PE20120663A1 - Anticuerpos anti-htnf alfa cristalinos - Google Patents

Anticuerpos anti-htnf alfa cristalinos

Info

Publication number
PE20120663A1
PE20120663A1 PE2012000080A PE2012000080A PE20120663A1 PE 20120663 A1 PE20120663 A1 PE 20120663A1 PE 2012000080 A PE2012000080 A PE 2012000080A PE 2012000080 A PE2012000080 A PE 2012000080A PE 20120663 A1 PE20120663 A1 PE 20120663A1
Authority
PE
Peru
Prior art keywords
htnf alpha
aqueous
alpha crystalline
refers
crystalization
Prior art date
Application number
PE2012000080A
Other languages
English (en)
Inventor
Anette Koenigsdorfer
Wolfgang Fraunhofer
Hans-Juergen Krause
David W Borhani
Gerhard Winter
Stefan Gottschalk
Original Assignee
Abbvie Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39364990&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120663(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Biotechnology Ltd filed Critical Abbvie Biotechnology Ltd
Publication of PE20120663A1 publication Critical patent/PE20120663A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

SE REFIERE A UN METODO DE CRISTALIZACION DISCONTINUA PARA CRISTALIZAR UN ANTICUERPO ANTI-hTNF ALFA TAL COMO D2E7 O ADALIMUMAB QUE COMPRENDE: A) PROVEER UNA SOLUCION ACUOSA DE DICHO ANTICUERPO MEZCLADO CON UNA SAL DE FOSFATO INORGANICO COMO AGENTE DE CRISTALIZACION TAL COMO UNA SAL DE FOSFATO MONOACIDO; Y B) INCUBAR LA MEZCLA DE CRISTALIZACION ACUOSA A UNA TEMPERATURA DE 4ºC A 37ºC HASTA QUE SE FORMEN LOS CRISTALES DE DICHO ANTICUERPO, EN DONDE EL pH DE LA MEZCLA DE CRISTALIZACION ACUOSA ES DE 3 A 5 Y TIENE UNA SOLUCION AMORTIGUADORA TAL COMO ACETATO DE SODIO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA
PE2012000080A 2006-10-27 2007-10-26 Anticuerpos anti-htnf alfa cristalinos PE20120663A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85510406P 2006-10-27 2006-10-27

Publications (1)

Publication Number Publication Date
PE20120663A1 true PE20120663A1 (es) 2012-06-01

Family

ID=39364990

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012000080A PE20120663A1 (es) 2006-10-27 2007-10-26 Anticuerpos anti-htnf alfa cristalinos
PE2007001461A PE20081258A1 (es) 2006-10-27 2007-10-26 ANTICUERPOS ANTI-hTNFALFA CRISTALINOS

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2007001461A PE20081258A1 (es) 2006-10-27 2007-10-26 ANTICUERPOS ANTI-hTNFALFA CRISTALINOS

Country Status (21)

Country Link
US (4) US8034906B2 (es)
EP (2) EP2684895A1 (es)
JP (2) JP2010507670A (es)
KR (2) KR20090101893A (es)
CN (2) CN101616932A (es)
AR (1) AR063429A1 (es)
AU (1) AU2007318120B2 (es)
BR (1) BRPI0717335A2 (es)
CA (1) CA2667655A1 (es)
CL (1) CL2007003094A1 (es)
ES (1) ES2442258T3 (es)
IL (1) IL198223A (es)
MX (1) MX2009004351A (es)
NZ (3) NZ597676A (es)
PE (2) PE20120663A1 (es)
RU (2) RU2486296C2 (es)
SG (1) SG176427A1 (es)
TW (2) TWI417302B (es)
UY (1) UY30662A1 (es)
WO (1) WO2008057240A2 (es)
ZA (1) ZA201306383B (es)

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US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
MX336813B (es) * 1996-02-09 2016-02-02 Abbvie Biotechnology Ltd Anticuerpos humanos que ligan el tnfa humano.
CA2817619A1 (en) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
WO2004009776A2 (en) * 2002-07-19 2004-01-29 Abbott Biotechnology Ltd. TREATMENT OF TNFα RELATED DISORDERS
US20090280065A1 (en) * 2006-04-10 2009-11-12 Willian Mary K Uses and Compositions for Treatment of Psoriasis
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
TW201705980A (zh) * 2004-04-09 2017-02-16 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
WO2006041970A2 (en) * 2004-10-08 2006-04-20 Abbott Biotechnology Ltd. Treatment of respiratory syncytial virus (rsv) infection
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EP2089428A4 (en) 2010-11-03
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AR063429A1 (es) 2009-01-28
RU2009119988A (ru) 2010-12-10
RU2013103322A (ru) 2014-07-27
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