NO996290L - 3-benzylpiperidiner - Google Patents

3-benzylpiperidiner

Info

Publication number
NO996290L
NO996290L NO996290A NO996290A NO996290L NO 996290 L NO996290 L NO 996290L NO 996290 A NO996290 A NO 996290A NO 996290 A NO996290 A NO 996290A NO 996290 L NO996290 L NO 996290L
Authority
NO
Norway
Prior art keywords
compounds
formula
preparation
brain
drugs
Prior art date
Application number
NO996290A
Other languages
English (en)
Other versions
NO996290D0 (no
Inventor
Henning Boettcher
Helmut Pruecher
Hartmut Greiner
Christoph Seyfried
Andrew Barber
Joseph-Maria Martinez
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO996290D0 publication Critical patent/NO996290D0/no
Publication of NO996290L publication Critical patent/NO996290L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen vedrører piperidin- derivater med formel (I) hvor R1, R2, m og k har de i krav l angitte betydninger, og deres salter, nye mellomprodukter og en fremgangsmåte for fremstilling av forbindelsene ifølge oppfinnelsen. Forbindelsene med formel (I) er sterke a-reseptorligander og utviser 5-HT-gjenopptakshemmende virkninger, og kan anvendes til frem- stilling av legemidler, f.eks. for behandling av forstyrrelser i sentral- nervesystemet, av slaganfall, hjerne- eller ryggmargstraumer eller av iskemiske tilstander.
NO996290A 1997-06-18 1999-12-17 3-benzylpiperidiner NO996290L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19725664A DE19725664A1 (de) 1997-06-18 1997-06-18 3-Benzylpiperidine
PCT/EP1998/003429 WO1998057953A1 (de) 1997-06-18 1998-06-08 3-benzylpiperidine

Publications (2)

Publication Number Publication Date
NO996290D0 NO996290D0 (no) 1999-12-17
NO996290L true NO996290L (no) 1999-12-17

Family

ID=7832780

Family Applications (1)

Application Number Title Priority Date Filing Date
NO996290A NO996290L (no) 1997-06-18 1999-12-17 3-benzylpiperidiner

Country Status (19)

Country Link
US (1) US6333339B1 (no)
EP (1) EP0993458B1 (no)
JP (1) JP2002511082A (no)
KR (1) KR20010013750A (no)
CN (1) CN1260791A (no)
AR (1) AR011483A1 (no)
AT (1) ATE236897T1 (no)
AU (1) AU8214598A (no)
BR (1) BR9810622A (no)
CA (1) CA2294379A1 (no)
DE (2) DE19725664A1 (no)
HU (1) HUP0003997A3 (no)
NO (1) NO996290L (no)
PL (1) PL337229A1 (no)
RU (1) RU2194047C2 (no)
SK (1) SK172799A3 (no)
TW (1) TW487706B (no)
WO (1) WO1998057953A1 (no)
ZA (1) ZA985254B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1249051C (zh) 2000-04-28 2006-04-05 阿卡蒂亚药品公司 毒蕈碱性激动剂
DE10050236A1 (de) * 2000-10-11 2002-04-25 Merck Patent Gmbh Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen
WO2002069973A1 (en) * 2001-03-02 2002-09-12 Sepracor, Inc. Piperidine-piperazine ligand for neurotransmitter receptors
DE10305739A1 (de) * 2003-02-11 2004-08-19 Merck Patent Gmbh Benzofuranderivate
AU2006271804B2 (en) * 2005-07-21 2011-03-31 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives as V1A receptor antagonists
RU2329044C1 (ru) * 2006-11-16 2008-07-20 Андрей Александрович Иващенко Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство
TWI410420B (zh) * 2008-02-05 2013-10-01 Dainippon Sumitomo Pharma Co 苄基哌啶化合物
CA2871766C (en) * 2011-12-08 2020-06-16 The Board Of Regents Of The University Of Texas System Piperidine-based small molecule 5-hydroxytryptamine 2c receptor (5-ht2cr) allosteric modulators
KR102508562B1 (ko) 2017-01-10 2023-03-10 석 영 정 직무능력 예측을 포함하는 직무 자동매칭 서비스 및 그를 이용하는 컴퓨팅 장치

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2961867D1 (en) * 1978-06-24 1982-03-04 Merck Patent Gmbh Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US5116846A (en) 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
US5814644A (en) 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
GB9314758D0 (en) 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
WO1998028292A1 (en) * 1996-12-23 1998-07-02 Smithkline Beecham Corporation Novel piperidine containing compounds

Also Published As

Publication number Publication date
ZA985254B (en) 1999-04-13
WO1998057953A1 (de) 1998-12-23
BR9810622A (pt) 2000-10-03
JP2002511082A (ja) 2002-04-09
EP0993458A1 (de) 2000-04-19
DE59807879D1 (de) 2003-05-15
NO996290D0 (no) 1999-12-17
ATE236897T1 (de) 2003-04-15
RU2194047C2 (ru) 2002-12-10
HUP0003997A3 (en) 2001-04-28
AR011483A1 (es) 2000-08-16
DE19725664A1 (de) 1998-12-24
CN1260791A (zh) 2000-07-19
EP0993458B1 (de) 2003-04-09
HUP0003997A2 (en) 2001-03-28
SK172799A3 (en) 2000-06-12
CA2294379A1 (en) 1998-12-23
US6333339B1 (en) 2001-12-25
PL337229A1 (en) 2000-08-14
AU8214598A (en) 1999-01-04
TW487706B (en) 2002-05-21
KR20010013750A (ko) 2001-02-26

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application