PE20121349A1 - N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos - Google Patents

N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos

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Publication number
PE20121349A1
PE20121349A1 PE2012000461A PE2012000461A PE20121349A1 PE 20121349 A1 PE20121349 A1 PE 20121349A1 PE 2012000461 A PE2012000461 A PE 2012000461A PE 2012000461 A PE2012000461 A PE 2012000461A PE 20121349 A1 PE20121349 A1 PE 20121349A1
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Prior art keywords
tert
butylpyrazole
ilamino
oxopyrrolidin
triazin
Prior art date
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PE2012000461A
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English (en)
Inventor
Percy H Carter
Robert J Cherney
Victor W Rosso
Jun Li
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Bristol Myers Squibb Co
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Publication of PE20121349A1 publication Critical patent/PE20121349A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract

REFERIDA AL COMPUESTO N-((1R,2S,5R)-5-(TERT-BUTILAMINO)-2-((S)-3-(7-TERT-BUTILPIRAZOLO[1,5-A][1,3,5]TRIAZIN-4-ILAMINO)-2-OXOPIRROLIDIN-1-IL)CICLOHEXIL)ACETAMIDA DE FORMULA (I) O UNA SAL DEL MISMO. TAMBIEN ESTA REFERIDA A UNA FORMA CRISTALINA DEL COMPUESTO, UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHO COMPUESTO TIENE ACTIVIDAD SOBRE EL RECEPTOR DE QUIMIOCINAS Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, ALERGICAS, AUTOINMUNES, METABOLICAS, CARDIOVASCULARES Y CANCER
PE2012000461A 2009-10-13 2010-10-12 N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos PE20121349A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25097809P 2009-10-13 2009-10-13

Publications (1)

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PE20121349A1 true PE20121349A1 (es) 2012-10-15

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PE2012000461A PE20121349A1 (es) 2009-10-13 2010-10-12 N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos

Country Status (28)

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US (3) US8383812B2 (es)
EP (2) EP2488523B8 (es)
JP (1) JP5759999B2 (es)
KR (1) KR20120102052A (es)
CN (1) CN102648201B (es)
AR (1) AR078627A1 (es)
AU (1) AU2010306968B2 (es)
BR (1) BR112012008650B1 (es)
CA (1) CA2777563A1 (es)
CL (1) CL2014000753A1 (es)
CO (1) CO6460737A2 (es)
DK (1) DK2488523T3 (es)
EA (2) EA020486B1 (es)
ES (1) ES2442897T3 (es)
HR (1) HRP20140072T1 (es)
IL (2) IL219121A0 (es)
MX (1) MX2012003720A (es)
NZ (2) NZ613580A (es)
PE (1) PE20121349A1 (es)
PL (1) PL2488523T3 (es)
PT (1) PT2488523E (es)
RS (1) RS53131B (es)
SI (1) SI2488523T1 (es)
SM (1) SMT201400020B (es)
TN (1) TN2012000132A1 (es)
TW (1) TW201120042A (es)
WO (1) WO2011046916A1 (es)
ZA (1) ZA201305994B (es)

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MX2017000580A (es) 2014-07-17 2017-09-01 Santen Pharmaceutical Co Ltd Agente profilactico o terapeutico para enfermedades del segmento posterior del ojo.
RU2019110779A (ru) 2016-09-14 2020-10-15 Новартис Аг Новые схемы введения агонистов fxr
PE20190972A1 (es) 2016-09-14 2019-07-09 Novartis Ag Combinacion de agonistas de fxr
SMT202200088T1 (it) 2017-07-20 2022-03-21 Bristol Myers Squibb Co Procedimento per la preparazione di n-((1r,2s,sr)-5-(tert-butilammino)-2-((s)-3-(7-tert-butilpirazolo[1,5-a][1,3,5]triazin-4-ilammino)-2-ossopirrolidin-1-il)cicloesil)acetammide
JP2021511344A (ja) 2018-01-22 2021-05-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 癌を治療する組成物および方法
BR112022009331A2 (pt) * 2019-11-13 2022-08-09 Rapt Therapeutics Inc Formas cristalinas do receptor de quimiocina c c antagonista tipo 4 e usos das mesmas
JP2023538533A (ja) 2020-08-07 2023-09-08 ブリストル－マイヤーズ スクイブ カンパニー 線維症の処置のための、ｃｃｒ２／５拮抗剤と組み合わせたｆｇｆ２１
WO2023092049A1 (en) * 2021-11-19 2023-05-25 Bristol-Myers Squibb Company Azirine pharmaceutical compositions
WO2024240025A1 (zh) * 2023-05-22 2024-11-28 无锡瓴方生物医药科技有限公司 一种联合用药物组合物及其应用

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