NZ242467A - Methods and compositions using oligonucleotides to treat mammalian tumour cells expressing neurotrophic factors - Google Patents

Methods and compositions using oligonucleotides to treat mammalian tumour cells expressing neurotrophic factors

Info

Publication number: NZ242467A
Authority: NZ; New Zealand
Prior art keywords: cell; bdnf; oligonucleotide; cells; neurotrophic factor
Prior art date: 1991-07-03

Application number

NZ242467A

Other languages

English (en)

Inventor

Stephen P Squinto

Steven H Nye

George D Yancopoulos

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-03

Filing date

1992-04-23

Publication date

1995-06-27

1992-04-23 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

1995-06-27 Publication of NZ242467A publication Critical patent/NZ242467A/en

Links

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- C07K14/475—Growth factors; Growth regulators
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity

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NZ242467A 1991-07-03 1992-04-23 Methods and compositions using oligonucleotides to treat mammalian tumour cells expressing neurotrophic factors NZ242467A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72878491A	1991-07-03	1991-07-03
US76267591A	1991-09-20	1991-09-20

Publications (1)

Publication Number	Publication Date
NZ242467A true NZ242467A (en)	1995-06-27

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ID=27111743

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Application Number	Title	Priority Date	Filing Date
NZ242467A NZ242467A (en)	1991-07-03	1992-04-23	Methods and compositions using oligonucleotides to treat mammalian tumour cells expressing neurotrophic factors

Country Status (9)

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EP (1)	EP0593663A4 (ja)
JP (1)	JPH06509333A (ja)
AU (1)	AU2322392A (ja)
CA (1)	CA2112799A1 (ja)
IE (1)	IE921315A1 (ja)
IL (1)	IL101683A0 (ja)
NZ (1)	NZ242467A (ja)
PT (1)	PT100424A (ja)
WO (1)	WO1993000909A1 (ja)

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US6902732B2 (en)	1992-06-12	2005-06-07	Massachusetts Institute Of Technology	Identification and characterization of a gene which protects cells from programmed cell death and uses therefor
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders
AU679752B2 (en) *	1993-05-28	1997-07-10	Cephalon, Inc.	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US5468872A (en) *	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5602309A (en) *	1993-10-04	1997-02-11	University Of Kentucky Research Foundation	Transgenic mice which overexpress nerve growth factor
WO1995022331A1 (en) *	1994-02-18	1995-08-24	Cephalon, Inc.	Aqueous indolocarbazole solutions
JPH11509193A (ja) *	1995-06-27	1999-08-17	ヘンリーエム．ジャクソンファウンデーションフォーザアドバンスメントオブミリタリーメディシン	細胞傷害を増強するための細胞周期動力学の動的遅延方法
US6274576B1 (en)	1995-06-27	2001-08-14	The Henry Jackson Foundation For The Advancement Of Military Medicine	Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
US5859311A (en) *	1995-11-27	1999-01-12	University Of Kentucky Research Foundation	Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
US6200968B1 (en)	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US7795246B2 (en)	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
EP1624936B1 (en) *	2003-05-16	2009-10-28	Universite Laval	Cns chloride modulation and uses thereof
WO2005110490A1 (en)	2004-05-14	2005-11-24	Universite Laval	Phospholipase c gamma modulation and uses thereof for management of pain and nociception
JP5866601B2 (ja)	2008-06-18	2016-02-17	ザテキサスエーアンドエムユニバーシティシステムＴｈｅＴｅｘａｓＡ＆ＭＵｎｉｖｅｒｓｉｔｙＳｙｓｔｅｍ	医薬組成物の製造方法
HK1210211A1 (en) *	2012-03-15	2016-04-15	科纳公司	Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
EA201492117A1 (ru) *	2012-05-16	2015-04-30	Рана Терапьютикс, Инк.	Композиции и способы для модулирования экспрессии bdnf

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US5229500A (en) *	1989-08-30	1993-07-20	Regeneron Pharmaceuticals, Inc.	Brain derived neurotrophic factor

1992
- 1992-04-23 IE IE131592A patent/IE921315A1/en unknown
- 1992-04-23 EP EP92915861A patent/EP0593663A4/en not_active Withdrawn
- 1992-04-23 NZ NZ242467A patent/NZ242467A/en unknown
- 1992-04-23 JP JP5502196A patent/JPH06509333A/ja active Pending
- 1992-04-23 CA CA002112799A patent/CA2112799A1/en not_active Abandoned
- 1992-04-23 IL IL101683A patent/IL101683A0/xx unknown
- 1992-04-23 WO PCT/US1992/003392 patent/WO1993000909A1/en not_active Ceased
- 1992-04-23 AU AU23223/92A patent/AU2322392A/en not_active Abandoned
- 1992-04-23 PT PT100424A patent/PT100424A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2112799A1 (en)	1993-01-21
AU2322392A (en)	1993-02-11
EP0593663A1 (en)	1994-04-27
WO1993000909A1 (en)	1993-01-21
IE921315A1 (en)	1993-01-13
JPH06509333A (ja)	1994-10-20
IL101683A0 (en)	1992-12-30
EP0593663A4 (en)	1996-10-30
PT100424A (pt)	1993-10-29

Publication	Publication Date	Title
NZ242467A (en)	1995-06-27	Methods and compositions using oligonucleotides to treat mammalian tumour cells expressing neurotrophic factors
US5990088A (en)	1999-11-23	Method for treating kaposi's sarcoma with antisense oligonucleotides
KR0171210B1 (ko)	1999-02-01	암치료용 항감작 올리고뉴클레오티드
Matsushima et al.	1993	Expression of trk A cDNA in neuroblastomas mediates differentiation in vitro and in vivo
Sherman et al.	1993	Basic fibroblast growth factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes
Shingo et al.	2001	Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
CA2174098C (en)	2011-01-25	Method of inducing and maintaining neuronal cells
Springer et al.	1994	Expression of GDNF mRNA in rat and human nervous tissue
Frantz et al.	2001	Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes
EP1352061B9 (de)	2007-03-07	Verfahren zur hemmung der expression eine zielgens
Welker et al.	2000	Nerve growth factor‐β induces mast‐cell marker expression during in vitro culture of human umbilical cord blood cells
WO1994015645A1 (en)	1994-07-21	Antisense molecules directed against genes of the raf oncogene family
CA1320446C (en)	1993-07-20	Modulation of lymphokine-resistant cellular states by dsrnas
Smith et al.	2001	Regional differences in the expression of corticostriatal synaptic plasticity
Wei et al.	2024	CXCL4: NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
US20040162257A1 (en)	2004-08-19	Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
Nathanson	2012	Regulation of neurokine receptor signaling and trafficking
WO2001022970A9 (en)	2002-08-01	Therapy with 2-5a and interferon
Iocca et al.	2003	Tumor necrosis factor-α acts as a complete mitogen for primary rat hepatocytes
KR20050103476A (ko)	2005-10-31	Ｈｉｆ-1 유전자 발현을 저해하는 안티센스올리고뉴클레오타이드
Israel	1986	The evolution of clinical molecular genetics: neuroblastoma as a model tumor
Suzuki et al.	1992	Dipyridamole enhances an anti‐proliferative effect of interferon in various types of human tumor cells
EP0658117B1 (en)	1998-06-24	Treatment of tumors with neurotrophic factors and cell proliferation inhibitors
Shikata et al.	2000	Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up‐regulation by interferon‐γ
CA2227370A1 (en)	1997-02-06	Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene