PE20152032A1 - Compuestos de 3,4-dihidroisoquinolin-2(1h)-il - Google Patents
Compuestos de 3,4-dihidroisoquinolin-2(1h)-ilInfo
- Publication number
- PE20152032A1 PE20152032A1 PE2015002534A PE2015002534A PE20152032A1 PE 20152032 A1 PE20152032 A1 PE 20152032A1 PE 2015002534 A PE2015002534 A PE 2015002534A PE 2015002534 A PE2015002534 A PE 2015002534A PE 20152032 A1 PE20152032 A1 PE 20152032A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydroisoquinolin
- compounds
- halogen
- formula
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a ciertos compuestos de 3,4 -dihidroisoquinolin-2(1H)-il, particularmente compuestos de formula I, y composiciones farmaceuticas de los mismos. La invencion ademas proporciona metodos para usar un compuestos de formula I para tratar el deterioro cognitivo asociado con la enfermedad de parkinson o esquizofrenia. Donde n es 0,1 o 2, R1 es halogeno, R2 es halogeno, H, etc. R3 es halogeno, H, etc. El compuestos preferido es: 2-(2,6-diclorofenil)-1-[1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3-4-dihidroisoquinolin-2(1H)-il]etanona
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361828740P | 2013-05-30 | 2013-05-30 | |
| US201361905329P | 2013-11-18 | 2013-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20152032A1 true PE20152032A1 (es) | 2016-01-28 |
Family
ID=50983199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002534A PE20152032A1 (es) | 2013-05-30 | 2014-05-27 | Compuestos de 3,4-dihidroisoquinolin-2(1h)-il |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8962654B2 (es) |
| EP (1) | EP3004061B8 (es) |
| JP (2) | JP6130590B2 (es) |
| KR (1) | KR101808933B1 (es) |
| CN (1) | CN105228985B (es) |
| AP (1) | AP2015008867A0 (es) |
| AU (2) | AU2014274435B2 (es) |
| BR (1) | BR112015029090B1 (es) |
| CA (1) | CA2912849C (es) |
| CL (1) | CL2015003444A1 (es) |
| CR (1) | CR20150622A (es) |
| CY (1) | CY1119361T1 (es) |
| DK (1) | DK3004061T3 (es) |
| DO (1) | DOP2015000289A (es) |
| EA (1) | EA029220B1 (es) |
| ES (1) | ES2647086T3 (es) |
| GT (1) | GT201500334A (es) |
| HR (1) | HRP20171696T1 (es) |
| HU (1) | HUE034607T2 (es) |
| JO (1) | JO3316B1 (es) |
| LT (1) | LT3004061T (es) |
| ME (1) | ME02838B (es) |
| MX (1) | MX373843B (es) |
| MY (1) | MY180751A (es) |
| NZ (1) | NZ713809A (es) |
| PE (1) | PE20152032A1 (es) |
| PH (1) | PH12015502658B1 (es) |
| PL (1) | PL3004061T3 (es) |
| PT (1) | PT3004061T (es) |
| RS (1) | RS56294B1 (es) |
| SG (1) | SG11201509310QA (es) |
| SI (1) | SI3004061T1 (es) |
| TN (1) | TN2015000514A1 (es) |
| TW (2) | TWI691488B (es) |
| UA (1) | UA118759C2 (es) |
| WO (1) | WO2014193781A1 (es) |
| ZA (1) | ZA201508213B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3140959A1 (en) | 2009-11-27 | 2011-06-03 | Genzyme Corporation | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| AR106332A1 (es) * | 2015-10-23 | 2018-01-03 | Lilly Co Eli | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona |
| CN108884050B (zh) * | 2016-04-13 | 2022-07-05 | Ucb生物制药私人有限公司 | 四氢异喹啉衍生物 |
| AU2018225556A1 (en) | 2017-02-21 | 2019-10-03 | Emory University | Chemokine CXCR4 receptor modulators and uses related thereto |
| EP3418270A1 (en) | 2017-06-19 | 2018-12-26 | Universidad Complutense De Madrid | Novel biphenylsulfoximines as allosteric modulators of the dopamine d1 receptor |
| EA202091323A1 (ru) | 2017-12-01 | 2020-10-09 | Юсб Байофарма Срл | Визуализирующие средства |
| TWI725408B (zh) * | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| TWI831896B (zh) * | 2018-12-18 | 2024-02-11 | 美商美國禮來大藥廠 | 用於治療多巴胺性cns病症之ly3154207劑量療法 |
| TWI825323B (zh) * | 2019-06-18 | 2023-12-11 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
| IL289317B2 (en) | 2019-07-01 | 2025-09-01 | UCB Biopharma SRL | Tetrahydroisoquinoline derivative is transformed as a positive allosteric modulator d1 |
| PH12021552825A1 (en) * | 2019-07-01 | 2022-10-03 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
| ES2976784T3 (es) * | 2020-10-07 | 2024-08-08 | Lilly Co Eli | Derivados de fenil-3,4-dihidroisoquinolin-2(1H)-il-etan-1-ona como moduladores alostéricos positivos del receptor de dopamina D1 |
| CA3198635A1 (en) * | 2020-12-03 | 2022-06-09 | UCB Biopharma SRL | Octahydroisoquinolinyl derivatives |
| ES3000719T3 (en) * | 2020-12-18 | 2025-03-03 | UCB Biopharma SRL | Dihydroisoquinolinyl derivatives |
| WO2022129267A1 (en) * | 2020-12-18 | 2022-06-23 | UCB Biopharma SRL | Amorphous solid dispersions |
| JP7798891B2 (ja) * | 2020-12-18 | 2026-01-14 | ユーシービー バイオファルマ エスアールエル | Ｄ１陽性アロステリック調節因子としての置換テトラヒドロイソキノリン誘導体 |
| US20240083925A1 (en) * | 2020-12-18 | 2024-03-14 | UCB Biopharma SRL | Prodrugs of 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone |
| CN117377470A (zh) * | 2021-03-08 | 2024-01-09 | 伊莱利利公司 | 美维达林和其他d1正向别构调节剂在幻觉和痴呆相关精神病的治疗中的用途 |
| EP4304577A1 (en) * | 2021-03-09 | 2024-01-17 | Eli Lilly And Co. | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68910999T2 (de) | 1988-02-19 | 1994-03-24 | Smithkline Beecham Farma | 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten. |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
| US5932590A (en) | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CN1293665A (zh) | 1998-02-18 | 2001-05-02 | 神经研究公司 | 新化合物及其用作阳性ampa受体调节剂 |
| ATE310728T1 (de) | 2000-05-11 | 2005-12-15 | Bristol Myers Squibb Co | Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga |
| US7601739B2 (en) | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
| US7541466B2 (en) | 2003-12-23 | 2009-06-02 | Genzyme Corporation | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases |
| CA2679735A1 (en) * | 2007-03-01 | 2008-09-12 | Janssen Pharmaceutica N.V. | Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor |
| US20120252853A1 (en) * | 2011-04-01 | 2012-10-04 | H. Lundbeck A/S | Positive allosteric modulators of nicotinic acetylcholine receptor |
| TW201331179A (zh) | 2011-12-21 | 2013-08-01 | Actelion Pharmaceuticals Ltd | 雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途 |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
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2014
- 2014-05-15 JO JOP/2014/0163A patent/JO3316B1/ar active
- 2014-05-16 TW TW103117402A patent/TWI691488B/zh active
- 2014-05-16 TW TW108104751A patent/TWI691489B/zh active
- 2014-05-27 MY MYPI2015704341A patent/MY180751A/en unknown
- 2014-05-27 PT PT147327563T patent/PT3004061T/pt unknown
- 2014-05-27 SG SG11201509310QA patent/SG11201509310QA/en unknown
- 2014-05-27 US US14/287,239 patent/US8962654B2/en active Active
- 2014-05-27 RS RS20170896A patent/RS56294B1/sr unknown
- 2014-05-27 MX MX2015016495A patent/MX373843B/es active IP Right Grant
- 2014-05-27 DK DK14732756.3T patent/DK3004061T3/en active
- 2014-05-27 LT LTEP14732756.3T patent/LT3004061T/lt unknown
- 2014-05-27 AP AP2015008867A patent/AP2015008867A0/xx unknown
- 2014-05-27 BR BR112015029090-6A patent/BR112015029090B1/pt active IP Right Grant
- 2014-05-27 KR KR1020157033616A patent/KR101808933B1/ko active Active
- 2014-05-27 PE PE2015002534A patent/PE20152032A1/es unknown
- 2014-05-27 JP JP2016516713A patent/JP6130590B2/ja active Active
- 2014-05-27 UA UAA201511029A patent/UA118759C2/uk unknown
- 2014-05-27 TN TN2015000514A patent/TN2015000514A1/en unknown
- 2014-05-27 NZ NZ71380914A patent/NZ713809A/en unknown
- 2014-05-27 WO PCT/US2014/039494 patent/WO2014193781A1/en not_active Ceased
- 2014-05-27 CA CA2912849A patent/CA2912849C/en active Active
- 2014-05-27 SI SI201430377T patent/SI3004061T1/sl unknown
- 2014-05-27 PL PL14732756T patent/PL3004061T3/pl unknown
- 2014-05-27 EA EA201592082A patent/EA029220B1/ru not_active IP Right Cessation
- 2014-05-27 CN CN201480031030.7A patent/CN105228985B/zh active Active
- 2014-05-27 EP EP14732756.3A patent/EP3004061B8/en active Active
- 2014-05-27 HR HRP20171696TT patent/HRP20171696T1/hr unknown
- 2014-05-27 AU AU2014274435A patent/AU2014274435B2/en active Active
- 2014-05-27 ME MEP-2017-221A patent/ME02838B/me unknown
- 2014-05-27 HU HUE14732756A patent/HUE034607T2/en unknown
- 2014-05-27 ES ES14732756.3T patent/ES2647086T3/es active Active
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2015
- 2015-11-06 ZA ZA2015/08213A patent/ZA201508213B/en unknown
- 2015-11-23 CR CR20150622A patent/CR20150622A/es unknown
- 2015-11-24 CL CL2015003444A patent/CL2015003444A1/es unknown
- 2015-11-26 GT GT201500334A patent/GT201500334A/es unknown
- 2015-11-27 DO DO2015000289A patent/DOP2015000289A/es unknown
- 2015-11-27 PH PH12015502658A patent/PH12015502658B1/en unknown
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2016
- 2016-10-07 AU AU2016238934A patent/AU2016238934B2/en active Active
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2017
- 2017-04-13 JP JP2017079775A patent/JP6387433B2/ja active Active
- 2017-10-05 CY CY20171101039T patent/CY1119361T1/el unknown
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