PE20190574A1 - Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno - Google Patents

Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno

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Publication number
PE20190574A1
PE20190574A1 PE2019000439A PE2019000439A PE20190574A1 PE 20190574 A1 PE20190574 A1 PE 20190574A1 PE 2019000439 A PE2019000439 A PE 2019000439A PE 2019000439 A PE2019000439 A PE 2019000439A PE 20190574 A1 PE20190574 A1 PE 20190574A1
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PE
Peru
Prior art keywords
modified
amino acid
methods
polypeptide
compositions
Prior art date
Application number
PE2019000439A
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English (en)
Inventor
James David Joseph
Jeffrey H Hager
John Lee Sensintaffar
Nhin Lu
Jing Qian
Nicholas D Smith
Original Assignee
Aragon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Aragon Pharmaceuticals Inc filed Critical Aragon Pharmaceuticals Inc
Publication of PE20190574A1 publication Critical patent/PE20190574A1/es

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Abstract

Referida a una proteina de fusion que comprende un polipeptido del receptor de androgeno (AR) que comprende al menos 95% de identidad de secuencia con un dominio de union a ligando que tiene la secuencia de aminoacidos de las posiciones de aminoacidos 554 a 919 en SEQ ID NO: 1 y que comprende una sustitucion de aminoacido F876L en SEQ ID NO: 1, en la que dicho polipeptido AR se fusiona con un polipeptido heterologo, una secuencia de senal de secrecion, una etiqueta de epitopo o una etiqueta de afinidad. Asimismo, se refiere a moleculas de ADNc que codifican el AR modificado, un vector, celula huesped, un microchip, un sistema para detectar un AR modificado, asi como tambien metodos de uso del AR modificado para el tratamiento de enfermedades o condiciones, lo que incluye a los canceres, tales como los canceres de prostata resistentes a la castracion, que son mediados o dependientes de los receptores de androgeno
PE2019000439A 2012-07-27 2013-07-26 Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno PE20190574A1 (es)

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US201261676842P 2012-07-27 2012-07-27
US201361783763P 2013-03-14 2013-03-14
US201361829123P 2013-05-30 2013-05-30

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PE2019001034A PE20190845A1 (es) 2012-07-27 2013-07-26 Metodos para determinar resistencia a terapia de receptor de androgeno
PE2019000439A PE20190574A1 (es) 2012-07-27 2013-07-26 Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno

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