PE20141185A1 - Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas - Google Patents

Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Info

Publication number
PE20141185A1
PE20141185A1 PE2013002829A PE2013002829A PE20141185A1 PE 20141185 A1 PE20141185 A1 PE 20141185A1 PE 2013002829 A PE2013002829 A PE 2013002829A PE 2013002829 A PE2013002829 A PE 2013002829A PE 20141185 A1 PE20141185 A1 PE 20141185A1
Authority
PE
Peru
Prior art keywords
ophthalmic compositions
new alternative
povidone iodide
alternative preservative
influentic
Prior art date
Application number
PE2013002829A
Other languages
English (en)
Inventor
Joseph A Capriotti
Bo Liang
C Michael Samson
Jason Stein
Michael Weiser
Original Assignee
Foresigth Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41417019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141185(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Foresigth Biotherapeutics Inc filed Critical Foresigth Biotherapeutics Inc
Publication of PE20141185A1 publication Critical patent/PE20141185A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/10—Halogens or compounds thereof
    • A61L12/105—Iodine, iodides or iodophores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA PREPARACION OFTALMICA CONSERVADA QUE COMPRENDE: A) YODURO DE POVIDONA (PVP-I) EN UNA CONCENTRACION SUFICIENTE PARA CONSERVAR DICHA PREPARACION OFTALMICA, B) UN MIEMBRO SELECCIONADO DEL GRUPO QUE CONSISTE DE UN COMPUESTO ANTIINFLAMATORIO ESTEROIDE, UN COMPUESTO ANTIBACTERIAL, UN COMPUESTO ANTIALERGICO, ENTRE OTROS, C) UN AGENTE VISCOSANTE, D) UN LUBRICANTE. DICHA PREPARACION AL CONTENER PVP-I PRESENTA MENOR POTENCIAL DE TOXICIDAD QUE OTRAS PREPARACIONES SIMILARES.
PE2013002829A 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas PE20141185A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12922208P 2008-06-12 2008-06-12
US20185408P 2008-12-15 2008-12-15

Publications (1)

Publication Number Publication Date
PE20141185A1 true PE20141185A1 (es) 2014-09-21

Family

ID=41417019

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010001131A PE20110162A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas
PE2013002829A PE20141185A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2010001131A PE20110162A1 (es) 2008-06-12 2009-06-10 Yoduro de povidona, un nuevo conservante alternativo para composiciones oftalmicas

Country Status (20)

Country Link
US (2) US20120027716A1 (es)
EP (2) EP3777536A1 (es)
JP (4) JP2011522891A (es)
KR (3) KR20160045153A (es)
CN (3) CN102118973A (es)
AU (1) AU2009258145A1 (es)
BR (1) BRPI0913417B1 (es)
CA (2) CA2937997A1 (es)
CL (1) CL2010001406A1 (es)
CO (1) CO6341526A2 (es)
DK (1) DK2291081T3 (es)
EC (1) ECSP11010755A (es)
ES (1) ES2810863T3 (es)
HK (1) HK1202074A1 (es)
MX (3) MX372536B (es)
NZ (3) NZ747878A (es)
PE (2) PE20110162A1 (es)
PL (1) PL2291081T3 (es)
PT (1) PT2291081T (es)
WO (1) WO2009151619A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263345A1 (en) * 2008-01-28 2009-10-22 Foresight Biotherapeutics, Inc. Otic compositions for the treatment of infections of the internal and external ear in mammals
AU2015252097A1 (en) * 2009-12-15 2015-11-19 Foresight Biotherapeutics, Inc. Non-irritating ophthalmic povidone-iodine compositions
AU2010339993A1 (en) * 2009-12-15 2012-07-26 Foresight Biotherapeutics, Inc. Non-irritating ophthalmic povidone-iodine compositions
WO2012073856A1 (ja) * 2010-11-29 2012-06-07 千寿製薬株式会社 ジフルプレドナートおよびトブラマイシンを含有する水中油型エマルジョン組成物
MX341189B (es) * 2011-01-18 2016-08-09 Senju Pharma Co Composicion liquida y acousa de bromfenaco, que tiene efectividad conservadora.
TWI717552B (zh) * 2011-05-12 2021-02-01 美商遠景生物製藥股份有限公司 具有類固醇類或非類固醇抗發炎藥之安定的普維酮－碘（Povidone-Iodine）組合物
TW201808311A (zh) * 2011-09-16 2018-03-16 遠景生物製藥股份有限公司 安定之普維酮-碘組成物
JP6161500B2 (ja) * 2012-10-05 2017-07-12 ロート製薬株式会社 ブロムフェナク含有組成物
WO2014207769A1 (en) 2013-06-27 2014-12-31 Mylan Laboratories Ltd Process for the preparation of nepafenac
DE102014010694A1 (de) 2014-07-09 2016-01-28 Beuth Hochschule Für Technik Berlin Jod enthaltende pharmazeutische Zusammensetzung mit antimikrobiellen Eigenschaften sowie Verfahren zur Herstellung
KR20190032629A (ko) * 2015-01-20 2019-03-27 벨로체 바이오파르마 엘엘씨 신규한 요오드포 조성물 및 사용 방법
ITUA20162425A1 (it) * 2016-04-08 2017-10-08 Medivis S R L Composizione oftalmica che comprende PVP-I
CA3039464C (en) * 2016-10-12 2026-02-17 Ps Therapy, Inc. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
JP6320616B1 (ja) * 2017-08-22 2018-05-09 ヴェローチェ・バイオファーマ・エルエルシー 新規眼科用組成物および使用方法
WO2020028055A1 (en) * 2018-07-31 2020-02-06 ADLER, Benjamin, Aaron Ophthalmic formulations and uses thereof
CA3244189A1 (en) * 2022-01-21 2025-06-13 Senju Usa, Inc. AQUEOUS LIQUID FORMULATION
WO2025027498A1 (en) * 2023-08-03 2025-02-06 Alcon Inc. Multidose preservative-free (mdpf) ophthalmic dose delivery with addition of formulation surfactants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
CA1303503C (en) * 1987-11-10 1992-06-16 Marc Plamondon Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
AU606515B2 (en) * 1988-03-09 1991-02-07 Alcon Laboratories, Inc. Combination of tobramycin and steroids for topical ophthalmic use
US5126127A (en) * 1991-07-16 1992-06-30 Euroceltique, S.A. Stabilized PVP-I solutions
US6328991B1 (en) * 1992-10-21 2001-12-11 John Myhling Composition and method for prevention of sexually transmitted diseases, including aids
US20040214785A1 (en) * 2003-03-10 2004-10-28 Xantech Pharmaceuticals, Inc. Surface sanitizing compositions with improved antimicrobial performance
US20050095205A1 (en) * 2003-10-31 2005-05-05 Ramesh Krishnamoorthy Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
WO2005046700A1 (ja) * 2003-11-14 2005-05-26 Senju Pharmaceutical Co., Ltd. アミノグリコシド系抗生物質およびブロムフェナクを含有する水溶液製剤
US7767217B2 (en) 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20070297990A1 (en) * 2006-06-27 2007-12-27 Shah Mandar V Self-preserving composition

Also Published As

Publication number Publication date
MX2010013670A (es) 2011-06-24
BRPI0913417A2 (pt) 2020-08-04
HK1202074A1 (en) 2015-09-18
EP2291081A1 (en) 2011-03-09
KR20110018414A (ko) 2011-02-23
EP3777536A1 (en) 2021-02-17
JP2011522891A (ja) 2011-08-04
CO6341526A2 (es) 2011-11-21
CA2727605C (en) 2016-10-04
JP2021035984A (ja) 2021-03-04
EP2291081A4 (en) 2013-10-23
JP2019052172A (ja) 2019-04-04
CN104189911A (zh) 2014-12-10
KR20160045153A (ko) 2016-04-26
MX338674B (es) 2016-04-27
NZ747878A (en) 2020-07-31
KR20180014859A (ko) 2018-02-09
BRPI0913417B1 (pt) 2021-06-08
ECSP11010755A (es) 2011-07-29
PT2291081T (pt) 2020-09-10
MX372536B (es) 2020-03-23
CL2010001406A1 (es) 2011-07-08
CA2937997A1 (en) 2009-12-17
WO2009151619A1 (en) 2009-12-17
JP2015129139A (ja) 2015-07-16
US20120027716A1 (en) 2012-02-02
EP2291081B1 (en) 2020-06-03
PE20110162A1 (es) 2011-04-06
ES2810863T3 (es) 2021-03-09
NZ603346A (en) 2014-05-30
AU2009258145A1 (en) 2009-12-17
CN102118973A (zh) 2011-07-06
PL2291081T3 (pl) 2021-01-25
DK2291081T3 (da) 2020-08-10
US20130251666A1 (en) 2013-09-26
CA2727605A1 (en) 2009-12-17
CN105944105A (zh) 2016-09-21
NZ625086A (en) 2015-11-27
JP6527341B2 (ja) 2019-06-05
MX2020003159A (es) 2020-07-29

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