OA13036A - Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof and use thereof as a medicament. - Google Patents

Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof and use thereof as a medicament. Download PDF

Info

Publication number: OA13036A
Authority: OA; OAPI
Prior art keywords: phenyl; formula; compounds; alkyl; alkanediyl
Prior art date: 2003-02-27

Application number

OA1200500249A

Other languages

English (en)

Inventor

Dirk Gretzke

Heiner Glombik

Eugen Falk

Jochen Goerlitzer

Stefanie Keil

Hans-Ludwig Schaefer

Christian Stapper

Wolfgang Wendler

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-27

Filing date

2004-02-19

Publication date

2006-11-10

2004-02-19 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2006-11-10 Publication of OA13036A publication Critical patent/OA13036A/en

Links

238000004519 manufacturing process Methods 0.000 title claims abstract description 5
238000000034 method Methods 0.000 title abstract description 8
125000002843 carboxylic acid group Chemical group 0.000 title abstract description 4
125000000753 cycloalkyl group Chemical group 0.000 title abstract description 4
239000003814 drug Substances 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 256
150000003839 salts Chemical class 0.000 claims abstract description 22
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239000008103 glucose Substances 0.000 claims abstract description 5
230000004129 fatty acid metabolism Effects 0.000 claims abstract description 4
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical group O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims description 93
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 42
-1 cyclohexane-1,3-diyl Chemical group 0.000 claims description 34
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238000011282 treatment Methods 0.000 claims description 18
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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OA1200500249A 2003-02-27 2004-02-19 Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof and use thereof as a medicament. OA13036A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10308354A DE10308354A1 (de)	2003-02-27	2003-02-27	Cycloalkylderivate mit biosteren Carbonsäure-Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
OA13036A true OA13036A (en)	2006-11-10

Family

ID=32920628

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500249A OA13036A (en)	2003-02-27	2004-02-19	Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof and use thereof as a medicament.

Country Status (30)

Country	Link
EP (1)	EP1601671B1 (pl)
JP (1)	JP2006519198A (pl)
KR (1)	KR20050106464A (pl)
CN (1)	CN100398537C (pl)
AR (1)	AR043426A1 (pl)
AT (1)	ATE437874T1 (pl)
AU (1)	AU2004215676B2 (pl)
BR (1)	BRPI0407867A (pl)
CA (1)	CA2516657A1 (pl)
CL (1)	CL2004000399A1 (pl)
CO (1)	CO5690552A2 (pl)
DE (2)	DE10308354A1 (pl)
DK (1)	DK1601671T3 (pl)
EC (1)	ECSP055984A (pl)
ES (1)	ES2330848T3 (pl)
HR (1)	HRP20050738A2 (pl)
MA (1)	MA27739A1 (pl)
MX (1)	MXPA05008989A (pl)
NO (1)	NO20054397L (pl)
OA (1)	OA13036A (pl)
PA (1)	PA8596601A1 (pl)
PE (1)	PE20050294A1 (pl)
PL (1)	PL377754A1 (pl)
PT (1)	PT1601671E (pl)
RU (1)	RU2005129996A (pl)
TN (1)	TNSN05205A1 (pl)
TW (1)	TW200508229A (pl)
UY (1)	UY28208A1 (pl)
WO (1)	WO2004076447A1 (pl)
ZA (1)	ZA200505764B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2007001634A (es)	2004-08-11	2007-04-23	Kyorin Seiyaku Kk	Nuevo derivado de acido amino benzoico ciclico.
NZ566877A (en)	2005-09-29	2010-05-28	Sanofi Aventis	Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPO713297A0 (en) *	1997-06-02	1997-06-26	Fujisawa Pharmaceutical Co., Ltd.	Oxazole compound
DE69941777D1 (de) *	1998-03-10	2010-01-21	Ono Pharmaceutical Co	Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
NZ515087A (en) *	1999-04-28	2003-11-28	Aventis Pharma Gmbh	Tri-aryl acid derivatives as PPAR receptor ligands
GB9914977D0 (en) *	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
EP1182251A1 (en) *	2000-08-11	2002-02-27	Yissum Research Development Company of the Hebrew University of Jerusalem	Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB
NZ526687A (en) *	2000-12-25	2004-08-27	Ono Pharmaceutical Co	Dihydronaphthalene derivative compounds and drugs containing these compounds as the active ingredient

2003
- 2003-02-27 DE DE10308354A patent/DE10308354A1/de not_active Withdrawn
2004
- 2004-02-19 ES ES04712484T patent/ES2330848T3/es not_active Expired - Lifetime
- 2004-02-19 EP EP04712484A patent/EP1601671B1/de not_active Expired - Lifetime
- 2004-02-19 WO PCT/EP2004/001585 patent/WO2004076447A1/de not_active Ceased
- 2004-02-19 HR HR20050738A patent/HRP20050738A2/xx not_active Application Discontinuation
- 2004-02-19 DK DK04712484T patent/DK1601671T3/da active
- 2004-02-19 CA CA002516657A patent/CA2516657A1/en not_active Abandoned
- 2004-02-19 KR KR1020057016054A patent/KR20050106464A/ko not_active Ceased
- 2004-02-19 RU RU2005129996/04A patent/RU2005129996A/ru not_active Application Discontinuation
- 2004-02-19 AT AT04712484T patent/ATE437874T1/de not_active IP Right Cessation
- 2004-02-19 BR BRPI0407867-5A patent/BRPI0407867A/pt not_active IP Right Cessation
- 2004-02-19 AU AU2004215676A patent/AU2004215676B2/en not_active Ceased
- 2004-02-19 OA OA1200500249A patent/OA13036A/en unknown
- 2004-02-19 JP JP2006501891A patent/JP2006519198A/ja active Pending
- 2004-02-19 PT PT04712484T patent/PT1601671E/pt unknown
- 2004-02-19 CN CNB2004800054491A patent/CN100398537C/zh not_active Expired - Fee Related
- 2004-02-19 MX MXPA05008989A patent/MXPA05008989A/es active IP Right Grant
- 2004-02-19 PL PL377754A patent/PL377754A1/pl not_active Application Discontinuation
- 2004-02-19 DE DE502004009823T patent/DE502004009823D1/de not_active Expired - Lifetime
- 2004-02-25 TW TW093104696A patent/TW200508229A/zh unknown
- 2004-02-27 AR ARP040100628A patent/AR043426A1/es not_active Application Discontinuation
- 2004-02-27 PE PE2004000207A patent/PE20050294A1/es not_active Application Discontinuation
- 2004-02-27 UY UY28208A patent/UY28208A1/es unknown
- 2004-02-27 CL CL200400399A patent/CL2004000399A1/es unknown
- 2004-02-27 PA PA20048596601A patent/PA8596601A1/es unknown
2005
- 2005-07-19 ZA ZA200505764A patent/ZA200505764B/en unknown
- 2005-08-26 CO CO05085513A patent/CO5690552A2/es not_active Application Discontinuation
- 2005-08-26 TN TNP2005000205A patent/TNSN05205A1/en unknown
- 2005-08-26 EC EC2005005984A patent/ECSP055984A/es unknown
- 2005-08-26 MA MA28462A patent/MA27739A1/fr unknown
- 2005-09-22 NO NO20054397A patent/NO20054397L/no unknown

Also Published As

Publication number	Publication date
KR20050106464A (ko)	2005-11-09
CL2004000399A1 (es)	2005-04-08
RU2005129996A (ru)	2006-01-27
AR043426A1 (es)	2005-07-27
CN100398537C (zh)	2008-07-02
PE20050294A1 (es)	2005-05-26
PT1601671E (pt)	2009-10-15
CO5690552A2 (es)	2006-10-31
ZA200505764B (en)	2006-05-31
JP2006519198A (ja)	2006-08-24
PA8596601A1 (es)	2004-09-16
DE502004009823D1 (de)	2009-09-10
AU2004215676B2 (en)	2010-01-21
CA2516657A1 (en)	2004-09-10
EP1601671A1 (de)	2005-12-07
TW200508229A (en)	2005-03-01
ES2330848T3 (es)	2009-12-16
NO20054397D0 (no)	2005-09-22
UY28208A1 (es)	2004-09-30
TNSN05205A1 (en)	2007-06-11
NO20054397L (no)	2005-11-23
DE10308354A1 (de)	2004-12-23
AU2004215676A1 (en)	2004-09-10
EP1601671B1 (de)	2009-07-29
ATE437874T1 (de)	2009-08-15
MXPA05008989A (es)	2005-10-18
MA27739A1 (fr)	2006-02-01
DK1601671T3 (da)	2009-11-16
PL377754A1 (pl)	2006-02-20
ECSP055984A (es)	2006-01-16
WO2004076447A1 (de)	2004-09-10
CN1753887A (zh)	2006-03-29
BRPI0407867A (pt)	2006-03-01
HRP20050738A2 (en)	2006-08-31

Publication	Publication Date	Title
US7148246B2 (en)	2006-12-12	Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
US7598281B2 (en)	2009-10-06	Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes
US20080015238A1 (en)	2008-01-17	Cycloalkylmethoxy-substituted acetic acid derivatives, processes for their preparation and their use as pharmaceuticals
US7160911B2 (en)	2007-01-09	Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals
EP1586573B1 (en)	2007-02-07	Oxadiazolones, processes for their preparation and their use as pharmaceuticals
AU2004216519B2 (en)	2009-03-26	1,3-substituted cycloalkyl derivatives containing acidic, mainly heterocyclic groups, corresponding production method and use of said derivatives as medicaments
AU2004215676B2 (en)	2010-01-21	Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof, and use thereof as a medicament
JP2006519196A (ja)	2006-08-24	Ｐｐａｒ受容体モジュレーターとしての分枝側鎖を有するアリールシクロアルキル誘導体、その製造方法および医薬としてのその使用
US7956077B2 (en)	2011-06-07	2-{-3,′2-(phenyl)-oxazol-4-ylmethoxyl-cyclohexyl methoxy}-propionic acid derivatives used as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes
US20040220261A1 (en)	2004-11-04	Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
CA2610074A1 (en)	2007-01-04	6-oxazol-4-ylmethoxy-alkoxymethyl substituted benzoic acid derivatives forming ppar ligands, methods for production and the use thereof in the form of drugs