OA10696A - Utilisation de dérivés tricycliques du 1,4-dihydro-1,4-dioxo 1h-naphtalène, nouveaux composés obtenus et leur application en thérapeutique. - Google Patents

Utilisation de dérivés tricycliques du 1,4-dihydro-1,4-dioxo 1h-naphtalène, nouveaux composés obtenus et leur application en thérapeutique. Download PDF

Info

Publication number: OA10696A
Authority: OA; OAPI
Prior art keywords: dihydro; dioxo; thiazole; new product; naphtho
Prior art date: 1995-12-12

Application number

OA9800080A

Other languages

English (en)

French (fr)

Inventor

Odile Boutherin-Falson

Stephanie Desquand-Billiald

Anita Favrou

Michel Finet

Olivier Tembo

Jean Luc Torregrosa

Sylvie Yannic-Arnoult

Marquer Florence Domagala-Le

Original Assignee

Innothera Lab Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-12

Filing date

1998-06-12

Publication date

2002-11-26

1998-06-12 Application filed by Innothera Lab Sa filed Critical Innothera Lab Sa

2002-11-26 Publication of OA10696A publication Critical patent/OA10696A/fr

Links

150000001875 compounds Chemical class 0.000 title claims description 42
230000001225 therapeutic effect Effects 0.000 title abstract description 3
150000003839 salts Chemical class 0.000 claims abstract description 19
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
125000003118 aryl group Chemical group 0.000 claims abstract description 9
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 9
230000002757 inflammatory effect Effects 0.000 claims abstract description 8
206010030113 Oedema Diseases 0.000 claims abstract description 5
201000010099 disease Diseases 0.000 claims abstract description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 4
125000005843 halogen group Chemical group 0.000 claims abstract description 4
239000001257 hydrogen Substances 0.000 claims abstract description 4
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 3
125000005842 heteroatom Chemical group 0.000 claims abstract description 3
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 13
VTVVATVHWHSKRM-UHFFFAOYSA-N 8-methoxy-2-phenylbenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C=3C(OC)=CC=CC=3C(=O)C=2N=C1C1=CC=CC=C1 VTVVATVHWHSKRM-UHFFFAOYSA-N 0.000 claims description 9
230000004872 arterial blood pressure Effects 0.000 claims description 9
RIGRHQRUQGLHKC-UHFFFAOYSA-N 2-amino-3-bromo-6-fluoronaphthalene-1,4-dione Chemical compound FC1=CC=C2C(=O)C(N)=C(Br)C(=O)C2=C1 RIGRHQRUQGLHKC-UHFFFAOYSA-N 0.000 claims description 7
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 7
BQHURORABWQSBR-UHFFFAOYSA-N 2-amino-3-chloro-6-methylnaphthalene-1,4-dione Chemical compound O=C1C(N)=C(Cl)C(=O)C2=CC(C)=CC=C21 BQHURORABWQSBR-UHFFFAOYSA-N 0.000 claims description 6
CKMGFAPTTIUTOR-UHFFFAOYSA-N 3-amino-2-bromo-5-methoxynaphthalene-1,4-dione Chemical compound O=C1C(Br)=C(N)C(=O)C2=C1C=CC=C2OC CKMGFAPTTIUTOR-UHFFFAOYSA-N 0.000 claims description 6
OLRLFLYEECOSIQ-UHFFFAOYSA-N 3-amino-2-bromo-6-fluoronaphthalene-1,4-dione Chemical compound C1=C(F)C=C2C(=O)C(N)=C(Br)C(=O)C2=C1 OLRLFLYEECOSIQ-UHFFFAOYSA-N 0.000 claims description 6
JUOYZQOSMGRKEA-UHFFFAOYSA-N 5-methoxy-2-phenylbenzo[f][1,3]benzothiazole-4,9-dione Chemical compound N=1C=2C(=O)C=3C(OC)=CC=CC=3C(=O)C=2SC=1C1=CC=CC=C1 JUOYZQOSMGRKEA-UHFFFAOYSA-N 0.000 claims description 6
QAEKLBWGHLEVTE-UHFFFAOYSA-N 7-methoxy-2-phenylbenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C3=CC(OC)=CC=C3C(=O)C=2N=C1C1=CC=CC=C1 QAEKLBWGHLEVTE-UHFFFAOYSA-N 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 6
PYQLLNKOBQDNOD-UHFFFAOYSA-N 2,3-dibromo-5-methoxynaphthalene-1,4-dione Chemical group O=C1C(Br)=C(Br)C(=O)C2=C1C=CC=C2OC PYQLLNKOBQDNOD-UHFFFAOYSA-N 0.000 claims description 5
LYVAXRGHTGGEBJ-UHFFFAOYSA-N 2-amino-3-bromo-5-methoxynaphthalene-1,4-dione Chemical compound O=C1C(N)=C(Br)C(=O)C2=C1C=CC=C2OC LYVAXRGHTGGEBJ-UHFFFAOYSA-N 0.000 claims description 5
206010040070 Septic Shock Diseases 0.000 claims description 5
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
239000001301 oxygen Substances 0.000 claims description 5
230000036303 septic shock Effects 0.000 claims description 5
201000002282 venous insufficiency Diseases 0.000 claims description 5
ZCAPVKVQKGVVEP-UHFFFAOYSA-N 2,3-dibromo-5-fluoronaphthalene-1,4-dione Chemical compound O=C1C(Br)=C(Br)C(=O)C2=C1C=CC=C2F ZCAPVKVQKGVVEP-UHFFFAOYSA-N 0.000 claims description 4
TZJASHIDYNOMFL-UHFFFAOYSA-N 2,3-dibromo-5-methylnaphthalene-1,4-dione Chemical compound O=C1C(Br)=C(Br)C(=O)C2=C1C=CC=C2C TZJASHIDYNOMFL-UHFFFAOYSA-N 0.000 claims description 4
WCNZRLIEPPOFCH-UHFFFAOYSA-N 2,3-dibromo-6-fluoronaphthalene-1,4-dione Chemical compound O=C1C(Br)=C(Br)C(=O)C2=CC(F)=CC=C21 WCNZRLIEPPOFCH-UHFFFAOYSA-N 0.000 claims description 4
QMVLNNDZQQMMHT-UHFFFAOYSA-N 2-(furan-2-yl)-5-methoxybenzo[f][1,3]benzothiazole-4,9-dione Chemical compound N=1C=2C(=O)C=3C(OC)=CC=CC=3C(=O)C=2SC=1C1=CC=CO1 QMVLNNDZQQMMHT-UHFFFAOYSA-N 0.000 claims description 4
PTBHGQZZVAILEN-UHFFFAOYSA-N 3-amino-2-chloro-6-methylnaphthalene-1,4-dione Chemical compound O=C1C(Cl)=C(N)C(=O)C2=CC(C)=CC=C21 PTBHGQZZVAILEN-UHFFFAOYSA-N 0.000 claims description 4
DBDLTJRCKGCKSK-UHFFFAOYSA-N 5-methoxynaphthalene-1,4-dione Chemical compound O=C1C=CC(=O)C2=C1C=CC=C2OC DBDLTJRCKGCKSK-UHFFFAOYSA-N 0.000 claims description 4
230000007170 pathology Effects 0.000 claims description 4
230000035939 shock Effects 0.000 claims description 4
WODGMQAJBGQELR-UHFFFAOYSA-N 2-(1,3-thiazol-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C3=CC=CC=C3C(=O)C=2N=C1C1=NC=CS1 WODGMQAJBGQELR-UHFFFAOYSA-N 0.000 claims description 3
XUFYAZPAMNFIPW-UHFFFAOYSA-N 2-(2-fluorophenyl)-1h-benzo[f]benzimidazole-4,9-dione Chemical compound FC1=CC=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2N1 XUFYAZPAMNFIPW-UHFFFAOYSA-N 0.000 claims description 3
XNADZOBJRIJMMY-UHFFFAOYSA-N 2-(2-fluorophenyl)benzo[f][1,3]benzoxazole-4,9-dione Chemical compound FC1=CC=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2O1 XNADZOBJRIJMMY-UHFFFAOYSA-N 0.000 claims description 3
KVNGKHBBAJGPLK-UHFFFAOYSA-N 2-(3-methylphenyl)benzo[f][1,3]benzoxazole-4,9-dione Chemical compound CC1=CC=CC(C=2OC3=C(C(C4=CC=CC=C4C3=O)=O)N=2)=C1 KVNGKHBBAJGPLK-UHFFFAOYSA-N 0.000 claims description 3
QACAEHLFWZCANV-UHFFFAOYSA-N 2-(4-bromofuran-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound BrC1=COC(C=2SC3=C(C(C4=CC=CC=C4C3=O)=O)N=2)=C1 QACAEHLFWZCANV-UHFFFAOYSA-N 0.000 claims description 3
UOHJTGWIWLKOFH-UHFFFAOYSA-N 2-(5-aminofuran-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound O1C(N)=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2S1 UOHJTGWIWLKOFH-UHFFFAOYSA-N 0.000 claims description 3
SIMPADCLDHQYQI-UHFFFAOYSA-N 2-(5-bromofuran-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound O1C(Br)=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2S1 SIMPADCLDHQYQI-UHFFFAOYSA-N 0.000 claims description 3
DIRFZICDHCBSNE-UHFFFAOYSA-N 2-(5-chlorofuran-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound O1C(Cl)=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2S1 DIRFZICDHCBSNE-UHFFFAOYSA-N 0.000 claims description 3
AWQDKXZMIPOUHG-UHFFFAOYSA-N 2-(5-nitrofuran-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound O1C([N+](=O)[O-])=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2S1 AWQDKXZMIPOUHG-UHFFFAOYSA-N 0.000 claims description 3
PQKOTJDKHSLTLO-UHFFFAOYSA-N 2-(5-phenyl-1,3-oxazol-2-yl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C3=CC=CC=C3C(=O)C=2N=C1C(O1)=NC=C1C1=CC=CC=C1 PQKOTJDKHSLTLO-UHFFFAOYSA-N 0.000 claims description 3
UQKJPDYJFTVJOA-UHFFFAOYSA-N 2-(furan-2-yl)-8-methoxybenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C=3C(OC)=CC=CC=3C(=O)C=2N=C1C1=CC=CO1 UQKJPDYJFTVJOA-UHFFFAOYSA-N 0.000 claims description 3
CTCDJSQYICTGPT-UHFFFAOYSA-N 2-amino-3-bromo-5-fluoronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(N)=C(Br)C(=O)C2=C1F CTCDJSQYICTGPT-UHFFFAOYSA-N 0.000 claims description 3
DEIOLVIXEQNANK-UHFFFAOYSA-N 2-amino-3-bromo-5-methylnaphthalene-1,4-dione Chemical compound O=C1C(N)=C(Br)C(=O)C2=C1C=CC=C2C DEIOLVIXEQNANK-UHFFFAOYSA-N 0.000 claims description 3
PPWXETUTFRZGNR-UHFFFAOYSA-N 2-pyridin-4-ylbenzo[f][1,3]benzothiazole-4,9-dione;sulfuric acid Chemical compound OS(O)(=O)=O.S1C=2C(=O)C3=CC=CC=C3C(=O)C=2N=C1C1=CC=NC=C1 PPWXETUTFRZGNR-UHFFFAOYSA-N 0.000 claims description 3
JISXAFDAZIGTGT-UHFFFAOYSA-N 2-thiophen-2-ylbenzo[f][1,3]benzoxazole-4,9-dione Chemical compound O1C=2C(=O)C3=CC=CC=C3C(=O)C=2N=C1C1=CC=CS1 JISXAFDAZIGTGT-UHFFFAOYSA-N 0.000 claims description 3
VBGCFJTVRSMYFJ-UHFFFAOYSA-N 7-methyl-2-(4-oxofuran-2-yl)-4h-benzo[f][1,3]benzothiazol-9-one Chemical compound S1C=2C(=O)C3=CC(C)=CC=C3CC=2N=C1C1=CC(=O)CO1 VBGCFJTVRSMYFJ-UHFFFAOYSA-N 0.000 claims description 3
QLPMNLPHWFASFB-UHFFFAOYSA-N 7-methyl-2-phenylbenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C3=CC(C)=CC=C3C(=O)C=2N=C1C1=CC=CC=C1 QLPMNLPHWFASFB-UHFFFAOYSA-N 0.000 claims description 3
UFQQAIJDUDGRKQ-UHFFFAOYSA-N 8-hydroxy-2-phenylbenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C=3C(O)=CC=CC=3C(=O)C=2N=C1C1=CC=CC=C1 UFQQAIJDUDGRKQ-UHFFFAOYSA-N 0.000 claims description 3
208000019695 Migraine disease Diseases 0.000 claims description 3
206010027599 migraine Diseases 0.000 claims description 3
SPTHAPOLVDKHEU-UHFFFAOYSA-N 2,3-dimethylbenzo[f]benzimidazole-4,9-dione;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C(=O)C(N=C(N3C)C)=C3C(=O)C2=C1 SPTHAPOLVDKHEU-UHFFFAOYSA-N 0.000 claims description 2
WBYCJQNVYQHORN-UHFFFAOYSA-N 2-(2,4-difluorophenyl)benzo[f][1,3]benzothiazole-4,9-dione Chemical compound FC1=CC(F)=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2S1 WBYCJQNVYQHORN-UHFFFAOYSA-N 0.000 claims description 2
HWTVJTHJMSXSOF-UHFFFAOYSA-N 2-(2-chlorophenyl)benzo[f][1,3]benzoxazole-4,9-dione Chemical compound ClC1=CC=CC=C1C1=NC(C(C2=CC=CC=C2C2=O)=O)=C2O1 HWTVJTHJMSXSOF-UHFFFAOYSA-N 0.000 claims description 2
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NJPRVJMBTWGYAB-UHFFFAOYSA-N 2-(furan-2-yl)-6-methoxybenzo[f][1,3]benzothiazole-4,9-dione Chemical compound N=1C=2C(=O)C3=CC(OC)=CC=C3C(=O)C=2SC=1C1=CC=CO1 NJPRVJMBTWGYAB-UHFFFAOYSA-N 0.000 claims description 2
JTZQOZNCHKHLLN-UHFFFAOYSA-N 2-(furan-2-yl)-7-methoxybenzo[f][1,3]benzothiazole-4,9-dione Chemical compound S1C=2C(=O)C3=CC(OC)=CC=C3C(=O)C=2N=C1C1=CC=CO1 JTZQOZNCHKHLLN-UHFFFAOYSA-N 0.000 claims description 2
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FMYCGBHYGJLPJE-UHFFFAOYSA-N 3-amino-2-bromo-5-fluoronaphthalene-1,4-dione Chemical compound C1=CC(F)=C2C(=O)C(N)=C(Br)C(=O)C2=C1 FMYCGBHYGJLPJE-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/30—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by two rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/24—Quinones containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

OA9800080A 1995-12-12 1998-06-12 Utilisation de dérivés tricycliques du 1,4-dihydro-1,4-dioxo 1h-naphtalène, nouveaux composés obtenus et leur application en thérapeutique. OA10696A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9514683A FR2742153B1 (fr)	1995-12-12	1995-12-12	Utilisation de derives tricycliques du 1,4-dihydro-1,4- dioxo-1h-naphtalene, nouveaux composes obtenus et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
OA10696A true OA10696A (fr)	2002-11-26

Family

ID=9485393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800080A OA10696A (fr)	1995-12-12	1998-06-12	Utilisation de dérivés tricycliques du 1,4-dihydro-1,4-dioxo 1h-naphtalène, nouveaux composés obtenus et leur application en thérapeutique.

Country Status (26)

Country	Link
US (1)	US6262095B1 (de)
EP (1)	EP0876356B1 (de)
JP (1)	JP2000501724A (de)
KR (1)	KR19990072080A (de)
AP (1)	AP889A (de)
AR (1)	AR005054A1 (de)
AT (1)	ATE207907T1 (de)
AU (1)	AU716199B2 (de)
BR (1)	BR9611935A (de)
CA (1)	CA2240279A1 (de)
CZ (1)	CZ181198A3 (de)
DE (1)	DE69616598D1 (de)
EE (1)	EE9800174A (de)
FR (1)	FR2742153B1 (de)
HU (1)	HUP9901247A3 (de)
ID (1)	ID16081A (de)
IL (1)	IL124558A0 (de)
LT (1)	LT4491B (de)
LV (1)	LV12188B (de)
NO (1)	NO982696L (de)
NZ (1)	NZ323967A (de)
OA (1)	OA10696A (de)
PL (1)	PL327168A1 (de)
RU (1)	RU2178791C2 (de)
TR (1)	TR199801069T2 (de)
WO (1)	WO1997021684A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999032115A1 (en) *	1997-12-19	1999-07-01	Advanced Research And Technology Institute, Inc.	Modulators of ryanodine receptors comprising 2-(aryl)-4,7-dioxobenzothiazoles and analogues thereof
ES2257461T3 (es) *	2000-12-21	2006-08-01	Bristol-Myers Squibb Company	Inhibidores de tiazolilo de tirosina quinasas de la familia tec.
TWI402261B (zh)	2006-06-19	2013-07-21	Takeda Pharmaceutical	三環化合物及其醫藥組成物
WO2007149484A2 (en)	2006-06-20	2007-12-27	Dana-Farber Cancer Institute	Inhibitors of usp1 deubiquitinating enzyme complex
WO2011137320A2 (en)	2010-04-30	2011-11-03	Dana-Farber Cancer Institute, Inc.	Small molecule inhibitors of usp1 deubiquitinating enzyme activity
WO2012047628A2 (en) *	2010-09-27	2012-04-12	Emory University	Methods of managing blood sugar levels and compositions related thereto
US9725425B1 (en)	2014-02-25	2017-08-08	Dana-Farber Cancer Institute, Inc.	Compounds and methods for treating cancer
RU2545091C1 (ru) *	2014-03-18	2015-03-27	Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН)	1-R-4,9-ДИОКСО-1H-НАФТО[2,3-d][1,2,3]ТРИАЗОЛ-4-ОКСИМ-2-ОКСИДЫ И ИХ ПРОИЗВОДНЫЕ, ОБЛАДАЮЩИЕ ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТЬЮ
WO2017106624A1 (en)	2015-12-18	2017-06-22	The Board Of Regents Of The University Of Texas System	Napthoquinones, pro-drugs, and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3039925A (en)	1957-04-24	1962-06-19	Bayer Ag	Compositions for the treatment of tuberculosis
US4746676A (en)	1984-09-12	1988-05-24	Rorer Pharmaceutical Corporation	Carboxyalkyl dipeptide compounds
JPH05112533A (ja) *	1991-05-08	1993-05-07	Upjohn Co:The	イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
AU4632893A (en) *	1992-07-29	1994-03-03	Agouron Pharmaceuticals, Inc.	Antiproliferative tricyclic compounds

1995
- 1995-12-12 FR FR9514683A patent/FR2742153B1/fr not_active Expired - Fee Related
1996
- 1996-12-10 US US09/043,831 patent/US6262095B1/en not_active Expired - Fee Related
- 1996-12-10 AU AU11018/97A patent/AU716199B2/en not_active Ceased
- 1996-12-10 EP EP96941734A patent/EP0876356B1/de not_active Expired - Lifetime
- 1996-12-10 IL IL12455896A patent/IL124558A0/xx unknown
- 1996-12-10 CA CA002240279A patent/CA2240279A1/fr not_active Abandoned
- 1996-12-10 BR BR9611935A patent/BR9611935A/pt unknown
- 1996-12-10 HU HU9901247A patent/HUP9901247A3/hu unknown
- 1996-12-10 PL PL96327168A patent/PL327168A1/xx unknown
- 1996-12-10 AP APAP/P/1998/001275A patent/AP889A/en active
- 1996-12-10 RU RU98113147/04A patent/RU2178791C2/ru active
- 1996-12-10 TR TR1998/01069T patent/TR199801069T2/xx unknown
- 1996-12-10 NZ NZ323967A patent/NZ323967A/en unknown
- 1996-12-10 CZ CZ981811A patent/CZ181198A3/cs unknown
- 1996-12-10 JP JP9521799A patent/JP2000501724A/ja active Pending
- 1996-12-10 DE DE69616598T patent/DE69616598D1/de not_active Expired - Lifetime
- 1996-12-10 EE EE9800174A patent/EE9800174A/xx unknown
- 1996-12-10 WO PCT/FR1996/001973 patent/WO1997021684A1/fr not_active Ceased
- 1996-12-10 KR KR1019980704387A patent/KR19990072080A/ko not_active Ceased
- 1996-12-10 AT AT96941734T patent/ATE207907T1/de not_active IP Right Cessation
- 1996-12-12 AR ARP960105648A patent/AR005054A1/es unknown
- 1996-12-12 ID IDP963710A patent/ID16081A/id unknown
1998
- 1998-06-10 LT LT98-085A patent/LT4491B/lt not_active IP Right Cessation
- 1998-06-11 NO NO982696A patent/NO982696L/no not_active Application Discontinuation
- 1998-06-12 OA OA9800080A patent/OA10696A/fr unknown
- 1998-06-12 LV LVP-98-136A patent/LV12188B/en unknown

Also Published As

Publication number	Publication date
AP9801275A0 (en)	1998-06-30
IL124558A0 (en)	1998-12-06
NZ323967A (en)	2000-06-23
DE69616598D1 (de)	2001-12-06
LV12188A (lv)	1998-12-20
LV12188B (en)	1999-07-20
BR9611935A (pt)	1999-05-18
LT98085A (en)	1998-11-25
WO1997021684A1 (fr)	1997-06-19
AU716199B2 (en)	2000-02-24
ATE207907T1 (de)	2001-11-15
RU2178791C2 (ru)	2002-01-27
EE9800174A (et)	1998-12-15
CZ181198A3 (cs)	1998-09-16
US6262095B1 (en)	2001-07-17
FR2742153A1 (fr)	1997-06-13
CA2240279A1 (fr)	1997-06-19
HUP9901247A3 (en)	2000-08-28
NO982696L (no)	1998-08-11
JP2000501724A (ja)	2000-02-15
EP0876356B1 (de)	2001-10-31
PL327168A1 (en)	1998-11-23
LT4491B (lt)	1999-04-26
HUP9901247A2 (hu)	1999-08-30
AP889A (en)	2000-11-17
EP0876356A1 (de)	1998-11-11
AU1101897A (en)	1997-07-03
NO982696D0 (no)	1998-06-11
FR2742153B1 (fr)	1998-02-13
KR19990072080A (ko)	1999-09-27
TR199801069T2 (xx)	1998-08-21
AR005054A1 (es)	1999-04-07
ID16081A (id)	1997-09-04

Publication	Publication Date	Title
KR910005709B1 (ko)	1991-08-02	벤조티아졸 유도체
RU2336274C2 (ru)	2008-10-20	Замещенные 3-цианотиофенацетамиды в качестве антагонистов рецептора глюкагона
CA2150162C (fr)	2002-05-14	Nouveau n-pyridyl carboxamides et derives, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
EP0690050A1 (de)	1996-01-03	(Thia)cycloalkyl(b)indolderivate als 5-lipoxygenase Inhibitoren
EP3998257A1 (de)	2022-05-18	Flavaglin-derivate
EP0876356B1 (de)	2001-10-31	Verwendung von tricyclischen 1,4-dihydro-1,4-dioxo-1h-naphalen derivaten, neue verbindungen und ihre therapeutische verwendung
EP0503471A1 (de)	1992-09-16	Neue acylaminosubstituierte Hetrazepine
WO2010029986A1 (ja)	2010-03-18	スルホン酸エステル構造を導入したフェニル基を置換基として有する新規１，２，３，４－テトラヒドロキノキサリン誘導体からなるグルココルチコイド受容体アゴニスト
FR2742155A1 (fr)	1997-06-13	Utilisation de derives heteroaromatiques et tricycliques du 1,4-dihydro-1,4-dioxonaphtalene, nouveaux composes obtenus et leur application en therapeutique
FR2742151A1 (fr)	1997-06-13	Utilisation de derives de bicycles mono ou dicetoniques, nouveaux composes obtenus et leur application en therapeutique
FR2803299A1 (fr)	2001-07-06	NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
CA2557942C (fr)	2013-08-06	Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique
EP0646579A1 (de)	1995-04-05	Ketonische Indan Derivate und heterozyklische Analogen und ihre Anwendung in der Therapie
EP0098204A1 (de)	1984-01-11	Therapeutische Zusammensetzungen die N-substituierte Hydrazone enthalten und N-substituierte Hydrazone
WO1997021709A1 (fr)	1997-06-19	Utilisation de derives de tetracycles mono ou dicetoniques, nouveaux composes obtenus et leur application en therapeutique
MXPA98004717A (es)	1999-07-06	Utilizacion de derivados triciclicos de 1,4-dihidro-1,4-dioxo-1h-naftaleno, nuevos compuestos obtenidos y su aplicacion terapeutica
JP2003506376A (ja)	2003-02-18	１，２−ジヒドロ−１−オキソ−ピラジノ［１，２−ａ］インドール誘導体
SK289100B6 (sk)	2023-08-09	Zlúčenina cemtirestat disulfid, prekurzor inhibítora aldoketoreduktáz, spôsob jej prípravy, farmaceutický prostriedok s jej obsahom a jej použitie
JP2922930B2 (ja)	1999-07-26	ヒダントイン誘導体及びその用途
FR2764292A1 (fr)	1998-12-11	Utilisation de derives de tetracycles dicetoniques, nouveaux composes obtenus et leur application en therapeutique
EP0646574A1 (de)	1995-04-05	Ketonderivate des Indans, ihre Herstellung und ihre therapeutische Anwendung