP EP97945596A patent/EP0937066A1/en not_active Ceased
- 1997-11-04 IL IL12972697A patent/IL129726A0/en unknown
- 1997-11-04 HU HU9904143A patent/HUP9904143A3/en unknown
- 1997-11-04 PL PL97333412A patent/PL333412A1/en unknown
- 1997-11-04 SI SI9720071A patent/SI9720071A/en unknown
- 1997-11-04 EE EEP199900187A patent/EE9900187A/en unknown
- 1997-11-04 JP JP52168298A patent/JP2001503429A/en active Pending
- 1997-11-04 AU AU51033/98A patent/AU722489B2/en not_active Ceased
- 1997-11-04 CN CN97199418A patent/CN1235601A/en active Pending
- 1997-11-04 WO PCT/US1997/020036 patent/WO1998020009A1/en not_active Ceased
- 1997-11-04 EA EA199900451A patent/EA001154B1/en not_active IP Right Cessation
- 1997-11-04 NZ NZ335919A patent/NZ335919A/en unknown
- 1997-11-04 SK SK595-99A patent/SK59599A3/en unknown
-
1999
- 1999-04-29 LV LVP-99-75A patent/LV12374B/en unknown
- 1999-05-07 NO NO992229A patent/NO992229L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| LV12374A (en) | 1999-11-20 |
| NO992229D0 (en) | 1999-05-07 |
| SK59599A3 (en) | 1999-12-10 |
| BR9712755A (en) | 1999-10-19 |
| IL129726A0 (en) | 2000-02-29 |
| NZ335919A (en) | 2000-09-29 |
| HUP9904143A2 (en) | 2000-06-28 |
| JP2001503429A (en) | 2001-03-13 |
| EA001154B1 (en) | 2000-10-30 |
| CZ157499A3 (en) | 1999-11-17 |
| WO1998020009A1 (en) | 1998-05-14 |
| HUP9904143A3 (en) | 2002-11-28 |
| EA199900451A1 (en) | 1999-12-29 |
| AU722489B2 (en) | 2000-08-03 |
| EE9900187A (en) | 1999-12-15 |
| CN1235601A (en) | 1999-11-17 |
| KR20000053123A (en) | 2000-08-25 |
| EP0937066A1 (en) | 1999-08-25 |
| LV12374B (en) | 2000-04-20 |
| SI9720071A (en) | 1999-12-31 |
| CA2270963A1 (en) | 1998-05-14 |
| AU5103398A (en) | 1998-05-29 |
| PL333412A1 (en) | 1999-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1998045276A3 (en) | 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors | |
| NO20022095L (en) | Heterocyclic substituted pyrazolones | |
| EA200000840A1 (en) | ANTI-VIRUS DERIVATIVES OF PYRIMIDINE | |
| AU4802797A (en) | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv rever se transcriptase inhibitors and intermediates and processes for making the same | |
| NO20051695L (en) | Novel spirocondensed quinazolinones and their use as phosphodiesterase inhibitors | |
| WO2001029037A3 (en) | Condensed naphthyridines as hiv reverse transcriptase inhibitors | |
| DE60211539D1 (en) | IMIDAZOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HERPES VIRUS INFECTION | |
| WO2004100865A3 (en) | New benzimidazole derivatives | |
| NO984470L (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase | |
| NO20035791L (en) | New derivatives of oxazolidinones as antibacterial agents | |
| BR9811557A (en) | Derivatives of 2-) 4-aryl or heteroaryl-piperazin-1-ylmethyl) -1h-indole | |
| ES2151600T3 (en) | DERIVATIVES OF N- (3-AMINO-2-HYDROXIBUTE) SULFONAMIDE USED AS HIV PROTEASE INHIBITORS. | |
| NO20044549L (en) | Bis-cyclic 6-alkalidene penes as beta-lactamase inhibitors | |
| WO2004002410A3 (en) | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors | |
| YU62504A (en) | Tricyclic 2-pyrimidone compounds useful as hiv reverse transcriptase inhibitors | |
| NO20014864L (en) | Substituted 1,4-dihydroindeno [1,2-C] pyrazoles as inhibitors of tyrosine kinase | |
| WO2003051838A3 (en) | Protein kinase inhibitors | |
| NO992229L (en) | (4R, 5S, 6S, 7R) -Hexahydro-1- [5- (3-aminoinazol) methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2H-1,3- diazepin-2-one, its preparation and its use as an HIV protease inhibitor | |
| NO20044550L (en) | Heterotricyclyl 6-alkalidene penemes as beta-lactamase inhibitors | |
| DE60222465D1 (en) | PYRAZOLOPYRIDINE DERIVATIVES AS ANTI-HERPING AGENTS | |
| ATE274515T1 (en) | PYRAZOLOPYRIDINE DERIVATIVES | |
| NO983444D0 (en) | Benzo (c) quinolizine derivatives, their preparation and use as 5 <alfa> reductase inhibitors | |
| WO2002018323A3 (en) | Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors | |
| LT2003003A (en) | Tricyclic 2-pyridone compounds useful as hiv reverse transcriptase inhibitors | |
| NO992228L (en) | 1- (3-Aminoindazol-5-yl) -3-phenylmethylcyclic urea suitable as HIV protease inhibitor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |