OA11530A - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists. - Google Patents

Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists. Download PDF

Info

Publication number: OA11530A
Authority: OA; OAPI
Prior art keywords: added; compound; préparation; nmr; product
Prior art date: 1998-03-04

Application number

OA1200000238A

Other languages

English (en)

French (fr)

Inventor

Thomas E Rogers

Peter G Ruminski

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2004-05-17

1999-02-22 Application filed by Searle & Co filed Critical Searle & Co

2004-05-17 Publication of OA11530A publication Critical patent/OA11530A/en

Links

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150000001875 compounds Chemical class 0.000 claims abstract description 77
150000003839 salts Chemical class 0.000 claims abstract description 11
206010028980 Neoplasm Diseases 0.000 claims description 19
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230000002797 proteolythic effect Effects 0.000 description 1
238000010926 purge Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
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238000013207 serial dilution Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
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239000000741 silica gel Substances 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
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239000000661 sodium alginate Substances 0.000 description 1
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239000001509 sodium citrate Substances 0.000 description 1
230000009295 sperm incapacitation Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
229940086735 succinate Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
150000003585 thioureas Chemical class 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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229940038773 trisodium citrate Drugs 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA1200000238A 1998-03-04 1999-02-22 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists. OA11530A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
PCT/US1999/003281 WO1999044994A1 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Publications (1)

Publication Number	Publication Date
OA11530A true OA11530A (en)	2004-05-17

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200000238A OA11530A (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists.

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (is)
JP (1)	JP2002505323A (is)
KR (1)	KR20010041584A (is)
CN (1)	CN1214011C (is)
AP (1)	AP1244A (is)
AR (1)	AR018139A1 (is)
AU (1)	AU753230B2 (is)
BG (1)	BG104740A (is)
BR (1)	BR9908470A (is)
CA (1)	CA2322207A1 (is)
EA (1)	EA200000804A1 (is)
EE (1)	EE200000506A (is)
GE (1)	GEP20033118B (is)
HR (1)	HRP20000574A2 (is)
HU (1)	HUP0100865A3 (is)
ID (1)	ID25591A (is)
IL (1)	IL137653A0 (is)
IS (1)	IS5582A (is)
MY (1)	MY123908A (is)
NO (1)	NO315703B1 (is)
NZ (1)	NZ506598A (is)
OA (1)	OA11530A (is)
PL (1)	PL342726A1 (is)
SK (1)	SK13002000A3 (is)
TR (1)	TR200002542T2 (is)
UA (1)	UA71906C2 (is)
WO (1)	WO1999044994A1 (is)
YU (1)	YU52000A (is)
ZA (1)	ZA994406B (is)

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GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
DE60130910T2 (de)	2000-04-17	2008-07-10	Ucb Pharma, S.A.	Enamin-derivate als zell-adhäsionsmoleküle
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
CA2417059A1 (en)	2000-08-02	2002-02-07	Celltech R&D Limited	3-substituted isoquinolin-1-yl derivatives
EP1572210A1 (en) *	2002-12-20	2005-09-14	Pharmacia Corporation	The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2006257815A1 (en) *	2005-06-10	2006-12-21	Bipar Sciences, Inc.	PARP modulators and treatment of cancer
EP2131861A2 (en)	2007-03-01	2009-12-16	Mallinckrodt Inc.	Integrated photoactive small molecules and uses thereof
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
IN2015DN00099A (is)	2012-07-18	2015-05-29	Univ Saint Louis
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2015187774A1 (en) *	2014-06-04	2015-12-10	Monsanto Technology Llc	3,6-dichlorosalicylic acid compounds and related synthetic processes
HK1244806A1 (zh)	2015-12-30	2018-08-17	Saint Louis University	作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物
JP7661969B2 (ja)	2020-05-14	2025-04-15	Ｕｂｅ株式会社	１，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
JPWO2023085396A1 (is)	2021-11-12	2023-05-19

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MX9801716A (es) *	1995-08-30	1998-05-31	Searle & Co	Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
BR9908470A (pt)	2000-12-05
ID25591A (id)	2000-10-19
TR200002542T2 (tr)	2001-05-21
MY123908A (en)	2006-06-30
PL342726A1 (en)	2001-07-02
NZ506598A (en)	2003-07-25
JP2002505323A (ja)	2002-02-19
NO20004316D0 (no)	2000-08-30
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
SK13002000A3 (sk)	2001-07-10
EE200000506A (et)	2002-04-15
AU3294799A (en)	1999-09-20
EP1060164A1 (en)	2000-12-20
AP1244A (en)	2004-02-04
EA200000804A1 (ru)	2001-04-23
HUP0100865A3 (en)	2001-11-28
KR20010041584A (ko)	2001-05-25
ZA994406B (en)	2000-02-11
GEP20033118B (en)	2003-11-25
CA2322207A1 (en)	1999-09-10
AR018139A1 (es)	2001-10-31
WO1999044994A1 (en)	1999-09-10
YU52000A (sh)	2003-02-28
IL137653A0 (en)	2001-10-31
NO20004316L (no)	2000-11-06
CN1291978A (zh)	2001-04-18
CN1214011C (zh)	2005-08-10
HUP0100865A2 (hu)	2001-08-28
BG104740A (en)	2001-02-28
AU753230B2 (en)	2002-10-10
HRP20000574A2 (en)	2001-08-31
UA71906C2 (en)	2005-01-17
AP2000001893A0 (en)	2000-09-30

Publication	Publication Date	Title
AP1244A (en)	2004-02-04	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists.
CA2250586C (en)	2007-04-17	Meta-substituted phenylene sulphonamide derivatives
US6251944B1 (en)	2001-06-26	Para-substituted phenylene derivatives
US5773644A (en)	1998-06-30	Cyclopropyl alkanoic acid derivatives
AU702487B2 (en)	1999-02-25	Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
AU3449999A (en)	1999-11-01	Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists
US6372719B1 (en)	2002-04-16	ανβ3 integrin antagonists in combination with chemotherapeutic agents
MXPA05006732A (es)	2005-09-08	El isomero r de compuesto de beta-aminoacido como derivados de antagonistas de receptor de la integrina.
US6013651A (en)	2000-01-11	Meta-azacyclic amino benzoic acid compounds and derivatives thereof
US6689754B1 (en)	2004-02-10	Heterocyclic glycyl β-alanine derivatives
EP1156999B1 (en)	2004-11-17	Method for the preparation of a chiral-beta-amino ester
CZ20003218A3 (cs)	2001-03-14	Deriváty meta-azacyklické aminobenzoové kyseliny a jejich deriváty, které jsou antagonisty integrinu
MXPA00008427A (en)	2002-07-25	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists
EP1157985A1 (en)	2001-11-28	Para- substituted phenylene derivatives and their use as integrin antagonists
MXPA00009967A (en)	2001-07-31	Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists