OA12024A - Polymorphic salt. - Google Patents

Polymorphic salt. Download PDF

Info

Publication number: OA12024A
Authority: OA; OAPI
Prior art keywords: compound; polymorph; suitable solvent; daims; tetrahydrofuran
Prior art date: 1999-09-28

Application number

OA1200200077A

Other languages

English (en)

Inventor

Arthur Bentley

Simon Arnold Howard-Field

Ronald James Ogilvie

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-14

Publication date

2006-04-19

2000-09-14 Application filed by Pfizer filed Critical Pfizer

2006-04-19 Publication of OA12024A publication Critical patent/OA12024A/en

Links

150000003839 salts Chemical class 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 28
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RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract 3
229910052802 copper Inorganic materials 0.000 claims abstract 3
239000010949 copper Substances 0.000 claims abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 25
239000000203 mixture Substances 0.000 claims description 23
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 22
239000002904 solvent Substances 0.000 claims description 13
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 11
238000010992 reflux Methods 0.000 claims description 9
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
239000002002 slurry Substances 0.000 claims description 5
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
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JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
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LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA1200200077A 1999-09-28 2000-09-14 Polymorphic salt. OA12024A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9922963.5A GB9922963D0 (en)	1999-09-28	1999-09-28	Polymorphic salt

Publications (1)

Publication Number	Publication Date
OA12024A true OA12024A (en)	2006-04-19

Family

ID=10861767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200077A OA12024A (en)	1999-09-28	2000-09-14	Polymorphic salt.

Country Status (50)

Country	Link
US (1)	US6369094B1 (de)
EP (1)	EP1233960B1 (de)
JP (1)	JP3795395B2 (de)
KR (1)	KR100479897B1 (de)
CN (1)	CN1155594C (de)
AP (1)	AP2004A (de)
AR (1)	AR025779A1 (de)
AT (1)	ATE246185T1 (de)
AU (1)	AU779580B2 (de)
BG (1)	BG65161B1 (de)
BR (1)	BR0014272A (de)
CA (1)	CA2379572C (de)
CO (1)	CO5180567A1 (de)
CR (1)	CR6561A (de)
CU (1)	CU23200A3 (de)
CZ (1)	CZ2002971A3 (de)
DE (1)	DE60004262T2 (de)
DK (1)	DK1233960T3 (de)
DZ (1)	DZ3254A1 (de)
EA (1)	EA004510B1 (de)
EE (1)	EE200200171A (de)
EG (1)	EG24143A (de)
ES (1)	ES2200911T3 (de)
GB (1)	GB9922963D0 (de)
GE (1)	GEP20043365B (de)
GT (1)	GT200000159A (de)
HK (1)	HK1048628B (de)
HR (1)	HRP20020270B1 (de)
HU (1)	HUP0202821A3 (de)
IL (1)	IL147154A (de)
IS (1)	IS2162B (de)
MA (1)	MA26821A1 (de)
MX (1)	MXPA02003311A (de)
MY (1)	MY121170A (de)
NO (1)	NO321936B1 (de)
NZ (1)	NZ516093A (de)
OA (1)	OA12024A (de)
PA (1)	PA8498901A1 (de)
PE (1)	PE20010662A1 (de)
PL (1)	PL354960A1 (de)
PT (1)	PT1233960E (de)
SI (1)	SI1233960T1 (de)
SK (1)	SK3982002A3 (de)
TN (1)	TNSN00187A1 (de)
TR (1)	TR200200804T2 (de)
TW (1)	TWI265926B (de)
UA (1)	UA72272C2 (de)
WO (1)	WO2001023377A2 (de)
YU (1)	YU2602A (de)
ZA (1)	ZA200202406B (de)

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US20060025387A1 (en) *	1998-12-23	2006-02-02	Cytoscan Sciences Llc	Compositions and methods for the treatment of disorders of the central and peripheral nervous systems
US8722668B2 (en) *	1998-12-23	2014-05-13	Daryl W. Hochman	Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
US8008283B2 (en) *	1998-12-23	2011-08-30	Neurotherapeutics Pharma, Inc.	Methods and compositions for the treatment of neuropsychiatric disorders
US7214711B2 (en) *	1998-12-23	2007-05-08	Neurotherapeutics Pharma Llc	Method of treating migraine headache without aura
GB0018968D0 (en) *	2000-08-02	2000-09-20	Pfizer Ltd	Particulate composition
US7132549B2 (en)	2003-05-30	2006-11-07	Pfizer Inc.	Process
GB0312478D0 (en) *	2003-05-30	2003-07-09	Pfizer Ltd	Improved process
EP3165220B2 (de) *	2004-12-03	2024-11-13	Merck Sharp & Dohme LLC	Pharmazeutische zusammensetzung mit anti-keimbildner
US20070149526A1 (en) *	2005-10-17	2007-06-28	Neurotherapeutics Pharma, L.L.C.	Diuretic and diuretic-like compound analogs
KR100814109B1 (ko) *	2006-01-09	2008-03-14	한국생명공학연구원	로다닌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 약학적 조성물
TWI394753B (zh) *	2006-03-17	2013-05-01	Otsuka Pharma Co Ltd	新穎替妥牟拉（ｔｅｔｏｍｉｌａｓｔ）晶體
WO2010116386A2 (en) *	2009-04-08	2010-10-14	Biophore India Pharmaceuticals Pvt. Ltd.	Novel polymorph of eletriptan hydrobromide and process for the preparation thereof
AU2010313571B2 (en)	2009-10-26	2014-07-31	Merck Sharp & Dohme Llc	Solid pharmaceutical compositions containing an integrase inhibitor

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US5559246A (en)	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5545644A (en)	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
HU225055B1 (en) *	1990-10-15	2006-05-29	Pfizer	Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
US5559129A (en)	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5607951A (en)	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
US5578612A (en)	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
GB9417310D0 (en) *	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
US5998462A (en) *	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds
EP0999841B1 (de) *	1997-07-03	2001-10-17	Pfizer Limited	Eletriptanhemisulfat und kaffein enthaltende pharmazeutische zusammenstellungen

1999
- 1999-09-28 GB GBGB9922963.5A patent/GB9922963D0/en not_active Ceased
2000
- 2000-07-25 TW TW089114850A patent/TWI265926B/zh not_active IP Right Cessation
- 2000-07-28 PA PA20008498901A patent/PA8498901A1/es unknown
- 2000-08-10 CO CO00059853A patent/CO5180567A1/es not_active Application Discontinuation
- 2000-09-14 AT AT00954864T patent/ATE246185T1/de not_active IP Right Cessation
- 2000-09-14 AU AU67213/00A patent/AU779580B2/en not_active Ceased
- 2000-09-14 CZ CZ2002971A patent/CZ2002971A3/cs unknown
- 2000-09-14 NZ NZ516093A patent/NZ516093A/xx unknown
- 2000-09-14 SI SI200030165T patent/SI1233960T1/xx unknown
- 2000-09-14 OA OA1200200077A patent/OA12024A/en unknown
- 2000-09-14 TR TR2002/00804T patent/TR200200804T2/xx unknown
- 2000-09-14 EP EP00954864A patent/EP1233960B1/de not_active Expired - Lifetime
- 2000-09-14 EA EA200200302A patent/EA004510B1/ru not_active IP Right Cessation
- 2000-09-14 DK DK00954864T patent/DK1233960T3/da active
- 2000-09-14 HK HK03100144.2A patent/HK1048628B/zh not_active IP Right Cessation
- 2000-09-14 HR HR20020270A patent/HRP20020270B1/xx not_active IP Right Cessation
- 2000-09-14 AP APAP/P/2002/002457A patent/AP2004A/en active
- 2000-09-14 EE EEP200200171A patent/EE200200171A/xx unknown
- 2000-09-14 HU HU0202821A patent/HUP0202821A3/hu unknown
- 2000-09-14 WO PCT/IB2000/001305 patent/WO2001023377A2/en not_active Ceased
- 2000-09-14 YU YU2602A patent/YU2602A/sh unknown
- 2000-09-14 PT PT00954864T patent/PT1233960E/pt unknown
- 2000-09-14 KR KR10-2002-7003963A patent/KR100479897B1/ko not_active Expired - Fee Related
- 2000-09-14 JP JP2001526529A patent/JP3795395B2/ja not_active Expired - Fee Related
- 2000-09-14 BR BR0014272-7A patent/BR0014272A/pt not_active Application Discontinuation
- 2000-09-14 ES ES00954864T patent/ES2200911T3/es not_active Expired - Lifetime
- 2000-09-14 MX MXPA02003311A patent/MXPA02003311A/es active IP Right Grant
- 2000-09-14 GE GE4699A patent/GEP20043365B/en unknown
- 2000-09-14 CA CA002379572A patent/CA2379572C/en not_active Expired - Fee Related
- 2000-09-14 SK SK398-2002A patent/SK3982002A3/sk unknown
- 2000-09-14 CN CNB00810798XA patent/CN1155594C/zh not_active Expired - Fee Related
- 2000-09-14 DE DE60004262T patent/DE60004262T2/de not_active Expired - Lifetime
- 2000-09-14 DZ DZ003254A patent/DZ3254A1/fr active
- 2000-09-14 IL IL14715400A patent/IL147154A/xx not_active IP Right Cessation
- 2000-09-14 UA UA2002032432A patent/UA72272C2/uk unknown
- 2000-09-14 PL PL00354960A patent/PL354960A1/xx not_active IP Right Cessation
- 2000-09-19 US US09/664,946 patent/US6369094B1/en not_active Expired - Fee Related
- 2000-09-25 EG EG20001216A patent/EG24143A/xx active
- 2000-09-26 MY MYPI20004476A patent/MY121170A/en unknown
- 2000-09-26 PE PE2000001010A patent/PE20010662A1/es not_active Application Discontinuation
- 2000-09-26 AR ARP000105032A patent/AR025779A1/es active IP Right Grant
- 2000-09-26 GT GT200000159A patent/GT200000159A/es unknown
- 2000-09-27 TN TNTNSN00187A patent/TNSN00187A1/fr unknown
2001
- 2001-12-10 CU CU20010293A patent/CU23200A3/es not_active IP Right Cessation
- 2001-12-19 BG BG106240A patent/BG65161B1/bg unknown
2002
- 2002-01-08 IS IS6223A patent/IS2162B/is unknown
- 2002-01-24 CR CR6561A patent/CR6561A/es not_active Application Discontinuation
- 2002-03-15 MA MA26556A patent/MA26821A1/fr unknown
- 2002-03-26 NO NO20021525A patent/NO321936B1/no not_active IP Right Cessation
- 2002-03-26 ZA ZA200202406A patent/ZA200202406B/en unknown

Also Published As

Publication number	Publication date
PT1233960E (pt)	2003-11-28
SI1233960T1 (en)	2003-12-31
ZA200202406B (en)	2003-05-28
AU779580B2 (en)	2005-01-27
TR200200804T2 (tr)	2002-07-22
US6369094B1 (en)	2002-04-09
TWI265926B (en)	2006-11-11
DK1233960T3 (da)	2003-10-27
MY121170A (en)	2005-12-30
PL354960A1 (en)	2004-03-22
CU23200A3 (es)	2007-04-06
IL147154A (en)	2005-11-20
ES2200911T3 (es)	2004-03-16
GT200000159A (es)	2002-03-20
AP2004A (en)	2009-06-10
EP1233960A2 (de)	2002-08-28
PA8498901A1 (es)	2004-02-07
EG24143A (en)	2008-08-06
BG65161B1 (bg)	2007-04-30
PE20010662A1 (es)	2001-06-23
EE200200171A (et)	2003-06-16
CO5180567A1 (es)	2002-07-30
AU6721300A (en)	2001-04-30
NO321936B1 (no)	2006-07-24
HK1048628B (zh)	2004-10-21
CN1155594C (zh)	2004-06-30
AP2002002457A0 (en)	2002-06-30
KR100479897B1 (ko)	2005-03-31
YU2602A (sh)	2004-11-25
BG106240A (en)	2002-07-31
BR0014272A (pt)	2002-05-21
ATE246185T1 (de)	2003-08-15
KR20020032627A (ko)	2002-05-03
AR025779A1 (es)	2002-12-11
HUP0202821A2 (hu)	2003-01-28
HRP20020270B1 (en)	2004-04-30
IL147154A0 (en)	2002-08-14
HK1048628A1 (en)	2003-04-11
GB9922963D0 (en)	1999-12-01
EA200200302A1 (ru)	2002-10-31
MXPA02003311A (es)	2002-10-04
SK3982002A3 (en)	2003-05-02
IS6223A (is)	2002-01-08
WO2001023377A2 (en)	2001-04-05
JP2003510318A (ja)	2003-03-18
CR6561A (es)	2005-04-04
CN1364166A (zh)	2002-08-14
DE60004262D1 (de)	2003-09-04
DZ3254A1 (fr)	2001-04-05
TNSN00187A1 (fr)	2005-11-10
DE60004262T2 (de)	2004-01-22
IS2162B (is)	2006-11-15
CA2379572C (en)	2006-11-14
HUP0202821A3 (en)	2003-12-29
WO2001023377A3 (en)	2002-03-07
CZ2002971A3 (cs)	2003-04-16
CA2379572A1 (en)	2001-04-05
EA004510B1 (ru)	2004-04-29
UA72272C2 (uk)	2005-02-15
GEP20043365B (en)	2004-05-10
NO20021525D0 (no)	2002-03-26
HRP20020270A2 (en)	2003-06-30
MA26821A1 (fr)	2004-12-20
NZ516093A (en)	2005-01-28
JP3795395B2 (ja)	2006-07-12
WO2001023377A9 (en)	2002-03-28
NO20021525L (no)	2002-03-26
EP1233960B1 (de)	2003-07-30

Publication	Publication Date	Title
US6380226B1 (en)	2002-04-30	Salts of an anti-migraine indole derivatives
JP5043825B2 (ja)	2012-10-10	Ｄｐｐ−ｉｖ阻害剤の新規な塩及び多形
TW200838512A (en)	2008-10-01	Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof
AU779580B2 (en)	2005-01-27	Polymorphic salt of an anti-migraine drug
CA2352392C (en)	2006-01-24	Eletriptan hydrobromide monohydrate
WO1997005129A1 (en)	1997-02-13	(r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridine-carboxamide, process for producing the same and medicinal composition containing the same
MXPA04010845A (es)	2005-01-25	Formas cristalinas novedosas de ondansetron, procesos para su preparacion, composiciones farmaceuticas que contienen las formas novedosas y metodos para tratar las nauseas utilizando las mismas.
AU2009292476A1 (en)	2010-03-18	Novel crystal forms of 4-(2-aminopyridin-4-yl)-3-(4fluoro- phenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyra-zole methanesulfonate and process for production of same
JPH09100276A (ja)	1997-04-15	（ｒ）−１−エチル−４−メチルヘキサヒドロ−１ｈ−１，４−ジアゼピン誘導体及びそれを含有する医薬