PE20121335A1 - Compuestos derivados de amida como inhibidores de raf cinasas - Google Patents

Compuestos derivados de amida como inhibidores de raf cinasas

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Publication number
PE20121335A1
PE20121335A1 PE2012000671A PE2012000671A PE20121335A1 PE 20121335 A1 PE20121335 A1 PE 20121335A1 PE 2012000671 A PE2012000671 A PE 2012000671A PE 2012000671 A PE2012000671 A PE 2012000671A PE 20121335 A1 PE20121335 A1 PE 20121335A1
Authority
PE
Peru
Prior art keywords
pyrrolo
pyrimidin
difluoro
carbonyl
phenyl
Prior art date
Application number
PE2012000671A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Wayne Spevak
Hanna Cho
Songyuan Shi
Chao Zhang
Ying Zhang
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of PE20121335A1 publication Critical patent/PE20121335A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

REFERIDA A UN DERIVADO DE AMIDA DE FORMULA (I), DONDE X ES N O C(R5); Y ES F, Cl, Br, CN, OH, ENTRE OTROS; R1 ES ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; R2 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R5 ES H, F, Cl, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[2,4-DIFLUORO-3-(4-METIL-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-FENIL]-4-TRIFLUOROMETIL-BENCENOSULFONAMIDA, ACIDO PROPANO-1-SULFONICO[3-(4-ETOXI-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-2,4-DIFLUORO-FENIL]-AMIDA, N-[2,4-DIFLUORO-3-(4-METOXI-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-FENIL]-4-PROPIL-BENCENOSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LAS UNA O MAS PROTEINAS CINASAS RAF Y SON UTILES EN EL TRATAMIENTO DE MELANOMA, GLIOMA, CANCER PULMONAR, CANCER OVARICO, ENTRE OTROS
PE2012000671A 2009-11-18 2010-11-18 Compuestos derivados de amida como inhibidores de raf cinasas PE20121335A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26251009P 2009-11-18 2009-11-18
US38331010P 2010-09-15 2010-09-15

Publications (1)

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PE20121335A1 true PE20121335A1 (es) 2012-10-12

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PE2012000671A PE20121335A1 (es) 2009-11-18 2010-11-18 Compuestos derivados de amida como inhibidores de raf cinasas

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US (2) US8673928B2 (es)
EP (1) EP2501236B1 (es)
JP (2) JP2013511541A (es)
KR (1) KR20120097512A (es)
CN (2) CN105906631A (es)
AU (2) AU2010321883A1 (es)
BR (1) BR112012011792A2 (es)
CA (1) CA2781287C (es)
CL (1) CL2012001303A1 (es)
CO (1) CO6551689A2 (es)
ES (1) ES2627911T3 (es)
IL (1) IL219567A0 (es)
MA (1) MA33811B1 (es)
MX (1) MX2012005827A (es)
MY (1) MY156210A (es)
NZ (1) NZ599872A (es)
PE (1) PE20121335A1 (es)
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SMT201800230T1 (it) 2012-12-21 2018-07-17 Plexxikon Inc Composti e metodi per la modulazione della chinasi e loro indicazioni
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HRP20181392T1 (hr) 2013-03-15 2018-10-19 Plexxikon Inc. Heterociklični spojevi i njihova uporaba
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RU2012125070A (ru) 2013-12-27
CO6551689A2 (es) 2012-10-31
AU2016200485B2 (en) 2017-09-28
PH12012500981A1 (en) 2017-08-23
AU2010321883A1 (en) 2012-05-31
KR20120097512A (ko) 2012-09-04
JP2013511541A (ja) 2013-04-04
CA2781287A1 (en) 2011-05-26
JP6194389B2 (ja) 2017-09-06
EP2501236A4 (en) 2013-05-15
IL219567A0 (en) 2012-06-28
MY156210A (en) 2016-01-29
AU2016200485A1 (en) 2016-02-18
EP2501236B1 (en) 2017-03-29
JP2016185958A (ja) 2016-10-27
BR112012011792A2 (pt) 2015-10-13
US20110152258A1 (en) 2011-06-23
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US20140288070A1 (en) 2014-09-25
SG10201407718WA (en) 2015-01-29
EP2501236A1 (en) 2012-09-26
MX2012005827A (es) 2012-06-19
CN105906631A (zh) 2016-08-31
US8673928B2 (en) 2014-03-18
ES2627911T3 (es) 2017-08-01
MA33811B1 (fr) 2012-12-03
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WO2011063159A1 (en) 2011-05-26

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