PE20250453A1 - Piridazinonas y sus metodos de uso - Google Patents

Piridazinonas y sus metodos de uso

Info

Publication number
PE20250453A1
PE20250453A1 PE2024003155A PE2024003155A PE20250453A1 PE 20250453 A1 PE20250453 A1 PE 20250453A1 PE 2024003155 A PE2024003155 A PE 2024003155A PE 2024003155 A PE2024003155 A PE 2024003155A PE 20250453 A1 PE20250453 A1 PE 20250453A1
Authority
PE
Peru
Prior art keywords
compound
prodrug
pharmaceutically acceptable
pyridazinones
methods
Prior art date
Application number
PE2024003155A
Other languages
English (en)
Inventor
Mark W Ledeboer
Matthew H Daniels
Maolin Yu
Jean-Christophe P Harmange
Original Assignee
Goldfinch Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goldfinch Bio Inc filed Critical Goldfinch Bio Inc
Publication of PE20250453A1 publication Critical patent/PE20250453A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona un procedimiento para preparar el Compuesto 100. Este procedimiento comprende el hacer reaccionar el Compuesto 100-3 con el Compuesto 100-2 para producir el Compuesto 100-1 en presencia de N,N-diisopropiletilamina (DIEA). Posteriormente, se desprotege el Compuesto 100-1 con acido trifluoroacetico (TFA) en presencia de diclorometano (DCM) para producir el Compuesto 100. Tambien se reivindica el profarmaco del Compuesto 100 o una sal farmaceuticamente aceptable del mismo, y una composicion farmaceutica que comprende dicho profarmaco y un vehiculo farmaceuticamente aceptable.
PE2024003155A 2018-09-18 2019-09-18 Piridazinonas y sus metodos de uso PE20250453A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862732728P 2018-09-18 2018-09-18
US201862780553P 2018-12-17 2018-12-17
PCT/US2019/051680 WO2020061162A1 (en) 2018-09-18 2019-09-18 Pyridazinones and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20250453A1 true PE20250453A1 (es) 2025-02-19

Family

ID=69887813

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2021000320A PE20211774A1 (es) 2018-09-18 2019-09-18 Piridazinonas y sus metodos de uso
PE2024003155A PE20250453A1 (es) 2018-09-18 2019-09-18 Piridazinonas y sus metodos de uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2021000320A PE20211774A1 (es) 2018-09-18 2019-09-18 Piridazinonas y sus metodos de uso

Country Status (35)

Country Link
US (3) US10654850B2 (es)
EP (2) EP3852533B8 (es)
JP (2) JP7474243B2 (es)
KR (2) KR102890905B1 (es)
CN (1) CN112911935A (es)
AU (2) AU2019344928B2 (es)
BR (1) BR112021004926A2 (es)
CA (1) CA3113236A1 (es)
CL (1) CL2021000648A1 (es)
CO (1) CO2021004789A2 (es)
DK (1) DK3852533T3 (es)
EC (1) ECSP21026485A (es)
ES (1) ES2982498T3 (es)
FI (1) FI3852533T3 (es)
HR (1) HRP20240707T1 (es)
HU (1) HUE067188T2 (es)
IL (1) IL281438B2 (es)
LT (1) LT3852533T (es)
MA (1) MA71645A (es)
MD (1) MD3852533T2 (es)
MX (1) MX2021003152A (es)
MY (1) MY208106A (es)
PE (2) PE20211774A1 (es)
PH (1) PH12021550443A1 (es)
PL (1) PL3852533T3 (es)
PT (1) PT3852533T (es)
PY (1) PY1977703A (es)
RS (1) RS65558B1 (es)
SG (1) SG11202102053VA (es)
SI (1) SI3852533T1 (es)
SM (1) SMT202400201T1 (es)
TW (2) TWI894724B (es)
UA (1) UA128841C2 (es)
UY (1) UY38377A (es)
WO (1) WO2020061162A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018334290A1 (en) 2017-09-18 2020-04-02 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof
IL281438B2 (en) 2018-09-18 2023-12-01 Goldfinch Bio Inc Pyridazinones and methods of use thereof
IL286481B2 (en) * 2019-03-20 2025-12-01 Goldfinch Bio Inc Pyridazinones and methods of use thereof
WO2020206623A1 (en) * 2019-04-10 2020-10-15 Goldfinch Bio, Inc. Crystal forms
MX2021012310A (es) 2019-04-11 2021-11-12 Goldfinch Bio Inc Formulación de secado por aspersión de un inhibidor de trpc5 de piridazinona.
MX2022004049A (es) * 2019-10-04 2022-07-11 Goldfinch Bio Inc Tratamiento basado en biomarcadores de la glomeruloesclerosis focal y segmentaria y de la enfermedad renal diabetica.
TWI782504B (zh) * 2020-05-08 2022-11-01 美商美國禮來大藥廠 (三氟甲基)嘧啶-2-胺化合物
WO2022006278A1 (en) * 2020-07-01 2022-01-06 Angion Biomedica Corp. Reducing fibrosis and treating related diseases, disorders, and conditions
IL299623A (en) * 2020-07-03 2023-03-01 Wuhan Ll Science & Technology Development Co Ltd Heterocyclic compound and its use
EP4289846A4 (en) * 2021-02-07 2025-01-22 Wuhan LL Science and Technology Development Co., Ltd. HETEROCYCLIC COMPOUND, AND ITS INTERMEDIATE, PROCESS FOR THEIR PREPARATION AND THEIR USE
CN117940417A (zh) * 2021-09-10 2024-04-26 南京明德新药研发有限公司 卤素取代的哒嗪酮类化合物及其应用
WO2025250920A1 (en) 2024-05-31 2025-12-04 Gfb (Abc), Llc Pyridazinone phosphate compounds, pharmaceutical compositions, and medical uses thereof

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UA77526C2 (en) 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
JP2007524673A (ja) 2004-01-23 2007-08-30 アムジエン・インコーポレーテツド バニロイド受容体リガンドと治療におけるその使用
WO2005072308A2 (en) 2004-01-29 2005-08-11 Merck & Co., Inc. Cgrp receptor antagonists
DE102004044231A1 (de) 2004-09-14 2006-03-16 Henkel Kgaa Mittel zum Färben von keratinhaltigen Fasern
BRPI0517418A (pt) 2004-10-13 2008-10-07 Merck & Co Inc composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça
MX2009000884A (es) 2006-07-25 2009-06-05 Cephalon Inc Derivados de piridizinona.
JP2010521463A (ja) 2007-03-15 2010-06-24 シェーリング コーポレイション グルカンシンターゼの阻害剤として有用なピペラジン置換ビリダジノン誘導体
CA2699631A1 (en) * 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Pyridazinone compounds and p2x7 receptor inhibitors
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WO2013185284A1 (en) * 2012-06-12 2013-12-19 Abbott Laboratories Pyridinone and pyridazinone derivatives
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
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AU2018334290A1 (en) 2017-09-18 2020-04-02 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
IL281438B2 (en) * 2018-09-18 2023-12-01 Goldfinch Bio Inc Pyridazinones and methods of use thereof
IL286481B2 (en) * 2019-03-20 2025-12-01 Goldfinch Bio Inc Pyridazinones and methods of use thereof
WO2020206623A1 (en) * 2019-04-10 2020-10-15 Goldfinch Bio, Inc. Crystal forms
MX2021012310A (es) * 2019-04-11 2021-11-12 Goldfinch Bio Inc Formulación de secado por aspersión de un inhibidor de trpc5 de piridazinona.
MX2022004049A (es) * 2019-10-04 2022-07-11 Goldfinch Bio Inc Tratamiento basado en biomarcadores de la glomeruloesclerosis focal y segmentaria y de la enfermedad renal diabetica.

Also Published As

Publication number Publication date
MA71645A (fr) 2025-05-30
CN112911935A (zh) 2021-06-04
MX2021003152A (es) 2021-06-23
JP2024099595A (ja) 2024-07-25
JP7474243B2 (ja) 2024-04-24
HRP20240707T1 (hr) 2024-10-11
MY208106A (en) 2025-04-15
JP2022500359A (ja) 2022-01-04
SG11202102053VA (en) 2021-04-29
TW202430524A (zh) 2024-08-01
TWI894724B (zh) 2025-08-21
UA128841C2 (uk) 2024-11-06
EP3852533A4 (en) 2022-06-15
EP3852533A1 (en) 2021-07-28
PY1977703A (es) 2020-06-19
ECSP21026485A (es) 2021-07-30
MD3852533T2 (ro) 2024-08-31
SMT202400201T1 (it) 2024-07-09
AU2019344928A1 (en) 2021-04-29
US20200102301A1 (en) 2020-04-02
TWI828758B (zh) 2024-01-11
RS65558B1 (sr) 2024-06-28
US20220024917A1 (en) 2022-01-27
AU2025238155A1 (en) 2025-10-23
US20200283437A1 (en) 2020-09-10
AU2019344928B2 (en) 2025-07-03
LT3852533T (lt) 2024-06-10
CO2021004789A2 (es) 2021-07-30
US10654850B2 (en) 2020-05-19
US11046690B2 (en) 2021-06-29
TW202035402A (zh) 2020-10-01
IL281438B1 (en) 2023-08-01
IL281438B2 (en) 2023-12-01
WO2020061162A1 (en) 2020-03-26
CL2021000648A1 (es) 2021-08-06
IL281438A (en) 2021-04-29
EP3852533B8 (en) 2024-07-17
KR20210069652A (ko) 2021-06-11
BR112021004926A2 (pt) 2021-06-01
EP3852533B1 (en) 2024-02-28
KR20250171415A (ko) 2025-12-08
CA3113236A1 (en) 2020-03-26
PT3852533T (pt) 2024-05-31
DK3852533T3 (da) 2024-05-27
FI3852533T3 (fi) 2024-05-24
KR102890905B1 (ko) 2025-11-24
PE20211774A1 (es) 2021-09-08
SI3852533T1 (sl) 2024-10-30
UY38377A (es) 2020-04-30
EP4414365A1 (en) 2024-08-14
PH12021550443A1 (en) 2021-12-06
HUE067188T2 (hu) 2024-10-28
PL3852533T3 (pl) 2024-09-16
ES2982498T3 (es) 2024-10-16

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