NO992436L - N(imidazolylbutyl)benzensulfonamidderivater, deres fremstilling og terapeutiske anvendelse - Google Patents

N(imidazolylbutyl)benzensulfonamidderivater, deres fremstilling og terapeutiske anvendelse

Info

Publication number
NO992436L
NO992436L NO992436A NO992436A NO992436L NO 992436 L NO992436 L NO 992436L NO 992436 A NO992436 A NO 992436A NO 992436 A NO992436 A NO 992436A NO 992436 L NO992436 L NO 992436L
Authority
NO
Norway
Prior art keywords
alkyl
therapeutic use
imidazolylbutyl
preparation
benzenesulfonamide derivatives
Prior art date
Application number
NO992436A
Other languages
English (en)
Other versions
NO992436D0 (no
Inventor
Jean-Michel Altenburger
Gilbert Lassalle
Valurie Martin
Daniel Galtier
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO992436D0 publication Critical patent/NO992436D0/no
Publication of NO992436L publication Critical patent/NO992436L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsene vedrører forbindelser med formel (I) hvor R, og R'j, representerer hydrogen, halogen eller (C1-C4) alkyl, R2 representerer en 1-piperidin-l-yl gruppe, 1,2,3,6-tetrahydro- pyridin-1-yl som eventuelt er substituert, heksahydro-lH- azepin-1-yl, heptahydroazocin-1-yl, oktahydro-lH-azonin-1-yl, (a) (a-B = -CONR"), m = l til 2 og p = l til 2), (b) (Q er karbon eller nitrogen, D = (C-^-C^) alkyl eller -CH2CF3 .og r = l til 3, R3 representerer (C-^-C^ alkyl, -COR5 [R5 er (C^-C,,) - alkyl, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)nOH (n = l til 4)], -S02R6, -CONHRg, -SO2N{R6)2 (R6 er (C1-C4)- alkyl), R4 representerer hydrogen eller halogen og A repre- senterer fenyl eller heterosyklus som eventuelt er substi- tuert eller cyklo(C5-C8)alkyl. Forbindelsene har terapeutisk anvendelse.
NO992436A 1996-11-22 1999-05-20 N(imidazolylbutyl)benzensulfonamidderivater, deres fremstilling og terapeutiske anvendelse NO992436L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9614309A FR2756285B1 (fr) 1996-11-22 1996-11-22 Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
PCT/FR1997/002079 WO1998022443A1 (fr) 1996-11-22 1997-11-19 Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique

Publications (2)

Publication Number Publication Date
NO992436D0 NO992436D0 (no) 1999-05-20
NO992436L true NO992436L (no) 1999-07-22

Family

ID=9497920

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992436A NO992436L (no) 1996-11-22 1999-05-20 N(imidazolylbutyl)benzensulfonamidderivater, deres fremstilling og terapeutiske anvendelse

Country Status (20)

Country Link
EP (1) EP0946517A1 (no)
JP (1) JP2001504128A (no)
KR (1) KR20000069063A (no)
CN (1) CN1238765A (no)
AR (1) AR009627A1 (no)
AU (1) AU5226498A (no)
BG (1) BG103414A (no)
BR (1) BR9713291A (no)
CA (1) CA2270478A1 (no)
CO (1) CO4910158A1 (no)
CZ (1) CZ178299A3 (no)
EE (1) EE9900201A (no)
FR (1) FR2756285B1 (no)
HU (1) HUP9904599A2 (no)
IL (1) IL129546A0 (no)
NO (1) NO992436L (no)
SK (1) SK66799A3 (no)
TR (1) TR199901143T2 (no)
WO (1) WO1998022443A1 (no)
ZA (1) ZA9710515B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783521B1 (fr) * 1998-09-18 2002-04-26 Synthelabo Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique
FR2806722B1 (fr) * 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
ES2799309T3 (es) 2014-09-29 2020-12-16 Cellix Bio Private Ltd Compuestos y composiciones para el tratamiento de esclerosis múltiple
CN118459425B (zh) * 2024-04-29 2025-11-14 南通华祥医药科技有限公司 一种吡咯烷-1-胺-二盐酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) * 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
DE19548797A1 (de) * 1995-12-27 1997-07-03 Thomae Gmbh Dr K Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
AU5226498A (en) 1998-06-10
IL129546A0 (en) 2000-02-29
FR2756285A1 (fr) 1998-05-29
TR199901143T2 (xx) 1999-08-23
JP2001504128A (ja) 2001-03-27
WO1998022443A1 (fr) 1998-05-28
FR2756285B1 (fr) 1998-12-18
EP0946517A1 (fr) 1999-10-06
SK66799A3 (en) 2000-02-14
HUP9904599A2 (hu) 2000-06-28
CO4910158A1 (es) 2000-04-24
KR20000069063A (ko) 2000-11-25
BG103414A (en) 2000-01-31
CZ178299A3 (cs) 1999-08-11
BR9713291A (pt) 1999-10-26
ZA9710515B (en) 1998-06-10
NO992436D0 (no) 1999-05-20
EE9900201A (et) 1999-12-15
CA2270478A1 (en) 1998-05-28
AR009627A1 (es) 2000-04-26
CN1238765A (zh) 1999-12-15

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