NO984861L - Piperidiner og pyrrolidiner - Google Patents

Piperidiner og pyrrolidiner

Info

Publication number
NO984861L
NO984861L NO984861A NO984861A NO984861L NO 984861 L NO984861 L NO 984861L NO 984861 A NO984861 A NO 984861A NO 984861 A NO984861 A NO 984861A NO 984861 L NO984861 L NO 984861L
Authority
NO
Norway
Prior art keywords
compounds
formula
pyrrolidines
piperidines
novel
Prior art date
Application number
NO984861A
Other languages
English (en)
Other versions
NO984861D0 (no
Inventor
Joachim Morz
Ttcher Henning B
Ralf Devant
Hartmut Greiner
Gerd Bartoszyk
J Rgen Harting
Christoph Seyfried
Bengt Ronny Andersson
Lars Olov Hansson
Clas Ke Sonesson
F Nils Peter Stjernl
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO984861D0 publication Critical patent/NO984861D0/no
Publication of NO984861L publication Critical patent/NO984861L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Oppfinnelsen vedrører nye piperidin- og pyrrolidinderivater med formel (I). hvor,,, k, 1, m og n har betyd-ningene angitt i krav 1, og deres sal-ter, nye mellomprodukter og fremgangs-måter for fremstilling av forbindelsene ifølge oppfinnelsen. Forbindelsene med formel (I) virker som 5-HT-reseptor-antagonister og utviser 5-HT-gjenopp-taksinhiberende virkninger, og kan an-vendes til fremstillingen av medika-menter .
NO984861A 1996-04-18 1998-10-16 Piperidiner og pyrrolidiner NO984861L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (de) 1996-04-18 1996-04-18 Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
PCT/EP1997/001853 WO1997040038A1 (en) 1996-04-18 1997-04-14 Piperidines and pyrrolidines

Publications (2)

Publication Number Publication Date
NO984861D0 NO984861D0 (no) 1998-10-16
NO984861L true NO984861L (no) 1998-10-16

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984861A NO984861L (no) 1996-04-18 1998-10-16 Piperidiner og pyrrolidiner

Country Status (15)

Country Link
EP (1) EP0898569A1 (no)
JP (1) JP2000508670A (no)
KR (1) KR20000005505A (no)
AR (1) AR006690A1 (no)
AU (1) AU2696797A (no)
BR (1) BR9708677A (no)
CA (1) CA2252385A1 (no)
CZ (1) CZ330598A3 (no)
DE (1) DE19615232A1 (no)
HU (1) HUP9901389A3 (no)
NO (1) NO984861L (no)
PL (1) PL329351A1 (no)
SK (1) SK141998A3 (no)
WO (1) WO1997040038A1 (no)
ZA (1) ZA973301B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (de) 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
DE69903930T2 (de) * 1998-04-08 2003-07-17 Wyeth, Madison N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen
AU3765899A (en) * 1998-04-29 1999-11-16 American Home Products Corporation Serotonergic agents
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
CN1312802A (zh) * 1998-06-15 2001-09-12 美国家用产品公司 作为5－羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶
EP1140831A1 (en) * 1998-12-17 2001-10-10 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
DE69925160T2 (de) * 1998-12-17 2006-02-16 Wyeth Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
TR200101939T2 (tr) * 1999-01-28 2002-05-21 Bristol-Myers Squibb Company Antidepresan heterosiklik bileşikler
JP4159358B2 (ja) * 2000-12-27 2008-10-01 アクシオジェネシス アーゲー 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
EP4347559A4 (en) * 2021-06-02 2025-04-09 Saint Joseph's University FLUORINATED TRYPTAMINE COMPOUNDS, RELATED ANALOGUES AND METHODS USING THEM
EP4469453A1 (en) 2022-01-29 2024-12-04 Suven Life Sciences Limited Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
IL101722A (en) * 1991-05-02 1996-05-14 Wyeth John & Brother Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
KR20000005505A (ko) 2000-01-25
ZA973301B (en) 1997-10-24
AU2696797A (en) 1997-11-12
WO1997040038A1 (en) 1997-10-30
HUP9901389A2 (hu) 1999-08-30
PL329351A1 (en) 1999-03-29
BR9708677A (pt) 1999-08-03
EP0898569A1 (en) 1999-03-03
SK141998A3 (en) 1999-03-12
NO984861D0 (no) 1998-10-16
CA2252385A1 (en) 1997-10-30
DE19615232A1 (de) 1997-10-23
AR006690A1 (es) 1999-09-08
CZ330598A3 (cs) 1999-01-13
JP2000508670A (ja) 2000-07-11
HUP9901389A3 (en) 2000-09-28

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