OA09423A - Nouveaux dérivés du benzocycloheptène, leur procédé de préparation et les compositions pharmaceutiques les renfermant. - Google Patents

Nouveaux dérivés du benzocycloheptène, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Info

Publication number: OA09423A
Authority: OA; OAPI
Prior art keywords: alkyl; hydrogen; image; optionally substituted; benzocycloheptene
Prior art date: 1988-07-04

Application number

OA59605A

Other languages

English (en)

French (fr)

Inventor

Wierzbicki Michel

Hugon Pierre

Duhault Jacques

Lacour Francoise

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-04

Filing date

1989-07-04

Publication date

1992-10-15

1989-07-04 Application filed by Adir filed Critical Adir

1992-10-15 Publication of OA09423A publication Critical patent/OA09423A/xx

Links

ZVCPCZRXWGOICC-UHFFFAOYSA-N 1h-benzo[7]annulene Chemical class C1=CC=CC=C2CC=CC=C21 ZVCPCZRXWGOICC-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/14—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA59605A 1988-07-04 1989-07-04 Nouveaux dérivés du benzocycloheptène, leur procédé de préparation et les compositions pharmaceutiques les renfermant. OA09423A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8808989A FR2633617B1 (fr)	1988-07-04	1988-07-04	Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
OA09423A true OA09423A (fr)	1992-10-15

Family

ID=9368020

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA59605A OA09423A (fr)	1988-07-04	1989-07-04	Nouveaux dérivés du benzocycloheptène, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Country Status (15)

Country	Link
US (1)	US5079245A (de)
EP (1)	EP0354078B1 (de)
JP (1)	JPH0296542A (de)
AT (1)	ATE86603T1 (de)
AU (1)	AU612047B2 (de)
CA (1)	CA1334100C (de)
DE (1)	DE68905259T2 (de)
DK (1)	DK172604B1 (de)
ES (1)	ES2055125T3 (de)
FR (1)	FR2633617B1 (de)
IE (1)	IE64195B1 (de)
NZ (1)	NZ229796A (de)
OA (1)	OA09423A (de)
PT (1)	PT91050B (de)
ZA (1)	ZA895093B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0641539B2 (ja) *	1988-07-21	1994-06-01	東海カーボン株式会社	タイヤトレッドゴム配合用カーボンブラック
US5230878A (en) *	1989-10-02	1993-07-27	Tokai Carbon Co., Ltd.	Carbon black for tire tread rubber

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3836534A (en) *	1969-05-01	1974-09-17	Colgate Palmolive Co	5-piperazino-6-hydroxy-5h-benzo-cycloheptenes
CA969955A (en) *	1970-07-20	1975-06-24	Rene Viterbo	Dihydronaphthalene derivatives
FR2319332A1 (fr) *	1975-07-28	1977-02-25	Roussel Uclaf	Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits
US4237165A (en) *	1976-06-04	1980-12-02	Science Union Et Cie	Treatment of carbohydrate metabolism disorders
FR2359608A2 (fr) *	1976-07-26	1978-02-24	Roussel Uclaf	Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits
US4128666A (en) *	1977-08-18	1978-12-05	Smithkline Corporation	4 AND 5-Halo substituted 2-indanamine compounds
FR2409256A1 (fr) *	1977-11-18	1979-06-15	Roussel Uclaf	Nouveaux derives de la 5h-benzocycloepten-7-amine et leurs sels, procede de preparation et application a titre de medicament
DE2856856A1 (de) *	1978-01-09	1979-07-12	Sandoz Ag	Fettsaeure-amid-und-hydracid derivate, ihre herstellung und ihre verwendung als pharmazeutika
US4132737A (en) *	1978-02-27	1979-01-02	Eli Lilly And Company	Trifluoromethyl substituted 1-aminoindanes
EP0361577B1 (de) *	1988-09-19	1993-05-05	Akzo N.V.	Tetrahydronaphthalin und Indan-Derivate
DK0452390T3 (da) *	1989-01-09	1995-04-03	Upjohn Co	Halogensubstituerede aminotetraliner

1988
- 1988-07-04 FR FR8808989A patent/FR2633617B1/fr not_active Expired - Lifetime
1989
- 1989-06-29 CA CA000604396A patent/CA1334100C/fr not_active Expired - Fee Related
- 1989-07-03 PT PT91050A patent/PT91050B/pt not_active IP Right Cessation
- 1989-07-03 EP EP89401896A patent/EP0354078B1/de not_active Expired - Lifetime
- 1989-07-03 AT AT89401896T patent/ATE86603T1/de not_active IP Right Cessation
- 1989-07-03 IE IE214289A patent/IE64195B1/en not_active IP Right Cessation
- 1989-07-03 DE DE8989401896T patent/DE68905259T2/de not_active Expired - Fee Related
- 1989-07-03 ES ES89401896T patent/ES2055125T3/es not_active Expired - Lifetime
- 1989-07-03 NZ NZ229796A patent/NZ229796A/xx unknown
- 1989-07-04 OA OA59605A patent/OA09423A/xx unknown
- 1989-07-04 AU AU37814/89A patent/AU612047B2/en not_active Ceased
- 1989-07-04 ZA ZA895093A patent/ZA895093B/xx unknown
- 1989-07-04 DK DK198903326A patent/DK172604B1/da not_active IP Right Cessation
- 1989-07-04 JP JP1172828A patent/JPH0296542A/ja active Granted
- 1989-07-05 US US07/375,591 patent/US5079245A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU612047B2 (en)	1991-06-27
JPH0521898B2 (de)	1993-03-25
PT91050B (pt)	1995-01-31
AU3781489A (en)	1990-02-08
NZ229796A (en)	1991-11-26
ES2055125T3 (es)	1994-08-16
IE64195B1 (en)	1995-07-12
DK332689D0 (da)	1989-07-04
DK332689A (da)	1990-01-05
ZA895093B (en)	1990-03-28
FR2633617B1 (fr)	1991-02-08
FR2633617A1 (fr)	1990-01-05
JPH0296542A (ja)	1990-04-09
DK172604B1 (da)	1999-02-22
ATE86603T1 (de)	1993-03-15
CA1334100C (fr)	1995-01-24
US5079245A (en)	1992-01-07
DE68905259T2 (de)	1993-09-23
EP0354078A3 (en)	1990-05-23
IE892142L (en)	1990-01-04
PT91050A (pt)	1990-02-08
EP0354078B1 (de)	1993-03-10
EP0354078A2 (de)	1990-02-07
DE68905259D1 (de)	1993-04-15

Publication	Publication Date	Title
OA09482A (fr)	1992-11-15	"Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
DK0618898T3 (da)	1999-10-18	Amidinoderivater
ATE67496T1 (de)	1991-10-15	Thiazolidinderivate, verfahren zu deren herstellung und deren anwendung.
MX12317A (es)	1993-09-01	Derivados de ester nitrico y procedimiento para suobtencion.
ATE74352T1 (de)	1992-04-15	Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
CA1249830A (en)	1989-02-07	ANTIHISTAMINES WITH DIPHENYL AND PHENYLPYRIDYL GROUPS
DE69110828D1 (de)	1995-08-03	Heterozyklische Aminderivate, deren Herstellung und deren Verwendung.
OA07926A (fr)	1987-01-31	Nouveaux dérivés de la quinoléine, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2456109A1 (fr)	1980-12-05	Nouveaux derives a substituants heterocycliques de 7-oximinoacetamido-cephalosporines, utiles notamment comme antibiotiques, et leur procede de preparation
FR2684101B1 (fr)	1993-12-31	Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2633617B1 (fr)	1991-02-08	Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
MA19952A1 (fr)	1984-07-01	Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE2962856D1 (en)	1982-07-01	Hexahydro-1,4-oxazepines, process for their preparation and pharmaceutical compositions containing them
IE782313L (en)	1979-05-24	Naphthalene derivatives
IT1205114B (it)	1989-03-15	2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
FR2405236A1 (fr)	1979-05-04	Acides 5, 6, 7-trimethoxy-naphtalene et hydronaphtalene-(2)-carboxyliques et derives, leur preparation et leur application a titre de medicament
FR2677647B1 (fr)	1993-08-20	Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
ES8504701A1 (es)	1985-04-16	Procedimiento para preparar derivados de 3-aril-3-pirrolina