PE20121683A1 - DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75 - Google Patents

DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75

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Publication number
PE20121683A1
PE20121683A1 PE2012000828A PE2012000828A PE20121683A1 PE 20121683 A1 PE20121683 A1 PE 20121683A1 PE 2012000828 A PE2012000828 A PE 2012000828A PE 2012000828 A PE2012000828 A PE 2012000828A PE 20121683 A1 PE20121683 A1 PE 20121683A1
Authority
PE
Peru
Prior art keywords
heterociclo
piperazinil
atoms
inhibitores
alcanona
Prior art date
Application number
PE2012000828A
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English (en)
Inventor
Marco Baroni
Francoise Bono
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PE20121683A1 publication Critical patent/PE20121683A1/es

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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I): DONDE n ES 1 O 2; m ES 0 O 1; A REPRESENTA UN GRUPO HETEROCICLICO CONDENSADO DE FORMULA (Y); B ES H; -W- ES UN HETEROCICLO NITROGENADO TAL COMO (a), ENTRE OTROS; 1-2 REPRESENTA 1 O 2; R2 ES (b), ENTRE OTROS; U COMPLETA ES UN NUCLEO DE 6 ATOMOS, AROMATICO O SATURADO QUE CONTIENE 1 O 2 ATOMOS DE N, OPCIONALMENTE SUSTITUIDO O U COMPLETA ES UN NUCLEO DE 5 ATOMOS, AROMATICO O SATURADO, QUE CONTIENE UN ATOMO DE N, DE OXIGENO, ENTRE OTROS OPCIONALMENTE SUSTITUIDO; X Y X1 ES CH O N; R Y R1 ES H, HALOGENO, ENTRE OTROS; R3 Y R4 SON H O UN GRUPO ALQUILO C1-C6; R5 Y R6 SON INDEPENDIENTEMENTE H, HALOGENO, ALCOXI (C1-C4), ENTRE OTROS. ES COMPUESTO PREFERIDO: 1-(4-BENZO[b]TIOFEN-7-IL-3,6-DIHIDRO-2H-PIRIDIN-1-IL)-2-(3,5-DIMETIL-2,3,5,6-TETRAHIDRO-[1,2´]BIPIRAZINIL-4-IL)-ETANONA; ENTRE OTROS. REFERIDO ADEMAS A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA DIMERIZACION DEL RECEPTOR p75NTR SIENDO UTILES PARA EL TRATAMIENTO DE ESQUIZOFRENIA, EPILEPSIA, DEPRESION, INFARTO DE MIOCARDIO, PANCREATITIS
PE2012000828A 2009-12-14 2010-12-13 DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75 PE20121683A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0906025A FR2953836B1 (fr) 2009-12-14 2009-12-14 Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75

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PE20121683A1 true PE20121683A1 (es) 2012-12-06

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PE2012000828A PE20121683A1 (es) 2009-12-14 2010-12-13 DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75

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EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
IL326597A (en) 2019-10-07 2026-04-01 Contineum Therapeutics Inc Muscarinic acetylcholine m1 receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

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EP2513088A1 (fr) 2012-10-24
CA2784153A1 (fr) 2011-07-07
EA024403B1 (ru) 2016-09-30
DOP2012000146A (es) 2012-07-31
IL220273A (en) 2015-01-29
US20120245150A1 (en) 2012-09-27
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SG181711A1 (en) 2012-07-30
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UY33104A (es) 2011-07-29
WO2011080445A1 (fr) 2011-07-07
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