NZ515202A - Method for detecting and killing epithelial cancer cells - Google Patents

Method for detecting and killing epithelial cancer cells

Info

Publication number
NZ515202A
NZ515202A NZ515202A NZ51520201A NZ515202A NZ 515202 A NZ515202 A NZ 515202A NZ 515202 A NZ515202 A NZ 515202A NZ 51520201 A NZ51520201 A NZ 51520201A NZ 515202 A NZ515202 A NZ 515202A
Authority
NZ
New Zealand
Prior art keywords
marking agent
mitochondrial
agent
cells
cationic
Prior art date
Application number
NZ515202A
Other languages
English (en)
Inventor
Samuel D Bernal
Douglas D Burkett
Ralph E Green
Seth D Rose
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of NZ515202A publication Critical patent/NZ515202A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ515202A 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells NZ515202A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2000/005387 WO2001064110A1 (en) 2000-02-28 2000-02-28 Method for detecting and killing epithelial cancer cells
PCT/US2001/006318 WO2001064255A1 (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Publications (1)

Publication Number Publication Date
NZ515202A true NZ515202A (en) 2003-05-30

Family

ID=21741108

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ515202A NZ515202A (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Country Status (14)

Country Link
EP (1) EP1214101A4 (de)
JP (1) JP2003525044A (de)
KR (2) KR20080080681A (de)
CN (1) CN100544770C (de)
AU (2) AU2000237154A1 (de)
BR (1) BR0104747A (de)
CA (1) CA2370741A1 (de)
CZ (1) CZ20013861A3 (de)
IL (1) IL146141A0 (de)
MX (1) MXPA01010886A (de)
NO (1) NO20015242L (de)
NZ (1) NZ515202A (de)
RU (1) RU2226404C2 (de)
WO (2) WO2001064110A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
AU784558B2 (en) * 2000-06-30 2006-05-04 Zila Biotechnology, Inc. Rhodamine diagnostic agent and diagnostic methods for detections of epithelial cancer
JP2004509637A (ja) * 2000-09-26 2004-04-02 ジラ・インコーポレーテッド 浸潤癌の発生の早期予測のための方法
MXPA04002659A (es) * 2001-12-14 2004-06-18 Zila Inc Analisis molecular dirigido por tincion para pronostico y diagnostico de cancer.
US6890571B2 (en) 2002-05-14 2005-05-10 National Starch And Chemical Investment Holding Corporation Slowly digestible starch product
US7081261B2 (en) * 2002-05-14 2006-07-25 National Starch And Chemical Investment Holding Corporation Resistant starch prepared by isoamylase debranching of low amylose starch
US6929817B2 (en) 2002-05-14 2005-08-16 National Starch & Chemical Investment Holding Corporation Slowly digestible starch product
MXPA04012031A (es) * 2002-06-04 2005-03-07 Zila Biotechnology Inc Sustancia farmacologica azul de toluidina o y su uso para tincion in vivo y quimioterapia de tejidos displasicos.
CA2583427A1 (en) * 2004-09-30 2006-04-20 Zila Biotechnology, Inc. Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue
US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
RU2367365C1 (ru) * 2008-03-19 2009-09-20 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Способ хирургического лечения плоскоклеточного рака кожи без метастазов в регионарные лимфатические узлы
CN102497868A (zh) 2009-07-15 2012-06-13 N.V.努特里奇亚 用于刺激免疫系统的不可消化低聚糖的混合物
CN105510321A (zh) * 2011-12-29 2016-04-20 闫文广 用于上皮组织肿瘤细胞的检测剂组合物及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5194373A (en) * 1985-06-06 1993-03-16 Thomas Jefferson University Method of determining endothelial cell coverage of a prosthetic surface
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
DK0565668T3 (da) * 1991-10-31 2000-01-31 Zila Inc Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer
RU2127429C1 (ru) * 1995-06-06 1999-03-10 Эммануил Маркович Коган Способ диагностики гиперпластических процессов и рака эндометрия
ATE253380T1 (de) * 1996-01-16 2003-11-15 Zila Inc Verfahren und mittel zur in-vivo erkennung von mundhöhlenkrebs und von präkanzerösen zuständen
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
AU2592600A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
JP2004504615A (ja) * 2000-07-20 2004-02-12 ジラ・インク 形成異常の上皮組織を検出するための改良された診断方法
JP2004509637A (ja) * 2000-09-26 2004-04-02 ジラ・インコーポレーテッド 浸潤癌の発生の早期予測のための方法

Also Published As

Publication number Publication date
KR100907122B1 (ko) 2009-07-09
RU2226404C2 (ru) 2004-04-10
CA2370741A1 (en) 2001-09-07
JP2003525044A (ja) 2003-08-26
KR20080080681A (ko) 2008-09-04
WO2001064110A1 (en) 2001-09-07
WO2001064255A1 (en) 2001-09-07
CN1365288A (zh) 2002-08-21
AU785489B2 (en) 2007-11-15
CZ20013861A3 (cs) 2002-08-14
CN100544770C (zh) 2009-09-30
AU4331601A (en) 2001-09-12
NO20015242L (no) 2001-11-29
EP1214101A1 (de) 2002-06-19
AU2000237154A1 (en) 2001-09-12
IL146141A0 (en) 2002-07-25
BR0104747A (pt) 2002-09-17
NO20015242D0 (no) 2001-10-26
KR20020000222A (ko) 2002-01-05
MXPA01010886A (es) 2002-05-06
EP1214101A4 (de) 2005-04-13

Similar Documents

Publication Publication Date Title
Nasimian et al. Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling
AU785489B2 (en) Method for detecting and killing epithelial cancer cells
Muscella et al. [Pt (O, O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway
US6756063B2 (en) Methods and compositions for the treatment of human and animal cancers
Rodrigues et al. Acid-sensitive polyethylene glycol conjugates of doxorubicin: preparation, in vitro efficacy and intracellular distribution
JP2007508384A (ja) 癌を処置するための方法および組成物
HU228208B1 (en) Palladium-substituted bacteriochlorophyll derivatives and use thereof
KR102009560B1 (ko) 저산소환경에 의해 활성화되고 미토콘드리아에 대한 특이적 표적화가 가능한 항암 치료진단제
KR20140136525A (ko) 암 치료를 위한 화합물 및 방법
Duan et al. Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells
Dharap et al. Molecular targeting of BCL2 and BCLXL proteins by synthetic BCL2 homology 3 domain peptide enhances the efficacy of chemotherapy
Shao et al. Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells
Tsurui et al. Vitamin A protects the small intestine from methotrexate-induced damage in rats.
Wang et al. Transethosome‐Based Topical Administration Systems with Enhanced Penetration and Dual Actions for Treating EGFR‐Overexpressed Cutaneous Squamous Cell Carcinoma
EP2890374B1 (de) Zusammensetzungen und verfahren zur wirkstoffsensibilisierung oder inhibierung von krebszellen
US6649144B1 (en) Method for detecting and killing epithelial cancer cells
US20030017158A1 (en) Method for detecting and killing epithelial cancer cells
RU2713151C1 (ru) Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения
Mukherjee et al. Green Synthesis of Silver Nanoparticles Using Carica Papaya Leaf Extract and Its Anticancer Activities through Regulation of Microtubule Dynamics in Breast Cancer
Miyagi et al. Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts
PL229503B1 (pl) Formulacja farmaceutyczna zawierająca izotiocyjaniany i doksorubicynę do zastosowania w leczeniu nowotworów
Kosova et al. Anticancer effects of a newly-synthesized benzoxazole-derived 5-amino-2-[P-bromophenyl]-benzoxazole in breast cancer cell lines.
Abu-Setta et al. A Multimodal Study on the Ameliorative Potential of Metallo-Organic Compounds against Hepatocellular Carcinoma: Biochemical, Histological, Immunohistochemical, and Molecular Docking Approaches
Chaerunisaa et al. Cytotoxic Activity of Ethanolic Extract of Zanthoxylum acanthopodium DC. Fruit as Phytosomal System against MCF-7 Cell Line
Qiu et al. ATP‐Activated Tumor Targeting Therapy via Bioorthogonal Alkyne‐Calixarene Host–Guest Assembly

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
ASS Change of ownership

Owner name: ZILA BIOTECHNOLOGY, INC., US

Free format text: OLD OWNER(S): ZILA, INC.

RENW Renewal (renewal fees accepted)