PE20170120A1 - Compuestos novedosos de pirimidina sustituidos - Google Patents

Compuestos novedosos de pirimidina sustituidos

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Publication number
PE20170120A1
PE20170120A1 PE2017000068A PE2017000068A PE20170120A1 PE 20170120 A1 PE20170120 A1 PE 20170120A1 PE 2017000068 A PE2017000068 A PE 2017000068A PE 2017000068 A PE2017000068 A PE 2017000068A PE 20170120 A1 PE20170120 A1 PE 20170120A1
Authority
PE
Peru
Prior art keywords
pyrimidine compounds
novelty
membered
optionally substituted
compounds replaced
Prior art date
Application number
PE2017000068A
Other languages
English (en)
Inventor
Antonio Nardi
Florian Jakob
Ingo Konetzki
Tobias Craan
Christian Hesslinger
Robin Doodeman
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20170120A1 publication Critical patent/PE20170120A1/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

CLa presente invencion se refiere a compuestos de pirimidina sustituidos de formula (I), donde: A, B y C son CH o N; R1 y R2 son H o (C1-C6)-alquilo opcionalmente sustituido o R1 y R2 junto a N forman un anillo aromatico o no aromatico mono o biciclico de 3 a 12 miembros; R3 y R4 son H, (C1-C6)-alquilo o (C3-C6)-cicloalquilo o R3 y R4 junto a C firman un anillo cicloalquilo de 3 a 6 miembros; L es una union, O, S, entre otros; G es fenilo o heteroarilo de 5 o 6 miembros opcionalmente sustituidos. Tambien se refiere a un proceso de preparacion y una composicion farmaceutica. Dichos compuestos inhiben la enzima fosfodiesterasa 4 (PDE4), siendo utiles en el tratamiento de artritis reumatoide, artritis psoriasica, enfermedades respiratorias entre otras
PE2017000068A 2014-07-16 2015-07-16 Compuestos novedosos de pirimidina sustituidos PE20170120A1 (es)

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EP14002452 2014-07-16

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PE20170120A1 true PE20170120A1 (es) 2017-03-30

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US (2) US9540349B2 (es)
EP (2) EP3169681A1 (es)
JP (1) JP6738795B2 (es)
KR (1) KR20170029614A (es)
CN (1) CN107074812B (es)
AR (1) AR101196A1 (es)
AU (1) AU2015291478B2 (es)
BR (1) BR112017000821A2 (es)
CA (1) CA2955070A1 (es)
CL (1) CL2017000104A1 (es)
CO (1) CO2017001528A2 (es)
EA (1) EA201790207A8 (es)
EC (1) ECSP17010238A (es)
IL (1) IL250022B (es)
MX (1) MX2017000524A (es)
PE (1) PE20170120A1 (es)
TW (1) TW201609707A (es)
WO (1) WO2016008593A1 (es)

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AR101197A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR107099A1 (es) * 2015-12-22 2018-03-21 Gruenenthal Gmbh Compuestos espiro-[indolin heterocicloalcano] como inhibidores de la fosfodiesterasa
AR107004A1 (es) * 2015-12-22 2018-03-07 Gruenenthal Gmbh Compuestos de indolina sustituidas como inhibidores fosfodiesterasa
JP7050054B2 (ja) * 2016-08-22 2022-04-07 メッドシャイン ディスカバリー インコーポレイテッド Ｐｄｅ４阻害剤としての縮合環系化合物
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH Novel substituted 3-indole and 3-indazole compounds as phosphodiesterase inhibitors
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH Novel substituted indole and indazole compounds as phosphodiesterase inhibitors
CN110407741B (zh) * 2018-04-26 2023-03-21 启元生物(杭州)有限公司 一种抗炎化合物及其制备和应用
CN119384420A (zh) * 2022-06-03 2025-01-28 多曼治疗学公司 新型par-2抑制剂

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EP3527561A1 (en) 2019-08-21
US9540349B2 (en) 2017-01-10
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BR112017000821A2 (pt) 2017-12-05
CN107074812A (zh) 2017-08-18
TW201609707A (zh) 2016-03-16
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US20160016937A1 (en) 2016-01-21
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