ATE284383T1 - Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen - Google Patents

Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen

Info

Publication number
ATE284383T1
ATE284383T1 AT98928356T AT98928356T ATE284383T1 AT E284383 T1 ATE284383 T1 AT E284383T1 AT 98928356 T AT98928356 T AT 98928356T AT 98928356 T AT98928356 T AT 98928356T AT E284383 T1 ATE284383 T1 AT E284383T1
Authority
AT
Austria
Prior art keywords
compounds
cells
transfer
production
nuclic acids
Prior art date
Application number
AT98928356T
Other languages
English (en)
Inventor
Gerardo Byk
Catherine Dubertret
Daniel Scherman
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE284383T1 publication Critical patent/ATE284383T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98928356T 1997-05-28 1998-05-25 Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen ATE284383T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706549A FR2763943B1 (fr) 1997-05-28 1997-05-28 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
PCT/FR1998/001041 WO1998054130A1 (fr) 1997-05-28 1998-05-25 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules

Publications (1)

Publication Number Publication Date
ATE284383T1 true ATE284383T1 (de) 2004-12-15

Family

ID=9507333

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98928356T ATE284383T1 (de) 1997-05-28 1998-05-25 Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen

Country Status (17)

Country Link
US (1) US6300321B1 (de)
EP (1) EP0984925B1 (de)
JP (1) JP4467084B2 (de)
KR (1) KR20010013029A (de)
CN (1) CN1131208C (de)
AT (1) ATE284383T1 (de)
AU (1) AU738320B2 (de)
BR (1) BR9809506A (de)
CA (1) CA2290664C (de)
DE (1) DE69828045T2 (de)
FR (1) FR2763943B1 (de)
HU (1) HUP0001937A3 (de)
IL (1) IL132951A0 (de)
NO (1) NO314497B1 (de)
PL (1) PL336983A1 (de)
WO (1) WO1998054130A1 (de)
ZA (1) ZA984440B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
PT1181304E (pt) 1999-04-08 2008-01-23 Antisoma Res Ltd Actividade antiproliferativa de oligonucleótidos ricos em g e método de utilização dos mesmos para ligação a nucleolina
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
CA2429803A1 (en) * 2000-11-29 2002-06-06 Gencell S.A. Neutral and anionic colloidal particles for gene delivery
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
WO2003106636A2 (en) * 2002-06-14 2003-12-24 Mirus Corporation Novel methods for the delivery of polynucleotides to cells
US7906122B2 (en) * 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
JP2006527763A (ja) * 2003-06-18 2006-12-07 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム スフィンゴ脂質のポリアルキルアミン抱合体
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
KR100699279B1 (ko) * 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
US7973084B2 (en) 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
EP1940773B1 (de) * 2005-08-10 2015-03-18 Johns Hopkins University Als antiparasitäre thepeutika und antikrebstherapeutika und als lysinspezifische demethylaseinhibitoren geeignete polyamine
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
DE21212055T1 (de) 2011-12-07 2022-08-04 Alnylam Pharmaceuticals, Inc. Biologisch abbaubare lipide zur freisetzung von wirkstoffen
CA2953341C (en) 2014-06-25 2023-01-24 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
CN108368028B (zh) 2015-10-28 2021-09-03 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
US12678515B2 (en) 2015-12-30 2026-07-14 Acuitas Therapeutics, Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
US11820728B2 (en) 2017-04-28 2023-11-21 Acuitas Therapeutics, Inc. Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
JP7355731B2 (ja) 2017-08-16 2023-10-03 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
US11524932B2 (en) 2017-08-17 2022-12-13 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
JP7461872B2 (ja) 2017-08-17 2024-04-04 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
EP3852911B1 (de) 2018-09-21 2025-01-22 Acuitas Therapeutics, Inc. Systeme und verfahren zur herstellung von lipidnanopartikeln und liposomen
CA3116576A1 (en) 2018-10-18 2020-04-23 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
PL3908568T3 (pl) 2019-01-11 2024-12-02 Acuitas Therapeutics, Inc. Lipidy do dostarczania środków czynnych w nanocząstkach lipidowych
KR20230051172A (ko) 2020-07-16 2023-04-17 아퀴타스 테라퓨틱스 인크. 지질 나노 입자에 사용하기 위한 양이온성 지질
WO2023114943A2 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960705771A (ko) * 1993-11-24 1996-11-08 벤자민 에프 맥그로우 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine)
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
AU723998B2 (en) * 1996-03-01 2000-09-07 Centre National De La Recherche Scientifique Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof

Also Published As

Publication number Publication date
FR2763943B1 (fr) 1999-07-09
ZA984440B (en) 1998-12-10
BR9809506A (pt) 2000-06-20
AU738320B2 (en) 2001-09-13
KR20010013029A (ko) 2001-02-26
CA2290664A1 (fr) 1998-12-03
NO995808D0 (no) 1999-11-26
HUP0001937A2 (hu) 2000-10-28
NO314497B1 (no) 2003-03-31
JP4467084B2 (ja) 2010-05-26
US6300321B1 (en) 2001-10-09
FR2763943A1 (fr) 1998-12-04
WO1998054130A1 (fr) 1998-12-03
EP0984925B1 (de) 2004-12-08
NO995808L (no) 1999-11-26
CN1257480A (zh) 2000-06-21
DE69828045T2 (de) 2005-12-01
HUP0001937A3 (en) 2003-10-28
EP0984925A1 (de) 2000-03-15
PL336983A1 (en) 2000-07-31
AU8022198A (en) 1998-12-30
JP2002502388A (ja) 2002-01-22
DE69828045D1 (de) 2005-01-13
CN1131208C (zh) 2003-12-17
CA2290664C (fr) 2010-04-13
IL132951A0 (en) 2001-03-19

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