PE20190177A1 - Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco - Google Patents

Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco

Info

Publication number
PE20190177A1
PE20190177A1 PE2018003192A PE2018003192A PE20190177A1 PE 20190177 A1 PE20190177 A1 PE 20190177A1 PE 2018003192 A PE2018003192 A PE 2018003192A PE 2018003192 A PE2018003192 A PE 2018003192A PE 20190177 A1 PE20190177 A1 PE 20190177A1
Authority
PE
Peru
Prior art keywords
seq
group
acid sequence
amino acid
sequence selected
Prior art date
Application number
PE2018003192A
Other languages
English (en)
Inventor
Lorenzo Benatuil
Milan Bruncko
Debra Chao
Kamel Izeradjene
Andrew S Judd
Andrew C Phillips
Andrew J Souers
Archana Thakur
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20190177A1 publication Critical patent/PE20190177A1/es

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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se refiere a un anticuerpo anti-hB7H3 aislado, en donde el anticuerpo comprende una region variable de cadena pesada que comprende, una CDR3 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 12, 35 y 27; una CDR2 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 140, 34, 11 y 26; y una CDR1 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 10, 25, 33; y una region variable de cadena ligera que comprende una CDR3 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 15, 39 y 31; una CDR2 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 7, 38, 30 y una CDR1 con una secuencia de aminoacidos seleccionada entre el grupo que consiste en la SEQ ID NO: 136, 138, 37, 14 y 29. Tambien se refiere a un conjugado de anticuerpo y un farmaco inhibidor de Bcl-xL tal como acido 6-[8-(1,3-benzotiazol-2-ilcarbamoil)-3,4-dihidroisoquinolin-2(H)-il]-3-[1-({3-[2-({2-[2-(carboximetoxi)etoxi]etil}amino)etoxi]-5,7-dimetiltriciclo[3.3.1.13,7]dec-1-il}metil)-5-metil-1H-pirazol-4-il]piridin-2-carboxilico, entre otros
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CR20180603A (es) 2019-07-29
SI3458479T1 (sl) 2021-08-31
RU2764651C2 (ru) 2022-01-19
UY37278A (es) 2018-01-31
CY1123783T1 (el) 2022-05-27
ZA201900059B (en) 2022-11-30
AU2017279550A1 (en) 2019-01-03
DK3458479T3 (da) 2021-02-08
US10640563B2 (en) 2020-05-05
CN109963870A (zh) 2019-07-02
JP2019528240A (ja) 2019-10-10
RU2018146948A3 (es) 2021-06-17
RU2018146948A (ru) 2020-07-14
TW201809003A (zh) 2018-03-16
EP3458479B1 (en) 2020-11-04
CA3027045A1 (en) 2017-12-14
CN116284404A (zh) 2023-06-23
TWI762487B (zh) 2022-05-01
SG11201811193TA (en) 2019-01-30
CO2018013471A2 (es) 2018-12-28
IL263600B1 (en) 2023-03-01

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