DK0893998T3 - Afgivelse af nikotin i tyktarmen med henblik på behandling af inflammatoriske tarmsygdomme - Google Patents

Afgivelse af nikotin i tyktarmen med henblik på behandling af inflammatoriske tarmsygdomme

Info

Publication number
DK0893998T3
DK0893998T3 DK97904516T DK97904516T DK0893998T3 DK 0893998 T3 DK0893998 T3 DK 0893998T3 DK 97904516 T DK97904516 T DK 97904516T DK 97904516 T DK97904516 T DK 97904516T DK 0893998 T3 DK0893998 T3 DK 0893998T3
Authority
DK
Denmark
Prior art keywords
nicotine
inflammatory bowel
delivery
treatment
large intestine
Prior art date
Application number
DK97904516T
Other languages
English (en)
Other versions
DK0893998T4 (da
Inventor
William Jeffery Sandborn
John Rhodes
Peter Rhodes
Brian Kenneth Evans
Original Assignee
Mayo Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24423169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0893998(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mayo Foundation filed Critical Mayo Foundation
Application granted granted Critical
Publication of DK0893998T3 publication Critical patent/DK0893998T3/da
Publication of DK0893998T4 publication Critical patent/DK0893998T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465Nicotine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
DK97904516T 1996-02-09 1997-02-07 Afgivelse af nikotin i tyktarmen med henblik på behandling af inflammatoriske tarmsygdomme DK0893998T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/605,319 US5846983A (en) 1996-02-09 1996-02-09 Colonic delivery of nicotine to treat inflammatory bowel disease
PCT/GB1997/000369 WO1997028801A1 (en) 1996-02-09 1997-02-07 Colonic delivery of nicotine to treat inflammatory bowel disease

Publications (2)

Publication Number Publication Date
DK0893998T3 true DK0893998T3 (da) 2003-08-11
DK0893998T4 DK0893998T4 (da) 2008-05-05

Family

ID=24423169

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97904516T DK0893998T4 (da) 1996-02-09 1997-02-07 Afgivelse af nikotin i tyktarmen med henblik på behandling af inflammatoriske tarmsygdomme

Country Status (20)

Country Link
US (1) US5846983A (da)
EP (1) EP0893998B2 (da)
JP (1) JP4283340B2 (da)
KR (1) KR100458636B1 (da)
CN (1) CN1127340C (da)
AT (1) ATE237330T1 (da)
AU (1) AU718971C (da)
CA (1) CA2246235C (da)
CZ (1) CZ293616B6 (da)
DE (1) DE69720985T3 (da)
DK (1) DK0893998T4 (da)
ES (1) ES2196303T5 (da)
HU (1) HUP9900950A3 (da)
MX (1) MX9806354A (da)
MY (1) MY122023A (da)
PL (1) PL187914B1 (da)
PT (1) PT893998E (da)
SK (1) SK284539B6 (da)
WO (1) WO1997028801A1 (da)
ZA (1) ZA971020B (da)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889028A (en) * 1996-02-09 1999-03-30 Mayo Foundation For Medical Education And Research Colonic delivery of nicotine to treat inflammatory bowel disease
GB9614902D0 (en) 1996-07-16 1996-09-04 Rhodes John Sustained release composition
US6268386B1 (en) * 1998-06-25 2001-07-31 Marshall Anlauf Thompson Nicotine beverage
EP1105141B1 (de) * 1998-08-06 2003-11-05 Wolfgang Stremmel Phosphatidylcholin als arzneimittel mit schleimhautschützender wirkung
AU764681C (en) * 1999-02-12 2005-07-07 Washington University Stimulating neutrophil function to treat inflammatory bowel disease
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
AU776567B2 (en) * 1999-11-01 2004-09-16 Evans, Brian K Composition for treatment of constipation and irritable bowel syndrome
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IT1318625B1 (it) 2000-07-14 2003-08-27 Roberto Valducci Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente.
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
ATE355854T1 (de) * 2000-08-03 2007-03-15 Antares Pharma Ipl Ag Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel
CA2341952A1 (en) 2001-03-23 2002-09-23 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US20050130990A1 (en) * 2001-03-23 2005-06-16 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US20060204598A1 (en) * 2001-12-10 2006-09-14 Thompson Marshall A Nicotine-alternative compositions and methods of producing such compositions
US20030108592A1 (en) * 2001-12-10 2003-06-12 Thompson Marshall Anlauf Method of producing a nicotine composition
US20050131031A1 (en) * 2001-12-10 2005-06-16 Thompson Marshall A. Method of producing a nicotine composition
US20100160376A1 (en) * 2001-12-10 2010-06-24 Marshall Anlauf Thompson Nicotine-alternative compositions and methods of producing such compositions
US7091357B2 (en) 2001-12-26 2006-08-15 University Of Kentucky Research Foundation Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
US8039459B2 (en) 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US8557804B2 (en) 2002-03-25 2013-10-15 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
ES2532906T5 (es) 2002-10-25 2022-03-23 Foamix Pharmaceuticals Ltd Espuma cosmética y farmacéutica
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US8084432B2 (en) * 2003-02-13 2011-12-27 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of pouchitis
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
DK1670433T3 (da) 2003-10-10 2012-03-12 Ferring Bv Transdermal farmaceutisk formulering til mindskelse af hudrester
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性(biosynchronous)経皮的薬物送達
WO2006080919A1 (en) * 2005-01-27 2006-08-03 Marshall Anlauf Thompson Method of producing a nicotine composition
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008103818A1 (en) * 2007-02-21 2008-08-28 University Of Louisville Research Foundation Therapeutic cotinine compositions
GB2468424B (en) * 2007-04-02 2011-11-09 Parkinson S Inst Methods and compositions for reduction of side effects of therapeutic treatments
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
CA2712120A1 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US10029013B2 (en) 2009-10-02 2018-07-24 Foamix Pharmaceuticals Ltd. Surfactant-free, water-free formable composition and breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
JP6855165B2 (ja) * 2012-06-15 2021-04-07 コナリス リサーチ インスティチュート アーゲー ニコチン酸および/もしくはニコチンアミドならびに/またはトリプトファンを含有する、腸内微生物叢によい影響を及ぼすための医薬組成物
WO2015086838A2 (en) 2013-12-13 2015-06-18 Conaris Research Institute Ag A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation
EP3079675B1 (en) 2013-12-13 2020-02-12 CONARIS research institute AG A pharmaceutical composition containing nicotinic acid and/or nicotinamide for use in beneficially influencing blood lipid levels by modifying the intestinal microbiota
GB201400442D0 (en) * 2014-01-10 2014-02-26 Sigmoid Pharma Ltd Compositions for use in the treatment of ulcerative colitis
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. 薬剤送達方法及びシステム
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
MX377365B (es) 2016-09-08 2025-03-10 Journey Medical Corp Composiciones y métodos para tratar rosácea y acné.
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited METHODS AND SYSTEMS FOR DRUG DELIVERY
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
CN114340615A (zh) 2019-08-12 2022-04-12 麻省理工学院 用于施用治疗剂的制品和方法
CN115089641B (zh) * 2022-05-25 2023-07-25 西安交通大学医学院第一附属医院 一种难治型溃疡性结肠炎灌肠剂及其制备方法
WO2025236078A1 (en) * 2024-05-09 2025-11-20 Tjp Labs Inc. Stabilized nicotine particles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3645036A1 (de) * 1986-11-18 1989-01-05 Forschungsgesellschaft Rauchen Nikotinhaltiges mittel
US4855142A (en) * 1987-02-27 1989-08-08 Ciba-Geigy Corporation Pharmaceutical plaster
IE62662B1 (en) * 1989-01-06 1995-02-22 Elan Corp Plc Use of nicotine in the treatment of conditions susceptible to said treatment
DK0540613T3 (da) * 1990-07-20 1996-04-01 Tillotts Pharma Ag Produkter og fremgangsmåder til behandling af fordøjelseskanalen
GEP19971086B (en) * 1991-02-22 1997-12-02 Tillotts Pharma Ag Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
KR0121127B1 (ko) * 1994-05-09 1997-11-13 강박광 이온성 고분자 네트웍을 갖는 피부약물전달체계
US5604231A (en) * 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5532254A (en) 1995-06-07 1996-07-02 Eli Lilly And Company Modulation of calcium channels using benzothiophenes
GB9614902D0 (en) * 1996-07-16 1996-09-04 Rhodes John Sustained release composition

Also Published As

Publication number Publication date
CZ293616B6 (cs) 2004-06-16
DK0893998T4 (da) 2008-05-05
AU718971C (en) 2008-01-31
ATE237330T1 (de) 2003-05-15
PT893998E (pt) 2003-07-31
ES2196303T5 (es) 2008-05-01
MX9806354A (es) 1998-10-31
DE69720985D1 (de) 2003-05-22
HUP9900950A3 (en) 2000-01-28
CN1210466A (zh) 1999-03-10
ES2196303T3 (es) 2003-12-16
MY122023A (en) 2006-03-31
JP2000505430A (ja) 2000-05-09
KR100458636B1 (ko) 2005-01-15
EP0893998B1 (en) 2003-04-16
CN1127340C (zh) 2003-11-12
DE69720985T3 (de) 2008-05-29
WO1997028801A1 (en) 1997-08-14
CA2246235C (en) 2007-06-12
HUP9900950A2 (hu) 1999-08-30
PL187914B1 (pl) 2004-10-29
SK106898A3 (en) 2000-12-11
PL328430A1 (en) 1999-02-01
US5846983A (en) 1998-12-08
ZA971020B (en) 1997-11-05
AU1729497A (en) 1997-08-28
CA2246235A1 (en) 1997-08-14
SK284539B6 (sk) 2005-06-02
EP0893998A1 (en) 1999-02-03
HK1019043A1 (en) 2000-01-21
EP0893998B2 (en) 2007-12-12
AU718971B2 (en) 2000-05-04
CZ245198A3 (cs) 1999-05-12
DE69720985T2 (de) 2004-02-05
JP4283340B2 (ja) 2009-06-24
KR19990082429A (ko) 1999-11-25

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