OA13111A - Anti-microbially active diamine-based guanine derivatives. - Google Patents
Anti-microbially active diamine-based guanine derivatives. Download PDFInfo
- Publication number
- OA13111A OA13111A OA1200500264A OA1200500264A OA13111A OA 13111 A OA13111 A OA 13111A OA 1200500264 A OA1200500264 A OA 1200500264A OA 1200500264 A OA1200500264 A OA 1200500264A OA 13111 A OA13111 A OA 13111A
- Authority
- OA
- OAPI
- Prior art keywords
- diamine
- guanidine
- mic
- use according
- molecular mass
- Prior art date
Links
- 150000004985 diamines Chemical class 0.000 title claims abstract description 11
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title description 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 10
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 6
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 125000003277 amino group Chemical group 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 238000006068 polycondensation reaction Methods 0.000 claims abstract description 3
- 230000000845 anti-microbial effect Effects 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- -1 triethylene glycol diamine Chemical class 0.000 claims description 7
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 150000002357 guanidines Chemical class 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 125000005702 oxyalkylene group Chemical group 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical compound NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 20
- 229940088679 drug related substance Drugs 0.000 description 20
- 238000012360 testing method Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 244000052616 bacterial pathogen Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 229940088710 antibiotic agent Drugs 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 241001480043 Arthrodermataceae Species 0.000 description 3
- 241000335423 Blastomyces Species 0.000 description 3
- 206010017533 Fungal infection Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 241000588748 Klebsiella Species 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 230000037304 dermatophytes Effects 0.000 description 3
- 208000024386 fungal infectious disease Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000005722 itchiness Effects 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000589291 Acinetobacter Species 0.000 description 2
- 241000588914 Enterobacter Species 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 206010041925 Staphylococcal infections Diseases 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 241000607447 Yersinia enterocolitica Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 230000006020 chronic inflammation Effects 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940098232 yersinia enterocolitica Drugs 0.000 description 2
- 241000588625 Acinetobacter sp. Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000588749 Klebsiella oxytoca Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000219470 Mirabilis Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241001502334 Mycobacterium avium complex bacterium Species 0.000 description 1
- 241000187484 Mycobacterium gordonae Species 0.000 description 1
- 241000186363 Mycobacterium kansasii Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002068 microbial inoculum Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0045303A AT500998B1 (de) | 2003-03-20 | 2003-03-20 | Antimikrobiell wirkendes arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA13111A true OA13111A (en) | 2006-11-10 |
Family
ID=32996821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200500264A OA13111A (en) | 2003-03-20 | 2004-03-17 | Anti-microbially active diamine-based guanine derivatives. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20060093573A1 (pl) |
| EP (1) | EP1605927B1 (pl) |
| JP (1) | JP4970931B2 (pl) |
| KR (1) | KR20060003331A (pl) |
| CN (1) | CN1767821A (pl) |
| AP (1) | AP2189A (pl) |
| AT (2) | AT500998B1 (pl) |
| AU (1) | AU2004222664B2 (pl) |
| BR (1) | BRPI0408541A (pl) |
| CA (1) | CA2518968A1 (pl) |
| CY (1) | CY1107251T1 (pl) |
| DE (1) | DE502004005903D1 (pl) |
| DK (1) | DK1605927T3 (pl) |
| EA (1) | EA012620B1 (pl) |
| ES (1) | ES2299828T3 (pl) |
| HR (1) | HRP20050819A2 (pl) |
| IL (1) | IL170994A (pl) |
| MX (1) | MXPA05009983A (pl) |
| OA (1) | OA13111A (pl) |
| PL (1) | PL1605927T3 (pl) |
| PT (1) | PT1605927E (pl) |
| SI (1) | SI1605927T1 (pl) |
| UA (1) | UA84418C2 (pl) |
| WO (1) | WO2004082671A1 (pl) |
| ZA (1) | ZA200507282B (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008031105A1 (en) * | 2006-09-08 | 2008-03-13 | Delaval Holdings Ab | Polymeric guanidine salt-based germicides |
| DE102008009591A1 (de) * | 2008-02-15 | 2009-08-20 | Galinski, Erwin A., Prof. Dr. | Zwitterionische Guanidiniumverbindungen als selektive antimikrobielle Wirkstoffe |
| CN102548396A (zh) * | 2009-04-30 | 2012-07-04 | 贝克特里弗里特公司 | 用于表面消毒的组合物 |
| DE102009029010A1 (de) * | 2009-08-31 | 2011-03-03 | Evonik Goldschmidt Gmbh | Antimikrobielle Etherguanidine |
| DE102009052721A1 (de) * | 2009-11-12 | 2011-05-26 | B. Braun Melsungen Ag | Verwendung polymerer oder oligomerer Wirkstoffe für medizinische Artikel |
| EP2632435A1 (en) * | 2010-10-29 | 2013-09-04 | Mindinvest Holdings Ltd. | Liposomal drug composition containing a polymeric guanidine derivative |
| AT516070B1 (de) * | 2014-07-31 | 2016-08-15 | Sealife Pharma Gmbh | Verfahren zur Herstellung von Polyguanidinen |
| EP3524055A1 (de) * | 2018-02-08 | 2019-08-14 | BCSK Biocid GmbH | Antibakterielles und spermizides gleitmittel |
| AT521124A1 (de) * | 2018-03-23 | 2019-10-15 | Bcsk Biocid Gmbh | Verfahren und Zusammensetzung zur Bekämpfung von Viren der Familie Picornaviridae |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2336605A (en) * | 1941-12-29 | 1943-12-14 | Du Pont | Pesticide |
| DE4002404A1 (de) * | 1990-01-27 | 1991-08-01 | Degussa | Loesungen polymerer guanidinsalze mit erhoehter biozidwirksamkeit, verfahren zu ihrer herstellung und verwendung |
| DE4002403A1 (de) * | 1990-01-27 | 1991-08-01 | Degussa | Verfahren zur herstellung von biozid wirksamen polymeren guanidinsalzen |
| CA2408191C (en) * | 2000-05-11 | 2006-11-14 | P.O.C. Oil Industry Technology Beratungsges.M.B.H. | Biocidal polymers based on guanidine salts |
| CA2434693A1 (en) * | 2001-01-18 | 2002-10-17 | Genzyme Corporation | Ionene polymers and their use as antimicrobial agents |
| AT501983B1 (de) * | 2003-02-04 | 2007-03-15 | Geopharma Produktionsgmbh | Zytostatisches arzneimittel enthaltend ein polymeres guanidinderivat |
-
2003
- 2003-03-20 AT AT0045303A patent/AT500998B1/de not_active IP Right Cessation
-
2004
- 2004-03-17 UA UAA200509898A patent/UA84418C2/ru unknown
- 2004-03-17 BR BRPI0408541-8A patent/BRPI0408541A/pt not_active IP Right Cessation
- 2004-03-17 JP JP2006503945A patent/JP4970931B2/ja not_active Expired - Fee Related
- 2004-03-17 HR HR20050819A patent/HRP20050819A2/xx not_active Application Discontinuation
- 2004-03-17 PT PT04721079T patent/PT1605927E/pt unknown
- 2004-03-17 AP AP2005003404A patent/AP2189A/xx active
- 2004-03-17 CA CA002518968A patent/CA2518968A1/en not_active Abandoned
- 2004-03-17 DK DK04721079T patent/DK1605927T3/da active
- 2004-03-17 DE DE502004005903T patent/DE502004005903D1/de not_active Expired - Lifetime
- 2004-03-17 EA EA200501485A patent/EA012620B1/ru not_active IP Right Cessation
- 2004-03-17 WO PCT/AT2004/000097 patent/WO2004082671A1/de not_active Ceased
- 2004-03-17 CN CNA2004800074828A patent/CN1767821A/zh active Pending
- 2004-03-17 MX MXPA05009983A patent/MXPA05009983A/es active IP Right Grant
- 2004-03-17 KR KR1020057017591A patent/KR20060003331A/ko not_active Ceased
- 2004-03-17 SI SI200430664T patent/SI1605927T1/sl unknown
- 2004-03-17 ES ES04721079T patent/ES2299828T3/es not_active Expired - Lifetime
- 2004-03-17 AU AU2004222664A patent/AU2004222664B2/en not_active Ceased
- 2004-03-17 OA OA1200500264A patent/OA13111A/en unknown
- 2004-03-17 EP EP04721079A patent/EP1605927B1/de not_active Expired - Lifetime
- 2004-03-17 AT AT04721079T patent/ATE383152T1/de not_active IP Right Cessation
- 2004-03-17 PL PL04721079T patent/PL1605927T3/pl unknown
-
2005
- 2005-09-09 ZA ZA200507282A patent/ZA200507282B/en unknown
- 2005-09-19 US US11/230,141 patent/US20060093573A1/en not_active Abandoned
- 2005-09-20 IL IL170994A patent/IL170994A/en not_active IP Right Cessation
-
2008
- 2008-03-19 CY CY20081100307T patent/CY1107251T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA84418C2 (ru) | 2008-10-27 |
| KR20060003331A (ko) | 2006-01-10 |
| AP2189A (en) | 2010-12-24 |
| HRP20050819A2 (en) | 2006-02-28 |
| EA012620B1 (ru) | 2009-10-30 |
| AP2005003404A0 (en) | 2005-12-31 |
| BRPI0408541A (pt) | 2006-03-07 |
| IL170994A (en) | 2010-06-30 |
| AU2004222664B2 (en) | 2009-12-03 |
| CY1107251T1 (el) | 2012-11-21 |
| US20060093573A1 (en) | 2006-05-04 |
| MXPA05009983A (es) | 2006-03-09 |
| EP1605927A1 (de) | 2005-12-21 |
| ZA200507282B (en) | 2006-12-27 |
| AT500998A1 (de) | 2006-05-15 |
| EA200501485A1 (ru) | 2006-04-28 |
| WO2004082671A1 (de) | 2004-09-30 |
| EP1605927B1 (de) | 2008-01-09 |
| DK1605927T3 (da) | 2008-05-13 |
| CA2518968A1 (en) | 2004-09-30 |
| PL1605927T3 (pl) | 2008-06-30 |
| JP2006520329A (ja) | 2006-09-07 |
| PT1605927E (pt) | 2008-04-07 |
| ATE383152T1 (de) | 2008-01-15 |
| JP4970931B2 (ja) | 2012-07-11 |
| AU2004222664A1 (en) | 2004-09-30 |
| AT500998B1 (de) | 2008-10-15 |
| ES2299828T3 (es) | 2008-06-01 |
| CN1767821A (zh) | 2006-05-03 |
| SI1605927T1 (sl) | 2008-06-30 |
| DE502004005903D1 (de) | 2008-02-21 |
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