PE20031066A1 - COMBINACION FARMACEUTICA DE UN INHIBIDOR SELECTIVO DE PDE4 Y UN AGONISTA DE RECEPTOR ß2-ADRENERGICO - Google Patents
COMBINACION FARMACEUTICA DE UN INHIBIDOR SELECTIVO DE PDE4 Y UN AGONISTA DE RECEPTOR ß2-ADRENERGICOInfo
- Publication number
- PE20031066A1 PE20031066A1 PE2002001175A PE2002001175A PE20031066A1 PE 20031066 A1 PE20031066 A1 PE 20031066A1 PE 2002001175 A PE2002001175 A PE 2002001175A PE 2002001175 A PE2002001175 A PE 2002001175A PE 20031066 A1 PE20031066 A1 PE 20031066A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- cycloalkyl
- receptor agonist
- cyclopentil
- Prior art date
Links
- 239000000048 adrenergic agonist Substances 0.000 title abstract 2
- 229940126157 adrenergic receptor agonist Drugs 0.000 title abstract 2
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 title abstract 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 title abstract 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 210000002345 respiratory system Anatomy 0.000 abstract 2
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002848 formoterol Drugs 0.000 abstract 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229960004017 salmeterol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMBINACION INHALADA DE a)UN INHIBIDOR SELECTIVO DE PDE4 DE FORMULA I DONDE R1 ES H, ALQUILO, ALCOXI, ALQUENILO, FENILO, N(CH3)2, CICLOALQUILO, CICLOALQUILO-ALQUILO, ACILO OPCIONALMENTE SUSTITUIDOS CON OH, ALQUILO, CF3, HALOGENO; R2 Y R3 SON H, ALQUILO, ALCOXI-ALQUILO, ALQUENILO, CICLOALQUILO, CICLOALQUILO-ALQUILO, HETEROCICLO-(CH2)n CON O, S, SULFONILO, N, NR4; R4 ES H, ALQUILO, UN GRUPO II; n ES 0-2; a ES 1-5; b Y c SON 0-1; R5 ES H, OH, ALQUILO, ALQUENILO, ALCOXI, CICLOALCOXI, HALOGENO, CF3, CO2R6, CONR6R7, ENTRE OTROS; R9 Y R10 SON H, ALQUILO, ALCOXI, ARILO, ARILOXI. SON COMPUESTOS PREFERIDOS 9-CICLOPENTIL-5,6-DIHIDRO-7-ETIL-3-FENIL-9H-PIRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-O]PIRIDINA; 3-BENCIL-9-CICLOPENTIL-5,6-DIHIDRO-7-ETIL-9H-PIRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-O]PIRIDINA; 9-CICLOPENTIL-5,6-DIHIDRO-7-ETIL-3-(TERBUTIL)-9H-PIRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-O]PIRIDINA; b)UN AGONISTA DE RECEPTOR ß2-ADRENERGICO TAL COMO SALMETEROL, FORMOTEROL. LA COMBINACION PROPORCIONA UN CONTROL OPTIMO DEL CALIBRE DE LAS VIAS RESPIRATORIAS, SIN EFECTOS PERIFERICOS INDESEADOS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE UNA ENFERMEDAD OBSTRUCTIVA DE LAS VIAS RESPIRATORIAS U OTRA ENFERMEDAD INFLAMATORIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0129395.0A GB0129395D0 (en) | 2001-12-07 | 2001-12-07 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20031066A1 true PE20031066A1 (es) | 2003-12-24 |
Family
ID=9927247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001175A PE20031066A1 (es) | 2001-12-07 | 2002-12-05 | COMBINACION FARMACEUTICA DE UN INHIBIDOR SELECTIVO DE PDE4 Y UN AGONISTA DE RECEPTOR ß2-ADRENERGICO |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20030119862A1 (es) |
| EP (1) | EP1455783A1 (es) |
| JP (1) | JP2005511657A (es) |
| KR (1) | KR20050044699A (es) |
| CN (1) | CN1599609A (es) |
| AP (1) | AP2004003054A0 (es) |
| AR (1) | AR037712A1 (es) |
| AU (1) | AU2002353255A1 (es) |
| BR (1) | BR0214776A (es) |
| CA (1) | CA2468676A1 (es) |
| CO (1) | CO5590899A2 (es) |
| EA (1) | EA200400640A1 (es) |
| EC (1) | ECSP045142A (es) |
| GB (1) | GB0129395D0 (es) |
| HN (1) | HN2002000356A (es) |
| HR (1) | HRP20040515A2 (es) |
| HU (1) | HUP0402546A3 (es) |
| IL (1) | IL162098A0 (es) |
| IS (1) | IS7277A (es) |
| MA (1) | MA27152A1 (es) |
| MX (1) | MXPA04004930A (es) |
| NO (1) | NO20042870L (es) |
| NZ (1) | NZ533030A (es) |
| OA (1) | OA12736A (es) |
| PA (1) | PA8560601A1 (es) |
| PE (1) | PE20031066A1 (es) |
| PL (1) | PL370770A1 (es) |
| SV (1) | SV2004001430A (es) |
| TN (1) | TNSN04102A1 (es) |
| TW (1) | TWI242433B (es) |
| UY (1) | UY27564A1 (es) |
| WO (1) | WO2003047578A1 (es) |
| ZA (1) | ZA200403905B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| TWI359675B (en) * | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| DE10360954B3 (de) * | 2003-12-23 | 2005-08-18 | Esparma Gmbh | Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen |
| WO2012098495A1 (en) * | 2011-01-19 | 2012-07-26 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition that includes revamilast and a beta-2 agonist |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69525978T2 (de) * | 1995-06-06 | 2002-12-19 | Pfizer | Trizyclische 5,6-dihydro-9h-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-alpha)pyridine |
| CZ293735B6 (cs) * | 1998-08-26 | 2004-07-14 | Smithkline Beecham Corporation | Farmaceutický prostředek pro léčbu plicní nemoci |
| CA2715683A1 (en) * | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
-
2001
- 2001-12-07 GB GBGB0129395.0A patent/GB0129395D0/en not_active Ceased
-
2002
- 2002-11-22 AP APAP/P/2004/003054A patent/AP2004003054A0/en unknown
- 2002-11-22 EA EA200400640A patent/EA200400640A1/ru unknown
- 2002-11-22 HU HU0402546A patent/HUP0402546A3/hu unknown
- 2002-11-22 OA OA1200400162A patent/OA12736A/en unknown
- 2002-11-22 WO PCT/IB2002/004922 patent/WO2003047578A1/en not_active Ceased
- 2002-11-22 JP JP2003548833A patent/JP2005511657A/ja not_active Withdrawn
- 2002-11-22 CA CA002468676A patent/CA2468676A1/en not_active Abandoned
- 2002-11-22 IL IL16209802A patent/IL162098A0/xx unknown
- 2002-11-22 MX MXPA04004930A patent/MXPA04004930A/es unknown
- 2002-11-22 PL PL02370770A patent/PL370770A1/xx not_active Application Discontinuation
- 2002-11-22 EP EP02788275A patent/EP1455783A1/en not_active Withdrawn
- 2002-11-22 KR KR1020047008613A patent/KR20050044699A/ko not_active Abandoned
- 2002-11-22 CN CNA028243935A patent/CN1599609A/zh active Pending
- 2002-11-22 HR HR20040515A patent/HRP20040515A2/hr not_active Application Discontinuation
- 2002-11-22 AU AU2002353255A patent/AU2002353255A1/en not_active Abandoned
- 2002-11-22 NZ NZ533030A patent/NZ533030A/en not_active IP Right Cessation
- 2002-11-22 BR BR0214776-9A patent/BR0214776A/pt not_active IP Right Cessation
- 2002-12-03 US US10/308,962 patent/US20030119862A1/en not_active Abandoned
- 2002-12-05 UY UY27564A patent/UY27564A1/es not_active Application Discontinuation
- 2002-12-05 HN HN2002000356A patent/HN2002000356A/es unknown
- 2002-12-05 AR ARP020104719A patent/AR037712A1/es unknown
- 2002-12-05 PE PE2002001175A patent/PE20031066A1/es not_active Application Discontinuation
- 2002-12-06 SV SV2002001430A patent/SV2004001430A/es not_active Application Discontinuation
- 2002-12-06 TW TW091135479A patent/TWI242433B/zh not_active IP Right Cessation
- 2002-12-06 PA PA20028560601A patent/PA8560601A1/es unknown
-
2003
- 2003-12-16 US US10/736,996 patent/US20040167153A1/en not_active Abandoned
-
2004
- 2004-05-20 ZA ZA200403905A patent/ZA200403905B/en unknown
- 2004-05-21 IS IS7277A patent/IS7277A/is unknown
- 2004-06-02 MA MA27712A patent/MA27152A1/fr unknown
- 2004-06-04 CO CO04052217A patent/CO5590899A2/es not_active Application Discontinuation
- 2004-06-04 TN TNP2004000102A patent/TNSN04102A1/fr unknown
- 2004-06-07 EC EC2004005142A patent/ECSP045142A/es unknown
- 2004-07-06 NO NO20042870A patent/NO20042870L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |