NZ239947A - 11-alkoxy camptothecin derivatives, preparation and pharmaceutical compositions - Google Patents

11-alkoxy camptothecin derivatives, preparation and pharmaceutical compositions

Info

Publication number
NZ239947A
NZ239947A NZ23994791A NZ23994791A NZ239947A NZ 239947 A NZ239947 A NZ 239947A NZ 23994791 A NZ23994791 A NZ 23994791A NZ 23994791 A NZ23994791 A NZ 23994791A NZ 239947 A NZ239947 A NZ 239947A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
camptothecin
hydrogen
liquid
Prior art date
Application number
NZ23994791A
Other languages
English (en)
Inventor
Patrick Lee Burk
Joseph Marian Fortunak
Antonietta Rose Mastrocola
Mark Mellinger
Jeffery Lee Wood
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NZ239947A publication Critical patent/NZ239947A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ23994791A 1990-09-28 1991-09-26 11-alkoxy camptothecin derivatives, preparation and pharmaceutical compositions NZ239947A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28

Publications (1)

Publication Number Publication Date
NZ239947A true NZ239947A (en) 1994-07-26

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ23994791A NZ239947A (en) 1990-09-28 1991-09-26 11-alkoxy camptothecin derivatives, preparation and pharmaceutical compositions

Country Status (24)

Country Link
US (1) US5734056A (2)
EP (1) EP0547165B1 (2)
JP (1) JP2848958B2 (2)
CN (1) CN1033509C (2)
AT (1) ATE186461T1 (2)
AU (1) AU664830B2 (2)
CA (1) CA2090967C (2)
CZ (1) CZ51593A3 (2)
DE (1) DE69131775T2 (2)
DK (1) DK0547165T3 (2)
ES (1) ES2137932T3 (2)
FI (1) FI931384A7 (2)
GR (1) GR3031823T3 (2)
HU (1) HUT70024A (2)
IE (1) IE913402A1 (2)
IL (1) IL99571A (2)
NO (1) NO931153D0 (2)
NZ (1) NZ239947A (2)
PT (1) PT99109B (2)
SI (1) SI9111599A (2)
SK (1) SK283693B6 (2)
WO (1) WO1992005785A1 (2)
YU (1) YU159991A (2)
ZA (1) ZA917748B (2)

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US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
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US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
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US7151179B2 (en) * 2003-05-12 2006-12-19 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
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US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
JP2008509211A (ja) * 2004-08-09 2008-03-27 シルパ・メディケア・リミテッド 塩酸イリノテカン三水和物の改良された製造方法
NZ554677A (en) * 2004-11-05 2010-08-27 Samyang Corp Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
ZA200800907B (en) * 2005-07-18 2010-04-28 Bipar Sciences Inc Treatment of cancer
US8349863B2 (en) * 2005-10-10 2013-01-08 Cipla Limited Crystalline polymorphic form of a camptothecin analogue
US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
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JP2010504079A (ja) * 2006-06-12 2010-02-12 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤を用いる疾病の治療方法
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
WO2008030883A2 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
CN101534836B (zh) * 2006-09-05 2011-09-28 彼帕科学公司 Parp抑制剂在制备治疗肥胖症的药物中的用途
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
CN101903025A (zh) * 2007-10-19 2010-12-01 彼帕科学公司 利用苯并吡喃酮-型parp抑制剂治疗癌症的方法和组合物
WO2009054332A1 (ja) 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. ピリドン置換ジヒドロピラゾロピリミジノン誘導体
US7732491B2 (en) * 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
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ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
RU2010128107A (ru) * 2007-12-07 2012-01-20 Байпар Сайенсиз, Инк. (Us) Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp
CN102046634B (zh) 2008-05-29 2013-04-24 日本迈科洛生物制药有限公司 喜树碱衍生物的制备方法
AU2010218781A1 (en) 2009-02-25 2011-07-28 Msd K.K. Pyrimidopyrimidoindazole derivative
WO2010101734A1 (en) 2009-03-06 2010-09-10 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
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JP2014504638A (ja) 2011-02-01 2014-02-24 グラクソスミスクライン インテレクチュアル プロパティ リミテッド 組合せ
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (en) * 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan
CA3017140A1 (en) * 2016-03-08 2017-09-14 Cheng Lab & Company, Llc Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline
WO2021173773A1 (en) 2020-02-25 2021-09-02 Mediboston, Inc. Camptothecin derivatives and conjugates thereof
US12521444B2 (en) 2021-02-25 2026-01-13 Fortvita Biologics Limited Anti-HER2 antibody-drug conjugates and uses thereof
US20250295771A1 (en) 2022-05-11 2025-09-25 Celgene Corporation Methods and uses related to t cell therapy and production of same

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JPS5842192B2 (ja) * 1974-05-18 1983-09-17 フセソユ−ズヌイ ナウチノ イスレドワ−チエレスキ− ヒミコ フアルマツエフチチエスキ− インスチツ−ト イメ−ニ エス オルジヨニキ−ゼ ５− オキシ −６− アミノメチルベンゾフランノ ユウドウタイノ セイホウ
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
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US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Also Published As

Publication number Publication date
FI931384L (fi) 1993-03-26
HU9300878D0 (en) 1993-06-28
SI9111599A (sl) 1998-02-28
ES2137932T3 (es) 2000-01-01
EP0547165A1 (en) 1993-06-23
CN1033509C (zh) 1996-12-11
US5734056A (en) 1998-03-31
HK1012283A1 (en) 1999-07-30
PT99109A (pt) 1992-08-31
WO1992005785A1 (en) 1992-04-16
DE69131775T2 (de) 2000-04-20
CZ51593A3 (en) 1994-01-19
DK0547165T3 (da) 2000-03-27
FI931384A0 (fi) 1993-03-26
DE69131775D1 (de) 1999-12-16
IL99571A0 (en) 1992-08-18
FI931384A7 (fi) 1993-03-26
CN1062731A (zh) 1992-07-15
ATE186461T1 (de) 1999-11-15
NO931153L (no) 1993-03-26
SK283693B6 (sk) 2003-12-02
EP0547165A4 (2) 1994-03-30
IL99571A (en) 2000-08-31
NO931153D0 (no) 1993-03-26
GR3031823T3 (en) 2000-02-29
ZA917748B (en) 1992-09-30
IE913402A1 (en) 1992-04-08
PT99109B (pt) 1999-02-26
JPH06501476A (ja) 1994-02-17
JP2848958B2 (ja) 1999-01-20
HUT70024A (en) 1995-09-28
EP0547165B1 (en) 1999-11-10
AU8739991A (en) 1992-04-28
SK25993A3 (en) 1993-07-07
AU664830B2 (en) 1995-12-07
CA2090967C (en) 2007-02-06
CA2090967A1 (en) 1992-03-29
YU159991A (sh) 1994-06-10

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