OA11669A - 5HT1 receptor agonists and metoclopramide for the treatment of migraine. - Google Patents

5HT1 receptor agonists and metoclopramide for the treatment of migraine. Download PDF

Info

Publication number: OA11669A
Authority: OA; OAPI
Prior art keywords: metoclopramide; migraine; treatment; receptor agonist; eletriptan
Prior art date: 1998-10-30

Application number

OA1200100100A

Other languages

English (en)

Inventor

George Harry Sands

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-30

Filing date

1999-10-18

Publication date

2005-01-05

1999-10-18 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-01-05 Publication of OA11669A publication Critical patent/OA11669A/en

Links

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206010027599 migraine Diseases 0.000 title claims abstract description 26
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200100100A 1998-10-30 1999-10-18 5HT1 receptor agonists and metoclopramide for the treatment of migraine. OA11669A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10632898P	1998-10-30	1998-10-30

Publications (1)

Publication Number	Publication Date
OA11669A true OA11669A (en)	2005-01-05

Family

ID=22310818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100100A OA11669A (en)	1998-10-30	1999-10-18	5HT1 receptor agonists and metoclopramide for the treatment of migraine.

Country Status (34)

Country	Link
US (2)	US6255334B1 (is)
EP (1)	EP1126840A1 (is)
JP (1)	JP2002528497A (is)
KR (1)	KR20010089363A (is)
CN (1)	CN1325304A (is)
AP (1)	AP2001002129A0 (is)
AR (1)	AR019246A1 (is)
AU (1)	AU5994799A (is)
BG (1)	BG105534A (is)
BR (1)	BR9914901A (is)
CA (1)	CA2348543A1 (is)
CO (1)	CO4950530A1 (is)
CZ (1)	CZ20011468A3 (is)
EA (1)	EA200100284A1 (is)
EE (1)	EE200100243A (is)
GT (1)	GT199900189A (is)
HK (1)	HK1040929A1 (is)
HR (1)	HRP20010298A2 (is)
HU (1)	HUP0104696A3 (is)
ID (1)	ID28291A (is)
IL (1)	IL141957A0 (is)
IS (1)	IS5898A (is)
MA (1)	MA26702A1 (is)
NO (1)	NO20012013D0 (is)
OA (1)	OA11669A (is)
PA (1)	PA8484801A1 (is)
PE (1)	PE20001284A1 (is)
PL (1)	PL347541A1 (is)
SK (1)	SK5522001A3 (is)
TN (1)	TNSN99203A1 (is)
TR (1)	TR200101174T2 (is)
TW (1)	TW524692B (is)
WO (1)	WO2000025778A1 (is)
ZA (1)	ZA200103322B (is)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6579898B2 (en) *	2001-03-01	2003-06-17	Pfizer Inc.	Compositions having improved bioavailability
GB0105131D0 (en) *	2001-03-01	2001-04-18	Pfizer Ltd	Compositions having improved bioavailability
NZ529417A (en)	2001-05-24	2006-11-30	Alexza Pharmaceuticals Inc	Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
WO2002094242A1 (en) *	2001-05-24	2002-11-28	Alexza Molecular Delivery Corporation	Delivery of rizatriptan or zolmitriptan through an inhalation route
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
CA2446904A1 (en)	2001-05-24	2003-04-03	Alexza Pharmaceuticals, Inc.	Delivery of drug esters through an inhalation route
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US7766013B2 (en) *	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7498019B2 (en)	2001-05-24	2009-03-03	Alexza Pharmaceuticals, Inc.	Delivery of compounds for the treatment of headache through an inhalation route
WO2003041693A1 (en) *	2001-11-09	2003-05-22	Alexza Molecular Delivery Corporation	Delivery of diazepam through an inhalation route
EP1446102A1 (en)	2001-11-21	2004-08-18	Alexza Molecular Delivery Corporation	Delivery of caffeine through an inhalation route
EP1503744A1 (en)	2002-05-13	2005-02-09	Alexza Molecular Delivery Corporation	Delivery of drug amines through an inhalation route
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7550133B2 (en) *	2002-11-26	2009-06-23	Alexza Pharmaceuticals, Inc.	Respiratory drug condensation aerosols and methods of making and using them
CN101371843B (zh)	2002-11-26	2012-09-26	艾利斯达医药品公司	洛沙平和阿莫沙平在制备治疗疼痛的药物中的应用
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
ATE510174T1 (de)	2003-05-21	2011-06-15	Alexza Pharmaceuticals Inc	Schlag gezündete unabhängige heizeinheit
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1765300A2 (en) *	2004-06-10	2007-03-28	Duramed Pharmaceuticals, Inc.	Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
US20050282879A1 (en) *	2004-06-17	2005-12-22	Foad Salehani	Methods and composition for treatment of migraine and symptoms thereof
AU2004322756B2 (en)	2004-08-12	2011-04-14	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heat packages
JP5833804B2 (ja) *	2005-04-13	2015-12-16	ニューラクソン，インコーポレーテッド	Ｎｏｓ阻害活性を有する置換インドール化合物
TW200808780A (en) *	2006-04-13	2008-02-16	Neuraxon Inc	1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
US20080139510A1 (en) *	2006-12-07	2008-06-12	Abe Rose	Treatment of migraine headaches with sublingual amino acids
US20080216828A1 (en)	2007-03-09	2008-09-11	Alexza Pharmaceuticals, Inc.	Heating unit for use in a drug delivery device
CA2705422A1 (en) *	2007-11-16	2009-05-22	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Methods for treating visceral pain
MX2010005343A (es) *	2007-11-16	2010-08-09	Neuraxon Inc	Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.
MX356032B (es) *	2007-11-16	2018-04-11	Neuraxon Inc	Compuestos indola y métodos para tratar el dolor visceral.
AU2013202680C1 (en) *	2008-04-28	2016-06-23	Zogenix, Inc.	Novel formulations for treatment of migraine
US12214118B2 (en)	2018-02-02	2025-02-04	Alexza Pharmaceuticals, Inc.	Electrical condensation aerosol device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5698571A (en) *	1994-10-05	1997-12-16	Eli Lilly And Company	5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
IL127956A0 (en) *	1996-07-11	1999-11-30	Farmarc Nederland Bv	Inclusion complex containing indole selective serotonin agonist
GB9709739D0 (en)	1997-05-14	1997-07-02	Merck Sharp & Dohme	Pharmaceutical formulation

1999
- 1999-09-01 US US09/387,990 patent/US6255334B1/en not_active Expired - Fee Related
- 1999-10-18 EP EP99971318A patent/EP1126840A1/en not_active Withdrawn
- 1999-10-18 EE EEP200100243A patent/EE200100243A/xx unknown
- 1999-10-18 ID IDW00200100930A patent/ID28291A/id unknown
- 1999-10-18 HU HU0104696A patent/HUP0104696A3/hu unknown
- 1999-10-18 IL IL14195799A patent/IL141957A0/xx unknown
- 1999-10-18 AU AU59947/99A patent/AU5994799A/en not_active Abandoned
- 1999-10-18 BR BR9914901-0A patent/BR9914901A/pt not_active IP Right Cessation
- 1999-10-18 CN CN99812756A patent/CN1325304A/zh active Pending
- 1999-10-18 PL PL99347541A patent/PL347541A1/xx not_active Application Discontinuation
- 1999-10-18 KR KR1020017005271A patent/KR20010089363A/ko not_active Ceased
- 1999-10-18 TR TR2001/01174T patent/TR200101174T2/xx unknown
- 1999-10-18 EA EA200100284A patent/EA200100284A1/ru unknown
- 1999-10-18 JP JP2000579219A patent/JP2002528497A/ja active Pending
- 1999-10-18 SK SK552-2001A patent/SK5522001A3/sk unknown
- 1999-10-18 CA CA002348543A patent/CA2348543A1/en not_active Abandoned
- 1999-10-18 AP APAP/P/2001/002129A patent/AP2001002129A0/en unknown
- 1999-10-18 HR HR20010298A patent/HRP20010298A2/hr not_active Application Discontinuation
- 1999-10-18 HK HK02102736.3A patent/HK1040929A1/zh unknown
- 1999-10-18 CZ CZ20011468A patent/CZ20011468A3/cs unknown
- 1999-10-18 WO PCT/IB1999/001694 patent/WO2000025778A1/en not_active Ceased
- 1999-10-18 OA OA1200100100A patent/OA11669A/en unknown
- 1999-10-27 TW TW088118594A patent/TW524692B/zh active
- 1999-10-27 MA MA25827A patent/MA26702A1/fr unknown
- 1999-10-27 PA PA19998484801A patent/PA8484801A1/es unknown
- 1999-10-27 TN TNTNSN99203A patent/TNSN99203A1/fr unknown
- 1999-10-28 AR ARP990105447A patent/AR019246A1/es not_active Application Discontinuation
- 1999-10-29 CO CO99068659A patent/CO4950530A1/es unknown
- 1999-10-29 GT GT199900189A patent/GT199900189A/es unknown
- 1999-10-29 PE PE1999001083A patent/PE20001284A1/es not_active Application Discontinuation
2001
- 2001-03-16 IS IS5898A patent/IS5898A/is unknown
- 2001-04-19 US US09/838,440 patent/US20010020036A1/en not_active Abandoned
- 2001-04-24 ZA ZA200103322A patent/ZA200103322B/en unknown
- 2001-04-24 NO NO20012013A patent/NO20012013D0/no not_active Application Discontinuation
- 2001-05-22 BG BG105534A patent/BG105534A/xx unknown

Also Published As

Publication number	Publication date
HUP0104696A3 (en)	2003-05-28
PL347541A1 (en)	2002-04-08
CA2348543A1 (en)	2000-05-11
NO20012013L (no)	2001-04-24
ID28291A (id)	2001-05-10
BR9914901A (pt)	2001-07-17
PE20001284A1 (es)	2000-11-22
CO4950530A1 (es)	2000-09-01
GT199900189A (es)	2001-04-21
IS5898A (is)	2001-03-16
PA8484801A1 (es)	2000-09-29
NO20012013D0 (no)	2001-04-24
KR20010089363A (ko)	2001-10-06
CZ20011468A3 (cs)	2002-04-17
CN1325304A (zh)	2001-12-05
JP2002528497A (ja)	2002-09-03
HK1040929A1 (zh)	2002-06-28
IL141957A0 (en)	2002-03-10
MA26702A1 (fr)	2004-12-20
TW524692B (en)	2003-03-21
AR019246A1 (es)	2001-12-26
EA200100284A1 (ru)	2001-10-22
ZA200103322B (en)	2002-06-10
WO2000025778A1 (en)	2000-05-11
SK5522001A3 (en)	2002-05-09
AP2001002129A0 (en)	2001-06-30
TNSN99203A1 (fr)	2005-11-10
EP1126840A1 (en)	2001-08-29
BG105534A (en)	2001-12-29
HRP20010298A2 (en)	2002-06-30
US6255334B1 (en)	2001-07-03
EE200100243A (et)	2002-12-16
US20010020036A1 (en)	2001-09-06
HUP0104696A2 (hu)	2002-05-29
TR200101174T2 (tr)	2001-10-22
AU5994799A (en)	2000-05-22

Publication	Publication Date	Title
OA11669A (en)	2005-01-05	5HT1 receptor agonists and metoclopramide for the treatment of migraine.
CN107921035B (zh)	2021-08-31	高苯丙氨酸血症及其治疗
KR20010092455A (ko)	2001-10-25	항우울 치료를 위한 5ｈｔ1 길항제
US20030216458A1 (en)	2003-11-20	Combination therapy for the treatment of migraine
AU3400900A (en)	2000-11-16	5HT1 receptor agonist and either a Cox-2 inhibitor or NSAID for the treatment of migraine
EP0635269B1 (en)	1999-11-03	Use of N-(Pyridinyl)-1H-Indol-1-Amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders
AU3253800A (en)	2000-11-16	Combination therapy for the treatment of migraine
AU4273000A (en)	2001-01-04	5HT1 receptor agonists, caffeine and either A COX-2 inhibitor or NSAID for the treatment of migraine
EP1115404B1 (en)	2004-01-14	Use of prostanoid antagonists for the treatment of primary headache disorders
MXPA01004297A (en)	2001-12-04	5ht1
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