OA11154A - Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid - Google Patents

Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid Download PDF

Info

Publication number: OA11154A
Authority: OA; OAPI
Prior art keywords: crystalline hydrated; compound; hydrated form; application; sodium
Prior art date: 1997-03-05

Application number

OA9900201A

Other languages

English (en)

French (fr)

Inventor

Zadeo Cimarosti

Paolo Maragni

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-05

Filing date

1999-09-02

Publication date

2003-04-16

1999-09-02 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

2003-04-16 Publication of OA11154A publication Critical patent/OA11154A/fr

Links

VDIRQCDDCGAGET-DHZHZOJOSA-N 4,6-dichloro-3-[(e)-(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1h-indole-2-carboxylic acid Chemical compound OC(=O)C=1NC2=CC(Cl)=CC(Cl)=C2C=1\C=C(C1=O)/CCN1C1=CC=CC=C1 VDIRQCDDCGAGET-DHZHZOJOSA-N 0.000 title claims 2
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239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

OA9900201A 1997-03-05 1999-09-02 Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid OA11154A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9704498.6A GB9704498D0 (en)	1997-03-05	1997-03-05	Chemical compound

Publications (1)

Publication Number	Publication Date
OA11154A true OA11154A (en)	2003-04-16

Family

ID=10808697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900201A OA11154A (en)	1997-03-05	1999-09-02	Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid

Country Status (29)

Country	Link
EP (1)	EP0966463A1 (is)
JP (1)	JP2001513796A (is)
KR (1)	KR20000075907A (is)
CN (1)	CN1249750A (is)
AP (1)	AP9901637A0 (is)
AR (1)	AR011178A1 (is)
AU (1)	AU6825198A (is)
BG (1)	BG103779A (is)
BR (1)	BR9808305A (is)
CA (1)	CA2282851A1 (is)
CO (1)	CO4940415A1 (is)
EA (1)	EA199900710A1 (is)
EE (1)	EE9900387A (is)
GB (1)	GB9704498D0 (is)
HR (1)	HRP980114A2 (is)
HU (1)	HUP0002109A2 (is)
ID (1)	ID24207A (is)
IL (1)	IL131489A0 (is)
IS (1)	IS5166A (is)
NO (1)	NO994303L (is)
NZ (1)	NZ337315A (is)
OA (1)	OA11154A (is)
PE (1)	PE51399A1 (is)
PL (1)	PL335652A1 (is)
SK (1)	SK119699A3 (is)
TR (1)	TR199902117T2 (is)
WO (1)	WO1998039327A1 (is)
YU (1)	YU43499A (is)
ZA (1)	ZA981791B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9704499D0 (en) *	1997-03-05	1997-04-23	Glaxo Wellcome Spa	Method of manufacture
GB9825988D0 (en) *	1998-11-27	1999-01-20	Pfizer Ltd	Indole derivatives
GB9915231D0 (en)	1999-06-29	1999-09-01	Pfizer Ltd	Pharmaceutical complex
US9737531B2 (en)	2012-07-12	2017-08-22	Glytech, Llc	Composition and method for treatment of depression and psychosis in humans
MX393950B (es)	2017-06-12	2025-03-24	Glytech Llc	Composicion y metodo para el tratamiento de la depresion y psicosis en humanos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9321221D0 (en) *	1993-10-14	1993-12-01	Glaxo Spa	Heterocyclic compounds

1997
- 1997-03-05 GB GBGB9704498.6A patent/GB9704498D0/en active Pending
1998
- 1998-03-03 PE PE1998000149A patent/PE51399A1/es not_active Application Discontinuation
- 1998-03-03 EE EEP199900387A patent/EE9900387A/xx unknown
- 1998-03-03 AP APAP/P/1999/001637A patent/AP9901637A0/en unknown
- 1998-03-03 AR ARP980100948A patent/AR011178A1/es unknown
- 1998-03-03 EA EA199900710A patent/EA199900710A1/ru unknown
- 1998-03-03 SK SK1196-99A patent/SK119699A3/sk unknown
- 1998-03-03 IL IL13148998A patent/IL131489A0/xx unknown
- 1998-03-03 YU YU43499A patent/YU43499A/sh unknown
- 1998-03-03 CA CA002282851A patent/CA2282851A1/en not_active Abandoned
- 1998-03-03 KR KR1019997007987A patent/KR20000075907A/ko not_active Withdrawn
- 1998-03-03 HU HU0002109A patent/HUP0002109A2/hu unknown
- 1998-03-03 CN CN98803053A patent/CN1249750A/zh active Pending
- 1998-03-03 EP EP98913613A patent/EP0966463A1/en not_active Withdrawn
- 1998-03-03 JP JP53813598A patent/JP2001513796A/ja active Pending
- 1998-03-03 BR BR9808305-8A patent/BR9808305A/pt not_active Application Discontinuation
- 1998-03-03 PL PL98335652A patent/PL335652A1/xx unknown
- 1998-03-03 ZA ZA9801791A patent/ZA981791B/xx unknown
- 1998-03-03 TR TR1999/02117T patent/TR199902117T2/xx unknown
- 1998-03-03 NZ NZ337315A patent/NZ337315A/en unknown
- 1998-03-03 AU AU68251/98A patent/AU6825198A/en not_active Abandoned
- 1998-03-03 WO PCT/EP1998/001146 patent/WO1998039327A1/en not_active Ceased
- 1998-03-03 CO CO98011404A patent/CO4940415A1/es unknown
- 1998-03-03 ID IDW990976A patent/ID24207A/id unknown
- 1998-03-04 HR HR9704498.6A patent/HRP980114A2/hr not_active Application Discontinuation
1999
- 1999-08-27 IS IS5166A patent/IS5166A/is unknown
- 1999-09-02 OA OA9900201A patent/OA11154A/fr unknown
- 1999-09-03 NO NO994303A patent/NO994303L/no not_active Application Discontinuation
- 1999-10-04 BG BG103779A patent/BG103779A/xx unknown

Also Published As

Publication number	Publication date
KR20000075907A (ko)	2000-12-26
CA2282851A1 (en)	1998-09-11
GB9704498D0 (en)	1997-04-23
AP9901637A0 (en)	1999-09-30
HUP0002109A2 (hu)	2001-04-28
CO4940415A1 (es)	2000-07-24
NO994303L (no)	1999-11-03
IS5166A (is)	1999-08-27
ZA981791B (en)	1999-09-03
PL335652A1 (en)	2000-05-08
IL131489A0 (en)	2001-01-28
AU6825198A (en)	1998-09-22
NO994303D0 (no)	1999-09-03
HRP980114A2 (en)	1998-12-31
NZ337315A (en)	2001-02-23
EA199900710A1 (ru)	2000-04-24
BG103779A (en)	2000-06-30
JP2001513796A (ja)	2001-09-04
EP0966463A1 (en)	1999-12-29
SK119699A3 (en)	2000-05-16
ID24207A (id)	2000-07-13
AR011178A1 (es)	2000-08-02
EE9900387A (et)	2000-04-17
YU43499A (sh)	2000-12-28
PE51399A1 (es)	1999-06-07
BR9808305A (pt)	2000-05-16
TR199902117T2 (xx)	2000-03-21
WO1998039327A1 (en)	1998-09-11
CN1249750A (zh)	2000-04-05

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