NZ219267A - Aromatic diamines useful in the treatment of angina, and preparation thereof - Google Patents

Aromatic diamines useful in the treatment of angina, and preparation thereof

Info

Publication number
NZ219267A
NZ219267A NZ219267A NZ21926787A NZ219267A NZ 219267 A NZ219267 A NZ 219267A NZ 219267 A NZ219267 A NZ 219267A NZ 21926787 A NZ21926787 A NZ 21926787A NZ 219267 A NZ219267 A NZ 219267A
Authority
NZ
New Zealand
Prior art keywords
angina
preparation
treatment
aromatic diamines
diamines useful
Prior art date
Application number
NZ219267A
Other languages
English (en)
Inventor
Harald Maschler
Original Assignee
Beecham Wuelfing Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Wuelfing Gmbh & Co Kg filed Critical Beecham Wuelfing Gmbh & Co Kg
Publication of NZ219267A publication Critical patent/NZ219267A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
NZ219267A 1986-02-15 1987-02-13 Aromatic diamines useful in the treatment of angina, and preparation thereof NZ219267A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868603765A GB8603765D0 (en) 1986-02-15 1986-02-15 Compounds

Publications (1)

Publication Number Publication Date
NZ219267A true NZ219267A (en) 1990-11-27

Family

ID=10593121

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ219267A NZ219267A (en) 1986-02-15 1987-02-13 Aromatic diamines useful in the treatment of angina, and preparation thereof

Country Status (11)

Country Link
US (1) US5494933A (da)
EP (1) EP0233762B1 (da)
JP (2) JP2543690B2 (da)
AU (1) AU6877987A (da)
DE (1) DE3781174T2 (da)
DK (1) DK75587A (da)
GB (1) GB8603765D0 (da)
HK (1) HK196796A (da)
NZ (1) NZ219267A (da)
PT (1) PT84294B (da)
ZA (1) ZA871062B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
IT1229214B (it) * 1989-03-31 1991-07-25 Alfa Wassermann S P A Contrada Processo per la sintesi della n metil 3,4 dimetossifeniletilamina
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
JP2534421B2 (ja) * 1990-10-25 1996-09-18 山之内製薬株式会社 トリメトキシベンゼン誘導体
FR2691064B3 (fr) * 1992-05-14 1996-01-12 Beecham Laboratoires Nouveau medicament pour le traitement de l'arythmie.
FR2694557B1 (fr) * 1992-08-05 1994-09-23 Synthelabo Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique.
FR2710059A1 (fr) * 1993-09-13 1995-03-24 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
FR2710065B1 (fr) * 1993-09-13 1996-10-04 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
FR2715652B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de N-[3-[(2,3-dihydro-1H-inden-2-yl)alkyl-amino]propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide leur préparation et leur application en thérapeutique.
TW281667B (da) * 1994-02-03 1996-07-21 Synthelabo
AU1949795A (en) * 1995-03-08 1996-09-23 Smithkline Beecham Laboratoires Pharmaceutiques Heterocyclycarboxamides and other compounds for the treatment of the cardiac arrhythmias
GB9513756D0 (en) * 1995-07-06 1995-09-06 Smithkline Beecham Plc Novel process & compounds
AR067584A1 (es) * 2007-07-20 2009-10-14 Hoffmann La Roche Un conjugado de un anticuerpo contra la cd4 y peptidos antifusogenicos

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670374A (en) * 1952-05-17 1954-02-23 Searle & Co N-dialkylaminoalkyl aminobenzanilides and n-aralkylaminobenzamides and their salts
GB862467A (en) * 1958-03-14 1961-03-08 American Cyanamid Co N-substituted anilides and acid addition salts thereof
US2944081A (en) * 1958-03-14 1960-07-05 American Cyanamid Co Diphenyl alkylenediamines and methods of preparing the same
FR965M (da) * 1960-02-04 1961-11-27
US3049552A (en) * 1960-11-03 1962-08-14 Merck & Co Inc Furfuryl isocyanates
US3049562A (en) * 1961-03-09 1962-08-14 American Cyanamid Co 1-(aralkyl, lower alkylamino lower alkyl), 1-phenyl, 3, 3-dilower alkylureas
GB1004071A (en) * 1961-07-03 1965-09-08 Council Scient Ind Res Substituted ª‰-phenethylamines and a process for the production thereof
DE1170961B (de) * 1962-04-19 1964-05-27 Roehm & Haas Gmbh Verfahren zur Herstellung von N-(N'-Methyl-N'-ª‰-phenaethylamino-tert.-butyl)-propionaniliden
GB1050132A (da) * 1963-03-01
US3196172A (en) * 1963-05-20 1965-07-20 American Cyanamid Co Trifluoromethylphenylalkylenediamines
US3365453A (en) * 1963-10-28 1968-01-23 Sterling Drug Inc 1-phenyl-4-lower-alkyl-2-piperazinones
GB1232787A (da) * 1967-08-08 1971-05-19
US3528990A (en) * 1967-11-14 1970-09-15 Colgate Palmolive Co 1-aminoalkyl derivatives of 2,1-benzisothiazoline
US3789073A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Adamantylalkylaminoalkyl benzamides
CH618571A4 (da) * 1970-05-16 1976-09-30
US4322434A (en) * 1979-05-04 1982-03-30 Schering Corporation N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
DE3242344A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
DE3428526A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminoalkohole, verfahren zu deren herstellung sowie diese verbindung enthaltende arzneimittel
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
JPH0328137A (ja) * 1989-06-23 1991-02-06 Nippon Sheet Glass Co Ltd 平坦な面を有するガラス容器成形方法

Also Published As

Publication number Publication date
DK75587A (da) 1987-08-16
ZA871062B (en) 1988-10-26
EP0233762A3 (en) 1989-05-10
PT84294A (en) 1987-03-01
JP2663258B2 (ja) 1997-10-15
JP2543690B2 (ja) 1996-10-16
EP0233762A2 (en) 1987-08-26
DK75587D0 (da) 1987-02-13
EP0233762B1 (en) 1992-08-19
PT84294B (pt) 1989-09-14
JPS62240653A (ja) 1987-10-21
US5494933A (en) 1996-02-27
AU6877987A (en) 1987-08-20
HK196796A (en) 1996-11-01
GB8603765D0 (en) 1986-03-19
DE3781174D1 (de) 1992-09-24
DE3781174T2 (de) 1993-02-11
JPH08268983A (ja) 1996-10-15

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