OA12868A - Ring-substituted diphenyl azetidinones, method forthe production thereof, medicaments containing sa id compounds and use thereof. - Google Patents

Ring-substituted diphenyl azetidinones, method forthe production thereof, medicaments containing sa id compounds and use thereof. Download PDF

Info

Publication number: OA12868A
Authority: OA; OAPI
Prior art keywords: alkyl; phenyl; crc6; cooh; radical
Prior art date: 2002-06-19

Application number

OA1200400330A

Other languages

English (en)

Inventor

Gerhard Jaehne

Wendelin Frick

Stefanie Flohr

Andreas Lindenschmidt

Heiner Glombik

Werner Kramer

Hubert Heuer

Hans-Ludwig Schaefer

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-19

Filing date

2003-06-04

Publication date

2006-09-15

2003-06-04 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2006-09-15 Publication of OA12868A publication Critical patent/OA12868A/en

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 128
238000004519 manufacturing process Methods 0.000 title claims abstract description 6
238000000034 method Methods 0.000 title abstract description 8
VDOXIAUNJCHYRC-UHFFFAOYSA-N 1,3-diphenylazetidin-2-one Chemical class O=C1C(C=2C=CC=CC=2)CN1C1=CC=CC=C1 VDOXIAUNJCHYRC-UHFFFAOYSA-N 0.000 title abstract description 5
239000003814 drug Substances 0.000 title abstract description 4
208000031226 Hyperlipidaemia Diseases 0.000 claims abstract description 3
229910052731 fluorine Inorganic materials 0.000 claims description 74
-1 COO(CrC6)-alkyl Chemical group 0.000 claims description 56
229910052739 hydrogen Inorganic materials 0.000 claims description 49
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 33
239000000556 agonist Substances 0.000 claims description 32
229910052794 bromium Inorganic materials 0.000 claims description 30
229910052801 chlorine Inorganic materials 0.000 claims description 30
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 21
125000004432 carbon atom Chemical group C* 0.000 claims description 21
229910052740 iodine Inorganic materials 0.000 claims description 20
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 20
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 17
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 16
235000000346 sugar Nutrition 0.000 claims description 15
239000002253 acid Substances 0.000 claims description 14
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 12
125000003118 aryl group Chemical group 0.000 claims description 12
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 10
235000001014 amino acid Nutrition 0.000 claims description 10
150000001413 amino acids Chemical class 0.000 claims description 10
239000011737 fluorine Substances 0.000 claims description 10
239000003112 inhibitor Substances 0.000 claims description 10
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 9
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 9
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238000010521 absorption reaction Methods 0.000 claims description 9
125000002015 acyclic group Chemical group 0.000 claims description 9
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 9
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 8
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125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
229910006069 SO3H Inorganic materials 0.000 claims description 6
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108010038807 Oligopeptides Proteins 0.000 claims description 5
125000000539 amino acid group Chemical group 0.000 claims description 5
150000002337 glycosamines Chemical class 0.000 claims description 5
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 4
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 4
229910018828 PO3H2 Inorganic materials 0.000 claims description 4
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125000001072 heteroaryl group Chemical group 0.000 claims description 4
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 4
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 4
SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical class COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims description 3
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125000000217 alkyl group Chemical group 0.000 claims description 3
230000003178 anti-diabetic effect Effects 0.000 claims description 3
230000001419 dependent effect Effects 0.000 claims description 3
239000000122 growth hormone Substances 0.000 claims description 3
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 3
229940039781 leptin Drugs 0.000 claims description 3
229950004994 meglitinide Drugs 0.000 claims description 3
238000002156 mixing Methods 0.000 claims description 3
108020001213 potassium channel Proteins 0.000 claims description 3
102000004146 ATP citrate synthases Human genes 0.000 claims description 2
108090000662 ATP citrate synthases Proteins 0.000 claims description 2
229940123208 Biguanide Drugs 0.000 claims description 2
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
101800002068 Galanin Proteins 0.000 claims description 2
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 2
102000000853 LDL receptors Human genes 0.000 claims description 2
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108010059705 Urocortins Proteins 0.000 claims description 2
239000003392 amylase inhibitor Substances 0.000 claims description 2
239000003963 antioxidant agent Substances 0.000 claims description 2
125000004429 atom Chemical group 0.000 claims description 2
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims description 2
OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 2
229960002802 bromocriptine Drugs 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims description 2
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 2
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims description 2
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SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 claims description 2
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150000001467 thiazolidinediones Chemical class 0.000 claims description 2
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SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 2
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SDOFMBGMRVAJNF-UHFFFAOYSA-N 6-aminohexane-1,2,3,4,5-pentol Chemical compound NCC(O)C(O)C(O)C(O)CO SDOFMBGMRVAJNF-UHFFFAOYSA-N 0.000 description 25
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238000006243 chemical reaction Methods 0.000 description 7
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MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 description 6
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HAZPLGUZDJSPTI-UHFFFAOYSA-N 4-[4-[[4-[3-(3-hydroxy-3-phenylpropyl)-2-oxo-4-phenylazetidin-1-yl]phenyl]methylcarbamoyl]phenoxy]benzoic acid Chemical compound C=1C=CC=CC=1C(O)CCC(C1=O)C(C=2C=CC=CC=2)N1C(C=C1)=CC=C1CNC(=O)C(C=C1)=CC=C1OC1=CC=C(C(O)=O)C=C1 HAZPLGUZDJSPTI-UHFFFAOYSA-N 0.000 description 5
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UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
229960002965 pravastatin Drugs 0.000 description 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
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239000011780 sodium chloride Substances 0.000 description 1
229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
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239000002904 solvent Substances 0.000 description 1
235000000891 standard diet Nutrition 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
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WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
XBXCNNQPRYLIDE-UHFFFAOYSA-N tert-butylcarbamic acid Chemical compound CC(C)(C)NC(O)=O XBXCNNQPRYLIDE-UHFFFAOYSA-N 0.000 description 1
BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
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YSMODUONRAFBET-WHFBIAKZSA-N threo-5-hydroxy-L-lysine Chemical compound NC[C@@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-WHFBIAKZSA-N 0.000 description 1
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SIOVKLKJSOKLIF-HJWRWDBZSA-N trimethylsilyl (1z)-n-trimethylsilylethanimidate Chemical compound C[Si](C)(C)OC(/C)=N\[Si](C)(C)C SIOVKLKJSOKLIF-HJWRWDBZSA-N 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
229960001641 troglitazone Drugs 0.000 description 1
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
239000004474 valine Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA1200400330A 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method forthe production thereof, medicaments containing sa id compounds and use thereof. OA12868A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10227506A DE10227506A1 (de)	2002-06-19	2002-06-19	Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number	Publication Date
OA12868A true OA12868A (en)	2006-09-15

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ID=29719281

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OA1200400330A OA12868A (en)	2002-06-19	2003-06-04	Ring-substituted diphenyl azetidinones, method forthe production thereof, medicaments containing sa id compounds and use thereof.

Country Status (30)

Country	Link
EP (1)	EP1517892B1 (fr)
JP (1)	JP2005533072A (fr)
CN (1)	CN1662493A (fr)
AR (1)	AR039689A1 (fr)
AT (1)	ATE478842T1 (fr)
AU (1)	AU2003242616B2 (fr)
BR (1)	BR0311940A (fr)
CA (1)	CA2490109A1 (fr)
DE (2)	DE10227506A1 (fr)
EC (1)	ECSP045498A (fr)
HN (1)	HN2003000183A (fr)
HR (1)	HRP20041203A2 (fr)
IL (1)	IL165791A0 (fr)
MA (1)	MA27252A1 (fr)
MX (1)	MXPA04012236A (fr)
MY (1)	MY135850A (fr)
NO (1)	NO20050073L (fr)
NZ (1)	NZ537304A (fr)
OA (1)	OA12868A (fr)
PA (1)	PA8576001A1 (fr)
PE (1)	PE20040577A1 (fr)
PL (1)	PL372690A1 (fr)
RS (1)	RS108504A (fr)
RU (1)	RU2315754C2 (fr)
SV (1)	SV2004001549A (fr)
TN (1)	TNSN04255A1 (fr)
TW (1)	TW200404774A (fr)
UY (1)	UY27851A1 (fr)
WO (1)	WO2004000804A1 (fr)
ZA (1)	ZA200409381B (fr)

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GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
US7447226B2 (en) *	2003-10-31	2008-11-04	International Business Machines Corporation	Methods and apparatus for continuous connectivity between mobile device and network using dynamic connection spreading
ATE485267T1 (de)	2003-12-23	2010-11-15	Astrazeneca Ab	Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
US7700597B2 (en)	2004-12-03	2010-04-20	Schering Corporation	Substituted piperazines as CB1 antagonists
BRPI0609614A2 (pt) *	2005-04-04	2010-04-20	Univ Pontificia Catolica Chile	uso de ezetimiba na prevenção e tratamento de litìases de colesterol na árvore biliar
DE602006010870D1 (de)	2005-06-20	2010-01-14	Schering Corp	Als antagonisten von histamin h3 geeignete piperidinderivate
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es)	2006-04-27	2008-07-02	Astrazeneca Ab	Compuestos derivados de 2-azetidinona y un metodo de preparacion
JP2010500300A (ja)	2006-08-08	2010-01-07	サノフィ−アベンティス	アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
KR20090091120A (ko) *	2006-11-02	2009-08-26	사노피-아벤티스 도이칠란트 게엠베하	향상된 약리학적 특성을 갖는 피페라진-1-설폰산으로 치환된 신규한 디페닐아제티디논
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2002
- 2002-06-19 DE DE10227506A patent/DE10227506A1/de not_active Withdrawn
2003
- 2003-01-17 HN HN2003000183A patent/HN2003000183A/es unknown
- 2003-06-02 SV SV2003001549A patent/SV2004001549A/es not_active Application Discontinuation
- 2003-06-04 AU AU2003242616A patent/AU2003242616B2/en not_active Ceased
- 2003-06-04 CN CN03814087XA patent/CN1662493A/zh active Pending
- 2003-06-04 BR BR0311940-8A patent/BR0311940A/pt not_active IP Right Cessation
- 2003-06-04 WO PCT/EP2003/005815 patent/WO2004000804A1/fr not_active Ceased
- 2003-06-04 RU RU2005101091/04A patent/RU2315754C2/ru not_active IP Right Cessation
- 2003-06-04 RS YUP-1085/04A patent/RS108504A/sr unknown
- 2003-06-04 HR HR20041203A patent/HRP20041203A2/xx not_active Application Discontinuation
- 2003-06-04 DE DE50313017T patent/DE50313017D1/de not_active Expired - Lifetime
- 2003-06-04 PL PL03372690A patent/PL372690A1/xx not_active Application Discontinuation
- 2003-06-04 AT AT03760591T patent/ATE478842T1/de active
- 2003-06-04 JP JP2004514660A patent/JP2005533072A/ja not_active Abandoned
- 2003-06-04 NZ NZ537304A patent/NZ537304A/en unknown
- 2003-06-04 MX MXPA04012236A patent/MXPA04012236A/es active IP Right Grant
- 2003-06-04 EP EP03760591A patent/EP1517892B1/fr not_active Expired - Lifetime
- 2003-06-04 OA OA1200400330A patent/OA12868A/en unknown
- 2003-06-04 CA CA002490109A patent/CA2490109A1/fr not_active Abandoned
- 2003-06-16 UY UY27851A patent/UY27851A1/es unknown
- 2003-06-17 AR ARP030102142A patent/AR039689A1/es unknown
- 2003-06-17 TW TW092116319A patent/TW200404774A/zh unknown
- 2003-06-18 PE PE2003000613A patent/PE20040577A1/es not_active Application Discontinuation
- 2003-06-18 PA PA20038576001A patent/PA8576001A1/es unknown
- 2003-06-18 MY MYPI20032289A patent/MY135850A/en unknown
2004
- 2004-11-22 ZA ZA200409381A patent/ZA200409381B/xx unknown
- 2004-12-08 MA MA27990A patent/MA27252A1/fr unknown
- 2004-12-15 IL IL16579104A patent/IL165791A0/xx unknown
- 2004-12-16 EC EC2004005498A patent/ECSP045498A/es unknown
- 2004-12-17 TN TNP2004000255A patent/TNSN04255A1/en unknown
2005
- 2005-01-06 NO NO20050073A patent/NO20050073L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
UY27851A1 (es)	2003-12-31
AR039689A1 (es)	2005-03-09
DE10227506A1 (de)	2004-01-08
DE50313017D1 (de)	2010-10-07
TW200404774A (en)	2004-04-01
HRP20041203A2 (en)	2005-06-30
IL165791A0 (en)	2006-01-15
MXPA04012236A (es)	2005-02-25
MA27252A1 (fr)	2005-03-01
NO20050073L (no)	2005-01-06
ZA200409381B (en)	2006-05-31
WO2004000804A1 (fr)	2003-12-31
AU2003242616B2 (en)	2008-12-11
SV2004001549A (es)	2004-03-19
TNSN04255A1 (en)	2007-03-12
PA8576001A1 (es)	2004-02-07
ATE478842T1 (de)	2010-09-15
PE20040577A1 (es)	2004-10-11
ECSP045498A (es)	2005-03-10
HN2003000183A (es)	2003-08-01
PL372690A1 (en)	2005-07-25
EP1517892B1 (fr)	2010-08-25
AU2003242616A1 (en)	2004-01-06
CN1662493A (zh)	2005-08-31
BR0311940A (pt)	2005-04-05
CA2490109A1 (fr)	2003-12-31
RU2315754C2 (ru)	2008-01-27
MY135850A (en)	2008-07-31
JP2005533072A (ja)	2005-11-04
EP1517892A1 (fr)	2005-03-30
NZ537304A (en)	2005-10-28
RS108504A (sr)	2007-02-05
RU2005101091A (ru)	2005-07-10

Publication	Publication Date	Title
AU2003242616B2 (en)	2008-12-11	Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
CA2431983C (fr)	2010-06-08	Nouveaux 1,2-diphenylazetidinones, procedes pour leur preparation, medicaments constitues de ces composes et leur utilisation pour traiter les anomalies du metabolisme des lipides
RU2287522C2 (ru)	2006-11-20	Замещенные кислотными группами дифенилазетидиноны, способ их получения, содержащие эти соединения лекарственные средства и их применение
CA2490108A1 (fr)	2003-12-31	Diphenylacetinidones a substitution cationique, procede de fabrication, medicaments contenant ces composes et utilisation
US7579339B2 (en)	2009-08-25	Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US20040077623A1 (en)	2004-04-22	Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ZA200304093B (en)	2004-04-23	Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism.
KR20050016583A (ko)	2005-02-21	환 치환된 디페닐 아제티디논, 이의 제조방법, 이를함유하는 약제 및 이의 용도
NZ537303A (en)	2006-06-30	Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof