OA12502A - Dérivés du mercaptoacétylamide, un procédé de leurpréparation et leur utilisation. - Google Patents

Dérivés du mercaptoacétylamide, un procédé de leurpréparation et leur utilisation. Download PDF

Info

Publication number: OA12502A
Authority: OA; OAPI
Prior art keywords: compound; aryl; alkyl; group; oxo
Prior art date: 2001-04-12

Application number

OA1200300267A

Other languages

English (en)

French (fr)

Inventor

Gary A Flynn

Jack Roger Koehl

Shujaath Mehdi

Barbara Ann Anderson

Manfred Gerken

Bernd Jablonka

Heinz-Werner Kleemann

Wolfgang Linz

Werner Seiz

Bernhard Seuring

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-03

Publication date

2006-05-29

2001-08-08 Priority claimed from GBGB0119305.1A external-priority patent/GB0119305D0/en

2002-04-03 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2006-05-29 Publication of OA12502A publication Critical patent/OA12502A/fr

Links

238000000034 method Methods 0.000 title claims abstract description 30
230000008569 process Effects 0.000 title claims abstract description 7
238000002360 preparation method Methods 0.000 title claims description 20
GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical class NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title abstract 2
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-1 C1-C10alkyl Chemical group 0.000 claims description 37
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 17
CMIRWXFQPVROKZ-UHFFFAOYSA-N 5h-2-benzazepine-4-carboxylic acid Chemical compound C1C(C(=O)O)=CN=CC2=CC=CC=C21 CMIRWXFQPVROKZ-UHFFFAOYSA-N 0.000 claims description 15
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims description 12
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GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 5
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HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
FRACPXUHUTXLCX-BELIEFIBSA-N tert-butyl N-{1-[(1S)-1-{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl}-2-cyclopropylethyl]-2-oxopyridin-3-yl}carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CN(C1=O)[C@@H](CC2CC2)C(=O)N[C@@H](C[C@@H]3CCNC3=O)[C@H](C(=O)NCC4=CC=CC=C4)O FRACPXUHUTXLCX-BELIEFIBSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
230000002861 ventricular Effects 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)

OA1200300267A 2001-04-12 2002-04-03 Dérivés du mercaptoacétylamide, un procédé de leurpréparation et leur utilisation. OA12502A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28330501P	2001-04-12	2001-04-12
GBGB0119305.1A GB0119305D0 (en)	2001-04-12	2001-08-08	Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (1)

Publication Number	Publication Date
OA12502A true OA12502A (fr)	2006-05-29

Family

ID=26246410

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200300267A OA12502A (fr)	2001-04-12	2002-04-03	Dérivés du mercaptoacétylamide, un procédé de leurpréparation et leur utilisation.

Country Status (26)

Country	Link
EP (1)	EP1381605B1 (cs)
JP (1)	JP4392167B2 (cs)
CN (1)	CN1245404C (cs)
AT (1)	ATE286898T1 (cs)
AU (1)	AU2002304804B2 (cs)
BG (1)	BG66387B1 (cs)
BR (1)	BR0208889A (cs)
CA (1)	CA2443488C (cs)
CZ (1)	CZ299708B6 (cs)
DE (1)	DE60202602T2 (cs)
EE (1)	EE05272B1 (cs)
ES (1)	ES2232752T3 (cs)
HR (1)	HRP20030823B1 (cs)
HU (1)	HU229612B1 (cs)
IL (1)	IL158289A0 (cs)
MA (1)	MA26098A1 (cs)
MX (1)	MXPA03008613A (cs)
NO (1)	NO325655B1 (cs)
NZ (1)	NZ528825A (cs)
OA (1)	OA12502A (cs)
PL (1)	PL209338B1 (cs)
PT (1)	PT1381605E (cs)
RU (1)	RU2286346C2 (cs)
SI (1)	SI1381605T1 (cs)
SK (1)	SK287616B6 (cs)
WO (1)	WO2002083671A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10229180A1 (de) *	2002-06-28	2004-01-29	Aventis Pharma Deutschland Gmbh	Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
US8993631B2 (en)	2010-11-16	2015-03-31	Novartis Ag	Method of treating contrast-induced nephropathy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5430145A (en) *	1990-10-18	1995-07-04	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2078758C (en) *	1991-09-27	2003-12-09	Alan M. Warshawsky	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
RU2127261C1 (ru) *	1993-06-11	1999-03-10	Эйсаи Ко., ЛТД	Производные аминокислоты
JP3563738B2 (ja) *	1993-06-11	2004-09-08	エーザイ株式会社	アミノ酸誘導体

2002
- 2002-04-03 DE DE60202602T patent/DE60202602T2/de not_active Expired - Lifetime
- 2002-04-03 RU RU2003132875/04A patent/RU2286346C2/ru not_active IP Right Cessation
- 2002-04-03 HU HU0303482A patent/HU229612B1/hu not_active IP Right Cessation
- 2002-04-03 PT PT02732549T patent/PT1381605E/pt unknown
- 2002-04-03 PL PL363034A patent/PL209338B1/pl unknown
- 2002-04-03 JP JP2002581426A patent/JP4392167B2/ja not_active Expired - Fee Related
- 2002-04-03 CZ CZ20032722A patent/CZ299708B6/cs not_active IP Right Cessation
- 2002-04-03 HR HR20030823A patent/HRP20030823B1/xx not_active IP Right Cessation
- 2002-04-03 EP EP02732549A patent/EP1381605B1/en not_active Expired - Lifetime
- 2002-04-03 NZ NZ528825A patent/NZ528825A/en not_active IP Right Cessation
- 2002-04-03 CA CA2443488A patent/CA2443488C/en not_active Expired - Fee Related
- 2002-04-03 MX MXPA03008613A patent/MXPA03008613A/es active IP Right Grant
- 2002-04-03 AU AU2002304804A patent/AU2002304804B2/en not_active Ceased
- 2002-04-03 OA OA1200300267A patent/OA12502A/fr unknown
- 2002-04-03 SI SI200230089T patent/SI1381605T1/xx unknown
- 2002-04-03 EE EEP200300500A patent/EE05272B1/xx not_active IP Right Cessation
- 2002-04-03 ES ES02732549T patent/ES2232752T3/es not_active Expired - Lifetime
- 2002-04-03 CN CNB028081005A patent/CN1245404C/zh not_active Expired - Fee Related
- 2002-04-03 IL IL15828902A patent/IL158289A0/xx unknown
- 2002-04-03 SK SK1255-2003A patent/SK287616B6/sk not_active IP Right Cessation
- 2002-04-03 WO PCT/EP2002/003668 patent/WO2002083671A1/en not_active Ceased
- 2002-04-03 AT AT02732549T patent/ATE286898T1/de active
- 2002-04-03 BR BR0208889-4A patent/BR0208889A/pt not_active Application Discontinuation
2003
- 2003-09-16 MA MA27312A patent/MA26098A1/fr unknown
- 2003-09-26 BG BG108203A patent/BG66387B1/bg unknown
- 2003-10-02 NO NO20034412A patent/NO325655B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
SI1381605T1 (en)	2005-06-30
HK1061690A1 (en)	2004-09-30
PL363034A1 (en)	2004-11-15
SK12552003A3 (sk)	2004-03-02
NO20034412D0 (no)	2003-10-02
PL209338B1 (pl)	2011-08-31
BG108203A (bg)	2004-12-30
NO325655B1 (no)	2008-06-30
DE60202602D1 (de)	2005-02-17
NO20034412L (no)	2003-10-02
MXPA03008613A (es)	2003-12-08
NZ528825A (en)	2005-04-29
CA2443488C (en)	2011-05-31
HUP0303482A2 (hu)	2004-01-28
JP4392167B2 (ja)	2009-12-24
CA2443488A1 (en)	2002-10-24
HRP20030823A2 (en)	2005-08-31
HUP0303482A3 (en)	2012-12-28
PT1381605E (pt)	2005-03-31
BG66387B1 (bg)	2013-11-29
SK287616B6 (sk)	2011-04-05
ES2232752T3 (es)	2005-06-01
ATE286898T1 (de)	2005-01-15
EE05272B1 (et)	2010-02-15
RU2286346C2 (ru)	2006-10-27
WO2002083671A1 (en)	2002-10-24
MA26098A1 (fr)	2004-04-01
CN1501926A (zh)	2004-06-02
DE60202602T2 (de)	2006-03-23
IL158289A0 (en)	2004-05-12
HRP20030823B1 (en)	2011-10-31
CZ20032722A3 (cs)	2004-01-14
JP2004525966A (ja)	2004-08-26
HU229612B1 (en)	2014-03-28
BR0208889A (pt)	2004-06-29
AU2002304804B2 (en)	2007-05-10
EP1381605B1 (en)	2005-01-12
CN1245404C (zh)	2006-03-15
RU2003132875A (ru)	2005-03-20
EP1381605A1 (en)	2004-01-21
EE200300500A (et)	2003-12-15
CZ299708B6 (cs)	2008-10-29

Publication	Publication Date	Title
US6602866B2 (en)	2003-08-05	Mercaptoacetylamide derivatives, a process for their preparation and their use
EP0031741A1 (fr)	1981-07-08	Nouveaux iminoacides substitués, leurs procédés de préparation et leur emploi comme inhibiteurs d'enzymes
BE851310A (fr)	1977-08-10	Nouveaux derives de la tetrahydro-equinocandine b
JP2001514632A (ja)	2001-09-11	新規ヘテロサイクリック化合物
FR2467845A1 (fr)	1981-04-30	Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
FR2707089A1 (fr)	1995-01-06	Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP2917204B1 (fr)	2016-09-28	Derives de 1h-indole-3-carboxamide et leurs utilisation comme antagonistes du p2y12
JP4392167B2 (ja)	2009-12-24	メルカプトアセチルアミド誘導体、その製造方法およびその使用
CA1327800C (fr)	1994-03-15	Derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2522663A1 (fr)	1983-09-09	Nouveaux alcaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments
CN116354892B (zh)	2025-08-29	一类sirt5蛋白抑制剂及其用途
MXPA04006937A (es)	2004-12-06	Intermedios para la preparacion de inhibidores de la glucogeno fosforilasa.
AU2002304804A1 (en)	2003-04-10	Mercaptoacetylamide derivatives, a process for their preparation and their use
TW200485B (cs)	1993-02-21
HK1061690B (en)	2006-08-11	Mercaptoacetylamide derivatives, a process for their preparation and their use
FR2528850A1 (fr)	1983-12-23	Nouveaux aminocyclols