NO995808L - Forbindelser, deres fremstilling og anvendelse for overfoering av nukleinsyrer inn i celler - Google Patents

Forbindelser, deres fremstilling og anvendelse for overfoering av nukleinsyrer inn i celler

Info

Publication number
NO995808L
NO995808L NO995808A NO995808A NO995808L NO 995808 L NO995808 L NO 995808L NO 995808 A NO995808 A NO 995808A NO 995808 A NO995808 A NO 995808A NO 995808 L NO995808 L NO 995808L
Authority
NO
Norway
Prior art keywords
compounds
nucleic acids
cells
transfer
preparation
Prior art date
Application number
NO995808A
Other languages
English (en)
Other versions
NO314497B1 (no
NO995808D0 (no
Inventor
Gerardo Byk
Cathrine Dubertret
Daniel Scherman
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO995808D0 publication Critical patent/NO995808D0/no
Publication of NO995808L publication Critical patent/NO995808L/no
Publication of NO314497B1 publication Critical patent/NO314497B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO19995808A 1997-05-28 1999-11-26 Lipopolyamin i D-, L- eller DL-form, deres fremstilling og anvendelse samtpreparater inneholdende forbindelsene NO314497B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706549A FR2763943B1 (fr) 1997-05-28 1997-05-28 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
PCT/FR1998/001041 WO1998054130A1 (fr) 1997-05-28 1998-05-25 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules

Publications (3)

Publication Number Publication Date
NO995808D0 NO995808D0 (no) 1999-11-26
NO995808L true NO995808L (no) 1999-11-26
NO314497B1 NO314497B1 (no) 2003-03-31

Family

ID=9507333

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995808A NO314497B1 (no) 1997-05-28 1999-11-26 Lipopolyamin i D-, L- eller DL-form, deres fremstilling og anvendelse samtpreparater inneholdende forbindelsene

Country Status (17)

Country Link
US (1) US6300321B1 (no)
EP (1) EP0984925B1 (no)
JP (1) JP4467084B2 (no)
KR (1) KR20010013029A (no)
CN (1) CN1131208C (no)
AT (1) ATE284383T1 (no)
AU (1) AU738320B2 (no)
BR (1) BR9809506A (no)
CA (1) CA2290664C (no)
DE (1) DE69828045T2 (no)
FR (1) FR2763943B1 (no)
HU (1) HUP0001937A3 (no)
IL (1) IL132951A0 (no)
NO (1) NO314497B1 (no)
PL (1) PL336983A1 (no)
WO (1) WO1998054130A1 (no)
ZA (1) ZA984440B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314926B1 (en) 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
WO2002043769A2 (en) * 2000-11-29 2002-06-06 Gencell S.A. Neutral and anionic colloidal particles for gene delivery
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
EP1513538A4 (en) * 2002-06-14 2007-08-22 Mirus Bio Corp Novel methods for introducing polynucleotides into cells
AU2004246904B2 (en) * 2003-06-18 2010-02-04 Biolab Ltd. Sphingolipids polyalkylamine conjugates for use in transfection
US7906122B2 (en) * 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
US7973084B2 (en) 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
KR100699279B1 (ko) 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
KR20080088570A (ko) * 2005-08-10 2008-10-02 더 존스 홉킨스 유니버시티 항기생충 및 항암 치료제 및 라이신-특이적인 디메틸라제억제제로 유용한 폴리아민
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
ES3065854T3 (en) 2011-12-07 2026-05-08 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
IL316479A (en) 2014-06-25 2024-12-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle compositions for nucleic acid delivery
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
RS63986B1 (sr) 2015-10-28 2023-03-31 Acuitas Therapeutics Inc Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
ES2981244T3 (es) 2017-04-28 2024-10-07 Acuitas Therapeutics Inc Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos
US11639329B2 (en) 2017-08-16 2023-05-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036030A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
US11542225B2 (en) 2017-08-17 2023-01-03 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP4501322A3 (en) 2017-08-17 2025-04-16 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
IL281615B2 (en) 2018-09-21 2026-01-01 Acuitas Therapeutics Inc Systems and methods for producing lipid nanoparticles and liposomes
US12583816B2 (en) 2018-10-18 2026-03-24 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
JP7523449B2 (ja) 2019-01-11 2024-07-26 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
JP7798855B2 (ja) 2020-07-16 2026-01-14 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子に使用するためのカチオン性脂質
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730405A4 (en) * 1993-11-24 1997-02-19 Megabios Corp AMPHIPHILE GUANIDINE DERIVATIVES
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
DE69703878T2 (de) * 1996-03-01 2001-04-26 Centre National De La Recherche Scientifique (C.N.R.S.), Paris Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen

Also Published As

Publication number Publication date
JP4467084B2 (ja) 2010-05-26
EP0984925B1 (fr) 2004-12-08
KR20010013029A (ko) 2001-02-26
IL132951A0 (en) 2001-03-19
PL336983A1 (en) 2000-07-31
EP0984925A1 (fr) 2000-03-15
CN1131208C (zh) 2003-12-17
DE69828045D1 (de) 2005-01-13
WO1998054130A1 (fr) 1998-12-03
CA2290664C (fr) 2010-04-13
NO314497B1 (no) 2003-03-31
AU738320B2 (en) 2001-09-13
CA2290664A1 (fr) 1998-12-03
NO995808D0 (no) 1999-11-26
AU8022198A (en) 1998-12-30
ATE284383T1 (de) 2004-12-15
FR2763943B1 (fr) 1999-07-09
US6300321B1 (en) 2001-10-09
HUP0001937A2 (hu) 2000-10-28
CN1257480A (zh) 2000-06-21
JP2002502388A (ja) 2002-01-22
FR2763943A1 (fr) 1998-12-04
HUP0001937A3 (en) 2003-10-28
BR9809506A (pt) 2000-06-20
DE69828045T2 (de) 2005-12-01
ZA984440B (en) 1998-12-10

Similar Documents

Publication Publication Date Title
NO995808D0 (no) Forbindelser, deres fremstilling og anvendelse for overföring av nukleinsyrer inn i celler
CY1119742T1 (el) Βιολογικα συστηματα μεταφορας πολλαπλου-συστατικου
NO962791D0 (no) Preparater inneholdende nukleinsyrer, deres fremstilling og anvendelse
MXPA03001511A (es) Imidazol-5-il-2-amino-pirimidinas como agentes para la inhibicion de la proliferacion celular.
DE50010727D1 (de) Flächiges Implantat
AR004357A1 (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
CL2008000057A1 (es) Composicion que comprende una enzima capaz de escindir un enlace para liberar una proteina o un carbohidrato de la superficie celular; uso de dicha enzima para tratar o aliviar el riesgo de una infeccion del tracto digestivo.
AU6059100A (en) Thermal and ph stable protein thickening agent and method of making the same
PT1169460E (pt) Preparacao de moleculas biologicamente activas.
IS5504A (is) Samsetning virk við meðhöndlun á getuleysi
AU1741601A (en) Mesenchymal stem cells and/or progenitor cells, their isolation and use
TR199802503A3 (tr) Endojen gen aktivasyonu için hücrelerin optimizasyonu.
FI970163L (fi) Mikro-organismien kiinteä kasvualusta, sen valmistus ja käyttö
NO20022022D0 (no) N-guanidinoalkylamider, deres fremstilling, deres anvendelse og farmasöytiske preparater omfattende disse
IL143983A0 (en) Use of cellular transport systems for the transfer of nucleic acids through the nuclear envelope
IT1317478B1 (it) Procedimento per la manipolazione e il trasferimento di forme per ilmontaggio di calzature.
MXPA02002838A (es) Derivados de piperazina sustituidos, su obtencion y uso como medicamentos.
PT1165031E (pt) Composicao do resorcinol
EA200000875A1 (ru) Белки, взаимодействующие с каспазой-8
WO1999038821A3 (fr) Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications
AU3609800A (en) Novel formulations of alkyllithiums with improved thermal stability, processes to produce these formulations and processes for using the same to improve stability of living polymer chain ends
WO2002028874A3 (en) Tumor proliferation inhibitors
DE60033943D1 (de) Schwefelfreie enzyme
NO20021634L (no) Fremstilling av rekombinante adenoviruser og adenovirusbanker
EP0882790A4 (en) MOLECULE OF THE TRAF FAMILY, THE CODING POLYNUCLEOTID FOR IT, AND ANTIBODIES AGAINST IT