NZ312671A - Capsules of encapsulating cells producing viral particles - Google Patents

Capsules of encapsulating cells producing viral particles

Info

Publication number: NZ312671A
Authority: NZ; New Zealand
Prior art keywords: viral particles; capsules; cells producing; producing viral; encapsulating cells
Prior art date: 1995-06-27

Application number

NZ312671A

Other languages

English (en)

Inventor

Robert Michael Saller

Walter H Gunzburg

Brian Salmons

Original Assignee

Bavarian Nordic Res Inst As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-27

Filing date

1996-06-24

Publication date

1999-10-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8097001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ312671(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-06-24 Application filed by Bavarian Nordic Res Inst As filed Critical Bavarian Nordic Res Inst As

1999-10-28 Publication of NZ312671A publication Critical patent/NZ312671A/xx

Links

239000002245 particle Substances 0.000 title abstract 3
230000003612 virological effect Effects 0.000 title abstract 2
239000002775 capsule Substances 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 3
230000001177 retroviral effect Effects 0.000 abstract 2
230000001225 therapeutic effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Virology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

NZ312671A 1995-06-27 1996-06-24 Capsules of encapsulating cells producing viral particles NZ312671A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK74095		1995-06-27
PCT/EP1996/002748 WO1997001357A1 (en)	1995-06-27	1996-06-24	Encapsulated cells producing viral particles

Publications (1)

Publication Number	Publication Date
NZ312671A true NZ312671A (en)	1999-10-28

Family

ID=8097001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ312671A NZ312671A (en)	1995-06-27	1996-06-24	Capsules of encapsulating cells producing viral particles

Country Status (21)

Country	Link
US (1)	US6776985B1 (2)
EP (1)	EP0835137B1 (2)
JP (2)	JP4119952B2 (2)
KR (1)	KR100484883B1 (2)
CN (1)	CN1187095C (2)
AT (1)	ATE309000T1 (2)
AU (1)	AU708273B2 (2)
CA (1)	CA2222559A1 (2)
CZ (1)	CZ286979B6 (2)
DE (1)	DE69633180D1 (2)
DK (1)	DK0835137T3 (2)
ES (1)	ES2253754T3 (2)
IL (1)	IL122119A (2)
NO (1)	NO321427B1 (2)
NZ (1)	NZ312671A (2)
PL (1)	PL185338B1 (2)
PT (1)	PT835137E (2)
RU (1)	RU2187301C2 (2)
SI (1)	SI0835137T1 (2)
UA (1)	UA65525C2 (2)
WO (1)	WO1997001357A1 (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3908274B2 (ja)	1995-03-09	2007-04-25	ゲーエスエフ−フォルシュンクスツェントラム・フュア・ウムベルト・ウント・ゲズントハイト・ゲーエムベーハー	遺伝子治療用の抗菌ペプチドをコードする治療用遺伝子を有するベクター
ATE309000T1 (de)	1995-06-27	2005-11-15	Bavarian Nordic As	Verkapselte zellen die virenpartikeln produzieren
US6540995B1 (en)	1996-03-27	2003-04-01	Bavarian Nordic Research Institute Gmbh	Encapsulated cells producing cytochrome P450
RU2185821C2 (ru)	1996-03-27	2002-07-27	Бавариан Нордик Рисерч Инститьют А/С	Трансдуцирующие цитохром р450 ретровирусные векторы
WO1999056660A1 (en)	1998-05-05	1999-11-11	Koninklijke Philips Electronics N.V.	Toothbrush comprising a brush member having a bristle field and an interdental bristle field
AU2005229434B2 (en)	2004-03-30	2010-09-30	Nsgene A/S	Therapeutic use of a growth factor, NsG33
JP2008540347A (ja)	2005-05-03	2008-11-20	フェテリネールメディツィニシュウニベルジテートウィーン	浸透性カプセル
CN101903049B (zh)	2007-12-20	2014-08-13	伊西康公司	包囊的肾组织
KR101250925B1 (ko) *	2011-10-28	2013-04-04	한화케미칼 주식회사	캡슐 세포용 구조체
GB201408233D0 (en)	2014-05-09	2014-06-25	Austrianova Singapore Pte Ltd	Use of polyanionic composition
FR3044016A1 (fr) *	2015-11-24	2017-05-26	Glaxosmithkline Ip Dev Ltd	Lignees cellulaires stables pour la production retrovirale
KR102067352B1 (ko) *	2015-11-24	2020-01-16	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	레트로바이러스 생산을 위한 일시적인 형질감염 방법
US11427809B2 (en)	2016-05-25	2022-08-30	Lonza Houston, Inc.	Methods for isolating adeno-associated virus using a polydialkylammonium salt
RU2688383C2 (ru) *	2017-07-10	2019-05-21	Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского"	Способ синтеза белка в культуре бактериальных клеток
CA3220737A1 (en) *	2021-05-21	2022-11-24	Bionaut Labs Ltd.	System and method for localized therapeutic treatment
CN115820683B (zh) *	2022-09-28	2024-04-05	西南大学	家蚕Cyp9a20基因及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4391909A (en) *	1979-03-28	1983-07-05	Damon Corporation	Microcapsules containing viable tissue cells
DD160393A3 (de) *	1980-11-14	1983-07-27	Horst Dautzenberg	Mikrokapseln und verfahren zu ihrer herstellung
US4686098A (en) *	1984-05-14	1987-08-11	Merck & Co., Inc.	Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
US4680174A (en) *	1984-05-24	1987-07-14	Damon Biotech, Inc.	Induction of immune response by immunization with encapsulated antigen-producing cells
EP0199362A3 (en) *	1985-04-26	1987-10-07	Massachusetts Institute Of Technology	System and apparatus for delayed and pulsed release of biologically active substances
CA1310924C (en) *	1986-04-24	1992-12-01	Francis P. Mccormick	Infective drug delivery system
WO1989011539A1 (en)	1988-05-17	1989-11-30	Sloan-Kettering Institute For Cancer Research	Retroviral vector
US5328470A (en) *	1989-03-31	1994-07-12	The Regents Of The University Of Michigan	Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
DE4021050A1 (de) *	1990-06-29	1992-01-02	Akad Wissenschaften Ddr	Verfahren zur herstellung von mikrokapseln
CA2051288C (en) *	1990-09-14	2002-02-05	Robert L. Martuza	Viral targeted destruction of neoplastic cells
WO1992010564A1 (en) *	1990-12-13	1992-06-25	The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce	Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
WO1994029437A1 (en)	1993-06-07	1994-12-22	University Of Medicine & Dentistry Of New Jersey	Highly-efficient, self-inactivating, recombination-free, u3-free retroviral vectors
US5688773A (en)	1994-08-17	1997-11-18	The General Hospital Corporation	Method of selectively destroying neoplastic cells
CA2198210C (en)	1994-09-02	2006-07-11	Gsf - Forschungszentrum Fur Umwelt Und Gesundheit Gmbh	Non self-inactivating, expression targeted retroviral vectors
ATE309000T1 (de)	1995-06-27	2005-11-15	Bavarian Nordic As	Verkapselte zellen die virenpartikeln produzieren
DK0848757T3 (da)	1995-09-06	2002-07-01	Austrian Nordic Biotherapeutic	Anvendelse af WAP eller MMTV regulatoriske sekvenser for målrettet ekspression af sammenkædede heterologe gener i humane mammae celler, inklusiv humane mammae carcinoma celler
RU2185821C2 (ru)	1996-03-27	2002-07-27	Бавариан Нордик Рисерч Инститьют А/С	Трансдуцирующие цитохром р450 ретровирусные векторы

1996
- 1996-06-24 AT AT96923905T patent/ATE309000T1/de not_active IP Right Cessation
- 1996-06-24 EP EP96923905A patent/EP0835137B1/en not_active Expired - Lifetime
- 1996-06-24 DE DE69633180T patent/DE69633180D1/de not_active Expired - Lifetime
- 1996-06-24 IL IL12211996A patent/IL122119A/en not_active IP Right Cessation
- 1996-06-24 JP JP50416597A patent/JP4119952B2/ja not_active Expired - Lifetime
- 1996-06-24 CA CA002222559A patent/CA2222559A1/en not_active Abandoned
- 1996-06-24 PT PT96923905T patent/PT835137E/pt unknown
- 1996-06-24 DK DK96923905T patent/DK0835137T3/da active
- 1996-06-24 ES ES96923905T patent/ES2253754T3/es not_active Expired - Lifetime
- 1996-06-24 KR KR1019970709807A patent/KR100484883B1/ko not_active Expired - Lifetime
- 1996-06-24 SI SI9630729T patent/SI0835137T1/sl unknown
- 1996-06-24 NZ NZ312671A patent/NZ312671A/xx not_active IP Right Cessation
- 1996-06-24 CN CNB961950501A patent/CN1187095C/zh not_active Expired - Fee Related
- 1996-06-24 PL PL96324289A patent/PL185338B1/pl not_active IP Right Cessation
- 1996-06-24 AU AU64154/96A patent/AU708273B2/en not_active Expired
- 1996-06-24 RU RU98101362/13A patent/RU2187301C2/ru not_active IP Right Cessation
- 1996-06-24 WO PCT/EP1996/002748 patent/WO1997001357A1/en not_active Ceased
- 1996-06-24 UA UA97126354A patent/UA65525C2/uk unknown
- 1996-06-24 CZ CZ19974195A patent/CZ286979B6/cs not_active IP Right Cessation
1997
- 1997-12-10 NO NO19975813A patent/NO321427B1/no not_active IP Right Cessation
- 1997-12-23 US US08/996,460 patent/US6776985B1/en not_active Expired - Lifetime
2007
- 2007-11-21 JP JP2007301109A patent/JP4848348B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL185338B1 (pl)	2003-04-30
EP0835137B1 (en)	2005-11-09
AU6415496A (en)	1997-01-30
IL122119A (en)	2004-06-01
ES2253754T3 (es)	2006-06-01
KR19990028491A (ko)	1999-04-15
DK0835137T3 (da)	2006-03-06
KR100484883B1 (ko)	2005-09-02
CZ419597A3 (cs)	1998-03-18
CZ286979B6 (en)	2000-08-16
RU2187301C2 (ru)	2002-08-20
HK1010139A1 (en)	1999-06-17
JPH11508768A (ja)	1999-08-03
AU708273B2 (en)	1999-07-29
CN1187095C (zh)	2005-02-02
DE69633180D1 (de)	2004-09-23
PT835137E (pt)	2004-12-31
NO321427B1 (no)	2006-05-08
JP2008101011A (ja)	2008-05-01
EP0835137A1 (en)	1998-04-15
NO975813L (no)	1998-02-23
JP4848348B2 (ja)	2011-12-28
UA65525C2 (en)	2004-04-15
JP4119952B2 (ja)	2008-07-16
US6776985B1 (en)	2004-08-17
IL122119A0 (en)	1998-04-05
SI0835137T1 (sl)	2006-04-30
CA2222559A1 (en)	1997-01-16
PL324289A1 (en)	1998-05-11
NO975813D0 (no)	1997-12-10
WO1997001357A1 (en)	1997-01-16
ATE309000T1 (de)	2005-11-15
CN1189104A (zh)	1998-07-29

Legal Events

Date	Code	Title	Description
2002-04-26	ASS	Change of ownership	Owner name: BAVARIAN NORDIC A/S, DK Free format text: OLD OWNER(S): AUSTRIAN NORDIC BIOTHERAPEUTICS AG; GSFFORSCHUNGSZENTRUM FUR UMWELT UND GESUNDHEIT GMBH Owner name: GSF-FORSCHUNGSZENTRUM FUR UMWELT UND GESUNDHEI, DE Free format text: OLD OWNER(S): AUSTRIAN NORDIC BIOTHERAPEUTICS AG; GSFFORSCHUNGSZENTRUM FUR UMWELT UND GESUNDHEIT GMBH
2003-07-25	RENW	Renewal (renewal fees accepted)
2006-07-28	RENW	Renewal (renewal fees accepted)
2009-06-26	RENW	Renewal (renewal fees accepted)
2016-06-24	EXPY	Patent expired

Publication	Publication Date	Title
IL122119A0 (en)	1998-04-05	Encapsulated cells producing viral particles
CA2092195A1 (en)	1992-03-22	Retroviral packaging cell line
AU6871398A (en)	1998-10-22	Method for enhancing expression of a foreign or endogenous gene product in pla nts
FR2727689B1 (2)	1997-02-28
EP0743958A4 (en)	1999-07-28	NON-VIRAL VECTOR
AU4867396A (en)	1996-09-04	Process of preparing therapeutic compositions containing nanoparticles
AU6933496A (en)	1997-03-27	Antagonists of the oncogenic activity of the MDM2 protein and their use in the treatment of cancers
WO1996019568A3 (en)	1996-09-06	Stabilized ribozyme analogs
CA2284859A1 (en)	1998-10-01	Nucleic acid molecule for a human skeletal muscle-specific receptor
EP0156592A3 (en)	1987-03-11	Substained release pharmaceutical capsules
WO1996007749A3 (en)	1996-03-28	Methods and compositions for inhibiting production of replication competent virus
PL336640A1 (en)	2000-07-03	Substituted 3,3-diamino-2- propenonitriles, their production and application
CA2432971A1 (en)	2002-07-04	Polypeptides
AU6934398A (en)	1998-11-24	A process for the synthesis of modified p-chiral nucleotide analogues
IL125795A0 (en)	1999-04-11	Retroviral vectors encoding a cytochrome p450 gene
WO1999020742A3 (en)	1999-07-01	A packaging cell line producing siv-pseudotyped mlv
PT83472A (en)	1986-11-01	Process for preparing improved antiinflammatory compositions containing piroxicam
IL134194A0 (en)	2001-04-30	Streptogramines, their preparation and compositions containing them
CA2331440A1 (en)	1999-11-25	Amphotropic retrovirus packaging cell line, process for its production and use thereof
WO1996033282A3 (en)	1996-12-12	High efficiency ex vivo transduction of cells by high titer recombinant retroviral preparations
NZ507942A (en)	2003-06-30	Viral chimeras comprised of CAEV and HIV-1 genetic elements
JPS646298A (en)	1989-01-10	Novel physiologically active polypeptide
HUT76859A (en)	1997-12-29	4-halo-2-fluoro-5-alkoxybenzoyl derivatives, process for preparing such compounds and intermediates thereof
WO1988004666A3 (en)	1988-08-11	Lung cytotoxic peptides
WO2001018039A3 (en)	2001-05-25	INCREASED PRODUCTION OF INTERFERON-$g(a)