OA12604A - Liquid pharmaceutical composition. - Google Patents

Liquid pharmaceutical composition. Download PDF

Info

Publication number: OA12604A
Authority: OA; OAPI
Prior art keywords: liquid; pharmaceutical composition; polyhydric alcohol; gabapentin; gaba analog
Prior art date: 2001-05-25

Application number

OA1200300296A

Other languages

English (en)

Inventor

Nemma Mahesh Kularni

Hans Richard Meyer-Wonnay

Nahid Sanii-Yahyai

Michael Schneider

Steven Bernard Silbering

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-25

Filing date

2002-04-29

Publication date

2006-06-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26968180&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12604(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-04-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-06-08 Publication of OA12604A publication Critical patent/OA12604A/en

Links

239000007788 liquid Substances 0.000 title claims abstract description 53
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 23
239000000203 mixture Substances 0.000 claims abstract description 56
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 34
150000005846 sugar alcohols Polymers 0.000 claims abstract description 21
238000000034 method Methods 0.000 claims abstract description 15
239000000843 powder Substances 0.000 claims abstract description 14
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 12
208000002193 Pain Diseases 0.000 claims abstract description 8
206010015037 epilepsy Diseases 0.000 claims abstract description 8
239000007787 solid Substances 0.000 claims abstract description 8
230000006378 damage Effects 0.000 claims abstract description 6
208000019901 Anxiety disease Diseases 0.000 claims abstract description 5
208000020925 Bipolar disease Diseases 0.000 claims abstract description 5
208000006083 Hypokinesia Diseases 0.000 claims abstract description 5
230000036506 anxiety Effects 0.000 claims abstract description 5
208000002173 dizziness Diseases 0.000 claims abstract description 5
230000002496 gastric effect Effects 0.000 claims abstract description 5
230000003483 hypokinetic effect Effects 0.000 claims abstract description 5
208000014674 injury Diseases 0.000 claims abstract description 5
230000008733 trauma Effects 0.000 claims abstract description 5
206010006002 Bone pain Diseases 0.000 claims abstract description 4
206010021639 Incontinence Diseases 0.000 claims abstract description 4
206010061218 Inflammation Diseases 0.000 claims abstract description 4
206010026749 Mania Diseases 0.000 claims abstract description 4
208000019695 Migraine disease Diseases 0.000 claims abstract description 4
208000000112 Myalgia Diseases 0.000 claims abstract description 4
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 4
230000004054 inflammatory process Effects 0.000 claims abstract description 4
206010022437 insomnia Diseases 0.000 claims abstract description 4
206010027599 migraine Diseases 0.000 claims abstract description 4
208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 3
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 81
229960002870 gabapentin Drugs 0.000 claims description 40
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 18
239000000796 flavoring agent Substances 0.000 claims description 17
229960001233 pregabalin Drugs 0.000 claims description 17
235000019634 flavors Nutrition 0.000 claims description 16
150000003951 lactams Chemical class 0.000 claims description 12
235000011187 glycerol Nutrition 0.000 claims description 10
239000003755 preservative agent Substances 0.000 claims description 10
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 9
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 9
239000000600 sorbitol Substances 0.000 claims description 9
235000010356 sorbitol Nutrition 0.000 claims description 9
239000000811 xylitol Substances 0.000 claims description 9
235000010447 xylitol Nutrition 0.000 claims description 9
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
229960002675 xylitol Drugs 0.000 claims description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
201000010099 disease Diseases 0.000 claims description 5
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
229930195725 Mannitol Natural products 0.000 claims description 4
229960003692 gamma aminobutyric acid Drugs 0.000 claims description 4
239000000594 mannitol Substances 0.000 claims description 4
235000010355 mannitol Nutrition 0.000 claims description 4
230000002335 preservative effect Effects 0.000 claims description 4
208000004998 Abdominal Pain Diseases 0.000 claims description 3
208000002881 Colic Diseases 0.000 claims description 3
235000003599 food sweetener Nutrition 0.000 claims description 3
201000001119 neuropathy Diseases 0.000 claims description 3
230000007823 neuropathy Effects 0.000 claims description 3
239000003765 sweetening agent Substances 0.000 claims description 3
JAWPQJDOQPSNIQ-UHFFFAOYSA-N 2-Azaspiro[4.5]decan-3-one Chemical compound C1NC(=O)CC21CCCCC2 JAWPQJDOQPSNIQ-UHFFFAOYSA-N 0.000 claims description 2
125000000468 ketone group Chemical group 0.000 claims 1
239000008203 oral pharmaceutical composition Substances 0.000 claims 1
208000018152 Cerebral disease Diseases 0.000 abstract 1
206010038419 Renal colic Diseases 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
208000021722 neuropathic pain Diseases 0.000 abstract 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 27
229960000583 acetic acid Drugs 0.000 description 19
239000006188 syrup Substances 0.000 description 12
235000020357 syrup Nutrition 0.000 description 12
239000000243 solution Substances 0.000 description 11
239000002253 acid Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
-1 for example Chemical compound 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
240000004760 Pimpinella anisum Species 0.000 description 6
235000012550 Pimpinella anisum Nutrition 0.000 description 6
235000019441 ethanol Nutrition 0.000 description 6
235000019640 taste Nutrition 0.000 description 5
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 4
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
229940041616 menthol Drugs 0.000 description 4
239000002671 adjuvant Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
210000003169 central nervous system Anatomy 0.000 description 3
229940116592 central nervous system diagnostic radiopharmaceuticals Drugs 0.000 description 3
229960000443 hydrochloric acid Drugs 0.000 description 3
235000011167 hydrochloric acid Nutrition 0.000 description 3
230000008569 process Effects 0.000 description 3
235000007265 Myrrhis odorata Nutrition 0.000 description 2
235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
235000017537 Vaccinium myrtillus Nutrition 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
230000000845 anti-microbial effect Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
235000019658 bitter taste Nutrition 0.000 description 2
235000021014 blueberries Nutrition 0.000 description 2
239000003086 colorant Substances 0.000 description 2
230000008570 general process Effects 0.000 description 2
239000011521 glass Substances 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
239000012669 liquid formulation Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000007363 ring formation reaction Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000000087 stabilizing effect Effects 0.000 description 2
239000000725 suspension Substances 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
239000002562 thickening agent Substances 0.000 description 2
OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
JXSBZOVCVUSLIO-NRPADANISA-N 2-[(1s,5s,6r)-6-(aminomethyl)-6-bicyclo[3.2.0]heptanyl]acetic acid Chemical compound C1CC[C@@H]2[C@](CN)(CC(O)=O)C[C@@H]21 JXSBZOVCVUSLIO-NRPADANISA-N 0.000 description 1
WRSFRDZQQUAKNA-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydrate Chemical compound O.OC(=O)CC1(CN)CCCCC1 WRSFRDZQQUAKNA-UHFFFAOYSA-N 0.000 description 1
LZBLSYMXABKJKB-UHFFFAOYSA-N 2-[7-(aminomethyl)-7-bicyclo[4.2.0]octanyl]acetic acid Chemical compound C1CCCC2C(CN)(CC(O)=O)CC21 LZBLSYMXABKJKB-UHFFFAOYSA-N 0.000 description 1
GUGXRXLTTHFKHC-UHFFFAOYSA-N 4-(2-methylpropyl)pyrrolidin-2-one Chemical compound CC(C)CC1CNC(=O)C1 GUGXRXLTTHFKHC-UHFFFAOYSA-N 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
208000012661 Dyskinesia Diseases 0.000 description 1
208000023105 Huntington disease Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000000851 Vaccinium corymbosum Species 0.000 description 1
244000077233 Vaccinium uliginosum Species 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229940124277 aminobutyric acid Drugs 0.000 description 1
230000001773 anti-convulsant effect Effects 0.000 description 1
230000001663 anti-spastic effect Effects 0.000 description 1
239000001961 anticonvulsive agent Substances 0.000 description 1
229960003965 antiepileptics Drugs 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000000306 component Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
230000007423 decrease Effects 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000011888 foil Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
150000004682 monohydrates Chemical group 0.000 description 1
229940072228 neurontin Drugs 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000008213 purified water Substances 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
235000019605 sweet taste sensations Nutrition 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)

OA1200300296A 2001-05-25 2002-04-29 Liquid pharmaceutical composition. OA12604A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29383201P	2001-05-25	2001-05-25
US34373301P	2001-10-25	2001-10-25

Publications (1)

Publication Number	Publication Date
OA12604A true OA12604A (en)	2006-06-08

Family

ID=26968180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200300296A OA12604A (en)	2001-05-25	2002-04-29	Liquid pharmaceutical composition.

Country Status (43)

Country	Link
US (2)	US20020198261A1 (de)
EP (1)	EP1395242B1 (de)
JP (1)	JP2004534764A (de)
KR (1)	KR100582963B1 (de)
CN (1)	CN100346779C (de)
AP (1)	AP1815A (de)
AR (1)	AR033922A1 (de)
AT (1)	ATE334656T1 (de)
AU (1)	AU2002258026B2 (de)
BG (1)	BG108376A (de)
BR (1)	BR0209973A (de)
CA (1)	CA2446574C (de)
CR (1)	CR7150A (de)
CY (1)	CY1105147T1 (de)
CZ (1)	CZ299755B6 (de)
DE (1)	DE60213592T2 (de)
DK (1)	DK1395242T3 (de)
DO (1)	DOP2002000403A (de)
EA (1)	EA008087B1 (de)
EE (1)	EE200300587A (de)
EG (1)	EG24078A (de)
ES (1)	ES2265040T3 (de)
GE (1)	GEP20053620B (de)
HR (1)	HRP20030833B1 (de)
HU (1)	HUP0401366A2 (de)
IL (1)	IL158359A0 (de)
IS (1)	IS2428B (de)
MA (1)	MA27026A1 (de)
MX (1)	MXPA03009392A (de)
MY (1)	MY128615A (de)
NO (1)	NO20035200D0 (de)
NZ (1)	NZ529173A (de)
OA (1)	OA12604A (de)
PA (1)	PA8545901A1 (de)
PE (1)	PE20030087A1 (de)
PL (1)	PL366384A1 (de)
PT (1)	PT1395242E (de)
RS (1)	RS87203A (de)
SI (1)	SI1395242T1 (de)
SK (1)	SK286227B6 (de)
SV (1)	SV2003001053A (de)
WO (1)	WO2002094220A1 (de)
ZA (1)	ZA200308393B (de)

Families Citing this family (35)

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2002
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Also Published As

Publication number	Publication date
EA200301152A1 (ru)	2004-04-29
US20040072904A1 (en)	2004-04-15
IS2428B (is)	2008-10-15
HUP0401366A2 (hu)	2004-11-29
NO20035200L (no)	2003-11-24
SV2003001053A (es)	2003-03-18
EE200300587A (et)	2004-02-16
JP2004534764A (ja)	2004-11-18
EP1395242B1 (de)	2006-08-02
RS87203A (sr)	2006-10-27
GEP20053620B (en)	2005-09-26
BG108376A (bg)	2005-04-30
CR7150A (es)	2004-02-23
CN1509165A (zh)	2004-06-30
DK1395242T3 (da)	2006-10-30
CY1105147T1 (el)	2010-03-03
IS6986A (is)	2003-10-09
AP2003002907A0 (en)	2003-12-31
MA27026A1 (fr)	2004-12-20
BR0209973A (pt)	2004-04-06
MXPA03009392A (es)	2004-01-29
PT1395242E (pt)	2006-11-30
ATE334656T1 (de)	2006-08-15
US7256216B2 (en)	2007-08-14
KR100582963B1 (ko)	2006-05-24
US20020198261A1 (en)	2002-12-26
CA2446574A1 (en)	2002-11-28
NO20035200D0 (no)	2003-11-24
HRP20030833A2 (en)	2004-08-31
CZ299755B6 (cs)	2008-11-12
ES2265040T3 (es)	2007-02-01
EP1395242A1 (de)	2004-03-10
KR20040003006A (ko)	2004-01-07
HK1062646A1 (zh)	2004-11-19
DE60213592D1 (de)	2006-09-14
EA008087B1 (ru)	2007-02-27
EG24078A (en)	2008-05-11
NZ529173A (en)	2005-07-29
CZ20033066A3 (cs)	2004-08-18
PE20030087A1 (es)	2003-02-14
HRP20030833B1 (en)	2007-04-30
PL366384A1 (en)	2005-01-24
WO2002094220A1 (en)	2002-11-28
DE60213592T2 (de)	2007-08-09
AU2002258026B2 (en)	2007-08-02
MY128615A (en)	2007-02-28
AR033922A1 (es)	2004-01-07
SK286227B6 (sk)	2008-05-06
ZA200308393B (en)	2005-04-26
CA2446574C (en)	2008-04-01
DOP2002000403A (es)	2002-11-30
SK14112003A3 (sk)	2004-08-03
SI1395242T1 (en)	2006-10-31
IL158359A0 (en)	2004-05-12
AP1815A (en)	2008-01-04
PA8545901A1 (es)	2003-09-05
CN100346779C (zh)	2007-11-07

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