OA12654A - Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances,and the use thereof. - Google Patents

Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances,and the use thereof. Download PDF

Info

Publication number: OA12654A
Authority: OA; OAPI
Prior art keywords: agonists; residue; compounds; inhibitors; matter
Prior art date: 2001-08-22

Application number

OA1200400057A

Other languages

English (en)

Inventor

Heiner Glombik

Wendelin Frick

Hans-Ludwig Schaefer

Werner Kramer

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-22

Filing date

2002-08-09

Publication date

2006-06-15

2001-08-22 Priority claimed from DE10140169A external-priority patent/DE10140169A1/de

2001-08-31 Priority claimed from DE10142456A external-priority patent/DE10142456A1/de

2002-08-09 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2006-06-15 Publication of OA12654A publication Critical patent/OA12654A/en

Links

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HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
229950005809 implitapide Drugs 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000017745 inborn carbohydrate metabolic disease Diseases 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
229960002725 isoflurane Drugs 0.000 description 1
125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
150000002584 ketoses Chemical class 0.000 description 1
229960004844 lovastatin Drugs 0.000 description 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
229960000299 mazindol Drugs 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
229940095102 methyl benzoate Drugs 0.000 description 1
210000001589 microsome Anatomy 0.000 description 1
229960001110 miglitol Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
LYAUICDWKQJAGX-UHFFFAOYSA-N n-(7-hydroxy-2,2,4,6-tetramethyl-1,3-dihydroinden-1-yl)-2-[4-(3-methoxyphenyl)piperazin-1-yl]acetamide Chemical compound COC1=CC=CC(N2CCN(CC(=O)NC3C(CC4=C3C(=C(C)C=C4C)O)(C)C)CC2)=C1 LYAUICDWKQJAGX-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
230000002474 noradrenergic effect Effects 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
YDCVQGAUCOROHB-UHFFFAOYSA-N oxadiazolidine-4,5-dione Chemical class O=C1NNOC1=O YDCVQGAUCOROHB-UHFFFAOYSA-N 0.000 description 1
235000010603 pastilles Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
238000001050 pharmacotherapy Methods 0.000 description 1
229960003562 phentermine Drugs 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
229920002744 polyvinyl acetate phthalate Polymers 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
229960002965 pravastatin Drugs 0.000 description 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000000700 radioactive tracer Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
229960000672 rosuvastatin Drugs 0.000 description 1
BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
HSNZZMHEPUFJNZ-SHUUEZRQSA-N sedoheptulose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO HSNZZMHEPUFJNZ-SHUUEZRQSA-N 0.000 description 1
229960004425 sibutramine Drugs 0.000 description 1
UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229960002855 simvastatin Drugs 0.000 description 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
229950005143 sitosterol Drugs 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
ZAOPBCHLHBOUPR-UHFFFAOYSA-N tert-butyl 1-[2-[di(propan-2-yl)amino]ethylcarbamoyl]-6-phenylmethoxy-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound C=1C=C2C(C(=O)NCCN(C(C)C)C(C)C)N(C(=O)OC(C)(C)C)CCC2=CC=1OCC1=CC=CC=C1 ZAOPBCHLHBOUPR-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
BJBUEDPLEOHJGE-IMJSIDKUSA-N trans-3-hydroxy-L-proline Chemical compound O[C@H]1CC[NH2+][C@@H]1C([O-])=O BJBUEDPLEOHJGE-IMJSIDKUSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
239000004474 valine Substances 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)
Saccharide Compounds (AREA)

OA1200400057A 2001-08-22 2002-08-09 Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances,and the use thereof. OA12654A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10140169A DE10140169A1 (de)	2001-08-22	2001-08-22	Kombinationspräparate von 1,4-Benzothiepin-1,1-dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung
DE10142456A DE10142456A1 (de)	2001-08-31	2001-08-31	Kombinationspräparate von 1,4-Benzothiepin-1,1dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung

Publications (1)

Publication Number	Publication Date
OA12654A true OA12654A (en)	2006-06-15

Family

ID=26009944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400057A OA12654A (en)	2001-08-22	2002-08-09	Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances,and the use thereof.

Country Status (29)

Country	Link
US (2)	US20030158119A1 (fr)
EP (1)	EP1425018B1 (fr)
JP (1)	JP2005501861A (fr)
KR (1)	KR20040032937A (fr)
CN (1)	CN1655792A (fr)
AR (1)	AR035285A1 (fr)
AT (1)	ATE411802T1 (fr)
AU (1)	AU2002333373B2 (fr)
BR (1)	BR0212031A (fr)
CA (1)	CA2457976A1 (fr)
CO (1)	CO5560550A2 (fr)
DE (1)	DE50212937D1 (fr)
HN (1)	HN2002000235A (fr)
HR (1)	HRP20040171A2 (fr)
HU (1)	HUP0401318A3 (fr)
IL (1)	IL160474A0 (fr)
MA (1)	MA26317A1 (fr)
MX (1)	MXPA04001328A (fr)
NO (1)	NO20040702L (fr)
NZ (1)	NZ531293A (fr)
OA (1)	OA12654A (fr)
PA (1)	PA8553201A1 (fr)
PE (1)	PE20030361A1 (fr)
PL (1)	PL366851A1 (fr)
RS (1)	RS11104A (fr)
RU (1)	RU2297222C2 (fr)
TN (1)	TNSN04034A1 (fr)
UY (1)	UY27419A1 (fr)
WO (1)	WO2003018024A1 (fr)

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US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1429756B1 (fr)	2001-09-21	2006-11-22	Schering Corporation	Methodes et combinaisons therapeutiques utiles pour le traitement du xanthome effectue avec des inhibiteurs d'absorption du sterol
CA2504916A1 (fr)	2002-11-06	2004-05-27	Schering Corporation	Inhibiteurs d'absorption de cholesterol pour le traitement de troubles auto-immuns
DE602004018617D1 (de)	2003-03-07	2009-02-05	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
WO2004081004A1 (fr)	2003-03-07	2004-09-23	Schering Corporation	Composes d'azetidinone substitues, formulations et utilisations de ceux-ci pour traiter l'hypercholesterolemie
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081002A1 (fr)	2003-03-07	2004-09-23	Schering Corporation	Composes d'azetidinone substitues, leurs formulations et utilisations en vue du traitement de l'hypercholesterolemie
DE102006053636B4 (de)	2006-11-14	2008-09-18	Sanofi-Aventis Deutschland Gmbh	Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
ATE493992T1 (de)	2006-11-14	2011-01-15	Sanofi Aventis Deutschland	Neue 1,4-benzothiepin-1,1-dioxidderivate mit verbesserten eigenschaften, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE102006053637B4 (de) *	2006-11-14	2011-06-30	Sanofi-Aventis Deutschland GmbH, 65929	Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE102006053635B4 (de) *	2006-11-14	2011-06-30	Sanofi-Aventis Deutschland GmbH, 65929	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
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EP4137137A1 (fr)	2010-05-26	2023-02-22	Satiogen Pharmaceuticals, Inc.	Inhibiteurs et satiogènes de recyclage d'acide biliaire pour le traitement du diabète, de l'obésité et d'états gastro-intestinaux inflammatoires
US9339543B2 (en)	2011-10-12	2016-05-17	Merck Sharp & Dohme Corp.	Pharmaceutical compositions that inhibit disproportionation
EA038594B1 (ru)	2011-10-28	2021-09-21	Шайр Хьюман Дженетик Терапис, Инк.	Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени
JP6217938B2 (ja)	2011-10-28	2017-10-25	ルメナファーマシューティカルズエルエルシー	小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
KR20160002773A (ko)	2013-03-15	2016-01-08	루메나 파마수티컬즈, 인코포레이티드	원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
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EP1289526A4 (fr)	2000-05-30	2005-03-16	Merck & Co Inc	Agonistes du recepteur de la melanocortine
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2002
- 2002-08-09 WO PCT/EP2002/008908 patent/WO2003018024A1/fr not_active Ceased
- 2002-08-09 AT AT02796213T patent/ATE411802T1/de not_active IP Right Cessation
- 2002-08-09 NZ NZ531293A patent/NZ531293A/en not_active IP Right Cessation
- 2002-08-09 HU HU0401318A patent/HUP0401318A3/hu unknown
- 2002-08-09 CA CA002457976A patent/CA2457976A1/fr not_active Abandoned
- 2002-08-09 DE DE50212937T patent/DE50212937D1/de not_active Expired - Lifetime
- 2002-08-09 EP EP02796213A patent/EP1425018B1/fr not_active Expired - Lifetime
- 2002-08-09 KR KR10-2004-7002440A patent/KR20040032937A/ko not_active Ceased
- 2002-08-09 MX MXPA04001328A patent/MXPA04001328A/es active IP Right Grant
- 2002-08-09 RS YU11104A patent/RS11104A/sr unknown
- 2002-08-09 AU AU2002333373A patent/AU2002333373B2/en not_active Ceased
- 2002-08-09 RU RU2004108119/15A patent/RU2297222C2/ru not_active IP Right Cessation
- 2002-08-09 HR HR20040171A patent/HRP20040171A2/xx not_active Application Discontinuation
- 2002-08-09 JP JP2003522542A patent/JP2005501861A/ja active Pending
- 2002-08-09 CN CNA028163109A patent/CN1655792A/zh active Pending
- 2002-08-09 OA OA1200400057A patent/OA12654A/en unknown
- 2002-08-09 IL IL16047402A patent/IL160474A0/xx unknown
- 2002-08-09 PL PL02366851A patent/PL366851A1/xx not_active Application Discontinuation
- 2002-08-09 BR BR0212031-3A patent/BR0212031A/pt not_active IP Right Cessation
- 2002-08-16 PE PE2002000742A patent/PE20030361A1/es not_active Application Discontinuation
- 2002-08-20 UY UY27419A patent/UY27419A1/es unknown
- 2002-08-20 HN HN2002000235A patent/HN2002000235A/es unknown
- 2002-08-20 AR ARP020103125A patent/AR035285A1/es not_active Application Discontinuation
- 2002-08-20 PA PA20028553201A patent/PA8553201A1/es unknown
- 2002-08-22 US US10/225,841 patent/US20030158119A1/en not_active Abandoned
2003
- 2003-11-03 US US10/699,967 patent/US7179792B2/en not_active Expired - Lifetime
2004
- 2004-02-11 MA MA27524A patent/MA26317A1/fr unknown
- 2004-02-18 NO NO20040702A patent/NO20040702L/no not_active Application Discontinuation
- 2004-02-19 CO CO04014418A patent/CO5560550A2/es not_active Application Discontinuation
- 2004-02-20 TN TNP2004000034A patent/TNSN04034A1/en unknown

Also Published As

Publication number	Publication date
EP1425018B1 (fr)	2008-10-22
EP1425018A1 (fr)	2004-06-09
CO5560550A2 (es)	2005-09-30
NO20040702L (no)	2004-05-19
US20030158119A1 (en)	2003-08-21
HUP0401318A2 (hu)	2004-10-28
HUP0401318A3 (en)	2008-03-28
TNSN04034A1 (en)	2006-06-01
IL160474A0 (en)	2004-07-25
HRP20040171A2 (en)	2004-10-31
RU2297222C2 (ru)	2007-04-20
PL366851A1 (en)	2005-02-07
MXPA04001328A (es)	2004-05-05
PE20030361A1 (es)	2003-05-27
BR0212031A (pt)	2004-08-03
CA2457976A1 (fr)	2003-03-06
HN2002000235A (es)	2003-02-18
MA26317A1 (fr)	2004-10-01
US7179792B2 (en)	2007-02-20
RS11104A (sr)	2006-12-15
RU2004108119A (ru)	2005-04-10
AR035285A1 (es)	2004-05-05
JP2005501861A (ja)	2005-01-20
KR20040032937A (ko)	2004-04-17
CN1655792A (zh)	2005-08-17
UY27419A1 (es)	2003-04-30
PA8553201A1 (es)	2004-08-31
NZ531293A (en)	2005-08-26
US20040097424A1 (en)	2004-05-20
AU2002333373B2 (en)	2006-12-14
ATE411802T1 (de)	2008-11-15
WO2003018024A1 (fr)	2003-03-06
DE50212937D1 (de)	2008-12-04

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