OA10998A - Use of benzopyranols to treat neurological disorders - Google Patents

Use of benzopyranols to treat neurological disorders Download PDF

Info

Publication number: OA10998A
Authority: OA; OAPI
Prior art keywords: pain; treatment; acetyl; dimethyl; compound
Prior art date: 1996-09-18

Application number

OA9900060A

Other languages

English (en)

Inventor

Andrew Parsons

Meryn Thompson

Neil Upton

John Morris Evans

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-18

Filing date

1999-03-18

Publication date

2003-03-04

1999-03-18 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-03-04 Publication of OA10998A publication Critical patent/OA10998A/en

Links

SERVTOXIOYSDQO-UHFFFAOYSA-N 2h-chromen-2-ol Chemical class C1=CC=C2C=CC(O)OC2=C1 SERVTOXIOYSDQO-UHFFFAOYSA-N 0.000 title 1
208000012902 Nervous system disease Diseases 0.000 title 1
208000025966 Neurological disease Diseases 0.000 title 1
208000002193 Pain Diseases 0.000 claims abstract description 18
238000011282 treatment Methods 0.000 claims abstract description 15
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
201000010099 disease Diseases 0.000 claims abstract description 10
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229910004679 ONO2 Inorganic materials 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

OA9900060A 1996-09-18 1999-03-18 Use of benzopyranols to treat neurological disorders OA10998A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9619492.3A GB9619492D0 (en)	1996-09-18	1996-09-18	Novel treatment

Publications (1)

Publication Number	Publication Date
OA10998A true OA10998A (en)	2003-03-04

Family

ID=10800127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900060A OA10998A (en)	1996-09-18	1999-03-18	Use of benzopyranols to treat neurological disorders

Country Status (30)

Country	Link
EP (1)	EP0939630B1 (id)
JP (1)	JP2001500520A (id)
KR (1)	KR20000036184A (id)
CN (1)	CN1230885A (id)
AP (1)	AP9901473A0 (id)
AR (1)	AR008838A1 (id)
AT (1)	ATE270102T1 (id)
AU (1)	AU730465B2 (id)
BG (1)	BG103252A (id)
BR (1)	BR9712030A (id)
CA (1)	CA2266681A1 (id)
DE (1)	DE69729735T2 (id)
DZ (1)	DZ2311A1 (id)
EA (1)	EA199900306A1 (id)
ES (1)	ES2223075T3 (id)
GB (1)	GB9619492D0 (id)
HU (1)	HUP9904638A3 (id)
ID (2)	ID23175A (id)
IL (1)	IL128786A0 (id)
MA (1)	MA24321A1 (id)
NO (1)	NO991292L (id)
NZ (1)	NZ334271A (id)
OA (1)	OA10998A (id)
PE (1)	PE109898A1 (id)
PL (1)	PL332313A1 (id)
SK (1)	SK35199A3 (id)
TR (1)	TR199900527T2 (id)
UY (1)	UY24717A1 (id)
WO (1)	WO1998011890A1 (id)
ZA (1)	ZA978359B (id)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7119214B2 (en) *	2004-04-13	2006-10-10	Cephalon France	Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
CA2726878A1 (en) *	2008-06-05	2009-12-10	Minster Research Limited	Novel treatments
WO2009147441A2 (en) *	2008-06-05	2009-12-10	Minster Research Limited	Novel treatments
WO2011067607A1 (en) *	2009-12-03	2011-06-09	Minster Research Ltd	Treatment of infectious diseases
HUE034911T2 (hu)	2009-07-27	2018-03-28	Gilead Sciences Inc	Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok
EP2506846A1 (en) *	2009-12-03	2012-10-10	Proximagen Limited	Treatment of allodynia and hyperalgesia
EP2588197B1 (en)	2010-07-02	2014-11-05	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
WO2012154760A1 (en)	2011-05-10	2012-11-15	Gilead Sciences, Inc.	Fused heterocyclic compounds as sodium channel modulators
UY34171A (es)	2011-07-01	2013-01-31	Gilead Sciences Inc	Compuestos heterocíclicos fusionados como moduladores del canal iónico
NO3175985T3 (id)	2011-07-01	2018-04-28
CN106397317B (zh) *	2016-09-26	2019-03-22	天津师范大学	1,2,3,4-四氢喹啉化合物及其合成方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9112721D0 (en) *	1991-06-13	1991-07-31	Smithkline Beecham Plc	Novel treatment
US5510375A (en) *	1993-11-19	1996-04-23	Warner-Lambert Company	Coumarin derivatives as protease inhibitors and antiviral agents
GB9411635D0 (en) *	1994-06-10	1994-08-03	Smithkline Beecham Plc	Novel treatment
DE69524871T2 (de) *	1994-06-10	2002-08-22	Smithkline Beecham P.L.C., Brentford	Benzopyrans und deren verwendung als therapeutische mittel

1996
- 1996-09-18 GB GBGB9619492.3A patent/GB9619492D0/en active Pending
1997
- 1997-09-15 EP EP97909300A patent/EP0939630B1/en not_active Expired - Lifetime
- 1997-09-15 ID IDW990097A patent/ID23175A/id unknown
- 1997-09-15 AT AT97909300T patent/ATE270102T1/de not_active IP Right Cessation
- 1997-09-15 TR TR1999/00527T patent/TR199900527T2/xx unknown
- 1997-09-15 HU HU9904638A patent/HUP9904638A3/hu unknown
- 1997-09-15 AU AU47047/97A patent/AU730465B2/en not_active Ceased
- 1997-09-15 ES ES97909300T patent/ES2223075T3/es not_active Expired - Lifetime
- 1997-09-15 NZ NZ334271A patent/NZ334271A/en unknown
- 1997-09-15 KR KR1019997002238A patent/KR20000036184A/ko not_active Withdrawn
- 1997-09-15 IL IL12878697A patent/IL128786A0/xx unknown
- 1997-09-15 CA CA002266681A patent/CA2266681A1/en not_active Abandoned
- 1997-09-15 EA EA199900306A patent/EA199900306A1/ru unknown
- 1997-09-15 DE DE69729735T patent/DE69729735T2/de not_active Expired - Fee Related
- 1997-09-15 SK SK351-99A patent/SK35199A3/sk unknown
- 1997-09-15 CN CN97197979A patent/CN1230885A/zh active Pending
- 1997-09-15 WO PCT/EP1997/005168 patent/WO1998011890A1/en not_active Ceased
- 1997-09-15 BR BR9712030A patent/BR9712030A/pt not_active IP Right Cessation
- 1997-09-15 AP APAP/P/1999/001473A patent/AP9901473A0/en unknown
- 1997-09-15 PL PL97332313A patent/PL332313A1/xx unknown
- 1997-09-15 JP JP10514309A patent/JP2001500520A/ja not_active Ceased
- 1997-09-16 UY UY24717A patent/UY24717A1/es not_active Application Discontinuation
- 1997-09-16 ID IDP973201A patent/ID19542A/id unknown
- 1997-09-16 AR ARP970104238A patent/AR008838A1/es not_active Application Discontinuation
- 1997-09-16 MA MA24799A patent/MA24321A1/fr unknown
- 1997-09-17 ZA ZA978359A patent/ZA978359B/xx unknown
- 1997-09-17 DZ DZ970161A patent/DZ2311A1/xx active
- 1997-09-18 PE PE1997000831A patent/PE109898A1/es not_active Application Discontinuation
1999
- 1999-03-15 BG BG103252A patent/BG103252A/xx unknown
- 1999-03-17 NO NO991292A patent/NO991292L/no not_active Application Discontinuation
- 1999-03-18 OA OA9900060A patent/OA10998A/en unknown

Also Published As

Publication number	Publication date
IL128786A0 (en)	2000-01-31
AU4704797A (en)	1998-04-14
JP2001500520A (ja)	2001-01-16
NO991292D0 (no)	1999-03-17
UY24717A1 (es)	2001-08-27
MA24321A1 (fr)	1998-04-01
DE69729735D1 (de)	2004-08-05
BR9712030A (pt)	1999-08-24
TR199900527T2 (xx)	1999-06-21
PE109898A1 (es)	1999-03-21
CN1230885A (zh)	1999-10-06
DE69729735T2 (de)	2005-07-14
ID23175A (id)	2000-03-23
AU730465B2 (en)	2001-03-08
NZ334271A (en)	2001-03-30
ATE270102T1 (de)	2004-07-15
DZ2311A1 (fr)	2002-12-28
CA2266681A1 (en)	1998-03-26
GB9619492D0 (en)	1996-10-30
AR008838A1 (es)	2000-02-23
SK35199A3 (en)	2000-07-11
WO1998011890A1 (en)	1998-03-26
HUP9904638A3 (en)	2001-08-28
ZA978359B (en)	1999-03-17
PL332313A1 (en)	1999-08-30
BG103252A (en)	1999-09-30
HUP9904638A2 (hu)	2001-05-28
EP0939630B1 (en)	2004-06-30
KR20000036184A (ko)	2000-06-26
NO991292L (no)	1999-03-17
AP9901473A0 (en)	1999-03-31
ES2223075T3 (es)	2005-02-16
EA199900306A1 (ru)	1999-08-26
ID19542A (id)	1998-07-23
EP0939630A1 (en)	1999-09-08

Publication	Publication Date	Title
DK169593B1 (da)	1994-12-19	Farmaceutiske præparater med forbedret stabilitet samt fremgangsmåde til stabilisering af et ACE-inhibitor lægemiddel
AU2003264385B2 (en)	2009-12-17	Crystal for oral solid drug and oral solid drug for dysuria treatment containing the same
EP0939630B1 (en)	2004-06-30	Use of benzopyranols to treat neurological disorders
WO2000012073A1 (en)	2000-03-09	Use of 5ht-6 antagonists
CN1119147C (zh)	2003-08-27	用于炎性肠疾病的k阿片激动剂
MX2010013312A (es)	2011-05-30	Tratamientos novedoos.
CA2726878A1 (en)	2009-12-10	Novel treatments
CA2335846A1 (en)	2000-01-06	Substituted benzopyran derivatives and their use as anticonvulsants
US6492415B2 (en)	2002-12-10	Use of benzopyranols to treat neurological disorders
CA1305420C (en)	1992-07-21	Pharmaceutical preparation having antihypertensive activity
CA1327163C (en)	1994-02-22	Anxiolytically active piperazine derivatives
TW448046B (en)	2001-08-01	Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity
EP1448181B1 (en)	2006-05-31	Pharmaceutical composition comprising a combination of metformin and a 4-oxobutanoic acid, and the use thereof for treating diabetes
KR0177894B1 (ko)	1999-03-20	항우울제
AU2010325756A1 (en)	2012-06-21	Treatment of allodynia and hyperalgesia
US5886021A (en)	1999-03-23	Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for vasodilatory treatment or prophylaxis
JPH0525167A (ja)	1993-02-02	緑内障の治療に有用な置換ベンゼン誘導体
CZ92999A3 (cs)	2000-05-17	Farmaceutický prostředek pro léčbu a/nebo profylaxi neurologických poruch a použití sloučenin obsahujících fosfor k výrobě léčiva
WO1987003807A1 (en)	1987-07-02	Oxazole derivatives and their use as anti-hyperglycaemic
CN110407789B (zh)	2021-03-19	一种防治骨质疏松的药物及其制备方法
US4795759A (en)	1989-01-03	Use of dibenz(CD,F)indoles
KR100194825B1 (ko)	1999-06-15	말초 순환 개선제
CN101362757A (zh)	2009-02-11	磺酰基取代的碳青霉烯类化合物
JPS63165317A (ja)	1988-07-08	製薬生成物
MXPA00010343A (en)	2001-07-31	Treatment of generalized anxiety disorder with paroxetine