NO985335L - 2,4-Diaminopyrimidinderivater - Google Patents
2,4-DiaminopyrimidinderivaterInfo
- Publication number
- NO985335L NO985335L NO985335A NO985335A NO985335L NO 985335 L NO985335 L NO 985335L NO 985335 A NO985335 A NO 985335A NO 985335 A NO985335 A NO 985335A NO 985335 L NO985335 L NO 985335L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- compounds
- substances
- lower alkyl
- drugs
- Prior art date
Links
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse vedrører forbindelser med den generelle formel (I), hvor R1 betyr lavere alkoksy, R2 betyr brom, lavere alkoksy eller hydroksy, R3 betyr hydrogen, lavere alkyl, cykloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl eller cyano, R4 og R5 hver uav- hengig betyr hydrogen, lavere alkyl, lavere alkoksy, halogen, hydroksy, amino, di(lavere alkyl)amino, cyano eller nitro, og Q betyr etynylen eller vinylen, farma- søytisk anvendbare salter derav, anvendelsen av disse forbindelser og deres salter som terapeutisk aktive substanser; legemidler basert på disse substanser og deres fremstilling; anvendelse av disse substanser som legemidler og for fremstilling av antibakterielt aktive legemidler; samt fremstillingen av forbindelsene med formel (I) og deres farmasøytisk akseptable salter og mellomprodukter ved deres fremstilling.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96107739 | 1996-05-15 | ||
| PCT/EP1997/002355 WO1997043277A1 (en) | 1996-05-15 | 1997-05-07 | 2,4-diaminopyrimidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO985335D0 NO985335D0 (no) | 1998-11-16 |
| NO985335L true NO985335L (no) | 1999-01-15 |
Family
ID=8222784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO985335A NO985335L (no) | 1996-05-15 | 1998-11-16 | 2,4-Diaminopyrimidinderivater |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5866583A (no) |
| EP (1) | EP0901488B1 (no) |
| JP (1) | JP3098259B2 (no) |
| KR (1) | KR100295509B1 (no) |
| CN (1) | CN1098260C (no) |
| AR (1) | AR007088A1 (no) |
| AT (1) | ATE227282T1 (no) |
| AU (1) | AU726416B2 (no) |
| BR (1) | BR9709251A (no) |
| CA (1) | CA2254117C (no) |
| CO (1) | CO4840509A1 (no) |
| CY (1) | CY2425B1 (no) |
| CZ (1) | CZ364698A3 (no) |
| DE (1) | DE69716901T2 (no) |
| DK (1) | DK0901488T3 (no) |
| ES (1) | ES2184089T3 (no) |
| HR (1) | HRP970260A2 (no) |
| IL (1) | IL126702A0 (no) |
| MA (1) | MA24182A1 (no) |
| NO (1) | NO985335L (no) |
| NZ (1) | NZ332481A (no) |
| PE (1) | PE78898A1 (no) |
| PL (1) | PL330277A1 (no) |
| PT (1) | PT901488E (no) |
| TR (1) | TR199802331T2 (no) |
| TW (1) | TW438796B (no) |
| WO (1) | WO1997043277A1 (no) |
| YU (1) | YU51498A (no) |
| ZA (1) | ZA973984B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998039328A1 (en) * | 1997-03-03 | 1998-09-11 | F.Hoffmann-La Roche Ag | Substituted 2,4-diaminopyrimidines |
| JP4174077B2 (ja) * | 1997-03-03 | 2008-10-29 | バジリア ファルマスーチカ アーゲー | 置換２，４−ジアミノピリミジン |
| US6277860B1 (en) * | 1999-10-29 | 2001-08-21 | Pfizer Inc | Furopyridine antibacterials |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| CA2528834A1 (en) * | 2003-06-13 | 2005-02-10 | Arena Pharmaceuticals, Inc. | 5-substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor rup25 for the treatment of dyslipidemia and related diseases |
| EP1653949A4 (en) * | 2003-08-07 | 2009-04-22 | Merck & Co Inc | PYRAZOL CARBOXAMIDE AS AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 |
| AU2004264356B2 (en) | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| DE102005062987A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| CA2695331A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
| RU2528406C2 (ru) * | 2008-11-21 | 2014-09-20 | Раквалиа Фарма Инк. | Новое производное пиразол-3-карбоксамида, обладающее антагонистической активностью в отношении рецептора 5-нт2в |
| US8716280B2 (en) * | 2009-01-21 | 2014-05-06 | Basilea Pharmaceutica Ag | Bicyclic antibiotics |
| EP2513063B1 (de) * | 2009-12-15 | 2013-11-06 | Bayer CropScience AG | Verfahren zur herstellung von 1-alkyl-/1-aryl-5-pyrazolcarbonsäurederivaten |
| EP2694509B1 (en) | 2011-04-05 | 2016-05-18 | Pfizer Limited | Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of tropomyosin-related kinases |
| DE102013208484B4 (de) | 2013-05-08 | 2018-04-26 | Wirtgen Gmbh | Vorrichtung zum Bearbeiten von Straßen- oder Bodenoberflächen, sowie Verfahren zum Lenken einer Straßenfräsmaschine |
| WO2020041556A1 (en) * | 2018-08-22 | 2020-02-27 | The Regents Of The University Of Colorado, A Body Corporate | N-substituted-1h-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same |
| AR117169A1 (es) * | 2018-11-28 | 2021-07-14 | Bayer Ag | (tio)amidas de piridazina como compuestos fungicidas |
| WO2021233861A1 (en) * | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Azabicyclic(thio)amides as fungicidal compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4013644A (en) * | 1976-03-15 | 1977-03-22 | G. D. Searle & Co. | [8 α(E), 13aβ]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethenyl)-6H-dibenzo[a,g]quinolizines and intermediates thereto |
| NO811630L (no) * | 1980-05-29 | 1981-11-30 | Bayer Ag | Imidazoazolalkensyreamider, nye mellomprodukter for deres fremstilling, deres fremstilling og deres anvendelse som legemiddel |
| US4594199A (en) * | 1983-09-19 | 1986-06-10 | E. R. Squibb & Sons, Inc. | Method for making phosphinic acid intermediates |
| WO1992008461A1 (en) * | 1990-11-14 | 1992-05-29 | Protos Corporation | Specific inhibition of dihydrofolate reductase and compounds therefor |
| NZ296532A (en) * | 1994-11-24 | 2000-02-28 | F | Substituted 5-benzyl-2,4,-diaminopyrimidines |
| WO1996040640A1 (en) * | 1995-06-07 | 1996-12-19 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
| CA2238521C (en) * | 1995-12-04 | 2005-08-16 | F. Hoffmann-La Roche Ag | Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial |
-
1997
- 1997-04-19 TW TW086105103A patent/TW438796B/zh active
- 1997-04-24 US US08/842,459 patent/US5866583A/en not_active Expired - Lifetime
- 1997-05-07 BR BR9709251A patent/BR9709251A/pt not_active IP Right Cessation
- 1997-05-07 JP JP09540486A patent/JP3098259B2/ja not_active Expired - Fee Related
- 1997-05-07 AT AT97923018T patent/ATE227282T1/de not_active IP Right Cessation
- 1997-05-07 NZ NZ332481A patent/NZ332481A/xx unknown
- 1997-05-07 ES ES97923018T patent/ES2184089T3/es not_active Expired - Lifetime
- 1997-05-07 EP EP97923018A patent/EP0901488B1/en not_active Expired - Lifetime
- 1997-05-07 CA CA002254117A patent/CA2254117C/en not_active Expired - Fee Related
- 1997-05-07 PT PT97923018T patent/PT901488E/pt unknown
- 1997-05-07 PL PL97330277A patent/PL330277A1/xx unknown
- 1997-05-07 AU AU28942/97A patent/AU726416B2/en not_active Ceased
- 1997-05-07 PE PE1997000356A patent/PE78898A1/es not_active Application Discontinuation
- 1997-05-07 IL IL12670297A patent/IL126702A0/xx unknown
- 1997-05-07 DE DE69716901T patent/DE69716901T2/de not_active Expired - Lifetime
- 1997-05-07 CZ CZ983646A patent/CZ364698A3/cs unknown
- 1997-05-07 DK DK97923018T patent/DK0901488T3/da active
- 1997-05-07 CN CN97194633A patent/CN1098260C/zh not_active Expired - Fee Related
- 1997-05-07 WO PCT/EP1997/002355 patent/WO1997043277A1/en not_active Ceased
- 1997-05-07 TR TR1998/02331T patent/TR199802331T2/xx unknown
- 1997-05-07 KR KR1019980709204A patent/KR100295509B1/ko not_active Expired - Fee Related
- 1997-05-08 ZA ZA9703984A patent/ZA973984B/xx unknown
- 1997-05-12 AR ARP970101966A patent/AR007088A1/es unknown
- 1997-05-14 CO CO97025823A patent/CO4840509A1/es unknown
- 1997-05-15 MA MA24620A patent/MA24182A1/fr unknown
- 1997-05-15 HR HR96107739.3A patent/HRP970260A2/xx not_active Application Discontinuation
-
1998
- 1998-11-13 YU YU51498A patent/YU51498A/sr unknown
- 1998-11-16 NO NO985335A patent/NO985335L/no not_active Application Discontinuation
-
2004
- 2004-02-20 CY CY0400011A patent/CY2425B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |