OA12384A - 3'-Prodrugs of 2'-deoxy-beta-l-nucleosides. - Google Patents

3'-Prodrugs of 2'-deoxy-beta-l-nucleosides. Download PDF

Info

Publication number: OA12384A
Authority: OA; OAPI
Prior art keywords: alkyl; compound; hydrogen; aryl; amino acid
Prior art date: 2000-06-15

Application number

OA1200200374A

Other languages

English (en)

Inventor

Martin L Bryant

Gilles Gosselin

Jean-Louis Imbach

Original Assignee

Idenix Cayman Ltd

Centre Nat Rech Scient

Univ Montpellier Ii

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-15

Filing date

2001-06-15

Publication date

2006-04-17

2001-06-15 Application filed by Idenix Cayman Ltd, Centre Nat Rech Scient, Univ Montpellier Ii filed Critical Idenix Cayman Ltd

2006-04-17 Publication of OA12384A publication Critical patent/OA12384A/en

Links

0 *C(C=C*1[C@](C2)C[C@](CO)C2O)=*C1=O Chemical compound *C(C=C*1[C@](C2)C[C@](CO)C2O)=*C1=O 0.000 description 4

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA1200200374A 2000-06-15 2001-06-15 3'-Prodrugs of 2'-deoxy-beta-l-nucleosides. OA12384A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US21210000P	2000-06-15	2000-06-15

Publications (1)

Publication Number	Publication Date
OA12384A true OA12384A (en)	2006-04-17

Family

ID=22789563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200374A OA12384A (en)	2000-06-15	2001-06-15	3'-Prodrugs of 2'-deoxy-beta-l-nucleosides.

Country Status (28)

Country	Link
EP (1)	EP1296995B1 (de)
JP (1)	JP4639032B2 (de)
KR (2)	KR20030032967A (de)
CN (3)	CN1900104A (de)
AP (1)	AP1771A (de)
AR (1)	AR035711A1 (de)
AT (1)	ATE411332T1 (de)
AU (2)	AU6692701A (de)
BR (1)	BR0111732A (de)
CA (1)	CA2413163C (de)
CZ (1)	CZ2003122A3 (de)
DE (1)	DE60136181D1 (de)
EA (1)	EA005774B1 (de)
ES (1)	ES2317912T3 (de)
IL (3)	IL153379A0 (de)
MA (1)	MA27126A1 (de)
MX (1)	MXPA02012443A (de)
MY (1)	MY141594A (de)
NO (1)	NO20026001L (de)
NZ (2)	NZ535246A (de)
OA (1)	OA12384A (de)
PE (1)	PE20020216A1 (de)
PL (1)	PL360404A1 (de)
PY (1)	PY0114386A (de)
UY (1)	UY26779A1 (de)
WO (1)	WO2001096353A2 (de)
YU (1)	YU94802A (de)
ZA (2)	ZA200300168B (de)

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EP1964569A3 (de)	2000-04-13	2009-07-22	Pharmasset, Inc.	3'- oder 2'-Hydroxymethyl-substituierte Nukleosidderivate zur Behandlung von Virusinfektionen
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
EP1736478B1 (de)	2000-05-26	2015-07-22	IDENIX Pharmaceuticals, Inc.	Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren
US6787526B1 (en)	2000-05-26	2004-09-07	Idenix Pharmaceuticals, Inc.	Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
EP1435974A4 (de)	2001-09-28	2006-09-06	Idenix Cayman Ltd	Verfahren und zusamemnsetzungen zur behandlung des hepatitis-c-virus mit 4'-modifizierten nucleosiden
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
TW200500375A (en)	2002-06-28	2005-01-01	Idenix Cayman Ltd	Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
NZ537662A (en)	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
PL374792A1 (en) *	2002-06-28	2005-10-31	Idenix (Cayman) Limited	2' and 3'-nucleoside prodrugs for treating flaviviridae infections
CN1678326A (zh) *	2002-06-28	2005-10-05	埃迪尼克斯(开曼)有限公司	用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
EP1572095B1 (de)	2002-09-13	2015-06-10	Novartis AG	Beta-l-2'-desoxynucleoside zur verwendung in der behandlung von resistenten hbv-stämmen
LT1576138T (lt)	2002-11-15	2017-06-26	Idenix Pharmaceuticals Llc	2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija
AU2003300901A1 (en)	2002-12-12	2004-06-30	Idenix (Cayman) Limited	Process for the production of 2'-branched nucleosides
WO2004084453A2 (en)	2003-03-20	2004-09-30	Microbiologica Quimica E Farmaceutica Ltd.	METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
KR20060015542A (ko)	2003-04-28	2006-02-17	이데닉스 (케이만) 리미티드	산업 규모의 뉴클레오시드 합성
HUE029877T2 (en)	2003-05-30	2017-04-28	Gilead Pharmasset Llc	Modified fluorinated nucleoside analogues
WO2005003374A2 (en)	2003-06-30	2005-01-13	Idenix (Cayman) Limited	SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES
US7754718B2 (en)	2004-05-05	2010-07-13	Yale University	Antiviral helioxanthin analogs
CN101023094B (zh)	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US8492539B2 (en)	2004-09-14	2013-07-23	Gilead Pharmasset Llc	Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7524831B2 (en)	2005-03-02	2009-04-28	Schering Corporation	Treatments for Flaviviridae virus infection
AU2006259348B2 (en)	2005-06-17	2010-07-22	Novartis Ag	Use of sanglifehrin in HCV
GB0609178D0 (en)	2006-05-09	2006-06-21	Univ Cardiff	Novel compounds
US7897737B2 (en)	2006-12-05	2011-03-01	Lasergen, Inc.	3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
TW200946541A (en)	2008-03-27	2009-11-16	Idenix Pharmaceuticals Inc	Solid forms of an anti-HIV phosphoindole compound
NZ590265A (en)	2008-06-11	2012-11-30	Lasergen Inc	Nucleotides and nucleosides and methods for their use in dna sequencing
AU2009329872B2 (en)	2008-12-23	2016-07-07	Gilead Pharmasset Llc	Synthesis of purine nucleosides
NZ593649A (en)	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Nucleoside analogs
PA8855601A1 (es)	2008-12-23	2010-07-27		Forformidatos de nucleósidos
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI583692B (zh)	2009-05-20	2017-05-21	基利法瑪席特有限責任公司	核苷磷醯胺
SG184324A1 (en)	2010-03-31	2012-11-29	Gilead Pharmasset Llc	Nucleoside phosphoramidates
EP2552203B1 (de)	2010-04-01	2017-03-22	Idenix Pharmaceuticals LLC.	Verbindungen und zusammensetzungen zur behandlung von virusinfektionen
CA2818853A1 (en)	2010-11-30	2012-06-07	Gilead Pharmasset Llc	2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
US9243025B2 (en)	2011-03-31	2016-01-26	Idenix Pharmaceuticals, Llc	Compounds and pharmaceutical compositions for the treatment of viral infections
CA2847892A1 (en)	2011-09-12	2013-03-21	Idenix Pharmaceuticals, Inc.	Compounds and pharmaceutical compositions for the treatment of viral infections
WO2013040257A1 (en)	2011-09-13	2013-03-21	Lasergen, Inc.	5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
EP2709613B2 (de)	2011-09-16	2020-08-12	Gilead Pharmasset LLC	Verfahren zur behandlung von hcv
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
AR090699A1 (es) *	2012-04-18	2014-12-03	Biocryst Pharm Inc	Compuestos inhibidores de la actividad de la arn polimerasa viral
EP2950786B1 (de)	2013-01-31	2019-11-27	Gilead Pharmasset LLC	Kombinationsformulierung zweier antiviraler verbindungen
PT3038601T (pt)	2013-08-27	2020-06-30	Gilead Pharmasset Llc	Formulação combinada de dois compostos antivirais
CA3096264A1 (en) *	2018-04-12	2019-10-17	Modis Therapeutics Inc.	Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools
CN116574146A (zh) *	2023-05-18	2023-08-11	沈阳农业大学	具有抗马铃薯y病毒属病毒活性的化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4958013A (en) *	1989-06-06	1990-09-18	Northwestern University	Cholesteryl modified oligonucleotides
IT1246983B (it) *	1990-11-13	1994-12-12	Consiglio Nazionale Ricerche	L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5559101A (en) *	1994-10-24	1996-09-24	Genencor International, Inc.	L-ribofuranosyl nucleosides
SE505648C2 (sv) *	1996-08-30	1997-09-22	Scania Cv Ab	Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul
PT2415776T (pt) *	1998-08-10	2016-07-07	Novartis Ag	Beta-l-2'-desoxi-nucleosidos para o tratamento da hepatite b

2001
- 2001-06-14 MY MYPI20012807A patent/MY141594A/en unknown
- 2001-06-15 CN CNA2006100741038A patent/CN1900104A/zh active Pending
- 2001-06-15 CN CNB018138020A patent/CN1295242C/zh not_active Expired - Fee Related
- 2001-06-15 BR BR0111732-7A patent/BR0111732A/pt not_active IP Right Cessation
- 2001-06-15 ES ES01944522T patent/ES2317912T3/es not_active Expired - Lifetime
- 2001-06-15 AU AU6692701A patent/AU6692701A/xx active Pending
- 2001-06-15 AP APAP/P/2003/002713A patent/AP1771A/en active
- 2001-06-15 CZ CZ2003122A patent/CZ2003122A3/cs unknown
- 2001-06-15 JP JP2002510494A patent/JP4639032B2/ja not_active Expired - Lifetime
- 2001-06-15 OA OA1200200374A patent/OA12384A/en unknown
- 2001-06-15 EP EP01944522A patent/EP1296995B1/de not_active Expired - Lifetime
- 2001-06-15 YU YU94802A patent/YU94802A/sh unknown
- 2001-06-15 PY PY200100114386A patent/PY0114386A/es unknown
- 2001-06-15 KR KR1020027017018A patent/KR20030032967A/ko not_active Abandoned
- 2001-06-15 UY UY26779A patent/UY26779A1/es not_active Application Discontinuation
- 2001-06-15 AR ARP010102881A patent/AR035711A1/es not_active Application Discontinuation
- 2001-06-15 PL PL36040401A patent/PL360404A1/xx not_active Application Discontinuation
- 2001-06-15 MX MXPA02012443A patent/MXPA02012443A/es active IP Right Grant
- 2001-06-15 DE DE60136181T patent/DE60136181D1/de not_active Expired - Lifetime
- 2001-06-15 EA EA200300023A patent/EA005774B1/ru not_active IP Right Cessation
- 2001-06-15 WO PCT/US2001/019147 patent/WO2001096353A2/en not_active Ceased
- 2001-06-15 KR KR1020077009124A patent/KR20070048277A/ko not_active Ceased
- 2001-06-15 AT AT01944522T patent/ATE411332T1/de not_active IP Right Cessation
- 2001-06-15 CA CA002413163A patent/CA2413163C/en not_active Expired - Lifetime
- 2001-06-15 PE PE2001000584A patent/PE20020216A1/es not_active Application Discontinuation
- 2001-06-15 AU AU2001266927A patent/AU2001266927B2/en not_active Ceased
- 2001-06-15 IL IL15337901A patent/IL153379A0/xx active IP Right Grant
- 2001-06-15 CN CNA2006101495863A patent/CN101012259A/zh active Pending
- 2001-06-15 NZ NZ535246A patent/NZ535246A/en unknown
- 2001-06-15 NZ NZ523632A patent/NZ523632A/en unknown
2002
- 2002-12-11 IL IL153379A patent/IL153379A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026001A patent/NO20026001L/no unknown
2003
- 2003-01-02 MA MA26989A patent/MA27126A1/fr unknown
- 2003-01-07 ZA ZA200300168A patent/ZA200300168B/en unknown
2004
- 2004-06-01 ZA ZA200404306A patent/ZA200404306B/xx unknown
2006
- 2006-10-25 IL IL178864A patent/IL178864A0/en unknown

Also Published As

Publication number	Publication date
ZA200404306B (en)	2005-06-15
KR20070048277A (ko)	2007-05-08
KR20030032967A (ko)	2003-04-26
MA27126A1 (fr)	2005-01-03
BR0111732A (pt)	2003-06-24
PL360404A1 (pl)	2004-09-06
PE20020216A1 (es)	2002-04-16
CN1295242C (zh)	2007-01-17
WO2001096353A3 (en)	2002-04-18
EA005774B1 (ru)	2005-06-30
DE60136181D1 (de)	2008-11-27
IL153379A (en)	2007-02-11
CA2413163A1 (en)	2001-12-20
CN1900104A (zh)	2007-01-24
ZA200300168B (en)	2004-07-07
EP1296995A2 (de)	2003-04-02
JP4639032B2 (ja)	2011-02-23
ES2317912T3 (es)	2009-05-01
AP2003002713A0 (en)	2003-03-31
AR035711A1 (es)	2004-07-07
MY141594A (en)	2010-05-14
CN101012259A (zh)	2007-08-08
MXPA02012443A (es)	2004-09-10
PY0114386A (es)	2004-04-01
EA200300023A1 (ru)	2003-08-28
EP1296995B1 (de)	2008-10-15
AP1771A (en)	2007-08-23
NZ523632A (en)	2005-03-24
AU6692701A (en)	2001-12-24
IL153379A0 (en)	2003-07-06
ATE411332T1 (de)	2008-10-15
NO20026001L (no)	2003-02-12
NO20026001D0 (no)	2002-12-13
UY26779A1 (es)	2001-12-28
NZ535246A (en)	2006-06-30
YU94802A (sh)	2006-03-03
CA2413163C (en)	2008-11-18
CZ2003122A3 (cs)	2003-06-18
AU2001266927B2 (en)	2006-12-14
CN1452627A (zh)	2003-10-29
WO2001096353A2 (en)	2001-12-20
JP2004533403A (ja)	2004-11-04
IL178864A0 (en)	2007-03-08

Publication	Publication Date	Title
OA12384A (en)	2006-04-17	3'-Prodrugs of 2'-deoxy-beta-l-nucleosides.
US6875751B2 (en)	2005-04-05	3′-prodrugs of 2′-deoxy-β-L-nucleosides
AU2001266927A1 (en)	2002-03-14	3'-prodrugs of 2'-deoxy-beta-L-nucleosides
US9095599B2 (en)	2015-08-04	O-(substituted benzyl) phosphoramidate compounds and therapeutic use
US9156874B2 (en)	2015-10-13	Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
EP2739154B1 (de)	2018-06-27	Vitamin-b6-derivate von nukleotiden, acyclonukleotiden und acyclonucleosid-phosphonaten
CN104640444B (zh)	2016-12-14	双肝脏靶向氨基磷酸酯和氨基膦酸酯前药
EP1274713B1 (de)	2004-03-10	Antivirale pyrimidin-nukleosid-analogen
US20030176370A1 (en)	2003-09-18	Anti-viral pyrimidine nucleoside analogues
WO2006094347A1 (en)	2006-09-14	Bicyclic nucleosides and nucleotides as therapeutic agents
US20140315850A1 (en)	2014-10-23	2',3'-Dideoxy-2'-alpha-Fluoro-2'-beta-C-Methylnucleosides and Prodrugs Thereof
CN110845560A (zh)	2020-02-28	苯丙氨酸酰胺化的核苷酸衍生物及其制备方法与应用
IE921083A1 (en)	1992-10-07	Substituted 2',3'-dideoxy-5-trifluoromethyluridines,¹processes for their preparation and their use in medicaments
RU2418795C2 (ru)	2011-05-20	Производные диоксолана для лечения рака
AU2007201035A1 (en)	2007-03-29	3'-Prodrugs of 2'-deoxy-beta-L-nucleosides