NO992229L - (4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor - Google Patents

(4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor

Info

Publication number
NO992229L
NO992229L NO992229A NO992229A NO992229L NO 992229 L NO992229 L NO 992229L NO 992229 A NO992229 A NO 992229A NO 992229 A NO992229 A NO 992229A NO 992229 L NO992229 L NO 992229L
Authority
NO
Norway
Prior art keywords
hiv protease
aminoinazol
diazepin
phenylmethyl
hexahydro
Prior art date
Application number
NO992229A
Other languages
English (en)
Other versions
NO992229D0 (no
Inventor
James David Rodgers
Patrick Yuk-Sun Lam
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NO992229D0 publication Critical patent/NO992229D0/no
Publication of NO992229L publication Critical patent/NO992229L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet en oppfinnelse vedrørende forbindelser av formel (I) eller farmasøytiske godtagbare saltformer eller prodrugformer herav, som er egnet som inhibitorer til HIV protease og til farmasøytiske sammensetninger og diagnosesett omfattende den selv samme og fremgangsmåter for anvendelse av den selv samme til behandling av virusinfeksjon eller som en analysestandard eller et reagens.
NO992229A 1996-11-08 1999-05-07 (4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor NO992229L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number Publication Date
NO992229D0 NO992229D0 (no) 1999-05-07
NO992229L true NO992229L (no) 1999-06-07

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992229A NO992229L (no) 1996-11-08 1999-05-07 (4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (no)
JP (1) JP2001503429A (no)
KR (1) KR20000053123A (no)
CN (1) CN1235601A (no)
AU (1) AU722489B2 (no)
BR (1) BR9712755A (no)
CA (1) CA2270963A1 (no)
CZ (1) CZ157499A3 (no)
EA (1) EA001154B1 (no)
EE (1) EE9900187A (no)
HU (1) HUP9904143A3 (no)
IL (1) IL129726A0 (no)
LV (1) LV12374B (no)
NO (1) NO992229L (no)
NZ (1) NZ335919A (no)
PL (1) PL333412A1 (no)
SI (1) SI9720071A (no)
SK (1) SK59599A3 (no)
WO (1) WO1998020009A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6870098A (en) * 1997-03-31 1998-10-22 Du Pont Merck Pharmaceutical Company, The Indazoles of cyclic ureas useful as hiv protease inhibitors
CA2335617C (en) * 1998-06-24 2009-12-15 Novirio Pharmaceuticals Limited Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69221309T2 (de) * 1991-10-11 1997-12-11 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors

Also Published As

Publication number Publication date
LV12374A (lv) 1999-11-20
NO992229D0 (no) 1999-05-07
SK59599A3 (en) 1999-12-10
BR9712755A (pt) 1999-10-19
IL129726A0 (en) 2000-02-29
NZ335919A (en) 2000-09-29
HUP9904143A2 (hu) 2000-06-28
JP2001503429A (ja) 2001-03-13
EA001154B1 (ru) 2000-10-30
CZ157499A3 (cs) 1999-11-17
WO1998020009A1 (en) 1998-05-14
HUP9904143A3 (en) 2002-11-28
EA199900451A1 (ru) 1999-12-29
AU722489B2 (en) 2000-08-03
EE9900187A (et) 1999-12-15
CN1235601A (zh) 1999-11-17
KR20000053123A (ko) 2000-08-25
EP0937066A1 (en) 1999-08-25
LV12374B (en) 2000-04-20
SI9720071A (sl) 1999-12-31
CA2270963A1 (en) 1998-05-14
AU5103398A (en) 1998-05-29
PL333412A1 (en) 1999-12-06

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