PE20060331A1 - Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos - Google Patents

Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos

Info

Publication number
PE20060331A1
PE20060331A1 PE2005000458A PE2005000458A PE20060331A1 PE 20060331 A1 PE20060331 A1 PE 20060331A1 PE 2005000458 A PE2005000458 A PE 2005000458A PE 2005000458 A PE2005000458 A PE 2005000458A PE 20060331 A1 PE20060331 A1 PE 20060331A1
Authority
PE
Peru
Prior art keywords
substituted
alkyl
cr20r21
cyanopyrrol
formula
Prior art date
Application number
PE2005000458A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Arkadiy Zinoviy Rubezhov
Jean Louise Helom
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20060331A1 publication Critical patent/PE20060331A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A LA PREPARACION DE ESTERES BORICOS O BOROSOS DE 2-CIANOPIRROL DE FORMULAS (A) a (H) MEDIANTE REACCION DE: a) UN AGENTE DE BORO DE FORMULA B(OR1)(OR2)(OR3) o B(R4)(R5)(R6); b) 2-CIANOPIRROL SUSTITUIDO DE FORMULA (I); Y, c) UNA BASE FUERTE NO NUCLEOFILICA TAL COMO DIISOPROPILAMINA DE Li; DONDE R1, R2 Y R3 SON ALQUILO C1-C6, CICLOALQUILO C3-C8 o HETEROALQUILO C1-C6 SUSTITUIDOS O NO; R4, R5 Y R6 SON HALOGENO, o ALQUILO C1-C6 SUSTITUIDO O NO; R7 ES ALQUILO C1-C6, ARILO o HETEROARILO SUSTITUIDOS O NO, o CORA; Q ES OH, NH2, CN, HALOGENO, ALQUILO C1-C6 SUSTITUIDO, o ALQUENILO C2-C6, ALQUINILO C2-C6, ALCOXI C1-C6, AMINOALQUILO C1-C6 SUSTITUIDOS O NO, o CORB; a ES 0 A 2; CC+ ES UN CONTRACATION; Y RA Y RB SON H, Y ALQUILO C1-C6, ALCOXI C1-C6 o AMINOALQUILO C1-C6 SUSTITUIDOS O NO. SE PREPARA ACIDO 2-CIANOPIRROL BORICO O BOROSO, HIDROLIZANDO DICHOS ESTERES O SUS SALES. SE HACE REACCIONAR EL ACIDO CON UN GLICOL DE FORMULA HO-(CR20R21)s-OH o UNA ALCANOLAMINA DE FORMULA HO-(CR20R21)s-N(R22)-(CR20R21)t-OH PARA OBTENER ESTERES DE BORATO DE FORMULA R18-B-O-R19-O- DONDE R18 ES 2-CIANOPIRROL SUSTITUIDO O NO; R19 ES (CR20R21)s o -(CR20R21)s-N(R22)-(CR20R21)t-; s Y t SON 1 A 5; R20 Y R21 SON H o ALQUILO C1-C6 SUSTITUIDO O NO; Y R22 ES H o ALQUILO C1-C6 Y ARILO SUSTITUIDOS O NO.SE PREPARAN SALES DE TRIFLUORBORATO DE 2-CIANOPIRROL HACIENDO REACCIONAR HF Y KF A DICHOS ESTERES.EL ACOPLAMIENTO INCLUYE LA REACCION DE LOS ESTERES FORMADOS, UN ARILO Y UN AGENTE DE ACOPLAMIENTO ORGANOMETALICO
PE2005000458A 2004-04-27 2005-04-25 Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos PE20060331A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56563604P 2004-04-27 2004-04-27
US64765605P 2005-01-27 2005-01-27

Publications (1)

Publication Number Publication Date
PE20060331A1 true PE20060331A1 (es) 2006-05-16

Family

ID=34967855

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000458A PE20060331A1 (es) 2004-04-27 2005-04-25 Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos

Country Status (7)

Country Link
US (2) US7446211B2 (es)
AR (1) AR049631A1 (es)
PA (1) PA8631101A1 (es)
PE (1) PE20060331A1 (es)
SV (1) SV2005002092A (es)
TW (1) TW200604137A (es)
WO (1) WO2005105817A2 (es)

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WO2005105817A2 (en) 2004-04-27 2005-11-10 Wyeth Coupling process for generating reactive boron­ containing derivatives of n-substituted pyrrole-2­ carbonitriles to produce biaryls
GT200500185A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
SI1778710T1 (sl) * 2004-08-13 2012-05-31 Wyeth Llc Derivati tanaprogeta metaboliti in njihove uporabe
MX2007013465A (es) 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado, composiciones y metodos para preparar las mismas.
CA2603786A1 (en) 2005-04-28 2006-11-02 Wyeth Purified form of tanaproget
DE602006013114D1 (de) 2005-04-28 2010-05-06 Wyeth Corp Mikronisiertes tanaproget und zusammensetzungen damit
MX2007013469A (es) 2005-04-28 2008-01-22 Wyeth Corp Forma ii polimorfa de tanaproget.
PE20070220A1 (es) 2005-07-29 2007-03-19 Wyeth Corp Proceso para la sintesis de moduladores del receptor de progesterona
US20070213526A1 (en) * 2006-03-07 2007-09-13 Wyeth Purification of progesterone receptor modulators
US8207337B2 (en) 2007-01-29 2012-06-26 Wako Pure Chemical Industries, Ltd. Reagent for organic synthesis reaction containing organic triol borate salt
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
EA201070715A1 (ru) * 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции
AU2021268664A1 (en) 2020-05-05 2022-10-20 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
CA3179702A1 (en) 2020-05-05 2021-11-11 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
JP2024537795A (ja) 2021-10-01 2024-10-16 ヌバレント， インク． ヘテロ芳香族大環状エーテル化合物の固体形態、薬学的組成物、及び調製

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Also Published As

Publication number Publication date
US7446211B2 (en) 2008-11-04
AR049631A1 (es) 2006-08-23
US20050272702A1 (en) 2005-12-08
US8129523B2 (en) 2012-03-06
WO2005105817A2 (en) 2005-11-10
SV2005002092A (es) 2005-12-13
US20090054663A1 (en) 2009-02-26
PA8631101A1 (es) 2006-09-08
WO2005105817A3 (en) 2006-01-12
TW200604137A (en) 2006-02-01

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