OA12414A - NMDA receptor agonist pharmaceutical compositions. - Google Patents

NMDA receptor agonist pharmaceutical compositions. Download PDF

Info

Publication number: OA12414A
Authority: OA; OAPI
Prior art keywords: pharmaceutical composition; composition; free; disease; percent
Prior art date: 2000-12-13

Application number

OA1200300145A

Other languages

English (en)

Inventor

Jinyang Hong

Yesook Kim

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-13

Filing date

2001-12-05

Publication date

2006-04-18

2001-12-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-04-18 Publication of OA12414A publication Critical patent/OA12414A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 28
239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 title abstract description 3
238000000034 method Methods 0.000 claims abstract description 15
QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 claims abstract description 11
238000001356 surgical procedure Methods 0.000 claims abstract description 10
210000003169 central nervous system Anatomy 0.000 claims abstract description 9
208000024827 Alzheimer disease Diseases 0.000 claims abstract description 8
208000006011 Stroke Diseases 0.000 claims abstract description 8
208000023105 Huntington disease Diseases 0.000 claims abstract description 6
208000019695 Migraine disease Diseases 0.000 claims abstract description 6
208000005314 Multi-Infarct Dementia Diseases 0.000 claims abstract description 6
208000002193 Pain Diseases 0.000 claims abstract description 6
208000028017 Psychotic disease Diseases 0.000 claims abstract description 6
208000030886 Traumatic Brain injury Diseases 0.000 claims abstract description 6
206010046543 Urinary incontinence Diseases 0.000 claims abstract description 6
201000004810 Vascular dementia Diseases 0.000 claims abstract description 6
206010015037 epilepsy Diseases 0.000 claims abstract description 6
206010027599 migraine Diseases 0.000 claims abstract description 6
208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 6
230000009529 traumatic brain injury Effects 0.000 claims abstract description 6
208000030507 AIDS Diseases 0.000 claims abstract description 5
206010012289 Dementia Diseases 0.000 claims abstract description 5
208000013016 Hypoglycemia Diseases 0.000 claims abstract description 5
208000018737 Parkinson disease Diseases 0.000 claims abstract description 5
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239000002249 anxiolytic agent Substances 0.000 claims abstract description 5
230000000949 anxiolytic effect Effects 0.000 claims abstract description 5
206010013663 drug dependence Diseases 0.000 claims abstract description 5
230000002218 hypoglycaemic effect Effects 0.000 claims abstract description 5
208000014674 injury Diseases 0.000 claims abstract description 5
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208000011117 substance-related disease Diseases 0.000 claims abstract description 5
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239000000203 mixture Substances 0.000 claims description 54
150000002500 ions Chemical class 0.000 claims description 27
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XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 13
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
239000001301 oxygen Substances 0.000 claims description 12
229910052760 oxygen Inorganic materials 0.000 claims description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
150000003839 salts Chemical class 0.000 claims description 11
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 10
BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 9
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 9
229910052742 iron Inorganic materials 0.000 claims description 9
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229940044613 1-propanol Drugs 0.000 claims description 8
RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 claims description 8
229940123150 Chelating agent Drugs 0.000 claims description 8
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 8
239000002738 chelating agent Substances 0.000 claims description 8
229910001431 copper ion Inorganic materials 0.000 claims description 8
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 7
-1 iron ion Chemical class 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims description 5
241000124008 Mammalia Species 0.000 claims description 5
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QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
150000001450 anions Chemical class 0.000 claims description 2
239000013522 chelant Substances 0.000 claims description 2
239000001384 succinic acid Substances 0.000 claims description 2
SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical group [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
150000003893 lactate salts Chemical group 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
230000000694 effects Effects 0.000 description 7
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XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical group CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
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102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 3
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 3
HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
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239000012086 standard solution Substances 0.000 description 3
238000005160 1H NMR spectroscopy Methods 0.000 description 2
JLVSRWOIZZXQAD-UHFFFAOYSA-N 2,3-disulfanylpropane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(S)CS JLVSRWOIZZXQAD-UHFFFAOYSA-N 0.000 description 2
LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
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DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
239000013011 aqueous formulation Substances 0.000 description 2
229910052786 argon Inorganic materials 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
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239000003153 chemical reaction reagent Substances 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
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239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 2
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238000004806 packaging method and process Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
150000004684 trihydrates Chemical class 0.000 description 2
MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
229940006190 2,3-dimercapto-1-propanesulfonic acid Drugs 0.000 description 1
KQKFQBTWXOGINC-UHFFFAOYSA-N 4-phenylpiperidin-4-ol Chemical compound C=1C=CC=CC=1C1(O)CCNCC1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 description 1
UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical compound C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 description 1
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QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
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239000004471 Glycine Substances 0.000 description 1
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WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
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XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
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JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
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GXHMMDRXHUIUMN-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O GXHMMDRXHUIUMN-UHFFFAOYSA-N 0.000 description 1
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YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA1200300145A 2000-12-13 2001-12-05 NMDA receptor agonist pharmaceutical compositions. OA12414A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25537200P	2000-12-13	2000-12-13

Publications (1)

Publication Number	Publication Date
OA12414A true OA12414A (en)	2006-04-18

Family

ID=22968017

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200300145A OA12414A (en)	2000-12-13	2001-12-05	NMDA receptor agonist pharmaceutical compositions.

Country Status (41)

Country	Link
US (2)	US6635270B2 (fr)
EP (1)	EP1347760B1 (fr)
JP (1)	JP2004515529A (fr)
KR (1)	KR100533407B1 (fr)
CN (1)	CN1273135C (fr)
AP (1)	AP1235A (fr)
AR (1)	AR035607A1 (fr)
AT (1)	ATE296629T1 (fr)
AU (2)	AU1845402A (fr)
BG (1)	BG107788A (fr)
BR (1)	BR0116085A (fr)
CA (1)	CA2431172A1 (fr)
CZ (1)	CZ20031543A3 (fr)
DE (1)	DE60111265T2 (fr)
DO (1)	DOP2001000300A (fr)
DZ (1)	DZ3484A1 (fr)
EA (1)	EA006489B1 (fr)
EC (1)	ECSP034655A (fr)
EE (1)	EE200300284A (fr)
ES (1)	ES2239648T3 (fr)
GE (1)	GEP20053568B (fr)
HR (1)	HRP20030473A2 (fr)
HU (1)	HUP0400645A2 (fr)
IL (1)	IL155810A0 (fr)
IS (1)	IS6811A (fr)
MA (1)	MA26970A1 (fr)
MX (1)	MXPA03005257A (fr)
NO (1)	NO20032678L (fr)
NZ (1)	NZ525742A (fr)
OA (1)	OA12414A (fr)
PA (1)	PA8534901A1 (fr)
PE (1)	PE20020710A1 (fr)
PL (1)	PL362080A1 (fr)
PT (1)	PT1347760E (fr)
SK (1)	SK6982003A3 (fr)
TN (1)	TNSN01173A1 (fr)
UA (1)	UA73619C2 (fr)
UY (1)	UY27068A1 (fr)
WO (1)	WO2002047685A2 (fr)
YU (1)	YU41103A (fr)
ZA (1)	ZA200303892B (fr)

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WO2014078568A1 (fr)	2012-11-14	2014-05-22	The Johns Hopkins University	Méthodes et compositions pour le traitement de la schizophrénie
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CA2899010A1 (fr)	2013-01-29	2014-08-07	Naurex, Inc.	Modulateurs spirolactames d'un recepteur nmda et leurs utilisations
MX375286B (es)	2013-01-29	2025-03-06	Aptinyx Inc	Moduladores de receptores nmda de espiro-lactama y sus usos.
CA2898863A1 (fr)	2013-01-29	2014-08-07	Naurex, Inc.	Modulateurs spirolactames d'un recepteur nmda et leurs utilisations
AU2014212501A1 (en)	2013-01-29	2015-07-30	Aptinyx, Inc.	Spiro-lactam NMDA receptor modulators and uses thereof
MX2016008369A (es)	2013-12-23	2016-12-15	Samyang Biopharmaceuticals	Composicion farmaceutica que incluye palonosetron.
JP6823083B2 (ja)	2016-05-19	2021-01-27	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
WO2017201285A1 (fr)	2016-05-19	2017-11-23	Aptinyx Inc.	Modulateurs spirolactames des récepteurs nmda et leurs utilisations
AU2017306158B2 (en)	2016-08-01	2021-10-14	Aptinyx Inc.	Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
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2001
- 2001-05-12 UA UA2003065485A patent/UA73619C2/uk unknown
- 2001-12-05 SK SK698-2003A patent/SK6982003A3/sk unknown
- 2001-12-05 AU AU1845402A patent/AU1845402A/xx active Pending
- 2001-12-05 ES ES01270205T patent/ES2239648T3/es not_active Expired - Lifetime
- 2001-12-05 GE GE5171A patent/GEP20053568B/en unknown
- 2001-12-05 PT PT01270205T patent/PT1347760E/pt unknown
- 2001-12-05 WO PCT/IB2001/002359 patent/WO2002047685A2/fr not_active Ceased
- 2001-12-05 AT AT01270205T patent/ATE296629T1/de not_active IP Right Cessation
- 2001-12-05 EE EEP200300284A patent/EE200300284A/xx unknown
- 2001-12-05 CZ CZ20031543A patent/CZ20031543A3/cs unknown
- 2001-12-05 EP EP01270205A patent/EP1347760B1/fr not_active Expired - Lifetime
- 2001-12-05 MX MXPA03005257A patent/MXPA03005257A/es active IP Right Grant
- 2001-12-05 YU YU41103A patent/YU41103A/sh unknown
- 2001-12-05 PL PL01362080A patent/PL362080A1/xx not_active Application Discontinuation
- 2001-12-05 OA OA1200300145A patent/OA12414A/en unknown
- 2001-12-05 JP JP2002549256A patent/JP2004515529A/ja active Pending
- 2001-12-05 KR KR10-2003-7007874A patent/KR100533407B1/ko not_active Expired - Fee Related
- 2001-12-05 EA EA200300514A patent/EA006489B1/ru not_active IP Right Cessation
- 2001-12-05 AU AU2002218454A patent/AU2002218454B2/en not_active Ceased
- 2001-12-05 CN CNB018203922A patent/CN1273135C/zh not_active Expired - Fee Related
- 2001-12-05 BR BR0116085-0A patent/BR0116085A/pt not_active IP Right Cessation
- 2001-12-05 US US10/010,827 patent/US6635270B2/en not_active Expired - Fee Related
- 2001-12-05 HR HR20030473A patent/HRP20030473A2/hr not_active Application Discontinuation
- 2001-12-05 HU HU0400645A patent/HUP0400645A2/hu unknown
- 2001-12-05 NZ NZ525742A patent/NZ525742A/en unknown
- 2001-12-05 CA CA002431172A patent/CA2431172A1/fr not_active Abandoned
- 2001-12-05 DZ DZ013484A patent/DZ3484A1/fr active
- 2001-12-05 DE DE60111265T patent/DE60111265T2/de not_active Expired - Fee Related
- 2001-12-05 IL IL15581001A patent/IL155810A0/xx unknown
- 2001-12-10 DO DO2001000300A patent/DOP2001000300A/es unknown
- 2001-12-11 AR ARP010105748A patent/AR035607A1/es unknown
- 2001-12-11 PE PE2001001235A patent/PE20020710A1/es not_active Application Discontinuation
- 2001-12-12 TN TNTNSN01173A patent/TNSN01173A1/fr unknown
- 2001-12-12 UY UY27068A patent/UY27068A1/es not_active Application Discontinuation
- 2001-12-13 AP APAP/P/2001/002376A patent/AP1235A/en active
- 2001-12-13 PA PA20018534901A patent/PA8534901A1/es unknown
2003
- 2003-05-08 IS IS6811A patent/IS6811A/is unknown
- 2003-05-09 BG BG107788A patent/BG107788A/bg unknown
- 2003-05-20 ZA ZA200303892A patent/ZA200303892B/en unknown
- 2003-06-03 MA MA27191A patent/MA26970A1/fr unknown
- 2003-06-12 NO NO20032678A patent/NO20032678L/no not_active Application Discontinuation
- 2003-06-13 EC EC2003004655A patent/ECSP034655A/es unknown
- 2003-08-19 US US10/643,441 patent/US20040039022A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2002047685A2 (fr)	2002-06-20
SK6982003A3 (en)	2004-08-03
NO20032678D0 (no)	2003-06-12
AU1845402A (en)	2002-06-24
YU41103A (sh)	2006-05-25
KR20030070060A (ko)	2003-08-27
NO20032678L (no)	2003-06-12
BR0116085A (pt)	2003-12-23
CN1273135C (zh)	2006-09-06
GEP20053568B (en)	2005-07-11
DZ3484A1 (fr)	2002-06-20
EP1347760A2 (fr)	2003-10-01
AP2001002376A0 (en)	2001-12-31
AU2002218454B2 (en)	2005-10-27
TNSN01173A1 (fr)	2005-11-10
EA200300514A1 (ru)	2003-10-30
KR100533407B1 (ko)	2005-12-02
DOP2001000300A (es)	2002-05-30
JP2004515529A (ja)	2004-05-27
IL155810A0 (en)	2003-12-23
US20040039022A1 (en)	2004-02-26
CN1479617A (zh)	2004-03-03
AP1235A (en)	2004-01-06
UY27068A1 (es)	2002-07-31
US6635270B2 (en)	2003-10-21
PE20020710A1 (es)	2002-08-09
PT1347760E (pt)	2005-09-30
DE60111265D1 (de)	2005-07-07
US20020111366A1 (en)	2002-08-15
PL362080A1 (en)	2004-10-18
UA73619C2 (en)	2005-08-15
MXPA03005257A (es)	2003-09-25
ZA200303892B (en)	2004-05-20
EE200300284A (et)	2003-10-15
EP1347760B1 (fr)	2005-06-01
CZ20031543A3 (cs)	2004-06-16
BG107788A (bg)	2004-01-30
PA8534901A1 (es)	2002-08-26
IS6811A (is)	2003-05-08
CA2431172A1 (fr)	2002-06-20
EA006489B1 (ru)	2005-12-29
WO2002047685A3 (fr)	2002-08-15
MA26970A1 (fr)	2004-12-20
HRP20030473A2 (en)	2005-04-30
DE60111265T2 (de)	2006-05-04
HK1059575A1 (en)	2004-07-09
ATE296629T1 (de)	2005-06-15
ECSP034655A (es)	2003-07-25
NZ525742A (en)	2005-07-29
ES2239648T3 (es)	2005-10-01
HUP0400645A2 (hu)	2004-06-28
AR035607A1 (es)	2004-06-16

Publication	Publication Date	Title
EP1347760B1 (fr)	2005-06-01	Compositions pharmaceutiques de l'agoniste du recepteur nmda
AU2002218454A1 (en)	2002-08-29	NMDA receptor agonist pharmaceutical compositions
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WO2007040535A1 (fr)	2007-04-12	Utilisation d'analogues de polyamine pour le traitement et la prévention de polypes intestinaux
RU2038080C1 (ru)	1995-06-27	Лекарственное средство для парентерального введения
AU2020345320B2 (en)	2025-09-04	Method for preventing precipitation of injectable solution containing p-boronophenylalanine
EP0365363B1 (fr)	1993-04-14	Compositions pour administration parentérale contenant la 1-diphényl méthyl-4-[(2-(4-méthylphényle)-5-méthyl-1H-imidazol-4-yl)-méthyl]-pipérazine
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RU2851166C1 (ru)	2025-11-19	Фармацевтическая композиция и ее применение
KR900002745B1 (ko)	1990-04-28	안정 주사용 진토제 조성물의 제조방법
HK40063208A (en)	2022-06-17	Method for preventing precipitation of injectable solution containing p-boronophenylalanine
CN107028968B (zh)	2020-12-04	一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
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HK40063844A (en)	2022-06-24	Pharmaceutical composition and use thereof