OA12878A - Method of promoting smoking cessation. - Google Patents

Method of promoting smoking cessation. Download PDF

Info

Publication number: OA12878A
Authority: OA; OAPI
Prior art keywords: smoking; composition; reboxetine; nicotine; effective amount
Prior art date: 2002-07-01

Application number

OA1200400348A

Other languages

English (en)

Inventor

Erik H F Wong

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-01

Filing date

2003-06-26

Publication date

2006-09-15

2003-06-26 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2006-09-15 Publication of OA12878A publication Critical patent/OA12878A/en

Links

230000005586 smoking cessation Effects 0.000 title claims abstract description 66
230000001737 promoting effect Effects 0.000 title claims abstract description 19
238000000034 method Methods 0.000 title description 18
229960003770 reboxetine Drugs 0.000 claims abstract description 59
CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 claims abstract description 59
239000003795 chemical substances by application Substances 0.000 claims abstract description 58
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 57
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 56
229960002715 nicotine Drugs 0.000 claims abstract description 54
239000000203 mixture Substances 0.000 claims abstract description 47
230000002708 enhancing effect Effects 0.000 claims abstract description 30
239000000935 antidepressant agent Substances 0.000 claims abstract description 28
229940005513 antidepressants Drugs 0.000 claims abstract description 27
230000001430 anti-depressive effect Effects 0.000 claims abstract description 21
229940044551 receptor antagonist Drugs 0.000 claims abstract description 17
239000002464 receptor antagonist Substances 0.000 claims abstract description 17
239000003401 opiate antagonist Substances 0.000 claims abstract description 16
239000002249 anxiolytic agent Substances 0.000 claims description 34
230000000949 anxiolytic effect Effects 0.000 claims description 34
SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 23
229960001058 bupropion Drugs 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 14
239000003826 tablet Substances 0.000 claims description 13
-1 inhalant Substances 0.000 claims description 12
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ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 claims description 10
DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 10
239000002775 capsule Substances 0.000 claims description 9
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SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 8
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 7
NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 claims description 6
QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims description 6
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RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 5
WYCLKVQLVUQKNZ-UHFFFAOYSA-N Halazepam Chemical compound N=1CC(=O)N(CC(F)(F)F)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 WYCLKVQLVUQKNZ-UHFFFAOYSA-N 0.000 claims description 5
WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims description 5
MWQCHHACWWAQLJ-UHFFFAOYSA-N Prazepam Chemical compound O=C1CN=C(C=2C=CC=CC=2)C2=CC(Cl)=CC=C2N1CC1CC1 MWQCHHACWWAQLJ-UHFFFAOYSA-N 0.000 claims description 5
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims description 5
ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 claims description 5
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UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 5
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DXXUGBPKQDTBQW-UHFFFAOYSA-L chlorisondamine Chemical compound [Cl-].[Cl-].ClC1=C(Cl)C(Cl)=C(Cl)C2=C1C[N+](CC[N+](C)(C)C)(C)C2 DXXUGBPKQDTBQW-UHFFFAOYSA-L 0.000 claims description 4
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DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 4
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BDIVMECULLJBMU-KSSFIOAISA-N erysodine Chemical compound OC1=C(OC)C=C2[C@]34C[C@@H](OC)C=CC3=CCN4CCC2=C1 BDIVMECULLJBMU-KSSFIOAISA-N 0.000 claims description 4
BDIVMECULLJBMU-UHFFFAOYSA-N erysodine Natural products OC1=C(OC)C=C2C34CC(OC)C=CC3=CCN4CCC2=C1 BDIVMECULLJBMU-UHFFFAOYSA-N 0.000 claims description 4
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QSLMDECMDJKHMQ-GSXCWMCISA-N maprotiline Chemical compound C12=CC=CC=C2[C@@]2(CCCNC)C3=CC=CC=C3[C@@H]1CC2 QSLMDECMDJKHMQ-GSXCWMCISA-N 0.000 claims description 4
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DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 claims description 4
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ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 claims description 4
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BWPIARFWQZKAIA-UHFFFAOYSA-N protriptyline Chemical compound C1=CC2=CC=CC=C2C(CCCNC)C2=CC=CC=C21 BWPIARFWQZKAIA-UHFFFAOYSA-N 0.000 claims description 4
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PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 claims description 4
HALWUDBBYKMYPW-STOWLHSFSA-M trimethaphan camsylate Chemical compound C1C[C@@]2(CS([O-])(=O)=O)C(=O)C[C@@H]1C2(C)C.C12C[S+]3CCCC3C2N(CC=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 HALWUDBBYKMYPW-STOWLHSFSA-M 0.000 claims description 4
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229960001844 tubocurarine Drugs 0.000 claims description 4
JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 claims description 4
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 3
GXFZCDMWGMFGFL-KKXMJGKMSA-N (+)-Tubocurarine chloride hydrochloride Chemical compound [Cl-].[Cl-].C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CC[NH+]3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 GXFZCDMWGMFGFL-KKXMJGKMSA-N 0.000 claims description 3
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GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 claims description 3
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

OA1200400348A 2002-07-01 2003-06-26 Method of promoting smoking cessation. OA12878A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39289302P	2002-07-01	2002-07-01

Publications (1)

Publication Number	Publication Date
OA12878A true OA12878A (en)	2006-09-15

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ID=30000949

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Application Number	Title	Priority Date	Filing Date
OA1200400348A OA12878A (en)	2002-07-01	2003-06-26	Method of promoting smoking cessation.

Country Status (22)

Country	Link
US (1)	US20040102440A1 (is)
EP (1)	EP1534254A2 (is)
JP (1)	JP2005531631A (is)
CN (1)	CN1665511A (is)
AP (1)	AP2004003188A0 (is)
AU (1)	AU2003253609A1 (is)
BR (1)	BR0312293A (is)
CA (1)	CA2491549A1 (is)
EA (1)	EA200401584A1 (is)
EC (1)	ECSP045517A (is)
HR (1)	HRP20041194A2 (is)
IL (1)	IL165882A0 (is)
IS (1)	IS7600A (is)
MA (1)	MA27597A1 (is)
MX (1)	MXPA05000296A (is)
NO (1)	NO20045535L (is)
OA (1)	OA12878A (is)
PL (1)	PL373620A1 (is)
RS (1)	RS115204A (is)
TN (1)	TNSN04267A1 (is)
WO (1)	WO2004002463A2 (is)
ZA (1)	ZA200410339B (is)

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2003
- 2003-06-24 US US10/602,447 patent/US20040102440A1/en not_active Abandoned
- 2003-06-26 AP AP200403187D patent/AP2004003188A0/xx unknown
- 2003-06-26 RS YUP-1152/04A patent/RS115204A/sr unknown
- 2003-06-26 MX MXPA05000296A patent/MXPA05000296A/es not_active Application Discontinuation
- 2003-06-26 EP EP03761901A patent/EP1534254A2/en not_active Ceased
- 2003-06-26 PL PL03373620A patent/PL373620A1/xx not_active Application Discontinuation
- 2003-06-26 BR BR0312293-0A patent/BR0312293A/pt not_active IP Right Cessation
- 2003-06-26 HR HR20041194A patent/HRP20041194A2/xx not_active Application Discontinuation
- 2003-06-26 CN CN038156369A patent/CN1665511A/zh active Pending
- 2003-06-26 WO PCT/US2003/016232 patent/WO2004002463A2/en not_active Ceased
- 2003-06-26 JP JP2004517572A patent/JP2005531631A/ja active Pending
- 2003-06-26 OA OA1200400348A patent/OA12878A/en unknown
- 2003-06-26 CA CA002491549A patent/CA2491549A1/en not_active Abandoned
- 2003-06-26 AU AU2003253609A patent/AU2003253609A1/en not_active Abandoned
- 2003-06-26 EA EA200401584A patent/EA200401584A1/ru unknown
2004
- 2004-12-16 IS IS7600A patent/IS7600A/is unknown
- 2004-12-17 NO NO20045535A patent/NO20045535L/no not_active Application Discontinuation
- 2004-12-17 MA MA28018A patent/MA27597A1/fr unknown
- 2004-12-20 IL IL16588204A patent/IL165882A0/xx unknown
- 2004-12-22 ZA ZA200410339A patent/ZA200410339B/en unknown
- 2004-12-28 EC EC2004005517A patent/ECSP045517A/es unknown
- 2004-12-30 TN TNP2004000267A patent/TNSN04267A1/fr unknown

Also Published As

Publication number	Publication date
HRP20041194A2 (en)	2005-06-30
EA200401584A1 (ru)	2005-08-25
EP1534254A2 (en)	2005-06-01
US20040102440A1 (en)	2004-05-27
TNSN04267A1 (fr)	2007-03-12
WO2004002463A3 (en)	2004-02-19
ECSP045517A (es)	2005-03-10
BR0312293A (pt)	2005-04-12
CA2491549A1 (en)	2004-01-08
ZA200410339B (en)	2006-07-26
CN1665511A (zh)	2005-09-07
MXPA05000296A (es)	2005-08-19
WO2004002463A2 (en)	2004-01-08
AU2003253609A1 (en)	2004-01-19
IS7600A (is)	2004-12-16
MA27597A1 (fr)	2005-11-01
JP2005531631A (ja)	2005-10-20
AP2004003188A0 (en)	2004-12-31
NO20045535L (no)	2005-01-27
RS115204A (sr)	2007-02-05
PL373620A1 (en)	2005-09-05
IL165882A0 (en)	2006-01-15

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