OA12924A - New spirocondensed quinazolinones and their use asphosphodiesterase inhibitors. - Google Patents

New spirocondensed quinazolinones and their use asphosphodiesterase inhibitors. Download PDF

Info

Publication number: OA12924A
Authority: OA; OAPI
Prior art keywords: alkyl; nr7r8; compound; formula; nr4r5
Prior art date: 2002-09-17

Application number

OA1200500073A

Other languages

English (en)

Inventor

Patrick Bernardelli

Fabrice Vergne

Chrystelle Mendes

Pierre Gerard Ducrot

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-17

Filing date

2003-09-08

Publication date

2006-10-13

2003-09-08 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-10-13 Publication of OA12924A publication Critical patent/OA12924A/en

Links

239000003112 inhibitor Substances 0.000 title description 6
AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 69
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
125000000217 alkyl group Chemical group 0.000 claims description 73
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 32
125000000623 heterocyclic group Chemical group 0.000 claims description 18
125000004429 atom Chemical group 0.000 claims description 16
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
201000010099 disease Diseases 0.000 claims description 13
229940123304 Phosphodiesterase 7 inhibitor Drugs 0.000 claims description 12
-1 SO2CH3 Chemical group 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 12
239000002606 phosphodiesterase VII inhibitor Substances 0.000 claims description 12
229910052717 sulfur Inorganic materials 0.000 claims description 12
229910052757 nitrogen Inorganic materials 0.000 claims description 10
125000002947 alkylene group Chemical group 0.000 claims description 9
125000004432 carbon atom Chemical group C* 0.000 claims description 9
229920006395 saturated elastomer Polymers 0.000 claims description 9
206010020751 Hypersensitivity Diseases 0.000 claims description 7
230000007815 allergy Effects 0.000 claims description 7
125000003118 aryl group Chemical group 0.000 claims description 7
125000004433 nitrogen atom Chemical group N* 0.000 claims description 7
208000022559 Inflammatory bowel disease Diseases 0.000 claims description 6
229910006069 SO3H Inorganic materials 0.000 claims description 6
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 6
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 6
208000030507 AIDS Diseases 0.000 claims description 5
206010003645 Atopy Diseases 0.000 claims description 5
201000004624 Dermatitis Diseases 0.000 claims description 5
206010028980 Neoplasm Diseases 0.000 claims description 5
208000001132 Osteoporosis Diseases 0.000 claims description 5
208000026935 allergic disease Diseases 0.000 claims description 5
208000006673 asthma Diseases 0.000 claims description 5
HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 5
201000011510 cancer Diseases 0.000 claims description 5
206010009900 Colitis ulcerative Diseases 0.000 claims description 3
206010010741 Conjunctivitis Diseases 0.000 claims description 3
206010018364 Glomerulonephritis Diseases 0.000 claims description 3
206010033645 Pancreatitis Diseases 0.000 claims description 3
201000004681 Psoriasis Diseases 0.000 claims description 3
206010052779 Transplant rejections Diseases 0.000 claims description 3
206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 3
201000006704 Ulcerative Colitis Diseases 0.000 claims description 3
125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims description 3
239000003085 diluting agent Substances 0.000 claims description 3
208000035475 disorder Diseases 0.000 claims description 3
206010015037 epilepsy Diseases 0.000 claims description 3
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201000006417 multiple sclerosis Diseases 0.000 claims description 3
201000000585 muscular atrophy Diseases 0.000 claims description 3
201000008482 osteoarthritis Diseases 0.000 claims description 3
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 3
206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
208000017520 skin disease Diseases 0.000 claims description 3
208000011580 syndromic disease Diseases 0.000 claims description 3
201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
208000023275 Autoimmune disease Diseases 0.000 claims description 2
208000011231 Crohn disease Diseases 0.000 claims description 2
229910006074 SO2NH2 Inorganic materials 0.000 claims description 2
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
238000002560 therapeutic procedure Methods 0.000 claims description 2
BIQDLXRMNLJNOR-UHFFFAOYSA-N 2-[2-(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetamide Chemical compound C1=2C(OCCNCC(=O)N)=CC=C(Cl)C=2NC(=O)NC21CCCCC2 BIQDLXRMNLJNOR-UHFFFAOYSA-N 0.000 claims 1
208000011623 Obstructive Lung disease Diseases 0.000 claims 1
SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
IMZMUNGROJZNFZ-UHFFFAOYSA-N n-[2-[2-(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]ethyl]acetamide Chemical compound C1=2C(OCCNCCNC(=O)C)=CC=C(Cl)C=2NC(=O)NC21CCCCC2 IMZMUNGROJZNFZ-UHFFFAOYSA-N 0.000 claims 1
238000000034 method Methods 0.000 abstract description 14
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238000005481 NMR spectroscopy Methods 0.000 description 15
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235000011152 sodium sulphate Nutrition 0.000 description 11
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OA1200500073A 2002-09-17 2003-09-08 New spirocondensed quinazolinones and their use asphosphodiesterase inhibitors. OA12924A (en)

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Application Number	Priority Date	Filing Date	Title
EP20020292275 EP1400244A1 (en)	2002-09-17	2002-09-17	New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

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US (1)	US7429598B2 (is)
EP (2)	EP1400244A1 (is)
JP (1)	JP2006501277A (is)
KR (1)	KR20050057371A (is)
CN (1)	CN1681507A (is)
AP (1)	AP2005003251A0 (is)
AR (1)	AR041271A1 (is)
AU (1)	AU2003259496A1 (is)
BR (1)	BR0314379A (is)
CA (1)	CA2499330C (is)
CO (1)	CO5540391A2 (is)
CR (1)	CR7728A (is)
EA (1)	EA200500312A1 (is)
EC (1)	ECSP055671A (is)
GT (1)	GT200300201A (is)
HN (1)	HN2003000285A (is)
HR (1)	HRP20050223A2 (is)
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MA (1)	MA27439A1 (is)
MX (1)	MXPA05002913A (is)
NO (1)	NO20051695L (is)
OA (1)	OA12924A (is)
PA (1)	PA8582801A1 (is)
PE (1)	PE20050073A1 (is)
PL (1)	PL375977A1 (is)
TN (1)	TNSN05073A1 (is)
TW (1)	TWI251590B (is)
UY (1)	UY27986A1 (is)
WO (1)	WO2004026818A1 (is)
ZA (1)	ZA200501381B (is)

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2002
- 2002-09-17 EP EP20020292275 patent/EP1400244A1/en not_active Withdrawn
2003
- 2003-09-08 KR KR1020057004511A patent/KR20050057371A/ko not_active Ceased
- 2003-09-08 WO PCT/IB2003/003965 patent/WO2004026818A1/en not_active Ceased
- 2003-09-08 HR HR20050223A patent/HRP20050223A2/hr not_active Application Discontinuation
- 2003-09-08 AP AP2005003251A patent/AP2005003251A0/xx unknown
- 2003-09-08 CN CNA038221284A patent/CN1681507A/zh active Pending
- 2003-09-08 AU AU2003259496A patent/AU2003259496A1/en not_active Abandoned
- 2003-09-08 OA OA1200500073A patent/OA12924A/en unknown
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- 2003-09-08 MX MXPA05002913A patent/MXPA05002913A/es active IP Right Grant
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- 2003-09-08 BR BR0314379A patent/BR0314379A/pt not_active IP Right Cessation
- 2003-09-08 EA EA200500312A patent/EA200500312A1/ru unknown
- 2003-09-08 PL PL37597703A patent/PL375977A1/xx not_active Application Discontinuation
- 2003-09-08 EP EP20030797455 patent/EP1542694A1/en not_active Withdrawn
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- 2003-09-17 US US10/667,111 patent/US7429598B2/en not_active Expired - Fee Related
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2005
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- 2005-03-10 CR CR7728A patent/CR7728A/es not_active Application Discontinuation
- 2005-03-11 EC ECSP055671 patent/ECSP055671A/es unknown
- 2005-03-16 CO CO05024530A patent/CO5540391A2/es not_active Application Discontinuation
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- 2005-03-17 MA MA28153A patent/MA27439A1/fr unknown
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Also Published As

Publication number	Publication date
PA8582801A1 (es)	2004-05-26
NO20051695L (no)	2005-04-05
TNSN05073A1 (fr)	2007-05-14
US20040106631A1 (en)	2004-06-03
KR20050057371A (ko)	2005-06-16
CA2499330C (en)	2009-04-28
MA27439A1 (fr)	2005-07-01
WO2004026818A1 (en)	2004-04-01
MXPA05002913A (es)	2005-05-27
HRP20050223A2 (en)	2005-10-31
US7429598B2 (en)	2008-09-30
CR7728A (es)	2005-06-08
ECSP055671A (es)	2005-05-30
EP1400244A1 (en)	2004-03-24
EP1542694A1 (en)	2005-06-22
ZA200501381B (en)	2006-11-29
IS7700A (is)	2005-02-17
CN1681507A (zh)	2005-10-12
EA200500312A1 (ru)	2005-08-25
UY27986A1 (es)	2004-04-30
PL375977A1 (en)	2005-12-12
GT200300201A (es)	2004-05-18
JP2006501277A (ja)	2006-01-12
CO5540391A2 (es)	2005-07-29
BR0314379A (pt)	2005-07-19
CA2499330A1 (en)	2004-04-01
AU2003259496A1 (en)	2004-04-08
AR041271A1 (es)	2005-05-11
PE20050073A1 (es)	2005-02-28
AP2005003251A0 (en)	2005-03-31
TWI251590B (en)	2006-03-21
HN2003000285A (es)	2004-11-23
TW200413333A (en)	2004-08-01

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