OA11666A - Method and composition for treating and preventingtuberculosis. - Google Patents

Method and composition for treating and preventingtuberculosis. Download PDF

Info

Publication number
OA11666A
OA11666A OA1200100095A OA1200100095A OA11666A OA 11666 A OA11666 A OA 11666A OA 1200100095 A OA1200100095 A OA 1200100095A OA 1200100095 A OA1200100095 A OA 1200100095A OA 11666 A OA11666 A OA 11666A
Authority
OA
OAPI
Prior art keywords
alkyl
mycobacterium
amino
aryl
calanolide
Prior art date
Application number
OA1200100095A
Other languages
English (en)
Inventor
Michael T Flavin
Yuh-Meei Lin
Ze-Qi Xu
Original Assignee
Sarawak Medichem Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarawak Medichem Pharmaceuticals Inc filed Critical Sarawak Medichem Pharmaceuticals Inc
Publication of OA11666A publication Critical patent/OA11666A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
OA1200100095A 1998-10-15 1999-10-14 Method and composition for treating and preventingtuberculosis. OA11666A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10440998P 1998-10-15 1998-10-15

Publications (1)

Publication Number Publication Date
OA11666A true OA11666A (en) 2004-12-08

Family

ID=22300328

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200100095A OA11666A (en) 1998-10-15 1999-10-14 Method and composition for treating and preventingtuberculosis.

Country Status (12)

Country Link
US (2) US6268393B1 (id)
EP (1) EP1143952B1 (id)
CN (1) CN1334727A (id)
AP (1) AP2001002115A0 (id)
AT (1) ATE233089T1 (id)
AU (1) AU1705400A (id)
CA (1) CA2346813A1 (id)
DE (1) DE69905616T2 (id)
EA (1) EA200100347A1 (id)
ID (1) ID29547A (id)
OA (1) OA11666A (id)
WO (1) WO2000021514A2 (id)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677350B1 (en) * 1999-09-22 2004-01-13 Advanced Life Sciences, Inc. Beta-fluoroethyl thiourea compounds and use
AU758744B2 (en) * 2000-10-31 2003-03-27 F. Hoffmann-La Roche Ag Methods for the analysis of non-proteinaceous components using a protease from a bacillus strain
EP1379529A2 (en) * 2001-03-16 2004-01-14 Sarawak Medichem Pharmaceuticals, Inc. Pyranocoumarin compounds as a novel pharmacophore with anti-tb activity
WO2003076444A1 (fr) * 2002-03-08 2003-09-18 Kuraray Co., Ltd. Intermediaires destines a la production de (+) calanolide a, procedes de production de ces intermediaires, et procede de production de (+) calanolide a a l'aide de ceux-ci
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
CA2574363A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Enantioselective method for separating sustituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
CA2615886A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
BRPI0613928A2 (pt) * 2005-07-27 2011-02-15 Wyeth Corp método para o tratamento de uma infecção ou doença bacteriana; composição; produto; e uso de cefepima ou de um sal farmaceuticamente aceitável da mesma e um composto de fórmula i ou um sal farmaceuticamente aceitável ou éster hidrolisável in vivo do mesmo
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
WO2007095187A2 (en) * 2006-02-13 2007-08-23 Trustees Of Boston University Compositions and methods for antibiotic potentiation and drug discovery
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
CA2704649C (en) * 2007-11-05 2015-02-17 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Tetracyclic dipyrano-coumarin compounds with anti-hiv and anti-mycobacterium tuberculosis activities
MY158809A (en) 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
CN102516217B (zh) * 2011-12-15 2014-03-12 四川大学 手性二氢色原酮骨架化合物及不对称合成
US9572809B2 (en) * 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591770A (en) * 1992-03-31 1997-01-07 The United States Of America As Represented By The Department Of Health And Human Services Calanolide and related antiretroviral compounds, compositions, and uses thereof
ES2134259T3 (es) * 1992-03-31 1999-10-01 Us Health Compuestos antiviricos calanolidas, composiciones y utilizacion de los mismos.
WO1994014789A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors
US6043271A (en) * 1994-08-03 2000-03-28 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (±)-calanolide A and intermediates thereof

Also Published As

Publication number Publication date
WO2000021514A3 (en) 2001-08-23
AP2001002115A0 (en) 2001-06-30
EA200100347A1 (ru) 2001-10-22
EP1143952B1 (en) 2003-02-26
US20010027209A1 (en) 2001-10-04
CA2346813A1 (en) 2000-04-20
ATE233089T1 (de) 2003-03-15
EP1143952A3 (en) 2002-09-11
EP1143952A2 (en) 2001-10-17
ID29547A (id) 2001-09-06
CN1334727A (zh) 2002-02-06
DE69905616T2 (de) 2003-08-14
DE69905616D1 (de) 2003-04-03
WO2000021514A2 (en) 2000-04-20
AU1705400A (en) 2000-05-01
US6268393B1 (en) 2001-07-31

Similar Documents

Publication Publication Date Title
OA11666A (en) Method and composition for treating and preventingtuberculosis.
US8580967B2 (en) Methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate and processes for the preparation thereof
EP2885303B1 (en) Deuterated baricitinib
US8217034B2 (en) Chemical compounds
EP0775130B1 (en) Method for the preparation of (+/-)-calanolide a and intermediates thereof
CA2879400A1 (en) Deuterated ibrutinib
TW200817402A (en) Substituted pteridines
WO1998038193A1 (en) Method for the preparation of (+)-calanolide a and analogues thereof
US5981770A (en) Method for the preparation of (+)-calanolide A and analogues thereof
US6670383B2 (en) Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity
US6277879B1 (en) Calanolide analogues and methods of their use
Pattanashetty et al. Discovery of new drugs and computational studies of coumarin-carprofen scaffolds as a novel class of anti-tubercular, anti-inflammatory and anti-bacterial agents
US20050085554A1 (en) Methods of treating disease through the administration of a manzamine analog or derivative
US5977385A (en) Method for the preparation of (+)-calanolide A and analogues thereof
ES2406479T3 (es) Derivado deuterado de 4-oxoquinolina para el tratamiento de la infección por VIH
US6900195B2 (en) Manzamines for treatment of drug resistant infection
MXPA01003772A (en) Method and composition for treating and preventing tuberculosis
Tiwari et al. Artemisinin analogues as a novel class of antimalarial agents: recent developments, current scenario and future perspectives
ES2972175T3 (es) Compuestos para el tratamiento de infecciones
EP2885267B1 (en) Deuterated idebenone
KR20150101436A (ko) 케르세틴-아미노산 접합체를 포함하는 항암 및 항생제 내성 억제효능을 보이는 조성물 및 그 방법
AU730178B2 (en) Method for the preparation of (+-)-calanolide A and intermediates thereof
Rapudi Synthesis of Novel-1, 3, 5-Triazine-Based-Anti-Tuberculosis Drugs.
WO2020107189A1 (en) Pyrrolidine compounds for the treatment of malaria
Valerio Synthesis of novel PfDHODH inhibitors based on 4-aminocoumarin structures